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A Novel Method for Forecasting Freak Wave Occurrence in A Short Crested Coastal Sea

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China Ocean Engineering 2024年第1期38卷 104-116页

作者： wang ying-guang State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Ocean and Civil Engineering Shanghai Jiao Tong UniversityShanghai 200240China

In order to forecast the distribution of crest amplitudes and the occurrence of freak waves in a short crested coastal sea,a novel transformed linear simulation method is initially proposed in this paper.A Hermite transformation model expressed as a monotonic cubic polynomial serves as the foundation for the novel simulation *** wave crest amplitude exceedance probabilities of two sea states-one with a directional wave spectrum based on the measured wave elevation data at the Yura coast and the other with a typical directional JONSWAP wave spectrum-have been predicted using the novel simulation method that has been *** likelihood that a particular critical wave crest amplitude will be exceeded is directly correlated with the probability that freak waves will *** is shown that the novel simulation approach suggested can provide predictions that are more precise than those obtained from the Rayleigh crest amplitude distribution model,the Jahns and Wheeler crest amplitude distribution model,or the conventional linear simulation *** study also demonstrated that the nonlinear simulation method is less effective than the novel simulation method in terms of efficiency.

关键词： wave crest amplitude freak waves short crested sea transformed linear simulation

Optimizing FeCoNiCrTi high-entropy alloy with hydrogen pumping effect to boost de/hydrogenation performance of magnesium hydride

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Rare Metals 2024年第7期43卷 3273-3285页

作者： Meng-Chen Song Fu-ying Wu Yi-qun Jiang Xiu-Zhen wang Hu Zhao Li-Xin Chen Liu-Ting Zhang School of Energy and Power Instrumental Analysis CenterJiangsu University of Science and Technology Max Planck Institute for Iron Research School of Mechanical and Aerospace Engineering Nanyang Technological University State Key Laboratory of Silicon Materials Department of Materials Science and EngineeringZhejiang University

The exploration of efficient,long-lived and cost-effective transition metal catalysts is highly desirable for the practical hydrogen storage of magnesium hydride（MgH2） in sustainable energy ***,FeCoNiCrTi high-entropy alloy（HEA） nanosheets were prepared via a facile wet chemical ball milling strategy and they were introduced into MgH2to boost the hydrogen storage *** refined HEA exhibited superior catalytic activity on *** contrast to additive-free MgH2,the initial desorption temperature of the constructed MgH2-HEA composite was reduced from 330.0 to 198.5℃ and a remarkable 51% reduction in the dehydrogenation activation energy was ***,the MgH2-HEA composite only required one-twentieth time of that consumed by pure MgH2to absorb 5.0 wt% of H2at 225℃.The synergy between the "hydrogen pumping" effect of Mg2Ni/Mg2NiH4and Mg2Co/Mg2CoH5couples,as well as the good dispersion of Fe,Cr and Ti on the surface of MgH2contributed to the enhanced de/hydrogenation performance of the MgH2-HEA *** study furnishes important steering for the design and fabrication of multiple transition metal catalysts and may push the commercial application of magnesium-based hydrides one step forward.

关键词： Hydrogen storage Magnesium hydride High-entropy alloys Catalysis

The current situation of semen analysis in China,based on a survey of 296 laboratories

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Asian Journal of Andrology 2024年第2期26卷 220-221页

作者： Long-Long Fu ying Liu Xiao-Wei wang Fang Zhou ying Guo Wen-Hong Lu Yi-qun Gu National Health Commission Key Laboratory of Male Reproductive Health Reproductive Health Research CenterNational Research Institute for Family PlanningBeijing 100081China Institute of Pediatric Research Children's Hospitalof Soochow UniversitySuzhou 215025China

Dear Editor,Semen analysis is a basic test to assess male fertility and is a fundamental test in assisted reproductive *** the first publication of World Health Organization(WHO)Laboratory Manual of Human Semen and Sperm-Cervical Mucus Interaction in 1980,to the publication of the WHO Manual,6th edition in 2021,these 40 years have been recognized as providing a global standard that is widely used in research and clinical laboratories *** WHO Manual,6th edition in Chinese,which we have been authorized by the WHO to translate,will be published soon.

关键词： technology. analysis translate

Procyanidin A_1 and its digestive products alleviate acrylamide-induced IPEC-J2 cell damage through regulating Keap1/Nrf2 pathway

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Food Science and Human Wellness 2024年第3期13卷 1475-1484页

作者： Fangfang Yan qun Lu Chengming wang Rui Liu College of Food Science and Technology Huazhong Agricultural UniversityWuhan 430070China Key Laboratory of Environment Correlative Dietology(Huazhong Agricultural University) Ministry of EducationWuhan 430070China Key Laboratory of Urban Agriculture in Central China Ministry of Agriculture and Rural AffairsWuhan 430070China

Our previous study has revealed that procyanidin A_(1)(A_(1))and its simulated digestive product(D-A,)can alleviate acrylamide(ACR)-induced intestine cell ***,the underlying mechanism remains *** this study,we elucidated the molecular mechanism for and D-A_(1) to alleviate ACR-stimulated IPEC-J2 cell *** slightly activated nuclear factor erythroid 2-related factor 2(Nrf2)signaling and its target genes,but this activation could not reduce intestine cell damage.A_(1) and D-A_(1) could alleviate ACR-induced cell damage,but the effect was abrogated in cells transiently transfected with Nrf2 small interfering RNA(siRNA).Further investigation confirmed that A_(1) and D-A_(1) interacted with Ketch-like ECH-associated protein 1(Keapl),which boosted the stabilization of Nrf2,subsequently promoted the translocation of Nrf2 into the nucleus,and further increased the expression of antioxidant proteins,thereby inhibiting glutathione(GSH)consumption,maintaining redox balance and eventually alleviating ACR-induced cell ***,there was no difference between A_(1) and D-A_(1) treated groups,indicating that A_(1) can tolerate gastrointestinal digestion and may be a potential compound to limit the toxicity of ACR.

关键词： Procyanidin A_1 Digestive products Acrylamide Nuclear factor erythroid 2-related factor 2(Nrf2) Intestinal cell damage

SCREEN:predicting single-cell gene expression perturbation responses via optimal transport

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Frontiers of Computer Science 2024年第3期18卷 255-257页

作者： Haixin wang Yunhan wang qun JIANG Yan ZHANG Shengquan CHEN Cadre Medical Department The 1st Clinical CenterChinese PLA General HospitalBeijing 100853China School of Statistics Renmin University of ChinaBeijing 100872China Ministry of Education Key Laboratory of Bioinformatics Bioinformatics Division of BNRISTDepartment of AutomationTsinghua UniversityBeijing 100084China School of Mathematical Sciences and LPMC Nankai UniversityTianjin 300071China

1 Introduction Recent advances in single-cell RNA sequencing(scRNA-seq)have enabled the study of how individual cells respond to various external perturbations such as drug stimulation at gene expression level[1].Precisely inferring perturbation responses allows us to explore how and why individual tumor cells evade cancer treatment,greatly advancing personalized medicine research and deepening our understanding of biological mechanisms[2].However,considering the high costs of sequencing and the complexity of obtaining perturbed samples,utilizing computational methods to predict cellular responses to perturbations holds great potential[2].

关键词： stimulation perturbation deepening

Tissue optical clearing enhances efficacy of vascular targeted photodynamic therapy of mouse dorsal skin

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 67-78页

作者： ying Liu Qiushi wang Yidi Liu ying wang Haixia Qiu Dan Zhu ying Gu Defu Chen School of Optics and Photonics Beijing Institute of TechnologyBeijing 100081P.R.China School of Medical Technology Beijing Institute of TechnologyBeijing 100081P.R.China Department of Laser Medicine First Medical Center of PLA General HospitalBeijing 100853P.R.China Britton Chance Center for Biomedical Photonics-MoE Key Laboratory for Biomedical Photonics A duanced Biomedical Imaging FacilityWuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074HubeiP.R.China Precision Laser Medical Diagnosis and Treatment Innovation Unit Chinese A cademy of Medical SciencesBeijing 100000P.R.China

Vascular-targeted photodynamic therapy(V-PDT)is an effective treatment for port wine stains(PWS).However,repeated treatment is usually needed to achieve optimal treatment outcomes,possibly due to the limited treatment light penetration depth in the PWS *** optical clearing technique can increase light penetration in depth by reducing light *** study aimed to investigate the V-PDT in combination with an optical clearing agent(OCA)for the therapeutic enhancement of V-PDT in the rodent skinfold window chamber *** responses were closely monitored with laser speckle contrast imaging(LSCI),optical coherence tomography angiography,and stereo microscope before,during,and after the *** further quantitatively demonstrated the effects of V-PDT in combination with OCA on the blood flow and blood vessel size of skin *** combination of OCA and V-PDT resulted in significant vascular damage,including vasoconstriction and the reduction of blood *** results indicate the promising potential of OCA for enhancing V-PDT for treating vascular-related diseases,including PWS.

关键词： Vascular-targeted photodynamic therapy(V-PDT) optical clearing agent(OCA) treatment efficacy enhancement skin-fold window chamber port wine stains

Surface modification by ligand growth strategy for dense copper bismuth film as photocathode to enhance hydrogen production activity

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Frontiers in Energy 2024年第1期18卷 89-100页

作者： Zhouzhou wang Qingwei WU Jieming wang ying YU Institute of Nanoscience and Nanotechnology College of Physical Science and TechnologyCentral China Normal UniversityWuhan 430079China

Hydrogen production from photoelectrochemical(PEC)water splitting has been regarded as a promising way to utilize renewable and endless solar ***,semiconductor film grown on photoelectrode suffers from numerous challenges,leading to the poor PEC ***,a straightforward sol-gel method with the ligand-induced growth strategy was employed to obtain dense and homogeneous copper bismuthate photocathodes for PEC hydrogen evolution *** various characterizations,it was found that the nucleation and surface growth of CuBi_(2)O_(4)layer induced by 2-methoxyethanol ligand(2-CuBi_(2)O_(4))demonstrated a decent crystallinity and coverage,as well as a large grain size and a low oxygen vacancy concentration,leading to the good ability of light absorption and carrier ***,under simulated sunlight irradiation(AM1.5G,100 mW/cm^(2)),the 2-CuBi_(2)O_(4)photocathode achieved an enhanced photocurrent density of−1.34 mA·cm^(−2)at 0.4 V versus the reversible hydrogen electrode and a promising applied bias photon-to-current efficiency of 0.586%.This surface modification by ligand growth strategy will shed light on the future design of advanced photoelectrodes for PEC water splitting.

关键词： copper bismuthate photocathode ligand growth strategy dense film PEC

Theoretical insights of the pharmaceutical compound fluoxetine in water:Role in direct photolysis and indirect photolysis by free radicals

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Journal of Environmental Sciences 2024年第8期142卷 269-278页

作者： ying Lu Se wang Yifan Shen School of Environmental Science and Engineering Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologyJiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution ControlNanjing University of Information Science and TechnologyNanjing 210044China

The frequent detection of pharmaceutical compounds in the environment has led to a growing awareness,which may pose a major threat to the aquatic *** this study,photodegradation(direct and indirect photolysis)of two different dissociation states of fluoxetine(FLU)was investigated in water,mainly including the determination of photolytic transition states and products,and the mechanisms of indirect photodegradation with·OH,CO_(3)^(*-)and NO_(3)^(*).The main direct photolysis pathways are defluorination and C–C bond *** addition,the indirect photodegradation of FLU in water is mainly through the reactions with·OH and NO_(3)^(*),and the photodegradation reaction with CO_(3)^(*-)is relatively difficult to occur in the water *** results provide a theoretical basis for understanding the phototransformation process of FLU in the water environment and assessing its potential risk.

关键词： Fluoxetine Photochemical mechanism Direct photolysis Free radical reaction DFT

Parallel intelligent education with ChatGPT

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Frontiers of Information Technology & Electronic Engineering 2024年第1期25卷 12-18页

作者： Jiacun wang ying TANG Ryan HARE Fei-Yue wang Department of Computer Science and Software Engineering Monmouth UniversityNew Jersey 07764USA Department of Electrical and Computer Engineering Rowan UniversityNew Jersey 08028USA Institute of Automation Chinese Academy of SciencesBeijing 100190China

This paper presents a framework for parallel intelligent education that involves physical and virtual learning for a personalized learning *** especially focus on Chat Generative Pre-trained Transformer(ChatGPT)owing to its considerable potential to supplement regular class *** address the strengths and weaknesses of learning with ***,we discuss the challenges and solutions of the proposed parallel intelligent education with ChatGPT.

关键词： education GPT intelligent