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Cellular & Molecular Immunology 2007年第1期4卷 1-13页

作者： Queenie Lai Kwan Lam Department of Pathology and Center of Infection and Immunology The University of Hong Kong

Leptin, a protein hormone produced by the adipocytes, has long been recognized to regulate metabolism, neuroendorine and other physiological functions. Early findings of increased leptin production during infection and inflammation and dysregulated immune response in leptin signaling-deficient mice provide strong evidence for the involvement of leptin in the immune responses. Recent data have established the regulatory function for leptin in immunity similar to the function of a pro-inflammatory cytokine, while gene-targeting studies also demonstrated an essential role of leptin in regulating hematopoiesis and lymphopoiesis. Moreover, there has been increasing evidence that leptin is involved in the pathogenesis of various autoimmune diseases. This review discusses recent advances in understanding the role of leptin in immunity and leptin-signaling pathways involved in modulating immune homeostasis and autoimmune pathogenesis. Cellular ＆ Molecular Immunology. 2007;4（1）：1-13.

关键词： leptin leptin signaling pro-inflammatory cytokine immune response autoimmune disease

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Leptin Signaling Protects NK Cells from Apoptosis During Development in Mouse Bone Marrow

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Cellular & Molecular Immunology 2009年第5期6卷 353-360页

作者： Cherry Kam Chun Lo Queenie Lai Kwan Lam Min Yang King-Hung Ko Lingyun Sun Rui Ma Shengjun Wang Huaxi Xu Sidney Tam Chang-You Wu Bo-Jiang Zheng Liwei Lu Departments of Pathology and Microbiology Center of Infection andImmunology The University of Hong Kong Hong Kong China Department of Rheumatology Drum Tower Hospital Nanjing UniversityMedical School Nanjing China Department of Immunology School of Medical Science and LaboratoryMedicine Jiangsu University. Zhenjiang China epartment of Pathology Queen Mary Hospital Hong Kong China Department of Immunology Sun Yat-Sen University Guangzhou China These authors contributed equally to this work Department of Pathology and Center of Infection and Immunology The University of Hong Kong Pokfulam Road Hong Kong China

Increasing evidence indicates a role of leptin in immune response, but it remains largely unclear whether leptin signaling is involved in regulating NK cell development in the bone marrow （BM）. In this study, we have characterized NK cell differentiation and maturation in the BM of leptin-receptor deficient db/db mice at a prediabetic stage. Although the BM cellularity was similar to the control value, the total number of NK cells was severely reduced in mutant mice. Flow cytometric analysis of db/db BM cells revealed significantly decreased frequencies of developing NK cells at various stages of differentiation. BM db/db NK cells displayed markedly increased apoptosis but maintained normal cell cycling status and proliferative capacity. Moreover, recombinant leptin could significantly enhance the survival of NK cells from wild-type mice in cultures. Further examination on NK cell functional activity showed that db/db NK cells exhibited normal intrinsic cytotoxicity with significantly increased IL-10 production. Taken together, our findings suggest that leptin signaling regulates NK cell development via enhancing the survival of immature NK cells in mouse BM.

关键词： NK cell bone marrow lymphocyte development

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Spinal deformity measurement using a low-density flexible array ultrasound transducer:A feasibility study with phantoms

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Medicine in Novel Technology and Devices 2021年第3期11卷 236-244页

作者： queenie Tsung kwan Shea Yan To Ling Timothy Tin-Yan Lee Yong Ping Zheng Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong Kong SARChina

Spinal deformities assessment using 3D ultrasound scanning has limitations in fitting onto different back surface contour as well as fitting within the gaps between subject and their spinal brace during bracing assessments.The study proposed a flexible array ultrasound transducer to overcome these limitations.The results demonstrated the feasibility of spinal deformity assessments with a flexible ultrasound array when arranged in four shapes,namely Linear,Concave,Convex,and S-shaped.For comparisons of imaging performance on spinous process using the four shapes,Convex and S-shaped transducer showed a depth dependence and lateral location dependence of the lateral intensity distribution of spinous process,respectively.S-shaped transducer had the least accurate prediction of the location of spinous process,with measurement error of 4.83.2 mm,it also showed poorer prediction on spinal curvature measurements.This is suggested to be due to the asymmetrical distortion to the spinous process due to the lateral location dependence of the image.However,the coronal curve prediction of spine phantom performed well with R-squared values of>0.97 in all transducer shapes.The results of this study paved the way for further investigation on the improvement of image quality and measurement accuracy under different shapes for the flexible array,mechanism of dynamic shape change during the scanning to fit different body contour,as well as extension from 1D to 2D flexible array.

关键词： Flexible ultrasound array Low-density array Spinal deformity 3D ultrasound

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