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Anti-hepatoma effect of arsenic trioxide on experimental liver cancer induced by 2-acetamidofluorene in rats

World Journal of Gastroenterology 2005年第38期11卷 5938-5943页

作者： Bing Tan jie-Fei Huang qun Wei Hong zhang Run-Zhou Ni Department of Digestive Medicine Affiliated Hospital of Nantong Medical College Nantong 226001 Jiangsu Province China

AIM： To study the anti-hepatoma efficiency of arsenic trioxide （As2O3） in the treatment of experimental rat hepatocellular carcinoma （HCC） induced by 2-acetamidofluorene （2-FAA） and to elucidate the possible mechanisms. METHODS： SD rats （2 mo old） had been fed with 2-FAA for 8 wk to induce HCC, and then they were treated with As2O3 or matrine. On d 29, the rats were killed and the liver was weighed and liver tumors were counted. The histological changes of liver tissue were observed under microscope, and the cellular dynamic parameters were studied by flow cytometry. Immunohistochemistry （two-step method） was used to observe the expression of vascular endothelial growth factor （VEGF） and micro-vessel density （MVD） on consecutive sections. The pathological parameters were also analyzed, the levels of serum aspartate aminotransferase （AST）, alanine aminotransferase （ALT）, total bilirubin （TBi）, and direct bilirubin （DBi）. RESULTS： The number of liver tumors decreased significantly in groups treated with As2O3, especially in medium-dose （1 mg/kg） group （t = 2.80, P〈0.01）. As2O3 caused HCC cell death via apoptosis; necrosis was seen and apoptosis was common when the dose was 1 mg/kg. Proliferation index decreased sharply in medium-dose （1 mg/kg） group （7.87±4.11 vs24.46±6.49, t= 2087, P〈0.01）, but not in 0.2 mg/kg group. However, S-phase fraction decreased dramatically in both groups, it reached the bottom level only when the dose was i mg/kg compared with control （0.40±0.13 vs3.01±0.51, t= 2.97, P〈0.01）, and it was obviously accompanied with accumulation of cells in G0/G1 （G0/G1 restriction）. The expressions of VEGF and MVD in medium-dose （1 mg/kg） group were significantly lower than normal saline group （0.63±0.74 vs2.44±0.88, P〈0.05; 15.75±3.99 vs47.44±13.41, t= 2.80, P〈0.01）. Compared with normal saline group, mediumand low-dose groups As203 and matrine lowered the levels of ALT in serum （61.46±9.46, 63.75±20.40, 61.18±13.00 vs 108.98±29.86, t= 2.14, P〈0.05）, but

关键词： Arsenic trioxide Liver cancer Cell proliferation

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Probing the ultrafast dynamics in nanomaterial complex systems by femtosecond transient absorption spectroscopy

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High Power Laser Science and Engineering 2016年第3期4卷 13-22页

作者： qun zhang Yi Luo Hefei National Laboratory for Physical Sciences at the Microscale Department of Chemical Physics and Synergetic Innovation Center of Quantum Information & Quantum Physics University of Science and Technology of China

Over the past decade the integration of ultrafast spectroscopy with nanoscience has greatly propelled the development of nanoscience, as the key information gleaned from the mechanistic studies with the assistance of ultrafast spectroscopy enables a deeper understanding of the structure–function interplay and various interactions involved in the *** mini-review presents an overview of the recent advances achieved in our ultrafast spectroscopy laboratory that address the ultrafast dynamics and related mechanisms in several representative nanomaterial complex systems by means of femtosecond time-resolved transient absorption spectroscopy. We attempt to convey instructive, consistent information regarding the important processes, pathways, dynamics, and interactions involved in the nanomaterial complex systems,most of which exhibit excellent performance in photocatalysis.

关键词： nanomaterials time-resolved femtosecond pump-probe transient absorption spectroscopy ultrafast dynamics

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Multipartite Entanglement in Heisenberg Model

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Communications in Theoretical Physics 2008年第6期49卷 1449-1452页

作者： REN jie ZHU Shi-qun School of Physical Science and Technology Suzhou University Suzhou 215006 China

The effects of anisotropy and magnetic field on multipartite entanglement of ground state in Heisenberg XY model are investigated. The multipartite entanglement increases as a function of the inverse strength of the external field when the degree of anisotropy is finite. There are two peaks when the degree of anisotropy is γ=±1. When the degree of anisotropy increases further, the multipartite entanglement will decrease and tend to a constant. The threshold of the inverse strength of the external field for generating multipartite entanglement generally decreases with the increasing of qubits.

关键词： multipartite entanglement ground state Heisenberg model

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Attack-Induced Entanglement of Noninteracting Fermi Gas

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Communications in Theoretical Physics 2008年第6期49卷 1439-1442页

作者： REN jie ZHU Shi-qun School of Physical Science and Technology Suzhou University Suzhou 215006 China

The bipartite entanglement in Fermi gas without interaction is investigated when there ace three fermions in the system. The negativity and the yon Neumann entropy are employed to measure the entanglement of the system. The position of the third fermion can affect the entanglement between the first and the second fermions. The entanglement can be enhanced or suppressed when the third fermion changes its position. When the two fermions are at the same position or when their distance is more than 2.0/kF, the third fermion cannot affect them.

关键词： Fermi gas entanglement entropy

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Severe Type of COVID-19:Pathogenesis,Warning Indicators and Treatment

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Chinese Journal of Integrative Medicine 2022年第1期28卷 3-11页

作者： SHI Ke LIU Yao zhang qun RAN Chong-ping HOU jie zhang Yi WANG Xian-bo Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing(100015)China Department of Gastroenterology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing(100007)China

Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2,is a major public health *** epidemic is unlikely to be contained until the global launch of safe and effective vaccines that could prevent serious illnesses and provide herd *** most patients have mild flu-like symptoms,some develop severe illnesses accompanied by multiple organ *** identification of pathophysiology and early warning biomarkers of a severe type of COVID-19 contribute to the treatment and prevention of serious ***,we review the pathophysiology,early warning indicators,and effective treatment of Chinese and Western Medicine for patients with a severe type of COVID-19.

关键词： coronavirus disease 2019 pathogenesis indicators treatment Chinese medicine

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Regulation of developmental and environmental signaling by interaction between microtubules and membranes in plant cells

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Protein & Cell 2016年第2期7卷 81-88页

作者： qun zhang Wenhua zhang College of Life Sciences State Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing AgriculturalUniversity Nanjing 210095 China

Cell division and expansion require the ordered arrangement of microtubules, which are subject to spatial and temporal modifications by developmental and environmental factors. Understanding how signals translate to changes in cortical microtubule organization is of fundamental importance. A defining feature of the cortical microtubule array is its association with the plasma membrane; modules of the plasma membrane are thought to play important roles in the mediation of microtubule organization. In this review, we highlight advances in research on the regulation of cortical microtubule organization by membrane-associated and membrane-tethered proteins and lipids in response to phytohormones and stress. The transmembrane kinase receptor Rho-like guanosine triphosphatase, phospholipase D, phosphatidic acid, and phosphoinositides are discussed with a focus on their roles in microtubule organization.

关键词： abiotic stresses cortical microtubule,lipids plasma membrane

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Ideal Spin Hydrodynamics from the Wigner Function Approach

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Chinese Physics Letters 2021年第11期38卷 37-43页

作者： Hao-Hao Peng Jun-jie zhang Xin-Li Sheng qun Wang Interdisciplinary Center for Theoretical Study and Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Peng Huanwu Center for Fundamental Theory Hefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China Key Laboratory of Quark and Lepton Physics(MOE) and Institute of Particle Physics Central China Normal UniversityWuhan 430079China

Based on the Wigner function in local equilibrium, we derive hydrodynamical quantities for a system of polarized spin-1/2 particles: the particle number current density, the energy-momentum tensor, the spin tensor, and the dipole moment tensor. Compared with ideal hydrodynamics without spin, additional terms at the first and second orders in the Knudsen number Κ_(n) and the average spin polarization Χ_(s) have been derived. The Wigner function can be expressed in terms of matrix-valued distributions, whose equilibrium forms are characterized by thermodynamical parameters in quantum statistics. The equations of motion for these parameters are derived by conservation laws at the leading and next-to-leading order Κ_(n) and Χ_(s).

关键词： frame Ideal Spin Hydrodynamics from the Wigner Function Approach

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An enriched environment promotes synaptic plasticity and cognitive recovery after permanent middle cerebral artery occlusion in mice

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Neural Regeneration Research 2019年第3期14卷 462-469页

作者： Chuan-jie Wang Yi Wu qun zhang Ke-Wei Yu Yu-Yang Wang Department of Rehabilitation Medicine Huashan Hospital Fudan University

Cerebral ischemia activates an endogenous repair program that induces plastic changes in neurons. In this study, we investigated the effects of environmental enrichment on spatial learning and memory as well as on synaptic remodeling in a mouse model of chronic cerebral ischemia, produced by subjecting adult male C57 BL/6 mice to permanent left middle cerebral artery occlusion. Three days postoperatively, mice were randomly assigned to the environmental enrichment and standard housing groups. Mice in the standard housing group were housed and fed a standard diet. Mice in the environmental enrichment group were housed in a cage with various toys and fed a standard diet. Then, 28 days postoperatively, spatial learning and memory were tested using the Morris water maze. The expression levels of growth-associated protein 43, synaptophysin and postsynaptic density protein 95 in the hippocampus were analyzed by western blot assay. The number of synapses was evaluated by electron microscopy. In the water maze test, mice in the environmental enrichment group had a shorter escape latency, traveled markedly longer distances, spent more time in the correct quadrant(northeast zone), and had a higher frequency of crossings compared with the standard housing group. The expression levels of growth-associated protein 43, synaptophysin and postsynaptic density protein 95 were substantially upregulated in the hippocampus in the environmental enrichment group compared with the standard housing group. Furthermore, electron microscopy revealed that environmental enrichment increased the number of synapses in the hippocampal CA1 region. Collectively, these findings suggest that environmental enrichment ameliorates the spatial learning and memory impairment induced by permanent middle cerebral artery occlusion. Environmental enrichment in mice with cerebral ischemia likely promotes cognitive recovery by inducing plastic changes in synapses.

关键词： nerve regeneration environmental enrichment cerebral ischemia cognitive recovery brain plasticity and reorganization synaptic plasticity electron microscopy growth-associated protein 43 synaptophysin postsynaptic density protein 95 permanent middle cerebral artery occlusion neural regeneration

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Existence and Regularity of Solution to the Generalized Tricomi Equation with a Singular Initial Datum at a Point

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Acta Mathematica Sinica,English Series 2012年第6期28卷 1135-1154页

作者： Kang qun zhang Department of Mathematics&IMS Nanjing University

In this paper, we study the existence and regularity of a solution to the initial datum problem of a semilinear generalized Tricomi equation in mixed-type initial datum on the degenerate plane is smooth away from the origin, domain. We suppose that an and has a conormal singularity at this point, then we show that in some mixed-type domain, the solution exists and is conormal with respect to the characteristic conic surface which is issued from the origin and has a cusp singularity.

关键词： Generalized Tricomi equation confluent hypergeometric function existence conormalregularity cusp singularity

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The Adjacency and Signless Laplacian Spectra of Cored Hypergraphs and Power Hypergraphs

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Journal of the Operations Research Society of China 2017年第1期5卷 27-43页

作者： Jun-jie Yue Li-Ping zhang Mei Lu Li-qun Qi Department of Mathematical Sciences Tsinghua UniversityBeijing 100084China State Key Laboratory of Space Weather Chinese Academy of SciencesBeijing 100910China Department of Applied Mathematics The Hong Kong Polytechnic UniversityHong KongChina

In this paper,we study the adjacency and signless Laplacian tensors of cored hypergraphs and power *** investigate the properties of their adjacency and signless Laplacian ***,we find out the largest H-eigenvalues of adjacency and signless Laplacian tensors for uniform *** also compute the H-spectra of sunflowers and some numerical results are reported for the H-spectra.

关键词： H-eigenvalue Hypergraph Adjacency tensor Signless Laplacian tensor Sunflower Squid

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