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Multiplexed imaging of tumor immune microenvironmental markers in locally advanced or metastatic non-small-cell lung cancer characterizes the features of response to PD-1 blockade plus chemotherapy

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Cancer Communications 2022年第12期42卷 1331-1346页

作者： Fengying Wu Tao Jiang Gongyan chen Yunchao Huang Jianying Zhou Lizhu Lin Jifeng Feng Zhehai Wang Yongqian Shu Jianhua Shi Yi Hu Qiming Wang Ying cheng Jianhua chen Xiaoyan Lin Yongsheng Wang Jianan Huang Jiuwei Cui Lejie Cao Yunpeng Liu Yiping Zhang Yueyin Pan Jun Zhao LiPing Wang Jianhua Chang qun chen Xiubao Ren Wei Zhang Yun Fan Zhiyong He Jian Fang Kangsheng Gu Xiaorong Dong Tao Zhang Wei Shi Jianjun Zou Xuejuan Bai Shengxiang Ren Caicun Zhou Department of Thoracic Medical Oncology Shanghai Pulmonary HospitalTongji University School of MedicineShanghai 200433P.R.China Department of Respiratory Medicine Harbin Medical University Cancer HospitalHarbinHeilongjiang 150000P.R.China Department of Thoracic Surgery Oncology Yunnan Cancer Hospital&The Third Affiliated Hospital of Kunming Medical University&Yunnan Cancer CenterKunmingYunnan 650118P.R.China Department of Respiratory Medicine The First Affiliated Hospital of Zhejiang UniversityHangzhouZhejiang 310009P.R.China Department of Oncology Center The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhouGuangdong 510405P.R.China Department of Thoracic Medical Oncology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjingJiangsu 210009P.R.China Department of Respiratory Shandong Cancer Hospital&InstituteJinanShandong 250117P.R.China Department of Oncology Jiangsu Province HospitalNanjingJiangsu 210000P.R.China Department of Medical Oncology Linyi Cancer HospitalLinyiShandong 276000P.R.China Department of Oncology Chinese PLA General HospitalBeijing 100853P.R.China Department of Respiratory Medicine Henan Cancer HospitalZhengzhouHenan 450000P.R.China Department of Thoracic Oncology Jilin Cancer HospitalChangchunJilin 130012P.R.China Department of Medical Oncology-Chest Hunan Cancer HospitalChangshaHunan 410006P.R.China Department of Oncology Fujian Medical University Union HospitalFuzhouFujian 350001P.R.China Department of Thoracic Medical Oncology West China HospitalSichuan UniversityChengduSichuan 610000P.R.China Department of Respiration First Affiliated Hospital of Suzhou UniversitySuzhouJiangsu 215002P.R.China Department of Medical Oncology The First Bethune Hospital of Jilin UniversityChangchunJilin 130021P.R.China Pulmonary and Critical Care Medicine The First Affiliated Hospital University of Science Technology of ChinaHefeiAnhui 230036P.R.China De

Background:Although programmed cell death 1(PD-1)blockade plus chemotherapy can significantly prolong the progression-free survival(PFS)and overall survival(OS)in first-line settings in patients with driver-negative advanced non-small-cell lung cancer(NSCLC),the predictive biomarkers remain undetermined.Here,we investigated the predictive value of tumor immune microenvironmental marker expression to characterize the response features to PD-1 blockade plus chemotherapy.Methods:Tumor tissue samples at baseline were prospectively collected from 144 locally advanced or metastatic NSCLC patients without driver gene alterations who received camrelizumab plus chemotherapy or chemotherapy alone.Tumor immune microenvironmental markers,including PD-1 ligand(PDL1),CD8,CD68,CD4 and forkhead box P3,were assessed using multiplex immunofluorescence(mIF)assays.Kaplan-Meier curveswere used to determine treatment outcome differences according to their expression status.Mutational profiles were compared between tumors with distinct expression levels of these markers and their combinations.Results:Responders had significantly higher CD8/PD-L1(P=0.015)or CD68/PD-L1 co-expression levels(P=0.021)than non-responders in the camrelizumab plus chemotherapy group,while no difference was observed in the chemotherapy group.Patients with high CD8/PD-L1 or CD68/PD-L1 co-expression level was associated with significantly longer PFS(P=0.002,P=0.024;respectively)and OS(P=0.006,P=0.026;respectively)than those with low co-expression in camrelizumab plus chemotherapy group.When comparing survival in the camrelizumab plus chemotherapy with chemotherapy by CD8/PD-L1 co-expression stratification,significantly better PFS(P=0.003)and OS(P=0.032)were observed in high co-expression subgroups.The predictive value of CD8/PD-L1 and CD68/PD-L1 co-expression remained statistically significant for PFS and OS when adjusting clinicopathological features.Although the prevalence of TP53 or KRAS mutations was similar between patients with and without CD8/PD-L1 or CD68

关键词： Non-small-cell lung cancer PD-1 CD8 CD68 tumor immune microenvironment

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基于头罩的地铁车辆司机室碰撞生存空间分析

技术与市场 2024年第6期31卷 75-80页

作者：林建鹯陈群蔡程程中车株洲电力机车有限公司湖南株洲412001

基于EN 15227:2020《铁路应用——铁路车辆的耐撞性要求》,以某A型地铁项目为例,不同于以往地铁车辆碰撞安全分析方法,增加了对司机室头罩、前窗玻璃、紧急、疏散门等部件有限元建模,模拟仿真上述部件在列车碰撞时的破坏变形情况,分析... 详细信息

基于EN 15227:2020《铁路应用——铁路车辆的耐撞性要求》,以某A型地铁项目为例,不同于以往地铁车辆碰撞安全分析方法,增加了对司机室头罩、前窗玻璃、紧急、疏散门等部件有限元建模,模拟仿真上述部件在列车碰撞时的破坏变形情况,分析得出司机室头罩等变形未侵入司机室生存空间的研究结论,符合标准要求。

关键词：头罩司机室碰撞生存空间

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Very long wave infrared quantum dot photodetector up to 18μm

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Light(Science & Applications) 2024年第4期13卷 772-782页

作者： Xiaomeng Xue qun Hao Menglu chen School of Optics and Photonics Beijing Institute of TechnologyBeijing 100081China. Westlake Institute for Optoelectronics FuyangHangzhou 311421China. Physics Department Changchun University of Science and TechnologyChangchun 130022China

Colloidal quantum dots(CQDs)are of interest for optoelectronic devices because of the possibility of high-throughput solution processing and the wide energy gap tunability from ultraviolet to infrared wavelengths.People may question about the upper limit on the CQD wavelength region.To date,although the CQD absorption already reaches terahertz,the practical photodetection wavelength is limited within mid-wave infrared.To figure out challenges on CQD photoresponse in longer wavelength,would reveal the ultimate property on these nanomaterials.What’s more,it motivates interest in bottom-up infrared photodetection with less than 10%cost compared with epitaxial growth semiconductor bulk.In this work,developing a re-growth method and ionic doping modification,we demonstrate photodetection up to 18μm wavelength on HgTe CQD.At liquid nitrogen temperature,the responsivity reaches 0.3 A/W and 0.13 A/W,with specific detectivity 6.6×108 Jones and 2.3×109 Jones for 18μm and 10μm CQD photoconductors,respectively.This work is a step toward answering the general question on the CQD photodetection wavelength limitation.

关键词： quantum wave ultraviolet

ADSORPTION OF LATERALLY INTERACTING 1-NAPHTHOL/1-NAPHTHYL-AMINE MIXTURES ON NONPOLAR SURFACES FROM AQUEOUS SOLUTIONS

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Chinese Journal of Polymer Science 2006年第1期24卷 73-80页

作者： Wei-ming Zhang Jin-long chen qun chen Ming-yang He Bing-cai Pan and Quan-xing Zhang a State Key Laboratory of Pollution Control and Resources Reuse,School of the Environment,Nanjing University,Nanjing 210093,China b Research Center for Engineering Technology of Organic Poison Control and Resources Reuse in Jiangsu Province,Nanjing 210038,China c Department of Chemical Engineering,Jiangsu Polytechnic,Changzhou 213016,China State Key Laboratory of Pollution Control and Resources Reuse School of the Environment Nanjing University Nanjing 210093 China Research Center for Engineering Technology of Organic Poison Control and Resources Reuse in Jiangsu Province Nanjing 210038 China Department of Chemical Engineering Jiangsu Polytechnic Changzhou 213016 China

The binary adsorption behavior of 1-naphthol/1-naphthylamine mixtures in water on nonpolar adsorbent Amberlite XAD4 was investigated at 293 K, 303 K and 313 K, respectively. The experimental uptakes of 1-naphthol and 1-naphthylamine in all binary-component systems of different molar ratios were obviously higher than the corresponding uptakes predicted by the extended Langmuir model, assuming no interaction between the adsorbed molecules of the two components. This phenomenon was attributed to the cooperative adsorption effect arising from the hydrogen bonding interaction between 1-naphthol and 1-naphthylamine molecules. A modified extended Langmuir model was proposed to describe the binary adsorption behavior by means of introducing a fitting parameter related with the cooperative adsorption effect of the adsorbates.

关键词： Modified model 1-Naphthol 1-Naphthylamine Adsorbate-adsorbate interaction Cooperative effect.

基于EN 45545-2的轨道交通车辆内饰地板防火性能研究

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电力机车与城轨车辆 2024年第3期47卷 72-76页

作者：陈群杨国纪王富宇中车株洲电力机车有限公司湖南株洲412001

内饰地板作为轨道交通车辆上常见的一类复合材料,其防火性能在整车防火性能中起着重要作用。文章基于EN 45545-2:2020标准,通过对不同材料、不同型号、不同组合的内饰地板进行制样和测试,研究内饰地板的防火性能及其变化规律。结果表明... 详细信息

内饰地板作为轨道交通车辆上常见的一类复合材料,其防火性能在整车防火性能中起着重要作用。文章基于EN 45545-2:2020标准,通过对不同材料、不同型号、不同组合的内饰地板进行制样和测试,研究内饰地板的防火性能及其变化规律。结果表明:绝大多数内饰地板能满足EN 45545-2:2020标准的HL2及以上的防火等级要求;面层材料对内饰地板的防火性能影响最大,但一定范围内的厚度变化对内饰地板防火性能的影响较小;底层材料对内饰地板的防火性能有一定影响,铝蜂窝地板厚度变化对内饰地板防火性能的影响较小,不影响整体的防火等级;中层材料常用环氧胶,但其量少而薄,因此使用不同品牌环氧胶的内饰地板防火性能差异不大,不影响整体的防火等级。

关键词：轨道交通车辆内饰地板防火性能防火等级

Refining murine heterotopic heart transplantation:A model to study ischemia and reperfusion injury in donation after circulatory death hearts

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Animal Models and Experimental Medicine 2021年第3期4卷 283-296页

作者： Mohammed Quader Renee Cholyway Niluka Wickramaratne Oluwatoyin Akande Martin Mangino Eleonora Mezzaroma Adolfo GMauro qun chen Alexander Kantlis Stefano Toldo Division of Cardiothoracic Surgery Pauley Heart CenterVirginia Commonwealth UniversityRichmondVAUSA School of Pharmacy Virginia Commonwealth UniversityRichmondVAUSA Division of Cardiology Pauley Heart CenterVirginia Commonwealth UniversityRichmondVAUSA

Heart transplantation is a lifesaving procedure,which is limited by the availability of donor hearts.Using hearts from donors after circulatory death,which have sustained global ischemia,requires thorough studies on reliable and reproducible models that developing researchers may not have mastered.By combining the most recent lit-erature and our recommendations based on observations and trials and errors,the methods here detail a sound in vivo heterotopic heart transplantation model for rats in which protective interventions on the ischemic heart can be studied,and thus al-lowing the scientific community to advance organ preservation research.Knowledge gathered from reproducible animal models allow for successful translation to clinical studies.

关键词： animal models cardiovascular biology cardiovascular disorders reproducibility

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泡绉千鸟格羊毛织物的设计与生产

上海纺织科技 2024年第4期52卷 53-55,114页

作者：瞿建新陈群马顺彬江苏工程职业技术学院江苏南通226007

设计了一种泡绉千鸟格羊毛织物。面料结构为局部双层,单层处由里层经纱和表层纬纱交织形成;双层处的表层由非弹力经纱与非弹力纬纱交织,形成鸟形图案;双层处的里层为含有莱卡纤维的白色弹力纱线交织。面料下机后,含有弹力纱线的里层组... 详细信息

设计了一种泡绉千鸟格羊毛织物。面料结构为局部双层,单层处由里层经纱和表层纬纱交织形成;双层处的表层由非弹力经纱与非弹力纬纱交织,形成鸟形图案;双层处的里层为含有莱卡纤维的白色弹力纱线交织。面料下机后,含有弹力纱线的里层组织收缩,不含弹力纱线的表层图案隆起,形成立体的泡绉千鸟格图案,具有明显的三维效果;图案的形状和大小由里层经纱和表层纬纱的交织点决定。

关键词：羊毛织物双层组织千鸟格泡绉弹力纱线工艺参数面料设计

一种高精度音频Sigma-Delta DAC的设计

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中国集成电路 2024年第1期33卷 76-81页

作者：郑晓燕陈群超福州大学物理与信息工程学院

设计了一种应用于音频Codec的高精度Sigma-Delta DAC,针对数字插值滤波器占用面积大的问题,提出了乘法器复用的方法,减少数字电路的硬件消耗。为解决Sigma-Delta调制器多比特量化引起的非线性问题,引入DWA(Data Weight Average)算法,提... 详细信息

设计了一种应用于音频Codec的高精度Sigma-Delta DAC,针对数字插值滤波器占用面积大的问题,提出了乘法器复用的方法,减少数字电路的硬件消耗。为解决Sigma-Delta调制器多比特量化引起的非线性问题,引入DWA(Data Weight Average)算法,提高系统的精度。此外,DCT(Direct Charge Transfer)电路用于实现数字域到模拟域的高精度转换。电路采用0.18μm CMOS工艺,整体DAC的信噪比为105.7dB@1150Hz,有效位数达到17.26bit。

关键词：插值滤波器乘法器 Sigma-Delta调制器 DCT电路

EFFECT OF WEAK INTERACTIONS ON PHENOL ADSORPTION FROM AQUEOUS SOLUTIONS BY AMINATED POLYMERIC ADSORBENTS

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Chinese Journal of Polymer Science 2006年第1期24卷 61-66页

作者： Wei-ming Zhang Jin-long chen Ai-min Li Bing-cai Pan qun chen Ming-yang He and Quan-xing Zhang a State Key Laboratory of Pollution Control and Resources Reuse,School of the Environment,Nanjing University,Nanjing 210093,China b Research Center for Engineering Technology of Organic Poison Control and Resources Reuse in Jiangsu Province,Nanjing 210038,China c Department of Chemical Engineering,Jiangsu Polytechnic University,Changzhou 213016,China State Key Laboratory of Pollution Control and Resources Reuse School of the Environment Nanjing University Nanjing 210093 China Research Center for Engineering Technology of Organic Poison Control and Resources Reuse in Jiangsu Province Nanjing 210038 China Department of Chemical Engineering Jiangsu Polytechnic University Changzhou 213016 China

Adsorption behaviors of phenol from aqueous solutions have been investigated in batch systems at 303 K and 318 K respectively, using hypercrosslinked polymeric adsorbent （CHA111）, aminated hypercrosslinked polymeric adsorbents （NDA101, NDA103, NDA105） and weakly basic polymeric adsorbent （D301） with a view to studying the effect of hydrogen bonding and Van der Waals interactions between adsorbate and the adsorbent. All adsorption isotherms can be well fitted by Langmuir and Freundlich equations. Compared with D301 driven by hydrogen bonding interaction only and CHA111 driven by Van der Waals interaction only, phenol adsorption on aminated adsorbents driven by both hydrogen bonding and Van der Waals interactions were apparently different, i.e., negative effect for NDA105, positive effect for NDA101 and synergistic effect for NDA103. In this synergistic action, some weak interactions would contribute more or less to the adsorption than they work individually.

关键词： Polymeric adsorbent Phenol Adsorption behaviours Negative effect Positive effect Synergistic effect.