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Effect of Stokes drift on upper ocean mixing

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Acta Oceanologica Sinica 2008年第2期27卷 11-20页

作者： LI Shuang SONG Jinbao sun qun Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China Graduate School Chinese Academy of Sciences Beijing 100039 China

Stokes drift is the main source of vertical vorticity in the ocean mixed layer. In the ways of Coriolis - Stokes forcing and Langmuir circulations, Stokes drift can substantially affect the whole mixed layer. A modified Mellor-Yamada 2. 5 level turbulence closure model is used to parameterize its effect on upper ocean mixing conventionally. Results show that comparing surface heating with wave breaking, Stokes drift plays the most important role in the entire ocean mixed layer, especially in the subsurface layer. As expected, Stokes drift elevates both the dissipation rate and the turbulence energy in the upper ocean mixing. Also, ilffluence of the surface heating, wave breaking and wind speed on Stokes drift is investigated respectively. Research shows that it is significant and important to assessing the Stokes drift into ocean mixed layer studying. The laboratory observations are supporting numerical experiments quantitatively.

关键词： Stokes drift Langmuir circulations Coriolis - Stokes forcing upper ocean mixing Mellor-Yamada 2. 5 turbulence model wave breaking surface heating

Ulcerative colitis complicated with colonic necrosis, septic shock and venous thromboembolism: A case report

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World Journal of Clinical Cases 2019年第16期7卷 2360-2366页

作者： Ming-Yu Zhu Li-qun sun Critical Care Unit the Second Affiliated Hospital of Nanjing Medical University

BACKGROUND Severe total colonic necrosis,septic shock and venous thromboembolism secondary to ulcerative colitis (UC) are rare and *** such severe complications have been reported in the *** SUMMARY We report a 36-year-old woman who developed total colonic necrosis and septic shock secondary to *** patient was treated with emergency surgery because computed tomography showed suspicious *** massive ascites occurred after operation and computed tomography angiography demonstrated portal vein,mesenteric vein and splenic vein *** patient was discharged from hospital after active *** Clinicians should pay attention to venous thrombosis,colonic necrosis and septic shock in UC *** observation of surgical indications and timely surgical intervention are the key to reduce mortality and complications in UC.

关键词： Ulcerative colitis Total colonic necrosis Venous thromboembolism Sepsis Septic shock Case report

Lentivirus mediated shRNA interference targeting MAT2B induces growth-inhibition and apoptosis in hepatocelluar carcinoma

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World Journal of Gastroenterology 2008年第29期14卷 4633-4642页

作者： qun wang Quan-Yan Liu Zhi-Su Liu qun Qian Quan sun Ding-Yu Pan Department of General Surgery Zhongnan Hospital Wuhan University Wuhan 430071 Hubei Province China

AIM: To investigate the effects of lentivirus vector mediated short hairpin RNA interference targeting methionine adenosyltransferase 2β gene (LV-shMAT2B) on hepatocelluar carcinoma (HCC) cells. METHODS: We constructed four plasmids of RNA interference targeting the MAT2B gene. After LV-shMAT2B was transfected with L-02 cells and two kinds of HCC cells, cell viability and proliferation were measured with MTT and [3H]thymidine assays respectively. Flow cytometry was used to assess cell apoptosis. The level of S-adenosyl methionine (SAMe) in HepG2 cells was evaluated. The expressions of cyclin D1, cyclin D2, bcl-xL and bcl-xS were detected with western blot. RESULTS: We constructed LV-shMAT2B successfully. LV-shMAT2B was safe for human normal liver cells. LV-shMAT2B caused dramatic reduction in proliferation compared with controls in HCC cells Bel-7402 (P = 0.054) and HepG2 (P = 0.031). Flow cytometry analysis showed that cell apoptosis caused by LV-shMAT2B was greater in HCC cells Bel-7402 and HepG2 than in control induced by scrambled siRNA (P = 0.047), but apoptosis rates in L-02 induced by LV-shMAT2B and scrambled siRNA respectively had no significant difference. Moreover, LV-shMAT2B significantly suppressed expression of MAT2B leading to growth-inhibition effect on HCC cells by down-regulating cyclin D1. Apoptosis induced by LV-shMAT2B was involved indown-regulating bcl-xL and up-regulating bcl-xS. CONCLUSION: LV-shMAT2B can induce cell apoptosis and growth-inhibition in HCC cells. MAT2B may be a therapy target in HCC in the future.

关键词： Lentivirus Methionine adenosyltransferase2β gene Growth inhibition Apoptosis Hepatocelluarcarcinoma

Advances on Seed Vigor Physiological and Genetic Mechanisms

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Agricultural Sciences in China 2007年第9期6卷 1060-1066页

作者： sun qun WANG Jian-hua sun Bao-qi Department of Seed Science College of Agriculture and Biotechnology China Agricultural University Beijing 100094 P.R.China

Seed vigor is a more promising seed quality character reflecting potential seed germination, field emergence and seed storage ability under different conditions than standard germination. Standard germination is influenced by genetic background and environmental effects during seed development and storage conditions. The latest research on physiological mechanism in seed vigor showed that at the late stage of seed development, the development of seed vigor involves some stress-resistant substances including late embryogenesis abundant （LEA） protein, oligosaccharides and abscisic acid （ABA）. Whereas the loss of seed vigor, or seed aging and deterioration, could be attributed to lipid peroxidation, chromosome deformation and genes aberrance, and embryo protein degradation, etc. Seed vigor is a quantitative character controlled by multi-genes. Genetic and quantitative trait locus （QTL） analyses on seed-vigor trait in model plants, such as Arabidopsis and rice, are mostly concentrated on related morphology traits, whereas few physiological traits have been researched. It was concluded that, all of the QTL genetic characteristics of seed vigorincluding QTL quantities, its locus on chromosome, genetic effects, and interaction effects between genetic and environment, differed with plant species and used seed-vigor traits.

关键词： seed vigor physiological and genetic mechanism QTL analyses

Scapular metastasis from acinic cell carcinoma of parotid gland:A case report

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World Journal of Clinical Cases 2025年第9期13卷 41-46页

作者： Deng-qun sun Chang-Chun Chen Duo-An Zheng Hai-Yan Xing Xue Peng Department of General Surgery The Chinese People’s Armed Police Forces Anhui Provincial Corps HospitalHefei 230001Anhui ProvinceChina Department of Radiology The Chinese People’s Armed Police Forces Anhui Provincial Corps HospitalHefei 230001Anhui ProvinceChina Department of Pathology The Chinese People’s Armed Police Forces Anhui Provincial Corps HospitalHefei 230001Anhui ProvinceChina

BACKGROUND Acinic cell carcinoma(ACC)is a malignant epithelial neoplasm that commonly occurs in the parotid *** is known to have a high recurrence rate and the potential to metastasize to the lung or cervical lymph ***,few cases of ACC with bone metastasis have been reported in the medical *** SUMMARY The clinical significance of this case report lies in the unique site of occurrence of the metastasis:To the best of our knowledge,this report is the only literature documenting ACC arising in a shoulder *** Unusual presentations of uncommon malignancies can present diagnostic challenges for both surgeons and *** is important to be aware of these rare occurrences in order to provide the best possible treatment for patients.

关键词： Acinic cell carcinoma Shoulder mass Scapular Metastasis Case report

Vehicle Active Steering Control Research Based on Two-DOF Robust Internal Model Control

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Chinese Journal of Mechanical Engineering 2016年第4期29卷 739-746页

作者： WU Jian LIU Yahui WANG Fengbo BAO Chunjiang sun qun ZHAO Youqun School of Mechanical and Automotive Engineering Liaocheng University State Key Laboratory of Automotive Safety and Energy Tsinghua University College of Energy and Power Engineering Nanjing University of Aeronautics and Astronautics

Because of vehicle＇s external disturbances and model uncertainties,robust control algorithms have obtained popularity in vehicle stability *** robust control usually gives up performance in order to guarantee the robustness of the control algorithm,therefore an improved robust internal model control（IMC） algorithm blending model tracking and internal model control is put forward for active steering system in order to reach high performance of yaw rate tracking with certain *** proposed algorithm inherits the good model tracking ability of the IMC control and guarantees robustness to model *** order to separate the design process of model tracking from the robustness design process,the improved 2 degree of freedom（DOF） robust internal model controller structure is given from the standard Youla *** of double lane change maneuver and those of crosswind disturbances are conducted for evaluating the robust control algorithm,on the basis of a nonlinear vehicle simulation model with a magic tyre *** show that the established 2-DOF robust IMC method has better model tracking ability and a guaranteed level of robustness and robust performance,which can enhance the vehicle stability and handling,regardless of variations of the vehicle model parameters and the external crosswind *** between performance and robustness of active steering control algorithm is solved and higher control performance with certain robustness to model uncertainties is obtained.

关键词： active steering internal model control model tracking robust performance crosswind disturbances

Antitumor bioactivity of adenovirus-mediated p27mt in colorectal cancer cell line SW480

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World Journal of Gastroenterology 2008年第38期14卷 5827-5833页

作者： Ze-qun sun Chang-Sheng Deng Shao-Yong Xu Yong Du Gastroenterology Department of Zhongnan Hospital Wuhan University East Lake Road Wuhan 430000 Hubei Province China Gastroenterology Department of Renmin Hospital Yunyang Medical College Shiyan 442000 Hubei Province China

AIM: To explore the antitumor bioactivity of adenovirus- mediated mutant type p27kip1 gene in a colorectal cancer cell line SW480. METHODS: We constructed recombinant adenovirus vector expressing a mutant type p27kip1 gene (ad- p27mt), with mutation of Thr-187/Pro-188 (ACGCCC) to Met-187/Ile-188 (ATGATC), and transduced into SW480 cells. Then we detected expression of p27, Bcl-2 and Bax protein in the transductants by Western blotting, cell cycle of transductants by a digital flow cytometric system, migrating potential with Boyden Chamber and SW480 tumor cell growth inhibition in vitro and in vivo. RESULTS: We found that a recombinant adenovirus vector of expressing ad-p27mt, with mutation of Thr-187/Pro-188 (ACGCCC) to Met-187/Ile-188 (ATGATC) has potent inhibition of SW480 tumor cell growth in vitro and in vivo. Furthermore, ad-p27mt induced cell apoptosis via regulating bax and bcl-2 expressions, and G1/S arrest in SW480 cells and inhibited cell migration. CONCLUSION: ad-p27mt has a strong anti-tumor bioactivity and has the potential to develop into new therapeutic agents for colorectal cancer.

关键词： p27 Adenovirus Antitumor bioactivity Colorectal cancer

Interannual variability of dimethylsulfide in the Yellow Sea

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Journal of Oceanology and Limnology 2022年第2期40卷 551-562页

作者： Sijia WANG qun sun Siyu LI Jiawei SHEN Qian LIU Liang ZHAO College of Marine and Environmental Sciences Tianjin University of Science and TechnologyTEDATianjin 300222China School of Marine Science and Technology Tianjin UniversityTianjin 300072China

The 22-year(1998-2019)surface seawater dimethylsulfi de(DMS)concentrations in the Yellow Sea(YS)were hindcasted based on satellite sea surface temperature(SST)and chlorophyll-a(Chl-a)data using a generalized additive mixed model(GAMM).A continuous monthly dataset of DMS concentration in the YS was obtained after using the data interpolation empirical orthogonal function(DINEOF)to reconstruct missing information in the ***,the interannual DMS variability in the YS was *** results indicated that the monthly climatological DMS concentration in the YS was 3.61 nmol/*** concentrations in the spring and summer were signifi cantly higher than those in the autumn and *** concentrations were highest in coastal YS waters and lowest primarily in off shore YS *** DMS variability between 1998 and 2019 was subdivided into two inverse phases:with the exception of the central YS,DMS increased before the turning point and decreased *** turning point in interannual DMS variation was earlier in the inshore YS as compared to the central *** analysis identifi ed some signifi cant patterns of interannual variation in the DMS anomaly in the *** a appeared to be the main factor infl uencing interannual trends in DMS in the *** DMS variability was under the joint control of Chl a and ***,short-term interannual DMS variation(2-3 years)was primarily related to SST,while longer term interannual DMS variation(6-8 years)was signifi cantly correlated with Chl a and SST.

关键词： interannual variability dimethylsulfi de hindcasting generalized additive mixed modelling Yellow Sea

Elevated serum levels of ghrelin and TNF-a in patients with cyanotic and acyanotic congenital heart disease

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World Journal of Pediatrics 2017年第2期13卷 122-128页

作者： Sai Zhang Gong-Liang Guo Li-Li Yang Li-qun sun Outpatient Department of Pediatrics No.1 Hospiml of Jilin UniversityChangchunChina Department of Cardiology the Third Hospital ofJilin UniversityChangchunChina Department of Gynecology and Obstetrics No.1 Hospital of Jilin UniversityChangchunChina

Background:The levels of ghrelin and tumor necrosis factor alpha (TNF-a) are considered biological markers of congenital heart diseases (CHD).The present meta-analysis was conducted to investigate the clinical significance of serum levels of ghrelin and TNF-α in children with (CHD).Methods:Chinese and English scientific literature databases were searched to retrieve published studies relevant to ghrelin,TNF-α and *** search was additionally employed to identify other relevant studies from *** retrieved studies were screened on the basis of our stringent inclusion and exclusion criteria to select high quality case-control studies for ***:We initially retrieved 108 published studies (20 in Chinese and 88 in English) from database ***,6 case-control studies (5 in English and 1 in Chinese) were enrolled in our meta-analysis,and contained a total of 160 cyanotic congenital heart disease (CCHD) patients and 215 acyanotic congenital heart disease (ACHD) patients,along with 162 healthy *** results of meta-analysis showed that serum levels of ghrelin and TNF-α in CCHD or ACHD children were significantly higher than those in healthy ***:Our meta-analysis results showed that serum levels of ghrelin and TNF-α are elevated in children with CHD,and could be used as effective biologic markers in early diagnosis of CHD.

关键词： acyanotic congenital heart disease cyanotic ghrelin meta-analysis TNF-α