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Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford

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World Journal of Gastroenterology 2020年第30期26卷 4428-4441页

作者： Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor quart-ul-ain rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance Centre for Inflammatory Bowel Diseases St John of God HospitalSubiaco 6008Western AustraliaAustralia Translational Gastroenterology Unit NIHR Oxford Biomedical Research CentreOxford University Hospitals NHS Foundation TrustJohn Radcliffe HospitalOxford OX39DUUnited Kingdom Inflammatory Bowel Disease Research Group Queensland institute of Medical ResearchHerston 4006QueenslandAustralia Department of Gastroenterology Mater HospitalBrisbane 4101QueenslandAustralia Department of Gastroenterology Mater HospitalSouth Brisbane 4101QueenslandAustralia of Gastroenterology Eastern HealthBox Hill 3128VictoriaAustralia Department of Gastroenterology Fiona Stanley HospitalMurdoch 6150Western AustraliaAustralia Department of Gastroenterology Austin HealthHeidelberg 3084VictoriaAustralia Department of Gastroenterology St Vincent’s HospitalFitzroy 3065VictoriaAustralia Department of Gastroenterology Northern HealthEpping 3076VictoriaAustralia Department of Gastroenterology The Alfred HospitalMelbourne 3004VictoriaAustralia Department of Gastroenterology St Vincent’s HospitalDarlinghurst 2010New South WalesAustralia Department of Gastroenterology Flinders Medical CentreBedford Park 5042South AustraliaAustralia Department of Gastroenterology Liverpool HospitalSydney 2170New South WalesAustralia Department of Gastroenterology Royal Adelaide Hospital&University of AdelaideAdelaide 5000South AustraliaAustralia Department of Gastroenterology Townsville HospitalDouglas 4814QueenslandAustralia Institute for Health Research University of Notre DameFremantle 6160Western AustraliaAustralia School of Medicine and Pharmacology University of Western AustraliaCrawley 6009Western AustraliaAustralia

BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)*** To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving *** A retrospective review of Australian and Oxford,United Kingdom data for UC *** response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were *** regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing *** outcomes were *** Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were *** clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo ***-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%Pulti-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 *** VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome.

关键词： Vedolizumab ulcerative colitis Outcomes

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Role of endoscopy in the surveillance and management of colorectal neoplasia in inflammatory bowel disease

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World Journal of Clinical Cases 2019年第1期7卷 1-9页

作者： Shaad Manchanda Qurat-ul-ain rizvi Rajvinder Singh Department of Gastroenterology Lyell McEwin Hospital School of Medicine University of Adelaide Eastern Health Department of Gastroenterology Box Hill Hospital

Endoscopy has become increasingly fundamental in the management of patients with inflammatory bowel disease(IBD). It is required for diagnosis, assessment of therapeutic response, postoperative follow up and in the surveillance of dysplasia. With rapid advances in technology, including high definition colonoscopy and chromoendoscopy, questions have arisen regarding the most appropriate surveillance and management strategies of colorectal neoplasia in IBD. We aim to review current surveillance strategies, explore the utility of new technologies, and examine the role of endoscopic resection, with the aim of clarifying these questions.

关键词： Inflammatory bowel disease Colorectal cancer High definition endoscopy Chromoendoscopy

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Transitioning patients with inflammatory bowel disease from hospital-based to rapid home-based infliximab: A stepwise, safety and patient-orientated process towards sustainability

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World Journal of Gastroenterology 2020年第36期26卷 5437-5449页

作者： Anuj Bohra Qurat-Al-ain rizvi Charlotte Yuen Yu Keung Abhinav Vasudevan Daniel R van Langenberg Department of Gastroenterology Eastern HealthBox Hill 3128VictoriaAustralia Eastern Health Clinical School Monash UniversityBox Hill 3128VictoriaAustralia

BACKGROUND Infliximab and other intravenous biologic infusions are increasingly used for chronic disorders like inflammatory bowel disease(IBD).Rapid infliximab and home-based infusions are attractive solutions to address resource and capacity issues for infusion centres,yet infliximab infusion reactions reportedly occur in up to 25%of patients with IBD,even at the manufacturers’recommended infusion duration of 2 *** To evaluate the safety,cost and patient satisfaction of transitioning from hospitalbased,standard 2 h to rapid home-based,30-min infliximab *** All patients receiving rapid infliximab infusions for IBD between 2014 to 2017(39 mo)were compared with those who received standard two-hour IFX infusions between 2005-2013(96 mo)at a single IBD ***(per-infusion and perindividual)including adverse drug reactions(ADR),duration(based on needledeparture time)and other clinical data were extracted from electronic medical *** logistical regression analysis assessed factors potentially associated with increased risk of ADRs to rapid *** primary outcome was the safety[as per relative risk(RR)of (ADR)of(1)rapid 30 m infusions(both hospital-and home-based)vs standard 2 h infliximab ***,relative cost per infusion and patient satisfaction and productivity were evaluated in rapid infusion recipients who transitioned to home-based *** Of 129 patients who received 1461 rapid IFX infusions(2014-2017)were compared with 169 patients who received 2214 standard IFX infusions(2005-2013).Within the rapid cohort,55(42.6%)were males,median age 42 years(range 18,86),114(84%)had Crohn’s disease(CD)with a median disease duration 5 years(0,36).Median needle to departure time was higher in the standard than the rapid protocol group,108(70,253)vs 50(33,90)min,(P<0.001),with a per infusion cost of$AUD 107.50 vs$49.77,respectively(both P<0.001).There was no difference in median infusion duration or costs between rapi

关键词： Inflammatory bowel disease Infliximab Safety Cost Therapy Drug reaction

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Optimal trajectory and heat load analysis of different shape lifting reentry vehicles for medium range application

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Defence Technology（防务技术） 2015年第4期11卷 350-361页

作者： S.Tauqeer ul Islam rizvi Lin-shu HE Da-jun XU School of Astronautics Beihang University

The objective of the paper is to compute the optimal burn-out conditions and control requirements that would result in maximum down-range/cross-range performance of a waverider type hypersonic boost-glide(HBG) vehicle within the medium and intermediate ranges,and compare its performance with the performances of wing-body and lifting-body vehicles vis-a-vis the g-load and the integrated heat load experienced by vehicles for the medium-sized launch vehicle under *** optimization studies were carried out by considering the heat rate and dynamic pressure *** trajectory optimization problem is modeled as a nonlinear,multiphase,constraint optimal control problem and is solved using a hp-adaptive pseudospectral *** modeling aspects of mass,aerodynamics and aerothermodynamics for the launch and glide vehicles have been *** was found that the optimal burn-out angles for waverider and wing-body configurations are approximately 5° and 14.8°,respectively,for maximum down-range performance under the constraint heat rate *** down-range and cross-range performance of HBG waverider configuration is nearly 1.3 and 2 times that of wing-body configuration *** integrated heat load experienced by the HBG waverider was found to be approximately an order of magnitude higher than that of a lifting-body configuration and 5 times that of a wing-body *** footprints and corresponding heat loads and control requirements for the three types of glide vehicles are discussed for the medium range launch vehicle under consideration.

关键词：再入飞行器载荷分析最佳轨迹翼身组合体形状最优控制问题控制要求运载火箭

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Cold plasma-induced effects on electromagnetic wave scattering in waveguides:a mode-matching analysis

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Communications in Theoretical Physics 2024年第3期76卷 144-156页

作者： Shahana rizvi Muhammad Afzal Department of Mathematics Capital University of Science and TechnologyIslamabadPakistan

This article presents advancements in an analytical mode-matching technique for studying electromagnetic wave propagation in a parallel-plate metallic rectangular *** technique involves projecting the solution onto basis functions and solving linear algebraic systems to determine scattering *** accuracy of this method is validated via numerical assessments,which involve the reconstruction of matching conditions and conservation *** study highlights the impact of geometric and material variations on reflection and transmission phenomena in the waveguide.

关键词： electromagnetic waves scattering cold plasma metallic conducting mode-matching technique

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A Novel Action Transformer Network for Hybrid Multimodal Sign Language Recognition

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Computers, Materials & Continua 2023年第1期74卷 523-537页

作者： Sameena Javaid Safdar rizvi Department of Computer Sciences School of Engineering and Applied SciencesBahria UniversityKarachi CampusKarachiPakistan

Sign language fills the communication gap for people with hearing and speaking *** includes both visual modalities,manual gestures consisting of movements of hands,and non-manual gestures incorporating body movements including head,facial expressions,eyes,shoulder shrugging,*** both gestures have been detected;identifying separately may have better accuracy,butmuch communicational information is *** sign language mechanism is needed to detect manual and non-manual gestures to convey the appropriate detailed message to *** novel proposed system contributes as Sign LanguageAction Transformer Network(SLATN),localizing hand,body,and facial gestures in video *** we are expending a Transformer-style structural design as a“base network”to extract features from a spatiotemporal *** impulsively learns to track individual persons and their action context inmultiple ***,a“head network”emphasizes hand movement and facial expression simultaneously,which is often crucial to understanding sign language,using its attention mechanism for creating tight bounding boxes around classified *** model’s work is later compared with the traditional identification methods of activity *** not only works faster but achieves better accuracy as *** achieves overall 82.66%testing accuracy with a very considerable performance of computation with 94.13 Giga-Floating Point Operations per Second(G-FLOPS).Another contribution is a newly created dataset of Pakistan Sign Language forManual and Non-Manual(PkSLMNM)gestures.

关键词： Sign language gesture recognition manual signs non-manual signs action transformer network

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Electromagnetic wave scattering in plasma beam-driven waveguides under strong magnetic fields

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Communications in Theoretical Physics 2024年第11期76卷 123-134页

作者： Shahana rizvi Muhammad Afzal Department of Mathematics Capital University of Science and TechnologyIslamabadPakistan Department of Mathematics and Natural Sciences Center for Applied Mathematics and BioinformaticsGulf University for Science&Technology32093 HawallyKuwait

This study analyzes the scattering of electromagnetic waves in a cold and uniform plasma-filled waveguide driven by an intense relativistic plasma beam under a strong magnetic *** strong interaction of plasma with electromagnetic waves enables its potential use in different types of *** Helmholtz equation governs the boundary value problem,which is solved by incorporating the mode matching *** the boundary and matching conditions and the derived orthogonality and dispersion relations in this scheme gives an exact solution to the scattering *** numerical results shed light on the occurrence of reflection and transmission and flow of *** power flux is plotted against angular frequency and various duct *** solution is completely validated through the benefit of analytical and numerical *** investigation of this structure reveals not only its mathematical,but also its physical features.

关键词： electromagnetic waves cold plasma mode matching technique

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Reflectometric and interferometric fiber optic sensor's principles and applications

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Frontiers of Optoelectronics 2019年第2期12卷 215-226页

作者： Muhammad Noaman ZAHID Jianliang JIANG Saad rizvi School of Optics and Photonics Beijing Institute of TechnologyBeijing 100081China

Fiber optic sensors have been widely used and studied in recent times. This paper presents operating principles and applications of fiber optic sensors namely reflectometric and interferometric fiber optic sensors. Majority of optical fiber sensors fall under these two broad categories. Both interferometric and reflectometric fiber optic sensors are becoming popular for their ease of use, flexibility, long distance sensing, and potentially noise free detection. Also, these sensors can easily be used in various applications such as structural health monitoring, perimeter intrusion detection, temperature monitoring, and other numerous applications. This paper broadly classifies fiber optic sensors into two subtypes. The paper further highlights different sensors based on their sensing resolution, range, spatial advantages, and applications.

关键词： fiber optic reflectometric interferometric optical fiber sensors sensor applications

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Development of a Bias Compensating Q-Learning Controller for a Multi-Zone HVAC Facility

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IEEE/CAA Journal of Automatica Sinica 2023年第8期10卷 1704-1715页

作者： Syed Ali Asad rizvi Amanda J.Pertzborn Zongli Lin IEEE the Department of Electrical and Computer Engineering Tennessee Technological UniversityCookevilleTN 38505 USA the Mechanical Systems and Controls Group in the Building Energy and Environment Division at the National Institute of Standards and Technology(NIST) GaithersburgMD 20899 USA the Charles L.Brown Department of Electrical and Computer Engineering University of VirginiaCharlottesvilleVA 22904-4743 USA

We present the development of a bias compensating reinforcement learning(RL)algorithm that optimizes thermal comfort(by minimizing tracking error)and control utilization(by penalizing setpoint deviations)in a multi-zone heating,ventilation,and air-conditioning(HVAC)lab facility subject to unmeasurable disturbances and unknown *** is shown that the presence of unmeasurable disturbance results in an inconsistent learning equation in traditional RL controllers leading to parameter estimation bias(even with integral action support),and in the extreme case,the divergence of the learning *** demonstrate this issue by applying the popular Q-learning algorithm to linear quadratic regulation(LQR)of a multi-zone HVAC environment and showing that,even with integral support,the algorithm exhibits bias issue during the learning phase when the HVAC disturbance is unmeasurable due to unknown heat gains,occupancy variations,light sources,and outside weather *** address this difficulty,we present a bias compensating learning equation that learns a lumped bias term as a result of disturbances(and possibly other sources)in conjunction with the optimal control *** results show that the proposed scheme not only recovers the bias-free optimal control parameters but it does so without explicitly learning the dynamic model or estimating the disturbances,demonstrating the effectiveness of the algorithm in addressing the above challenges.

关键词： HVAC control optimal tracking Q-learning reinforcement learning(RL)

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Interaction properties of solitons for a couple of nonlinear evolution equations

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Chinese Physics B 2021年第1期30卷 185-190页

作者： Syed Tahir Raza rizvi Ishrat Bibi Muhammad Younis Ahmet Bekir Department of Mathematics COMSATS University IslamabadLahore CampusPakistan Punjab University College of Information Technology University of the PunjabLahorePakistan Neighbourhood of Akcaglan Imarli Street Number 28/426030EskisehirTurkey

We study one-and two-soliton solutions for the Cahn–Allen(CA) equation and the Brethorton equation. The CA equation has broad spectrum of applications especially in anti-phase boundary motion and it is used in phase-field *** the Brethorton equation is a model for dispersive wave systems, it is used to find the resonant nonlinear interaction among three linear modes. We use the Hirota bilinear method to obtain one-and two-soliton solutions to the CA equation and the Brethorton equation.

关键词： Hirota bilinear method soliton interaction evolution equations

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