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Geriatric nursing competence of clinical nursing staff at different hospital levels in Chongqing,China:A cross-sectional study

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International Journal of Nursing Sciences 2024年第4期11卷 439-446,I0002页

作者： Jinfeng Long Yaling Li Wenping Chen Xiaoqun Wu Rongjuan Fu Li Dong Yi Huang Daibi Yi Zhihui Xu Yan Cheng qun tan Li Zhang Fu Ding Department of Nursing The First Afﬁliated Hospital of Chongqing Medical UniversityChongqingChina Department of Nursing People’s Hospital of Changshou ChongqingChongqingChina Department of Nursing Dianjiang People’s Hospital of ChongqingChongqingChina Department of Nephrology Yongchuan Hospital of Chongqing Medical UniversityChongqingChina Department of Medical Administration Health Commission of ChongqingChongqingChina Department of Nursing Chongqing University Three Gorges HospitalChongqingChina Department of Nursing People’s Hospital of HechuanChongqingChina Department of Geriatrics Chongqing University Fulin HospitalChongqingChina Department of Nursing People’s Hospital of ShizhuChongqingChina

Objectives:This study aimed to survey the geriatric nursing competencies of clinical nursing staff in Chongqing City,China,and provide suggestions to enhance these ***:This study was conducted in 204 hospitals in Southwest China from December 24,2022 to January 7,***“Geriatric Nursing Competence of Clinical Nurse Investigation Tool”was used to explore factors that inﬂuence geriatric nurses’competencies via stratiﬁed *** survey was conducted by distributing and collecting questionnaires through the online platform ***:A total of 10,692 nurses answered the *** these questionnaires,9,442 were *** total geriatric nursing competence score of the clinical nursing staff was 2.29±0.81,the secondary hospital score was 2.23±0.78,and the tertiary hospital’s overall mean score was 2.33±*** factors that inﬂuenced secondary hospitals included the department of medicine,age of nurses and total length of career(P<0.05).The factors that inﬂuenced tertiary hospitals included the department of medicine,age of nurses,nurses’professional title,and geriatric practical advanced nurses’certiﬁcation(P<0.05).Conclusions:Geriatric nursing competence among clinical nursing staff is imbalanced at a lower-middle level and is inﬂuenced by various ***ﬁndings highlight the need for further clinical training in geriatric *** training of geriatric nurses should focus on necessary clinical skills and on preparing them to adequately manage comprehensive geriatric syndromes.

关键词： Aged Clinical nursing Different hospital levels Geriatric nursing competence Geriatric advanced practice nurses

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超声辅助深共晶溶剂高效提取枳实辛弗林的工艺优化及提取动力学分析

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天然产物研究与开发 2024年第3期36卷 499-511,484页

作者：邵林子程玉娇黄林华谈安群王华西南大学中国农业科学院柑桔研究所国家柑桔工程技术研究中心重庆400712

为了研究超声辅助深共晶溶剂提取枳实辛弗林的最佳工艺条件及该提取过程的传质动力学模型,本研究采用Plackett-Burman试验、最陡爬坡试验结合Box-Behnken响应面法对超声辅助深共晶溶剂提取枳实辛弗林的关键工艺参数进行优化,基于Fick第... 详细信息

为了研究超声辅助深共晶溶剂提取枳实辛弗林的最佳工艺条件及该提取过程的传质动力学模型,本研究采用Plackett-Burman试验、最陡爬坡试验结合Box-Behnken响应面法对超声辅助深共晶溶剂提取枳实辛弗林的关键工艺参数进行优化,基于Fick第二定律建立超声辅助深共晶溶剂提取枳实辛弗林的提取动力学模型,通过测定在不同功率、不同提取时间下提取液中的辛弗林的质量浓度,对模型进行拟合验证,求解相应的动力学参数。结果表明,最优提取溶媒为一水甜菜碱-乳酸组成的深共晶溶剂(摩尔比1∶3,含水量50%),最佳工艺为:液料比39 mL/g,超声功率220 W,超声时间20 min,在此条件下,辛弗林得率为0.4284%,与模型预测值接近,且优于传统水回流提取法、85%乙醇回流提取法、超声辅助14%乙醇提取法、超声辅助70%甲醇提取法和超声辅助水提法。对动力学实验数据拟合得到的动力学一般方程和指数方程与动力学模型相关性良好,推算出了相应的速率常数、相对萃余率等动力学相关参数,拟合得到了半衰期和有效扩散系数回归方程,为枳实辛弗林的提取工艺优化和深入理论研究提供数据参考。

关键词：枳实辛弗林深共晶溶剂动力学模型超声辅助提取

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基于知识图谱的水电站设备故障根因分析方法

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人民长江 2024年第2期55卷 259-264页

作者：谈群苗洪雷秦拯朱玺郜振亚湖南大学信息科学与工程学院湖南长沙410082 华自科技股份有限公司湖南长沙410000

水电站设备故障成因复杂、关联性强,研究故障之间的成因关系及发生概率有助于快速确定故障原因和制定排查计划。根据专家经验与历史故障数据构建了水电站设备知识图谱,设计了基于知识图谱的智能故障诊断算法,利用Noisy Or模型实现一种... 详细信息

水电站设备故障成因复杂、关联性强,研究故障之间的成因关系及发生概率有助于快速确定故障原因和制定排查计划。根据专家经验与历史故障数据构建了水电站设备知识图谱,设计了基于知识图谱的智能故障诊断算法,利用Noisy Or模型实现一种近似推理算法,实现了根因的定量分析,并基于图推理分析相关现象和熵理论实现了排查建议的优化计算。该系统可给出全面、详细的建议和解释信息,允许用户自由交互,可以帮助用户快速开展排查故障。系统具有不依赖历史数据、准确性高、可解释性强、可动态更新等优点,为智慧水电站建设提供了先进平台。

关键词：水电站设备故障诊断知识图谱图推理熵

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复方蓝棕果片治疗前列腺增生电切术术后膀胱刺激证患者的临床研究

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中国临床药理学杂志 2024年第18期40卷 2670-2674页

作者：杜宇峰陈煌辉谭群杰郭小勇郴州市第一人民医院泌尿外科湖南郴州423000 宜章县第二人民医院泌尿外科湖南郴州423000

目的观察复方蓝棕果片对前列腺增生(BPH)电切术术后膀胱刺激证(BD)的效果。方法将BPH经尿道前列腺电切术患者分为试验组和对照组。对照组术后当天给予盐酸坦索罗辛缓释胶囊,每次0.2mg,每天1次,口服;试验组在对照组的基础上给予复方蓝棕... 详细信息

目的观察复方蓝棕果片对前列腺增生(BPH)电切术术后膀胱刺激证(BD)的效果。方法将BPH经尿道前列腺电切术患者分为试验组和对照组。对照组术后当天给予盐酸坦索罗辛缓释胶囊,每次0.2mg,每天1次,口服;试验组在对照组的基础上给予复方蓝棕果片,每次0.5g,每天3次,口服。2组均治疗4周。比较2组患者的临床疗效、前列腺症状、膀胱过度活动症状、尿动力学变化[最大逼尿肌压力(MDP)、最大尿流率(Qmax)、膀胱最大容量(MCC)]、BD发生情况、炎症反应指标[白细胞介素-6(IL-6)、IL-17、肿瘤坏死因子-α(TNF-α)],并进行安全性评价。结果对照组入组45例,试验组入组49例。治疗后,试验组总有效率为95.92%(47例/49例),对照组为82.22%(37例/45例),在统计学上差异有统计学意义(P0.05)。结论复方蓝棕果片治疗BPH经尿道前列腺电切术患者能减轻术后前列腺症及膀胱过度活动症状,改善尿动力学,减少BD发生,缓解炎症反应。

关键词：复方蓝棕果片前列腺增生经尿道前列腺电切术膀胱刺激证尿动力学炎症反应

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槲皮素联合铁死亡抑制药对草酸钙诱导的HK-2细胞损伤的影响

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中国临床药理学杂志 2024年第14期40卷 2028-2032页

作者：聂丙飞陈煌辉谭群杰杜宇峰郴州市第一人民医院泌尿外科湖南郴州423000 宜章县第二人民医院泌尿外科湖南郴州423000

目的探究槲皮素联合铁死亡抑制剂Ferrostain-1对草酸钙诱导的HK-2细胞损伤的影响。方法将HK-2细胞随机分为对照组(正常培养的细胞)、模型组(0.5 mmol·L^(-1)的草酸钙结晶)、槲皮素组(0.5 mmol·L^(-1)的草酸钙结晶+100μmol·L^(-1)槲... 详细信息

目的探究槲皮素联合铁死亡抑制剂Ferrostain-1对草酸钙诱导的HK-2细胞损伤的影响。方法将HK-2细胞随机分为对照组(正常培养的细胞)、模型组(0.5 mmol·L^(-1)的草酸钙结晶)、槲皮素组(0.5 mmol·L^(-1)的草酸钙结晶+100μmol·L^(-1)槲皮素)、抑制剂组(0.5 mmol·L^(-1)的草酸钙结晶+8μmol·L^(-1) Ferrostain-1)、联合组(0.5 mmol·L^(-1)的草酸钙结晶+100μmol·L^(-1)槲皮素+8μmol·L^(-1) Ferrostain-1)。用细胞计数试剂盒8(CCK-8)实验检测细胞存活率,用蛋白质印迹实验检测细胞谷胱甘肽过氧化物酶(GPX4)等铁死亡相关蛋白表达,用流式细胞术和Tunel实验检测细胞凋亡,用试剂盒法检测细胞铁离子及抗氧化指标水平。结果对照组、模型组、槲皮素组、抑制剂组、联合组的细胞存活率分别为(100.00±2.55)%、(54.49±4.11)%、(64.26±6.30)%、(58.03±3.04)%和(79.37±4.29)%,GPX4蛋白表达水平分别为0.98±0.11、0.33±0.05、0.56±0.05、0.78±0.07和1.11±0.11,细胞凋亡率分别为(4.15±0.28)%、(23.12±2.49)%、(17.28±1.07)%、(15.08±1.41)%和(8.95±0.75)%,Fe2+水平分别为(100.00±0.87)%、(162.55±14.70)%、(149.09±9.50)%、(144.95±11.12)%和(131.76±12.18)%,超氧化物歧化酶(SOD)水平分别为(58.67±3.46)、(21.56±1.32)、(33.60±2.03)、(35.15±3.02)和(44.27±3.89)U·mL^(-1);模型组的上述指标与对照组比较,槲皮素组、抑制剂组、联合组的上述指标与模型组比较,联合组的上述指标与槲皮素组、抑制剂组比较,在统计学上差异均有统计学意义(均P<0.05)。结论铁死亡抑制剂可增强槲皮素体外对草酸钙诱导的肾小管上皮细胞损伤的抑制作用。

关键词：槲皮素草酸钙肾结石铁死亡细胞损伤细胞凋亡

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Strong invariance principle for a counterbalanced random walk

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 370-380页

作者： tan Hui-qun HU Zhi-shui DONG Liang International Institute of Finance School of ManagementUniversity of Science and Technology of ChinaHefei 230026China Center for Basic Teaching and Experiment Nanjing University of Science and TechnologyJiangyin 214443China

We study a counterbalanced random walkS_(n)=X_(1)+…+X_(n),which is a discrete time non-Markovian process andX_(n) are given recursively as *** n≥2,X_(n) is a new independent sample from some fixed law̸=0 with a fixed probability p,andX_(n)=−X_(v(n))with probability 1−p,where v(n)is a uniform random variable on{1;…;n−1}.We apply martingale method to obtain a strong invariance principle forS_(n).

关键词： random walk martingale invariance principle

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Protective Effects of Phellodendron Species on Bone Health: A Novel Perspective on Their Potentials in Treating Osteoporosis and Osteoarthritis

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Chinese Journal of Integrative Medicine 2024年第4期30卷 379-384页

作者： XIN Li tan Guo-yao ZHANG Qiang ZHANG qun Good Clinical Practice Development Guangdong Provincial Key Laboratory of Bone and Joint Degeneration DiseasesThe Third Affiliated Hospital of Southern Medical UniversityGuangzhou(510630)China Department of Pharmacy Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou(510120)China

Phellodendron(PN)species,traditionally used in Chinese medicine for centuries,hold promise as a potential treatment for osteoporosis(OP)and osteoarthritis(OA)due to their bioactive *** bioactive compounds,including berberine and palmatine,exhibit anti-inflammatory,antioxidant,and bone-protective properties,contributing to their potential therapeutic benefits in promoting bone health and preventing bone ***,challenges such as the need for standardized preparation and dosing,limited clinical studies,and potential interactions with other medications hinder their clinical ***,the rich history of PN species in Chinese medicine provides a promising foundation for future investigation into their potential as alternative treatments for OP and *** research is needed to fully understand the underlying mechanisms of action and explore the clinical implications of PN for bone health.

关键词： Phellodendron species bone health osteoporosis osteoarthritis review

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Circulating tumor cells with epithelial-mesenchymal transition markers as potential biomarkers for the diagnosis of lung cancer

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World Journal of Clinical Cases 2021年第12期9卷 2721-2730页

作者： Sha-Sha Jiang Chun-Guo Mao Yong-Geng Feng Bin Jiang Shao-Lin Tao qun-You tan Bo Deng Department of Thoracic Surgery Institute of Surgery ResearchDaping HospitalArmy Medical UniversityChongqing 400042China

BACKGROUND Circulating tumor cells(CTCs) can be clustered into three subtypes according to epithelial-mesenchymal transition(EMT) markers: CTCs with epithelial markers(E-CTCs), CTCs with mesenchymal markers(M-CTCs), and CTCs with both markers(E&M-CTCs). CTC detection has clinical implications in the diagnosis of lung cancer(LC).AIM To clarify the diagnostic value of CTCs categorized by EMT markers in *** The study included 106 patients with lung adenocarcinoma, including 42 groundglass opacities(GGO) and 64 solid lesions, who underwent surgery between July 2015 and December 2019. Eleven patients with benign tumors and seventeen healthy controls were included. CTCs in peripheral blood and associated EMT markers were detected preoperatively using the CanPatrol TM technique. The diagnostic power of CTCs for discriminating LC cases from controls was analyzed by the receiver operating characteristic(ROC) curve. The CytoploRare technique was used in 20 cases and 18 controls for validation, and Kappa values were calculated to evaluate consistency between *** Of the 106 LC cases, 94(89.6%) had at least one CTC. CTCs were detectable in 35(83.3%) of 42 GGO cases. Total CTCs and E&M-CTCs were significantly more frequent in LC cases than in benign or healthy controls. The proportion of MCTCs plus E&M-CTCs increased gradually from healthy controls, to benign controls, to LC cases. The area under the ROC curve of total CTCs and E&M-CTCs was > 0.8 and > 10.75, respectively. The combined sensitivity of total-CTCs and E&M-CTCs was 85.85% for LC patients(80.95% for GGO patients) and the specificity was 78.57%.The Kappa value was 0.415,indicating relative consistency between CanPatrol TM and *** CTC detection is valuable for distinguishing LC from controls,and particularly E&M-CTC detection warrants further study.

关键词： Circulating tumor cells Epithelial-to-mesenchymal transition Diagnosis Lung cancer Ground-glass opacities CanPatrol

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Diagnosis of chest pain with foregut symptoms in Chinese patients

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World Journal of Gastroenterology 2009年第6期15卷 742-747页

作者： Bo Deng Ru-Wen Wang Yao-Guang Jiang qun-You tan Xiang-Li Liao Jing-Hai Zhou Yun-Ping Zhao Tai-Qian Gong Zheng Ma Thoracic Surgery Department Institute of Surgery Research Daping Hospital The Third Military Medical University Chongqing 400042 China

AIM:To evaluate the diagnosis of chest pain with foregut symptoms in Chinese patients. METHODS:Esophageal manometric studies, 24-h introesophageal pH monitoring and 24-h electrocardiograms(Holter electrocardiography)were performed in 61 patients with chest pain. RESULTS:Thirty-nine patients were diagnosed with non-specific esophageal motility disorders(29 patients with abnormal gastroesophageal reflux and eight patients with myocardial ischemia).Five patients had diffuse spasm of the esophagus plus abnormal gastroesophageal reflux(two patients had concomitant myocardial ischemia),and one patient was diagnosed with nutcracker esophagus. CONCLUSION:The esophageal manometric studies, 24-h intra-esophageal pH monitoring and Holter electrocardiography are significant for the differential diagnosis of chest pain,particularly in patients with foregut *** cases of esophageal motility disorders,pathological gastroesophageal reflux may be a major cause of chest pain with non-specific esophageal motility *** of the esophageal smooth muscle might affect the heart-coronary smooth muscle,leading to myocardial ischemia.

关键词： Chest pain Esophageal manometric Twenty-four-hour intra-esophageal pH monitoring Holter electrocardiography

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Predictors of postoperative myasthenic crisis in patients with myasthenia gravis after thymectomy

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Chinese Medical Journal 2011年第8期124卷 1246-1250页

作者： CHU Xiang-yang XUE Zhi-qiang WANG Ru-wen tan qun-you aDepartment of Thoracic Surgery Chinese People's LiberationArmy General Hospital Beijing 100853 China Department of Thoracic Surgery Daping Hospital Third MilitaryMedical University Chongqing 400042 China

Background Thymectomy is considered the most effective treatment in patients with myasthenia gravis. This study aimed to explore the predictors of postoperative myasthenic crisis in patients with myasthenia gravis after *** Clinical records of 243 patients with myasthenia gravis who underwent thymectomy were reviewed retrospectively. The following factors were analyzed in relation to the occurrence of myasthenic crisis after thymectomy：gender, age, duration of symptoms, Osserman stage, history of myasthenic crisis, concomitant diseases, preoperative pyridostigmine dose, preoperative steroid therapy, operation approach, operation time, presence of thymoma, major postoperative *** Forty-four patients experienced postoperative myasthenic crisis during the first month after *** analysis revealed that Osserman stage （RR=0.0976, P=0.000）, history of myasthenic crisis （RR=0.2309,P=0.012）, preoperative pyridostigmine dose （RR=0.4349, P=0.016）, thymoma （RR=0.0606, P=0.000）, and major postoperative complications （RR=0.1094, P=0.000） were significantly related to postoperative myasthenic *** Logistic regression analysis showed that Osserman stage （Ⅱb＋Ⅲ＋Ⅳ）（RR=0.0953, P=0.000）, thymoma （RR=0.0294, P=0.000）, and major postoperative complications （RR=0.0424, P=0.000） independently predict postoperative myasthenic *** Osserman stage （Ⅱb＋Ⅲb＋Ⅳ）, thymoma and major postoperative complications are independent predictors of postoperative myasthenic crisis in patients with myasthenia gravis who underwent thymectomy.

关键词： myasthenia gravis thymoma thymectomy

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