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PNPLA3 and TM6SF2 polymorphisms in Brazilian patients with nonalcoholic fatty liver disease

World Journal of Hepatology 2020年第10期12卷 792-806页

作者： quelson coelho lisboa Mateus Jorge Nardelli Patrícia de Araújo Pereira Débora Marques Miranda Stephanie Nunes Ribeiro Raissa Soares Neves Costa Camila Azevedo Versiani Paula Vieira Teixeira Vidigal Teresa Cristina de Abreu Ferrari Claudia Alves Couto Departament de Clínica Médica Faculty of MedicineUniversidade Federal de Minas GeraisBelo Horizonte 30130100Brazil

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is becoming the most common chronic liver disease worldwide,with significant morbidity associated with nonalcoholic steatohepatitis(NASH).Genome-wide association studies demonstrated that the variants rs738409 C/G in the PNPLA3 and rs58542926 C/T in the TM6SF2 genes are determinants of inter-individual and ethnicity-related differences in hepatic fat content and NAFLD *** To investigate PNPLA3 and TM6SF2 genotype frequency and their association with NAFLD development and progression in Brazilian *** This cross-sectional case-control study enrolled 285 individuals from the Gastroenterology and Hepatology clinics at a university hospital in *** case patients(n=148)were confirmed to have NAFLD by the identification of hepatic steatosis on ultrasonography and exclusion of other causes of liver *** to the clinical protocol,patients underwent liver biopsy when at high risk for NASH and/or advanced fibrosis(n=65).Steatohepatitis was confirmed in 54 *** who did not have biopsy indication or NASH on histology were considered to have simple steatosis(n=94).The control group(n=137)was selected among patients that attended the Intestinal Disease clinic and was composed of subjects without abnormalities on abdominal ultrasonography and normal liver biochemical *** individuals underwent PNPLA3 and TM6SF2 genotype *** PNPLA3 CC,CG and GG genotype frequencies were 37%,44%and 19%,respectively,in NAFLD patients and were 58%,31%and 10%in controls(P<0.001).In a model adjusted for gender,age,body mass index and type 2 diabetes mellitus,the G allele increased the chance of NAFLD(OR=1.69,95%CI:1.21-2.36,P=0.002)and NASH(OR=3.50,95%CI:1.84-6.64,P<0.001).The chance of NASH was even higher with GG homozygosis(OR=5.53,95%CI:2.04-14.92,P=0.001).No association was found between G allele and the features of metabolic *** histological assessment,PNPLA3 genoty

关键词： Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Genetic variation Single nucleotide polymorphism Genotype Brazil Fibrosis

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Initial medication adherence in newly diagnosed glaucoma patients:three adherence measures

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International Journal of Ophthalmology(English edition) 2023年第4期16卷 630-637页

作者： Joana Menino Pedro Camacho Andrécoelho Escola Superior de Tecnologia da Saúde Instituto Politécnico de LisboaLisbon 1990-096Portugal H&TRC-Health&Technology Research Center ESTeSLEscola Superior de Tecnologia da SaúdeInstituto Politécnico de LisboaLisbon 1990-096Portugal iNOVA4Health NOVA Medical SchoolFaculdade de Ciências MédicasNMSFCMUniversidade NOVA de LisboaLisbon 1150-82Portugal Instituto de Oftalmologia Dr.Gama Pinto Lisbon 1150-255Portugal

AIM:To determine initial medication adherence in newly diagnosed glaucoma patients treated with anti-glaucoma ***:This retrospective and observational study included all patients diagnosed with glaucoma in the Primary Health Care units in Portugal during the years 2012 and 2013,which in consequence received a first prescription for anti-glaucoma *** was collected from electronic prescribing records of the primary care units and from pharmacy claims *** of glaucoma treatment and early discontinuation were measured,and the combination of(non)-initiation and early discontinuation accounted for initial medication(non)-***:A total of 3548 new glaucoma patients(40.1%male;59.9%female)were *** 1133(31.9%)patients were initially classified as non-users,since there was no pharmacy claim found for their first prescription for glaucoma ***,277(11.5%)patients early discontinued their treatment,acquiring only their first ***,the initial medication non-adherence rate was 39.7%since 1410 patients either didn’t initiate treatment or discontinued it ***:This study,reveals a major opportunity to improve glaucoma treatment and its control,since a large proportion of patients fail to engage with their prescribed therapy,which implies that implementation of individual or group strategies that enable patients with glaucoma to correctly perform their treatment is still needed.

关键词： glaucoma glaucoma treatment initiation early discontinuation initial medication adherence

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The effect of non-pharmaceutical interventions on COVID-19 outcomes:A heterogeneous age-related generalisation of the SEIR model

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Infectious Disease Modelling 2023年第3期8卷 742-768页

作者： Jorge M.Mendes Pedro S.coelho NOVA Information Management School(NOVAIMS) Universidade Nova de LisboaCampus de Campolide1070-312LisbonPortugal NOVA Cairo at the Knowledge Hub Universities New Admnistrative CapitalCairoEgypt

Successive generalisations of the basic SEIR model have been proposed to accommodate the different needs of the organisations handling the SARS-CoV-2 epidemic and the assessment of the public health measures adopted and named under the common um-brella of Non-Pharmaceutical Interventions(NPIs).So far,these generalisations have not been able to assess the ability of these measures to avoid infection by the SARS-CoV-2 and thus their contribution to contain the spread of the *** work proposes a new generalisation of SEIR model and includes a heterogeneous and age-related generation of infections that depends both on a probability that a contact generates the transmission of the disease and a contact *** results show(1)thanks to the universal wearing of facial coverings,the probability that a contact provokes the transmission of the disease was reduced by at least 50%and(2)the impact of the other NPI is so significant that otherwise Portugal would have gone into a non-sustainable situation of having 80%of its population infected in the first 300 days of the *** situation would have led to a number of deaths almost twenty times higher than the number that was actually recorded by December 26th,***,the results suggest that even if the requirement of universal wearing of facial coverings was adopted sooner jointly with closing workplaces and resorting to teleworking would have postponed the peak of the incidence,altought the epidemic path would have result in a number of infections hardly managed by the National Health ***,results confirm that(3)the health authorities adopted a conservative approach on the criteria to consider an infected individual not infective any longer;and(4)the most effective NPIs and stringency levels either impacting on self-protection against infection or reducing the contacts that would eventually result in infection are,in decreasing order of importance,the use of Facial coverings,Workplace clos

关键词： eventually otherwise string

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The CASTOR-K Code,Recent Developments and Applications

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Plasma Science and Technology 2015年第2期17卷 89-96页

作者： F.NABAIS D.BORBA R.coelho A.FIGUEIREDO J.FERREIRA N.LOUREIRO P.RODRIGUES Associao EURATOM/IST Instituto de Plasmas e Fuso Nuclear-Instituto Superior TcnicoUniversidade de Lisboa

The CASTOR-K code is a hybrid magnetohydrodynamic （MHD）-drift kinetic code developed for the study of MHD modes in the presence of energetic ion populations. It allows a fast assessment of the linear stability of the modes, as well as an accurate calculation of damping due to thermal species （Landau damping）. These capabilities make the code an invaluable tool for parametric studies and data analysis. In recent years, CASTOR-K has been mostly used to analyze JET data, including the identification of mechanisms involved in the expulsion of energetic ions from the plasma. However, in order to prepare the code to be used for a wider range of tokamaks including ITER, the code is being subject to a series of important improvements. These improvements aim not only to introduce new physics in the code but also to make it capable of exchanging data with other codes through its integration in modelling infrastructures. In this paper a description of the CASTOR-K code is presented, as well as a summary of the most important results obtained with this code and a description of the new improvements being implemented.

关键词： controlled fusion tokamaks plasma instabilities magnetohydrodynamics(MHD) Alfven waves energetic particles

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Dynamical Demixing of a Binary Mixture Under Sedimentation

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Communications in Computational Physics 2023年第1期33卷 1-21页

作者： Andre S.Nunes Rodrigo C.V.coelho Vasco C.Braz Margarida M.Telo da Gama Nuno A.M.Araujo Centro de F´ısica Te´orica e Computacional Faculdade de CiˆenciasUniversidade de LisboaP-1749-016 LisboaPortugal Departamento de F´ısica Faculdade de CienciasUniversidade de LisboaP-1749-016 LisboaPortugal Electric Ant Lab Science Park 1061098 XGAmsterdamThe Netherlands

We investigate the sedimentation dynamics of a binary mixture,the species of which differ by their Stokes coefficients but are identical *** analyze the sedimentation dynamics and the morphology of the final deposits using Brownian dynamics simulations for mixtures with a range of sedimentation velocities of both *** addition,we use the lattice Boltzmann method to study hydrodynamic *** found a threshold in the difference of the sedimentation velocities above which the species in the final deposit are *** degree of segregation increases with the difference in the Stokes coefficients or the sedimentation velocities above the *** propose a simple analytical model that captures the main features of the simulated deposits.

关键词： Sedimentation Brownian dynamics lattice Boltzmann method

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Experimental and simulation assessments of underwater light propagation

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Frontiers of Optoelectronics 2019年第4期12卷 405-412页

作者： Fatah ALMABOUADA Manuel Adler ABREU Joao M.P.coelho Kamal Eddine AIADI Faculte des Mathematiques et des Sciences de la Matiere Departement de PhysiqueUniversite Kasdi Merbah OuarglaOuargla 30000Algerie Centre de Developpement des Technologies Avancees Division Milieux Ionises&LasersAlger 16303Algerie Laboratorio de Optica Laser e SistemasFaculdade de Ciencias da Universidade de Lisboa Campus do LumiarEstrada do Pago do LumiarLisboa 1649-03&Portugal Faculte des Mathematiques et des Sciences de la Matiere Laboratoire LENREZAUniversite Kasdi Merbah OuarglaOuargla 30000Algerie

This paper investigates the light propagation through several types of water by experimental and *** Zemax-ray tracing software allowed to simulate the propagation of light in water and to observe the receiver response by reproducing the real conditions of *** underwater environment has been reproduced by a 1.2 m long water tube and 20 cm in diameter with a glass window fitted on one *** use of tap water with different amounts of sand leads toward three types of water with different attenuation coefficients(0.133,0.343,0.580 m^-1).The light transmission in the three types of water was experimentally evaluated using a doubled Nd:YAG laser with energy of 4.3 mJ and a pulse width of 20 *** were done between simulation and experimental results.

关键词： underwater light propagation attenuation coefficient telescope laser range finder

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指标在流域管理规划和战略环境评价过程中的应用(下)

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环境影响评价 2019年第5期41卷 I0005-I0013页

作者： Rosa Santos coelho Pedro S.coelho Tomas B.Ramos Paula Antunes 吴成志(译) 张怡悦(译) 卿野(译) Faculdade de Ciencias e Tecnologia Departamento de Ciencias e Engenharia do AmbienteCenter for Environmental and Sustainability Research (CENSE)Universidade NOVA de LisboaCampus da CaparicaCaparicaPortugal Instituto Politecnico de Santarem Escola Superior AgrariaSantaremPortugal Faculdade de Ciencias e Tecnologia Departamento de Ciencias e Engenharia do AmbienteMarine and Environmental Sciences Centre (MARE)Universidade NOVA de LisboaCampus da CaparicaCaparicaPortugal 三捷环境工程咨询(杭州)有限公司

流域管理规划(RBMP)和战略环境影响评价(SEA)过程通常需要使用指标来评估规划方案的可持续性、与利益相关者进行沟通并对决策提供支持。这项研究的目的是为了支持主要过程和调查指标的使用效果,并分析整合后的情况。葡萄牙RBMP的内容分... 详细信息

流域管理规划(RBMP)和战略环境影响评价(SEA)过程通常需要使用指标来评估规划方案的可持续性、与利益相关者进行沟通并对决策提供支持。这项研究的目的是为了支持主要过程和调查指标的使用效果,并分析整合后的情况。葡萄牙RBMP的内容分析及相应的SEA报告采用了概念框架来支持其内容的定性分析。主要的发现是指标通常被用于SEA和规划报告中。被分析的文件中使用了大量的指标,其中大多数指标是定量的,并在组织、选择和验证时使用了差别很大的方法。通常这些过程都不需要公众参与。此研究给出了需要改进的方面,例如还需研究是否有需要增加利益相关者在指标发展过程中的参与度、标准化和交叉性指标使用时的相关性以及两个过程中都使用的关键性指标的确定。

关键词：河流流域管理规划环境影响评价指标概念框架内容分析

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Fisher's perceptions about a marine protected area over time

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Aquaculture and Fisheries 2020年第5期5卷 273-281页

作者： Cristina Pita Barbara Horta e Costa Gustavo Franco Rui coelho Inês Sousa Emanuel J.Gonçalves Jorge M.S.Gonçalves Karim Erzini Department of Environment and Planning&Centre for Environmental and Marine Studies(CESAM) University of AveiroPortugal Center of Marine Sciences CCMARUniversity of AlgarveCampus de Gambelas8005-139FaroPortugal MARE-Marine and Environmental Sciences Centre ISPAInstituto UniversitárioRua Jardim Do Tabaco 341149-041LisboaPortugal Instituto Português Do Mar a da Atmosfera IP(IPMA)-Polo OlhãoAv.5 de Outubro8700-305OlhãoPortugal

The perceptions of fishers towards the Arrábida Marine Park,a marine protected area(MPA)in the west coast of Portugal,were studied through face-to-face interviews in two different moments of the MPA life ***'perceptions about the MPA and the impact it had on the fishing activity over time were identified just before the full implementation of the zoning and regulations of the management plan and 10 years *** study aimed to investigate fishers'knowledge,acceptance and perceptions about the MPA changed with time,if support for the MPA was linked to the impact of the MPA on the fishing activity,and if fishers'perceptions about the impact of the MPA on the fishing activity match with local landings *** show that although knowledge about the marine park significantly improved over time,fishers'acceptance did not.A decrease on fishers'support was not substantial but *** such as the disagreement with regulations reinforced concerns raised during the implementation of the marine park,particularly in relation to the top-down decision-making,which commonly confers minor participation,recognition and legitimacy to ***,fisheries benefits were still not perceived by local fishers,though they are central for fishers'***,the perceived negative impacts of the park seemed to be more related to social aspects and individual interests than to impacts on *** adequate management,enforcement and participation of local fishers is still possible and are advocated here as to contribute to the expected socioecological outcomes and respective support,leading to the future successful performance of the Arrábida Marine *** fishers’perceptions towards an MPA over time is central and should be included on periodical socioecological monitoring and inform an effective adaptive management.

关键词： Arrabida Marine Park(AMP) Local fisheries Perceptions Attitudes Fishers'support Decision-making Marine protected area Changes over time

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Bayesian Estimation in Dam Monitoring Networks

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Journal of Civil Engineering and Architecture 2011年第2期5卷 185-190页

作者： Joo Manuel Martins Casaca Pedro Jorge Bele Mateus Joeo de Jesus Isidoro coelho National Laboratoty for Civil Engineering Lisbon 1700-066 Portugal Faculty of Science University of Lisbon Lisboa 1749-016 Portugal

A Bayesian estimator with informative prior distributions （a multi-normal and an inverted gamma distribution）, adequate to displacement estimation at dam displacement monitoring networks, is presented. The hyper-parameters of the prior distributions are obtained by Bayesian empirical methods with non-informative meta-priors. The performances of the Bayes estimator and the classical generalized lest squares estimator are compared using two measurements of the horizontal monitoring network of a concrete gravity dam： the Penha Garcia dam （Portugal）. In order to test the robustness of the two estimators, a gross error is added to one of the measured horizontal directions： the Bayes estimator proves to be significantly more robust than the classic maximum likelihood estimator.

关键词： Bayes estimator hyper-parameter parametric elicitation prior distribution.

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Social Responsibility and Environmental Sustainability： The Case of Caixa Geral de Dep6sitos （Portugal） and Vale （Brazil）

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Chinese Business Review 2011年第5期10卷 352-375页

作者： Jose Antonio Candeias Bonito Filipe Manuel Francisco Pacheco coelho Manuel Alberto M. Ferreira Ivo Cunha Figueredo Instituto Universitario de lisboa （ISCTE-IUL） UNIDE-IUL Lisboa Portugal lnstituto Superior de Economia e Gestao （ISEG-UTL） SOCIUS. Lisboa Portugal Instituto Universitairio de lisboa （ISCTE-IUL） Lisboa Portugal

Social responsibility requires a set of duties and obligations, whether individuals or firms in relation to society and to the communities in which the organization is operating. The tradition of social intervention in Portugal dates from the fifteenth century and the founding of Mercy. However, environmental issues have never been felt in a sensitive position in responsible business, given the weakness of industrial development which lasted until the 60＇s. In Brazil, the corporate social responsibility is still particularly a big challenge, since the actions of social responsibility have not contributed effectively to improve the living conditions of society and the transformation of existing social reality. The purpose of this study is to emphasize the perspective of environmental sustainability that underpins the more general concept of social responsibility and, through the case study Caixa Geral de Dep6sitos, assess the strengths and weaknesses of the development of measures of social responsibility in this area in Portugal, and present the case of the company Vale, carrying out business in Brazil

关键词： social responsibility sustainable development environmental sustainability Caixa Geral deDepositos Vale

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