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Deficiency of Autophagy-Related Gene 5 in Keratinocytes Leads to Aggravation of Epidermal Damage in 2,4-Dinitrochlorobenzene-Induced Allergic Contact Dermatitis

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International Journal of Dermatology and Venereology 2023年第4期6卷 214-223页

作者： Yi-qun Zhang Ta Xiao Chang-Jun Song Yang-Ying Ke Xiang gao Min Li Heng gu Xu Chen Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences&Peking Union Medical CollegeNanjingJiangsu 210042China State Key Laboratory of Pharmaceutical Biotechnology MOE Key Laboratory of Model Animals for Disease StudyJiangsu Key Laboratory of Molecular MedicineModel Animal Research CenterNational Resource Center for Mutant Mice of ChinaSchool of MedicineNanjing UniversityNanjingJiangsu 210061China School of Public Health Nanjing Medical UniversityNanjingJiangsu 211166China Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases Chinese Academy of Medical SciencesNanjingJiangsu 210042China.

Objective:The interrelationship between apoptosis and autophagy plays an important role in many pathophysiological processes,however,whether their interplay is involved in allergic contact dermatitis(ACD)has not yet been ***,we conducted this study to determine whether keratinocyte-specific autophagy-related gene 5(ATG5)deficiency can regulate apoptosis to inhibit skin damage in mice with 2,4-dinitrochlorobenzene(DNCB)-induced ***:This study involved keratinocyte-specificAtg5 conditional knockout(cKO)mice(Krt14cre/+-Atg5flox/flox)and control mice(Krt14+/+-Atg5flox/flox).We painted DNCB on the right ear of each mouse to induce *** scoring and measurements of ear weight and thickness were performed to evaluate inflammation *** immunohistochemical assay was performed to analyze immune cell *** study and TUNEL staining were performed to compare the differences in skin lesions betweenAtg5 cKO mice and control *** and western blotting were used to examine the levels of ATG5 and apoptosis-related *** results were statistically analyzed byt ***:After DNCB stimulation of mice ears,we observed a more severe phenotype inAtg5 cKO mice than in control mice(dermatitis score:7.500±2.588vs.3.250±0.822,P=0.003).Further analysis of ATG5 protein confirmed keratinocyte-specific ablation ofAtg5 in cKO mice and showed that DNCB did not influence ATG5 *** assay revealed that the infiltrated immune cells were not involved in aggravation of the phenotype of DNCB-stimulatedAtg5 cKO ***,the histological study(P=0.024),TUNEL staining(P=0.024),immunofluorescence(P=0.036),and western blotting showed that the increase in keratinocyte death,especially apoptosis,contributed to aggravation of the phenotype of DNCB-stimulatedAtg5 cKO ***:Deficiency ofAtg5 in keratinocytes increases apoptosis,aggravating skin damage in DNCB-induced ACD *** has no relation

关键词： allergic contact dermatitis autophagy-related gene 5 apoptosis autophagy

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海底管道失稳过程的模型试验研究

岩土工程学报 2000年第3期22卷 304-308页

作者：高福平顾小芸浦群中国科学院力学研究所北京100080

直接铺设于砂质海床上的管道的失稳是一“流—管—土”耦合问题。本文利用U形水槽产生的振荡流对管道的失稳过程进行了模拟 ,通过改变管道水下重量、管径和加载历史研究管道失稳的条件。在试验结果的基础上 ,初步得到了管道失稳的临界F... 详细信息

直接铺设于砂质海床上的管道的失稳是一“流—管—土”耦合问题。本文利用U形水槽产生的振荡流对管道的失稳过程进行了模拟 ,通过改变管道水下重量、管径和加载历史研究管道失稳的条件。在试验结果的基础上 ,初步得到了管道失稳的临界Fr数与管重无量纲参数之间的关系曲线。

关键词：海底管道管道失稳振荡流砂质海床水槽

非有效接地电网单相电弧接地故障的建模及仿真

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电力系统自动化 2009年第13期33卷 63-67页

作者：顾荣斌蔡旭陈海昆金之俭高伟国上海交通大学电子信息与电气工程学院上海市200240 上海电力公司市南供电公司上海市200233

单相电弧接地故障是中压配电网中的主要故障形式,建立准确的接地电弧模型对于故障分析是十分必要的。文中比较了现有的几种电弧模型的优缺点,在基于弧隙能量平衡理论的动态电弧模型的基础上建立了接地电弧模型,在PSCAD平台上构建了10kV... 详细信息

单相电弧接地故障是中压配电网中的主要故障形式,建立准确的接地电弧模型对于故障分析是十分必要的。文中比较了现有的几种电弧模型的优缺点,在基于弧隙能量平衡理论的动态电弧模型的基础上建立了接地电弧模型,在PSCAD平台上构建了10kV配电网模型及接地电弧模型。通过与实际实验波形的比较,表明接地电弧模型能有效地反映接地电弧的性质。然后将此模型用于仿真2种不同的间歇性电弧接地故障,其过电压倍数符合实际情况,从而间接证明了接地电弧模型的正确性。

关键词：电孤仿真接地电弧模型 PSCAD平台间歇性电弧接地

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多媒体会议系统共享白板工具的设计与实现

小型微型计算机系统 2000年第7期21卷 690-693页

作者：高旭沈苏彬赵桂平顾冠群计算机网络与信息集成教育部重点实验室南京210096 东南大学计算机科学与工程系南京210096 南京邮电学院南京210003

本文从分析共享白板的功能入手 ,探讨了共享白板涉及的关键技术 ,如可靠传输、发言权控制和远程指针技术 .在此基础上 ,论文定义了共享白板的主要数据结构和信息分组格式 ,最后给出了共享白板工具

关键词：多媒体会议系统共享白板组播 Internet网

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混凝土骨料有限元模型自动生成方法

大连理工大学学报 2006年第5期46卷 641-646页

作者：高巧红关振群顾元宪尹艳辉大连理工大学工业装备结构分析国家重点实验室

针对圆形、椭圆形、多边形三种剖面形状的骨料夹杂分别给出了混凝土的二维有限元建模方法,为细观结构研究提供了全自动的建模工具.提出了一种新的以面积为标度的任意两椭圆骨料侵入的判别准则,有效地克服了椭圆形骨料几何模型生成中的... 详细信息

针对圆形、椭圆形、多边形三种剖面形状的骨料夹杂分别给出了混凝土的二维有限元建模方法,为细观结构研究提供了全自动的建模工具.提出了一种新的以面积为标度的任意两椭圆骨料侵入的判别准则,有效地克服了椭圆形骨料几何模型生成中的效率瓶颈问题;提出了综合考虑边数、形状、尺寸等随机特性的多边形骨料生成方法,并简单有效地保证了多边形骨料为凸的性质,使所建的随机几何模型能够更好地模拟人工骨料和再生骨料;对生成的几何模型,运用改进的推进波前法一次性生成所有骨料的有限元网格,为进一步的复合材料细观结构和宏观力学性能的多尺度计算打下了基础.最后用几个算例验证了算法的有效性.

关键词：混凝土骨料数值模拟计算模型网格生成

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人员疏散出口选择行为的演化博弈模型

计算机工程与设计 2013年第2期34卷 638-642页

作者：刘群刘磊高轶顾金重庆邮电大学计算机科学与技术研究所重庆400065

为了研究多出口条件下疏散人员出口选择这一动态过程,在元胞自动机模型的基本框架下,建立基于演化博弈理论的疏散仿真模型,模型中采用最优反应动态机制来研究疏散人员出口选择的演化过程。最后通过仿真实验分析了出口保持率,视野范围以... 详细信息

为了研究多出口条件下疏散人员出口选择这一动态过程,在元胞自动机模型的基本框架下,建立基于演化博弈理论的疏散仿真模型,模型中采用最优反应动态机制来研究疏散人员出口选择的演化过程。最后通过仿真实验分析了出口保持率,视野范围以及初始策略对出口选择的影响。实验结果表明,该模型能够较明显的反应疏散过程中疏散人员出口选择的动态过程。

关键词：人员疏散元胞自动机演化博弈论最优反应动态出口选择

Characterization and mapping of the multi-component release kinetics of a Traditional Chinese Medicine dosage form using a modified LC/MS/MS method and chemomic release kinetic theory

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Acta Pharmaceutica Sinica B 2011年第2期1卷 106-114页

作者： Hai-yan Li Xiang-yong Cui Feng gao Peter York qun Shao Xian-zhen Yin Tao guo Zhen guo Jing-kai gu Ji-wen Zhang Center for Drug Delivery System Shanghai Institute of Materia MedicaState Key Laboratory of Drug ResearchChinese Academy of SciencesShanghai 201203China Research Center for Drug Metabolism Jilin UniversityChangchun 130021China Institute of Pharmaceutical Innovation University of BradfordBradfordWest Yorkshire BD71DPUnited Kingdom College of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China

It is essential to develop effective methods for the quality control of the traditional medicine with multiple ***,few researches on the quality control have been conducted to interpret the holistic characteristics of the traditional medicine in terms of dissolution/*** this study,the multi-component release kinetics of Traditional Chinese Medicine(TCM)dosage forms was characterized and mapped by multivariate analysis techniques in the field of‘‘-omics’’.The Liuweidihuang pill was used as a model *** multi-component release kinetics of the concentrated and water-honeyed Liuweidihuang pills at rotation speeds of 50 and 100 rpm were analyzed by chemomic release kinetic theory and modified LC/MS/MS *** features of 103(concentrated pills)and 101(water-honeyed pills)were selected with a linear correlation coefficient Z0.99 between mass responses and *** compose the chemomic standard spectrum,the relative abundance of both mass features was no less than 1%as compared with an internal *** correlation coefficients between six samples of various solutions were in line with analytical requirements of precision(rZ0.985).The score plots of principal component analysis showed that the concentrated Liuweidihuang pills presented better chemomic release reproducibility than the water-honeyed ***,the impact of rotation speed on the chemomic release was less *** heat maps of hierarchical clustering analysis did not show significant changes in individual clusters of mass features along different time intervals,reflecting the release integrity of the mass ***,both multivariate analysis methods,the principal component analysis and the hierarchical clustering analysis,seemed to be effective techniques to demonstrate the multiple component release performance of *** research provided the basis of a new strategy for the quality control procedures of the dissolution/release for the tradi

关键词： Chemomic release kinetics Liuweidihuang pills Principal component analysis Hierarchical clustering analysis Multi-component