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ADVISING score:a reliable grading scale based on injury and response for intracerebral haemorrhage

Stroke & Vascular Neurology 2023年第2期8卷 111-118页

作者： Yan Wan Hongxiu Guo Shaoli Chen Jiang Chang David Wang Rentang Bi Man Li Ke Shi Zhaowei Wang Daokai Gong Jingwen Xu quanwei he Bo Hu Department of Neurology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina School of Public health Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Neurovascular Division Department of NeurologyBarrow Neurological Institute/Saint Joseph Hospital Medical CenterPhoenixArizonaUSA Department of Neurology Qianjiang Central HospitalQianjiangHubeiChina Department of Neurology Jingzhou Central HospitalJingzhouHubeiChina Department of Neurology Honghu People's HospitalHonghuHubeiChina

Background Intracerebral haemorrhage(ICH)is the most devastating form of stroke causing high morbidity and *** aimed to develop a novel clinical score incorporating multisystem markers to predict functional dependence at 90 days after *** We analysed data from Chinese Cerebral hemorrhage:Mechanism and Intervention *** logistic regression analysis was used to identify the factors associated with 90-day functional dependency(the modified Rankin Scale≥3)after ICH and develop the ADVISING scoring *** test the scoring system,a total of 2111 patients from Hubei province were included as the training cohort,and 733 patients from other three provinces in China were included as an external validation *** We found nine variables to be significantly associated with functional dependency and included in the ADVISING score system:age,deep location of haematoma,volume of haematoma,National Institutes of health Stroke Scale,aspartate transaminase,international normalised ratio,neutrophil-lymphocyte ratio,fasting blood glucose and glomerular filtration *** were divided into 12 different categories by using these nine potential *** proportion of patients who were functionally dependent increased with higher ADVISING scores,which showed good discrimination and calibration in both the training cohort(C-statistic,0.866;p value of Hosmer-Lemeshow test,0.195)and validation cohort(C-statistic,0.884;p value of Hosmer-Lemeshow test,0.853).The ADVISING score also showed better discriminative performance compared with the other five existing ICH scores(p<0.001).Conclusions ADVISING score is a reliable tool to predict functional dependency at 90 days after ICH.

关键词： score statistic reliable

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Consensus for prevention and management of coronavirus disease 2019 (COVID-19) for neurologists

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Stroke & Vascular Neurology 2020年第2期5卷 146-151页

作者： Huijuan Jin Candong Hong Shengcai Chen Yifan Zhou Yong Wang Ling Mao Yanan Li quanwei he Man Li Ying Su David Wang Longde Wang Bo Hu Department of Neurology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Neurovascular Division Department of NeurologyBarrow Neurological Institute/Saint Joseph Hospital Medical CenterPhoenixAZUSA Stroke Prevention and Control Steering Committee National Health Commission of the People’s Republic of ChinaBeijingChina

Coronavirus disease 2019(COVID‐19)has become a pandemic disease *** COVID-19 directly invades lungs,it also involves the nervous ***,patients with nervous system involvement as the presenting symptoms in the early stage of infection may easily be misdiagnosed and their treatment *** become silent contagious sources or‘virus spreaders’.In order to help neurologists to better understand the occurrence,development and prognosis,we have developed this consensus of prevention and management of COVID‐*** can also assist other healthcare providers to be familiar with and recognise COVID-19 in their evaluation of patients in the clinic and hospital environment.

关键词： prevention involvement prognosis

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Clinical time course of COVID-19, its neurological manifestation and some thoughts on its management

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Stroke & Vascular Neurology 2020年第2期5卷 177-179页

作者： Yifan Zhou Wei Li David Wang Ling Mao Huijuan Jin Yanan Li Candong Hong Shengcai Chen Jiang Chang quanwei he Mengdie Wang Bo Hu Department of Neurology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Neurology Army Medical Center of PLAChongqing 400042China Neurovascular Division Barrow Neurological InstituteSaint Joseph Hospital Medical CenterPhoenixArizona 85013USA Department of Epidemiology and Biostatistics Key Laboratory for Environment and HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Sciences and TechnologyWuhan 430030China

Coronavirus disease-2019(COVID‐19)has become a global ***-19 runs its course in two phases,the initial incubation phase and later clinical symptomatic *** in the initial incubation phase often have insidious clinical symptoms,but they are still highly *** the later clinical symptomatic phase,the immune system is fully activated and the disease may enter the severe infection stage in this *** many patients are known for their respiratory symptoms,they had neurological symptoms in their first 1-2 days of clinical symptomatic phase,and ischaemic stroke occurred 2 weeks after the onset of the clinical symptomatic *** key is to prevent a patient from progressing to this severe infection from mild *** are sharing our experience on prevention and management of COVID-19.

关键词： neurological clinical prevention

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冷冻消融协同仑伐替尼和程序性死亡受体1单抗治疗不可切除肝细胞癌的效果及安全性分析

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临床肝胆病杂志 2024年第3期40卷 539-549页

作者：刘腾常秀娟何权威徐然杨永平解放军总医院第五医学中心肝病医学部北京100039

目的分析程序性死亡受体1(PD-1)单抗是否提高冷冻消融联合仑伐替尼治疗不可切除性肝细胞癌(uHCC)患者的疗效和安全性。方法回顾性收集2018年1月—2022年12月在解放军总医院第五医学中心治疗的uHCC患者232例,其中128例接受冷冻消融联合... 详细信息

目的分析程序性死亡受体1(PD-1)单抗是否提高冷冻消融联合仑伐替尼治疗不可切除性肝细胞癌(uHCC)患者的疗效和安全性。方法回顾性收集2018年1月—2022年12月在解放军总医院第五医学中心治疗的uHCC患者232例,其中128例接受冷冻消融联合仑伐替尼(二联)治疗,104例接受冷冻消融联合仑伐替尼和PD-1单抗(三联)治疗,用倾向性评分匹配方法(PSM)以1∶1进行匹配,经匹配后两组各86例。评估匹配后的2组患者客观缓解率(ORR)和疾病控制率(DCR)、总生存期(OS)、无进展生存期(PFS)和不良事件发生情况。定量资料若符合正态分布2组间比较采用成组t检验;非正态分布2组间比较采用Mann-Whitney U检验。定性资料采用χ^(2)检验进行2组间比较。绘制生存曲线,运用KaplanMeier法计算2组患者的生存率,并利用Log-rank检验比较2组差异。通过Cox回归模型计算风险比(HR)和95%置信区间(95%CI),实现预后影响因素的单因素及多因素分析。结果中位随访时间为28个月,三联组死亡33例(38.0%),二联组死亡40例(46.0%)。三联治疗组的ORR和DCR较二联组明显增高(ORR:35.6%vs 14.5%,P=0.008;DCR:86.1%vs64.1%,P=0.003)。三联组的OS和PFS较二联组均显著提高(P值分别为0.045、0.026)。单因素和多因素Cox风险比例模型分析显示治疗方案(HR=0.60,P=0.038)、AFP水平(HR=2.37,P=0.001)是影响OS的独立危险因素;治疗方案(HR=0.65,P=0.025)、糖尿病(HR=1.94,P=0.005)、之前是否接受过局部治疗(HR=0.63,P=0.014)、远处转移(HR=0.58,P=0.009)是影响PFS的独立危险因素。两组患者不良反应发生率相当,无明显差异(P值均>0.05)。结论对于uHCC患者,冷冻消融联合仑伐替尼和PD-1单抗三联治疗较冷冻消融联合仑伐替尼二联治疗显著提高了疗效,改善患者生存情况,而且不增加不良反应事件,为优化不可切除性肝癌的治疗方案提供了临床依据。

关键词：癌,肝细胞冷冻外科手术仑伐替尼免疫检查点抑制剂

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基于吞咽障碍指数问卷的信息化延续护理在神经内科吞咽障碍患者中的应用

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中国康复 2021年第7期36卷 418-422页

作者：曾令丹尹雪贺权威卫敏华中科技大学同济医学院附属协和医院神经内科武汉430022

目的:出院前根据吞咽障碍指数问卷(DHI)的评估,吞咽障碍延续护理小组成员为神经内科吞咽障碍患者制订个体化的延续护理措施,并依托微信平台开展信息化的延续性护理。方法:采取目的抽样法,选取2019年1~12月神经内科出院的102例存在吞咽... 详细信息

目的:出院前根据吞咽障碍指数问卷(DHI)的评估,吞咽障碍延续护理小组成员为神经内科吞咽障碍患者制订个体化的延续护理措施,并依托微信平台开展信息化的延续性护理。方法:采取目的抽样法,选取2019年1~12月神经内科出院的102例存在吞咽障碍的患者,随机分为观察组和对照组各51例。对照组采取神经内科常规延续护理,观察组在常规延续护理基础上实施基于DHI评估的信息化延续护理。于干预1周、1个月后分别采用DHI、体重指数(BMI)比较2组的吞咽功能、心理障碍、营养状况,干预1个月后采用患者满意度评分表对护理服务进行评分。结果:观察组出院后1周、1个月的DHI总分及3个维度得分均低于对照组,体重指数评分高于对照组,差异具有统计学意义(P<0.05);出院1个月后,观察组患者满意度明显高于对照组(P<0.05)。结论:基于DHI评估的信息化延续护理能够改善神经内科吞咽障碍患者康复及营养状况,改善患者心理障碍,并能提高患者对医护人员满意度,促进医患关系和谐,值得进一步的推广和应用。

关键词：吞咽障碍吞咽障碍指数问卷延续护理微信平台信息化

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超声波衍射时差法分层检测技术在球罐安装中的应用

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钢结构 2013年第7期28卷 78-81页

作者：贺全伟平雪原何云陈德超邓昌明武汉一冶钢结构有限责任公司武汉430415

随着我国超声波衍射时差法(简称TOFD)检测标准的出台,应用TOFD检测技术对1000m3氧气球罐进行TOFD检测,并对壁厚58mm的安装焊缝对接接头进行分层检测。通过合理设置工艺参数,得到了良好的检测效果。TOFD检测技术具有安全环保、扫查记录... 详细信息

随着我国超声波衍射时差法(简称TOFD)检测标准的出台,应用TOFD检测技术对1000m3氧气球罐进行TOFD检测,并对壁厚58mm的安装焊缝对接接头进行分层检测。通过合理设置工艺参数,得到了良好的检测效果。TOFD检测技术具有安全环保、扫查记录数字化存储、可以长久保存等优点。通过采用TOFD检测技术,不仅降低了检测成本、提高了检测效率,而且避免了球罐因采用传统γ射线检测需多次拆装脚手架,节约了施工成本,保证了施工进度,同时也提高了检测的可靠性。

关键词： TOFD检测球罐安装焊缝对接接头分层

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普洱市冬季低温冷害天气过程研究

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中低纬山地气象 2023年第5期47卷 56-63页

作者：王飞王晓君姚自伟高正南何泉威云南省普洱市气象台云南普洱665000 云南省普洱市人工影响天气中心云南普洱665000

利用常规地面、高空观测资料,灾情信息以及NCEP/NCAR、ECMWF再分析资料,对1999—2020年共22 a发生在普洱市的10次低温冷害天气过程进行分析,结果表明:(1)普洱市低温冷害天气过程可分为3类,不同类型高低层环流形势差异显著。(2)Ⅰ型以低... 详细信息

利用常规地面、高空观测资料,灾情信息以及NCEP/NCAR、ECMWF再分析资料,对1999—2020年共22 a发生在普洱市的10次低温冷害天气过程进行分析,结果表明:(1)普洱市低温冷害天气过程可分为3类,不同类型高低层环流形势差异显著。(2)Ⅰ型以低温雨雪灾害为主,受南支槽和冷空气共同影响;期间欧亚中高纬度500 hPa呈现为一槽一脊模态,东亚大槽由横转竖形成阶梯槽,并伴有南支槽稳定维持。(3)Ⅱ型过程开始至最强阶段主要形成低温雨雪灾害,最强至趋于结束阶段发生霜冻;期间欧亚中高纬度500 hPa形势表现为两槽一脊模态,东亚大槽偏浅,南支槽为快速东移型。(4)Ⅲ型主要以低温霜冻灾害为主,无南支槽配合;期间欧亚中高纬度500 hPa形势表现为两槽一脊模态,高压脊较强利于脊前西北气流下沉。(5)冷空气活动是3类低温冷害天气过程的共同特征,其差异主要表现在有无南支槽系统的配合;此外,普洱市上空850 hPa出现持续东北风、温度<8℃,可以作为低温冷害,包括低温雨雪或低温霜冻产生的重要指标。

关键词：普洱市冬季低温冷害南支槽预报指标

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A Chan–Vese Model Based on the Markov Chain for Unsupervised Medical Image Segmentation

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Tsinghua Science and Technology 2021年第6期26卷 833-844页

作者： quanwei Huang Yuezhi Zhou Linmi Tao Weikang Yu Yaoxue Zhang Li Huo Zuoxiang he Key Laboratory of Pervasive Computing(Ministry of Education)and the Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China School of Electronic and Information Engineering Beihang UniversityBeijing 100191China Department of Nuclear Medicine Peking Union Medical College HospitalBeijing 100730China School of Clinical Medicine Tsinghua Universityand also with Beijing Tsinghua Changgung HospitalBeijing 100084China

The accurate segmentation of medical images is crucial to medical care and research;however, many efficient supervised image segmentation methods require sufficient pixel level labels. Such requirement is difficult to meet in practice and even impossible in some cases, e.g., rare Pathoma images. Inspired by traditional unsupervised methods, we propose a novel Chan–Vese model based on the Markov chain for unsupervised medical image segmentation. It combines local information brought by superpixels with the global difference between the target tissue and the background. Based on the Chan–Vese model, we utilize weight maps generated by the Markov chain to model and solve the segmentation problem iteratively using the min-cut algorithm at the superpixel *** method exploits abundant boundary and local region information in segmentation and thus can handle images with intensity inhomogeneity and object sparsity. In our method, users gain the power of fine-tuning parameters to achieve satisfactory results for each segmentation. By contrast, the result from deep learning based methods is *** performance of our method is assessed by using four Computerized Tomography(CT) datasets. Experimental results show that the proposed method outperforms traditional unsupervised segmentation techniques.

关键词： medical image unsupervised segmentation Markov chain

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Single channel signal component separation using Bayesian estimation

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Journal of Systems Engineering and Electronics 2007年第1期18卷 33-39页

作者： Cai quanwei Wei Ping Xiao Xianci Coll. of Electronic Engineering Univ. of Electronic Science and Technology Chengdu 610054 P.R. China

A Bayesian estimation method to separate multicomponent signals with single channel observation is presented in this paper. By using the basis function projection, the component separation becomes a problem of limited parameter estimation. Then, a Bayesian model for estimating parameters is set up. The reversible jump MCMC （Monte Carlo Markov Chain） algorithmis adopted to perform the Bayesian computation. The method can jointly estimate the parameters of each component and the component number. Simulation results demonstrate that the method has low SNR threshold and better performance.

关键词： Signal component separation Single channel Bayesian estimation Reversible jump MCMC

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Design and experimental study of seed precise delivery mechanism for high-speed maize planter

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International Journal of Agricultural and Biological Engineering 2018年第4期11卷 81-87页

作者： quanwei Liu Tao Cui Dongxing Zhang Li Yang Yunxia Wang Xiantao he Mantao Wang College of Engineering China Agricultural UniversityBeijing 100083China School of Mechatronics Engineering Zhengzhou University of AeronauticsZhengzhou 450046China

Aiming at improving the seed spacing uniformity of maize planter at high forward speed,a seed precise delivery mechanism driven by electric motor has been developed and evaluated in *** mechanism was designed to deliver single seed from seed meter to ***’s movement from the seed release point in a seed meter to the seed delivery cavity in the belt was analyzed,the mathematical model of seed movement in the seed precise delivery mechanism was established based on seed delivery time analysis.A mechanical prototype was designed and associated control system was *** performance contrast experiment was conducted between a traditional seed tube and newly developed seed precise delivery mechanism,and test results indicated that the qualities of feed index of the seed precise delivery mechanism were higher than those of the traditional seed tube delivery mechanism,and the coefficients of variation of the seed precise delivery mechanism were lower than those of the traditional seed tube delivery mechanism when the forward speed of planter was set at 10 km/h,12 km/h and 14 km/h,*** indicated the seed precise delivery mechanism significantly improved seed spacing uniformity of maize planter compared with the traditional seed tube delivery mechanism.

关键词： seed precise delivery mechanism electric motor seed spacing uniformity delivery time mechanical prototype

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