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Grain refinement of Mg-Ca alloys by native MgO particles

Journal of Magnesium and Alloys 2024年第3期12卷 980-996页

作者： Shihao Wang Yun Wang quentin M.Ramasse Zhongyun Fan Super STEM Laboratory SciTech Daresbury CampusDaresbury WA44ADUK School of Chemical and Process Engineering University of LeedsLeeds LS29JTUK BCAST Brunel University LondonUxbridgeMiddlesex UB83PHUK

In Mg-Ca alloys the grain refining mechanism,in particular regarding the role of nucleant substrates,remains the object of *** native MgO is being recognised as a nucleating substrate accounting for grain refinement of Mg alloys,the possible interactions of MgO with alloying elements that may alter the nucleation potency have not been elucidated ***,we design casting experiments of Mg-xCa alloys varied qualitatively in number density of native MgO,which are then comprehensively studied by advanced electron *** results show that grain refinement is enhanced as the particle number density of MgO *** native MgO particles are modified by interfacial layers due to the co-segregation of Ca and N solute atoms at the MgO/Mg *** aberration-corrected scanning transmission electron microscopy and electron energy loss spectroscopy,we reveal the nature of these Ca/N interfacial layers at the atomic *** of the crystallographic termination of MgO,Ca and N co-segregate at the MgO/Mg interface and occupy Mg and O sites,respectively,forming an interfacial structure of a few atomic *** interfacial structure is slightly expanded,less ordered and defective compared to the MgO matrix due to compositional deviations,whereby the MgO substrate is altered as a poorer template to nucleate Mg *** solidification in a TP-1 mould,the impotent MgO particles account for the grain refining mechanism,where they are suggested to participate into nucleation and grain initiation processes in an explosive *** work not only reveals the atomic engineering of a substrate through interfacial segregation but also demonstrates the effectiveness of a strategy whereby native MgO particles can be harnessed for grain refinement in Mg-Ca alloys.

关键词： Mg-Ca alloy Grain refinement MgO Interfacial segregation STEM/EELS Solidification.

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Extended wet sieving method for determination of complete particle size distribution of general soils

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 242-257页

作者： Shengnan Ma Yi Song Jiawei Liu Xingyu Kang Zhongqi quentin Yue Department of Civil Engineering The University of Hong KongHong KongChina

The traditional standard wet sieving method uses steel sieves with aperture?0.063 mm and can only determine the particle size distribution(PSD)of gravel and sand in general *** paper extends the traditional method and presents an extended wet sieving *** extended method uses both the steel sieves and the nylon filter cloth *** apertures of the cloth sieves are smaller than 0.063 mm and equal 0.048 mm,0.038 mm,0.014 mm,0.012 mm,0.0063 mm,0.004 mm,0.003 mm,0.002 mm,and 0.001 mm,*** extended method uses five steps to separate the general soil into many material sub-groups of gravel,sand,silt and clay with known particle size *** complete PSD of the general soil is then calculated from the dry masses of the individual material *** extended method is demonstrated with a general soil of completely decomposed granite(CDG)in Hong Kong,*** silt and clay materials with different particle size ranges are further examined,checked and verified using stereomicroscopic observation,physical and chemical property *** results further confirm the correctness of the extended wet sieving method.

关键词： Particle size distribution(PSD) General soil Silt Clay Wet sieving Physical and chemical properties

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Digital monitoring of rotary-percussive drilling with down-the-hole hammer for profiling weathered granitic ground

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1615-1636页

作者： Wendal Victor Yue Siyuan Wu Manchao He Yafei Qiao Zhongqi quentin Yue Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai200092China Department of Civil Engineering Faculty of EngineeringThe University of Hong KongPokfulam RoadHong KongChina State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyBeijing100083China Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education Tongji UniversityShanghai200092China

Rock and geotechnical engineering investigations involve drilling holes in ground with or without retrieving soil and rock samples to construct the subsurface ground *** the basis of an actual soil nailing drilling for a slope stability project in Hong Kong,this paper further develops the drilling process monitoring(DPM)method for digitally profiling the subsurface geomaterials of weathered granitic rocks using a compressed airflow driven percussive-rotary drilling machine with down-the-hole(DTH)*** transducers are installed on the drilling machine and record the chuck displacement,DTH rotational speed,and five pressures from five compressed airflows in real-time *** mechanism and operations of the drilling machine are elaborated in detail,which is essential for understanding and evaluating the drilling data.A MATLAB program is developed to automatically filter the recorded drilling data in time series and classify them into different drilling processes in sub-time *** processes include penetration,push-in with or without rod,pull-back with or without rod,rod-tightening and *** drilling data are further reconstructed to plot the curve of drill-bit depth versus the net drilling time along each of the six *** curve is found to contain multiple linear segments with a constant penetration rate,which implies a zone of homogenous geomaterial with different weathering *** effect from fluctuation of the applied pressures is evaluated *** analyses are presented for accurately assess and verify the underground profiling and strength in weathered granitic rock,which provided the basis of using DPM method to confidently assess drilling measurements to interpret the subsurface profile in real time.

关键词： Drilling process monitoring(DPM) Down-the-hole(DTH)hammer Percussive-rotary drilling Weathering granitic rocks

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Tree species identity and interaction determine vertical forest structure in young planted forests measured by terrestrial laser scanning

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Forest Ecosystems 2024年第3期11卷 266-275页

作者： Mengxi Wang Lander Baeten Frieke Van Coillie Kim Calders Kris Verheyen quentin Ponette Haben Blondeel Bart Muys John Armston Hans Verbeeck Q-ForestLab Department of EnvironmentFaculty of Bioscience EngineeringGhent UniversityBelgium Forest&Nature Lab Department of EnvironmentFaculty of Bioscience EngineeringGhent UniversityBelgium Earth and Life Institute Université Catholique de Louvain(UCLouvain)Louvain-la-NeuveBelgium Department of Earth&Environmental Sciences KU LeuvenBelgium Department of Geographical Sciences University of MarylandCollege ParkMDUSA

Vertical forest structure is closely linked to multiple ecosystem characteristics,such as biodiversity,habitat,and *** tree species in planted forests has the potential to create diverse vertical forest structures due to the different physiological and morphological traits of the composing tree ***,the relative importance of species richness,species identity and species interactions for the variation in vertical forest structure remains unclear,mainly because traditional forest inventories do not observe vertical stand structure in *** laser scanning(TLS),however,allows to study vertical forest structure in an unprecedented ***,we used TLS single scan data from 126 plots across three experimental planted forests of a largescale tree diversity experiment in Belgium to study the drivers of vertical forest *** plots were 9–11years old young pure and mixed forests,characterized by four levels of tree species richness ranging from monocultures to four-species mixtures,across twenty composition *** generated vertical plant profiles from the TLS data and derived six stand structural *** mixed models were used to test the effect of species richness on structural *** a hierarchical diversity interaction modelling framework,we further assessed species identity effect and various species interaction effects on the six stand structural *** results showed that species richness did not significantly influence most of the stand structure variables,except for canopy height and foliage height *** identity on the other hand exhibited a significant impact on vertical forest structure across all *** interaction effects were observed to be site-dependent due to varying site conditions and species pools,and rapidly growing tree species tend to dominate these ***,our results highlighted the importance of considering both species identity an

关键词： TreeDivNet FORBIO Stand structural complexity Terrestrial laser scanning Vertical forest structure Tree diversity Planted forests

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可以放在鞋盒中的数据中心

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科技纵览 2024年第6期 38-43,4页

作者： Anna Herr quentin Herr Imec

比利时微电子研究中心计划利用超导缩小计算机。科学家预测,到2040年,计算消耗的电力将占全球总量的50%。这一预测是在生成式人工智能爆发之前作出的。过去十多年来,训练大型人工智能模型所需的计算资源大约每6个月就会翻一番。按照这... 详细信息

比利时微电子研究中心计划利用超导缩小计算机。科学家预测,到2040年,计算消耗的电力将占全球总量的50%。这一预测是在生成式人工智能爆发之前作出的。过去十多年来,训练大型人工智能模型所需的计算资源大约每6个月就会翻一番。按照这个速度,到2030年,训练一个人工智能模型所需的计算资源将是当前十大超级计算机年度所需资源之和的100倍。简而言之,计算需要的巨大电力能源,很快将超出地球所能提供的范围。

关键词：数据中心超级计算机人工智能计算资源电力能源微电子生成式计算消耗

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Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1

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Protein & Cell 2024年第6期15卷 419-440页

作者： Wei Ma Lu Zhang Weilong Chen Zhaoxia Chang Juchuanli Tu Yuanyuan Qin Yuwen Yao Mengxue Dong Jiajun Ding Siqin Li Fengkai Li Qiaodan Deng Yifei Yang Tingting Feng Fanrong Zhang Xiying Shao Xueyan He Lixing Zhang Guohong Hu quentin Liu Yi-Zhou Jiang Shu Zhu Zhi Xiao Dan Su Tong Liu Suling Liu Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences State Key Laboratory of Genetic EngineeringCancer InstitutesDepartment of OncologyKey Laboratory of Breast Cancer in ShanghaiThe Shanghai Key Laboratory of Medical EpigeneticsShanghai Key Laboratory of Radiation OncologyThe International Co-laboratory of Medical Epigenetics and MetabolismMinistry of Science and TechnologyShanghai Medical CollegeFudan UniversityShanghai 200032China Intelligent Pathology Institute and Department of Pathology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230071China Department of Thyroid Breast and Vascular SurgeryXijing HospitalFourth Military Medical UniversityXi’an 710032China Institute of Immunology CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230027China Department of Pathology The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer (IBMC)Chinese Academy of SciencesHangzhou 310022China Department of Breast Surgery The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer (IBMC)Chinese Academy of SciencesHangzhou 310022China Department of Breast Medical Oncology The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer (IBMC)Chinese Academy of SciencesHangzhou 310022China Shanghai Institute of Nutrition and Health University of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhou 510060China Department of Breast Surgery Xiangya HospitalChangsha 410008China Department of Breast Surgery Tumor Hospital of Harbin Medic

Tumor-resident microbiota in breast cancer promotes cancer initiation and malignant ***,targeting microbiota to improve the effects of breast cancer therapy has not been investigated in ***,we evaluated the microbiota composition of breast tumors and found that enterotoxigenic Bacteroides fragilis(ETBF)was highly enriched in the tumors of patients who did not respond to taxane-based neoadjuvant ***,albeit at low biomass,secreted the toxic protein BFT-1 to promote breast cancer cell stemness and *** studies showed that BFT-1 directly bound to NOD1 and stabilized NOD1 ***1 was highly expressed on ALDH+breast cancer stem cells(BCSCs)and cooperated with GAK to phosphorylate NUMB and promote its lysosomal degradation,thereby activating the NOTCH1-HEY1 signaling pathway to increase ***1 inhibition and ETBF clearance increase the chemosensitivity of breast cancer by impairing BCSCs.

关键词： NOD1 breast chemotherapy

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The nature of cancer

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Frontiers of Medicine 2023年第4期17卷 796-803页

作者： Min Yan quentin Liu Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangzhou 510060China Institute of Cancer Stem Cell Cancer CenterDalian Medical UniversityDalian 116023China

Introduction Cancer heterogeneity has been characterized with distinct differentiation states,metabolic status,and microenvironmental features,accounting for diverse responses to *** view has proposed 14 hallmarks of cancer in order to provide a logical framework for the comprehensive understanding of the characteristics and processes responsible for malignant transformation and progression[1,2].

关键词： cancer Cancer malignant

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Fine-tuning cell organelle dynamics during mitosis by small GTPases

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Frontiers of Medicine 2022年第3期16卷 339-357页

作者： Zijian Zhang Wei Zhang quentin Liu Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Clinical Immunology The Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China Institute of Cancer Stem Cell Dalian Medical UniversityDalian 116044China

During mitosis,the allocation of genetic material concurs with organelle transformation and *** coordination of genetic material inheritance with organelle dynamics directs accurate mitotic progression,cell fate determination,and organismal *** GTPases belonging to the Ras superfamily regulate various cell organelles during *** the key regulators of membrane dynamics,the dysregulation of small GTPases is widely associated with cell organelle disruption in neoplastic and non-neoplastic diseases,such as cancer and Alzheimer’s *** discoveries shed light on the molecular properties of small GTPases as sophisticated modulators of a remarkably complex and perfect adaptors for rapid structure *** review collects current knowledge on small GTPases in the regulation of cell organelles during mitosis and highlights the mediator role of small GTPase in transducing cell cycle signaling to organelle dynamics during mitosis.

关键词： small GTPase cell organelle mitosis

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Overcoming the Electrode Challenges of High‑Temperature Proton Exchange Membrane Fuel Cells

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Electrochemical Energy Reviews 2023年第1期6卷 280-319页

作者： quentin Meyer Chujie Yang Yi Cheng Chuan Zhao School of Chemistry The University of New South WalesSydneyNSW 2052Australia Hunan Provincial Key Laboratory of Nonferrous Value-Added Metallurgy Central South UniversityChangsha 410083HunanChina

Proton exchange membrane fuel cells(PEMFCs)are becoming a major part of a greener and more sustainable ***,the costs of high-purity hydrogen and noble metal catalysts alongside the complexity of the PEMFC system severely hamper their *** PEMFCs at high temperatures(HT-PEMFCs,above 120℃)brings several advantages,such as increased tolerance to contaminants,more affordable catalysts,and operations without liquid water,hence considerably simplifying the *** recent progresses in proton exchange mem-branes for HT-PEMFCs have made this technology more viable,the HT-PEMFC viscous acid electrolyte lowers the active site utilization by unevenly diffusing into the catalyst layer while it acutely poisons the catalytic *** recent years,the synthesis of platinum group metal(PGM)and PGM-free catalysts with higher acid tolerance and phosphate-promoted oxygen reduction reaction,in conjunction with the design of catalyst layers with improved acid distribution and more triple-phase boundaries,has provided great opportunities for more efficient *** progress in these two interconnected fields is reviewed here,with recommendations for the most promising routes worthy of further *** these approaches,the performance and durability of HT-PEMFCs will be significantly improved.

关键词： High-temperature proton exchange membrane fuel cells Platinum catalysts Platinum-group metal-free catalysts Phosphate-tolerant electrode

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A Cross-sectional Real-life Study of the Prevalence,Severity,and Determinants of Metabolic Dysfunction-associated Fatty Liver Disease in Type 2 Diabetes Patients

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Journal of Clinical and Translational Hepatology 2023年第6期11卷 1377-1386页

作者： quentin Binet Audrey Loumaye Michel P Hermans Nicolas Lanthier Service d’Hépato-Gastroentérologie Cliniques universitaires Saint-LucUCLouvainBrusselsBelgium Service d’Endocrinologie et Nutrition Cliniques universitaires Saint-LucUCLouvainBrusselsBelgium

Background and Aims:Most data on liver assessment in type 2 diabetes mellitus(T2DM)patients are from retrospective cohorts with selection *** aimed at appraising the feasibility,results,and benefits of an outpatient systematic noninvasive screening for metabolic dysfunction-associated fatty liver disease(MAFLD)severity and determinants in T2DM ***:We conducted a 50-week crosssectional study enrolling adult T2DM outpatients from a diabetes *** algorithm based on guidelines was applied using simple bioclinical scores and,if applicable,ultrasound and/or ***:Two hundred and thirteen patients were *** age and body mass index were 62 years and 31 kg/m^(2) and 29% of patients had abnormal transaminase *** acceptance rate of additional liver examinations was 92%.The prevalence of MAFLD,advanced fibrosis and cirrhosis was 87%,11%,and 4%,*** than half of the cases of advanced fibrosis had not been suspected and were detected by this *** was associated with poor glycemic control,elevated transaminases,low HDL-C and the absence of peripheral arterial *** fibrosis was linked to high waist circumference and excessive alcohol consumption,which should be interpreted with caution owing to the small number of patients reporting excessive ***:Simple bioclinical tools allowed routine triage of T2DM patients for MAFLD severity,with high adherence of high-risk patients to subsequent noninvasive exams.

关键词： Noninvasive tests MAFLD Outpatient Steatosis Fibrosis

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