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大气红外波段的片上集成式偏振光谱成像器件

红外与激光工程 2024年第4期53卷 42-50页

作者：周健宇李全民王劲黄胜弟南京波长光电科技股份有限公司江苏南京211121

红外探测与遥感是气象观测的核心技术,红外辐射探测仪作为气象卫星的重要载荷,主要用于大气温度、湿度的定量化探测,其探测精度取决于光谱和偏振测量的通道数。常见的技术方案是通过组合滤光片与偏振片转轮实现光谱和偏振的探测,这造成... 详细信息

红外探测与遥感是气象观测的核心技术,红外辐射探测仪作为气象卫星的重要载荷,主要用于大气温度、湿度的定量化探测,其探测精度取决于光谱和偏振测量的通道数。常见的技术方案是通过组合滤光片与偏振片转轮实现光谱和偏振的探测,这造成了系统体积大、功耗高、通道数少的问题。发展片上集成式偏振光谱成像器件是解决上述问题的有效方法,已有研究主要采用薄膜谐振腔或共振微结构的阵列化方案,但二者都无法兼顾光谱和偏振选择的要求。有鉴于此,提出了一种基于薄膜微结构耦合调控的设计新思路,以13μm附近的大气红外波段为例,实现了片上集成式的偏振光谱成像,6个通道的平均透过率和消光比分别达到了94%和30。该器件有望在将来被广泛应用于偏振光谱成像领域中,同时,由于该器件对基底折射率并不敏感,基底的选择也会更加自由。

关键词：大气红外片上集成薄膜微结构偏振光谱成像

Research strategies in click chemistry: Measuring its cognitive contents and knowledge flow

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Chinese Chemical Letters 2023年第2期34卷 3-6页

作者： Jing Zhu Ming Chen He liang quanmin li Xuefeng Jiang Department of Philosophy East China Normal UniversityShanghai 200241China School of Journalism Fudan UniversityShanghai 200433China Shanghai Key Laboratory of Green Chemistry and Chemical Process Department of ChemistryEast China Normal UniversityShanghai 200062China

The issue about how outstanding scientists obtained innovative findings has drawn the interest of researchers in science, policy and scientometrics. Here, we attempt to address this question by using computational methods to measure the cognitive content and concepts of K. Barry Sharpless’ research and estimate the knowledge flow of his click chemistry to other fields. First, we traced Sharpless’ conceptual journey over time through topic modeling approach, mapping and clustering of the epistemic network from distant reading his publications. We find that connectivity and functions, the core features of click chemistry, are embodied in his constant search for simplicity. What makes simplicity possible is his continuous work with collaborators on reactivity and reaction mechanisms. Moreover, citation and link analysis show that click chemistry had a much richer impact on other research fields than what is generally acknowledged, and drew solutions to significant and practical questions back to chemistry from *** with these findings, we propose that the click chemistry philosophy follows the way that values nature’s principle. Chemistry has a clear-cut epistemic domain in modeling Nature. Thus, click chemistry as a concept on doing science beyond a connective technology goes across the boundaries between disciplines and impacts many other fields.

关键词： Click chemistry K.B.Sharpless Research strategies Connectivity History and philosophy of chemistry

广州抗逆转录病毒治疗后低水平HIV-1病毒载量感染者基因型耐药特征分析

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国际病毒学杂志 2024年第2期31卷 145-149页

作者：凌雪梅林雅晴李凌华李俊彬李全敏曾琨张楚瑜兰芸广州医科大学附属市八医院感染病中心 510440 广州医科大学附属市八医院传染病研究所 510440

目的分析广州市抗逆转录病毒治疗(antiretroviral therapy,ART)后HIV-1病毒载量介于50~200 copies/mL的感染者基因型耐药发生特征。方法募集2023年1月至7月广州医科大学附属市八医院感染门诊接受ART满6个月,且HIV-1病毒载量介于50~200 c... 详细信息

目的分析广州市抗逆转录病毒治疗(antiretroviral therapy,ART)后HIV-1病毒载量介于50~200 copies/mL的感染者基因型耐药发生特征。方法募集2023年1月至7月广州医科大学附属市八医院感染门诊接受ART满6个月,且HIV-1病毒载量介于50~200 copies/mL的感染者。用0.5 mL血浆于4℃超速离心浓缩病毒后提取RNA,经逆转录和巢式PCR扩增HIV-1 pol基因片段。获得基因序列经COMET HIV-1进行分型,并用Mega 11构建系统邻接法进化树验证亚型。经斯坦福HIV耐药数据库解析耐药发生情况。结果共随访11799例感染者,发现415例(3.5%)低水平病毒载量感染者。从完成检测的297例感染者中扩增获得154条pol基因片段序列(52.0%)。主要基因亚型为CRF01-AE(34.4%,53/154)和CRF07-BC(31.2%,48/154)。耐药相关突变(drug resistance mutations,DRMs)发生率为37.0%(57/154),最常见的DRMs为非核苷类逆转录酶抑制剂(NNRTIs)突变V179E(11.7%,18/154)和核苷类逆转录酶抑制剂(NRTIs)突变S68G(6.5%,10/154)和M184V(5.2%,8/154)。对任一药物耐药发生率为17.5%(27/154),其中NVP耐药率为11.7%(18/154),EFV耐药率为11.0%(17/154),RPV耐药率为10.4%(16/154)。结论广州ART后低水平病毒载量感染者耐药相关突变发生率较高(18.2%~37.0%),对我国常用的一线抗病毒药物存在不同程度耐药。应加强治疗后低病毒载量感染者的耐药监测,以优化治疗方案、改善临床结果。

关键词：人免疫缺陷病毒抗逆转录病毒治疗低病毒载量基因型耐药

Preconcentration/separation and determination of mercury using microcrystalline phenolphthalein modified by ethyl violet

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Rare Metals 2007年第1期26卷 79-84页

作者： li Hng li quanmin OUYANG Ruizhuo Department of Chemistry and Chemical Engineering Henan Institute of Science and Technology Xinxiang 453003 China The Key Laboratory of Environmental Pollution Control Technology of Henan Province College of Chemistry and Environmental Science Henan Normal University Xinxiang 453007 China

A novel method was developed for enrichment and separation of trace mercury using phenolphthalein modified by ethyl violet （EV）. The effects of different parameters, such as stirring time, various metal ions and salts, and the amounts of phenolphthalein, NH4SCN, and EV on the extraction rate of mercury were studied, to select the experimental conditions. Under optimum conditions, mercury can be adsorbed on the surface of microcrystalline phenolphthalein by the intermolecular acdon strength. The possible reaction mechanism for the enrichment of mercury was discussed in detail. Hg（Ⅱ） could be completely separated from Fe（Ⅱ）, Co（Ⅱ）, Ni（Ⅱ）, Mn（Ⅱ）, Cd（Ⅱ）, Cr（Ⅲ）, and Al（Ⅲ） in the solution. The proposed method has been successfully applied to the determination of trace mercury in industrial wastewater with the recoveries above 99%. The relative standard deviation for five replicate determinations of 0.04 μg·mL^-1 of Hg（Ⅱ） was found to be 1.4%, 1.1%, and 1.2%, respectively. The analytical results were very satisfactory.

关键词： separation and enrichment, microcrystalline phenolphthalein, mercury ethyl violet

Transcriptome analysis of CD4^(+)T cells from HIV-infected individuals receiving ART with LLV revealed novel transcription factors regulating HIV-1 promoter activity

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Virologica Sinica 2023年第3期38卷 398-408页

作者： Jingliang Chen Yaozu He Huolin Zhong Fengyu Hu Yonghong li Yeyang Zhang Xia Zhang Weiyin lin quanmin li Feilong Xu Shaozhen Chen Hui Zhang Weiping Cai linghua li Guangzhou Eighth People's Hospital Guangzhou Medical UniversityGuangzhou510060China Institute of Human Virology Key Laboratory of Tropical Disease Control of Ministry EducationGuangdong Engineering Research Center for Antimicrobial Agent and ImmunotechnologyZhongshan School of MedicineSun Yat-sen UniversityGuangzhou510080China Guangzhou Laboratory Bio-IslandGuangzhou510320China

Some HIV-infected individuals receiving ART develop low-level viremia(LLV),with a plasma viral load of 50-1000 copies/*** low-level viremia is associated with subsequent virologic *** peripheral blood CD4^(+)T cell pool is a source of ***,the intrinsic characteristics of CD4^(+)T cells in LLV which may contribute to low-level viremia are largely *** analyzed the transcriptome profiling of peripheral blood CD4^(+)T cells from healthy controls(HC)and HIV-infected patients receiving ART with either virologic sup-pression(VS)or *** identify pathways potentially responding to increasing viral loads from HC to VS and to LLV,KEGG pathways of differentially expressed genes(DEGs)were acquired by comparing VS with HC(VS-HC group)and LLV with VS(LLV-VS group),and overlapped pathways were *** of DEGs in key overlapping pathways showed that CD4^(+)T cells in LLV expressed higher levels of Th1 signature transcription factors(TBX21),toll-like receptors(TLR-4,-6,-7 and-8),anti-HIV entry chemokines(CCL3 and CCL4),and anti-IL-1βfactors(ILRN and IL1R2)compared to *** results also indicated activation of the NF-κB and TNF signaling pathways that could promote HIV-1 ***,we evaluated the effects of 4 and 17 tran-scription factors that were upregulated in the VS-HC and LLV-VS groups,respectively,on HIV-1 promoter *** studies revealed that CXXC5 significantly increased,while SOX5 markedly suppressed HIV-1 *** summary,we found that CD4^(+)T cells in LLV displayed a distinct mRNA profiling compared to that in VS,which promoted HIV-1 replication and r+eactivation of viral latency and may eventually contribute to virologic failure in patients with persistent ***5 and SOX5 may serve as targets for the development of latency-reversing agents.

关键词： HIV-1 Low-level viremia(LLV) Transcriptome HIV-1 promoter CXXC5 SOX5

Pre-treatment Drug Resistance Could Impact the 96-Week Antiretroviral Efficacy in Treatment-Naive HIV-1–Infected Patients in Guangdong,China

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Infectious Diseases & Immunity 2022年第4期2卷 233-238页

作者： Pengle Guo Yun Lan quanmin li Xuemei ling Junbin li Xiaoping Tang Fengyu Hu Weiping Cai linghua li Guangzhou Eighth People’s Hospital Guangzhou Medical UniversityGuangzhouGuangdong Province 510060China

Background:With the high prevalence of pre-treatment drug resistance(PDR)and the potential impact to the virological inhibition,the detection of PDR was particularly *** study aimed to determine the prevalence of PDR in Guangdong,China,and its impact on antiretroviral therapy(ART)in treatment-naive HIV ***:A retrospective cohort study was conducted.A total of 1936 HIV-1-infected treatment-naive patients in the clinic of the infectious department,Guangzhou Eighth People’s Hospital,between August 2018 and December 2019 were assayed for PDR mutations before initiating *** with PDR mutations(PDR arm)were screened and compared with those without drug-resistant mutations(non-PDR arm).The rate of HIV-1 virologic failure(VF)and CD4^(+)T-cell counts of the 2 arms were compared at the 96th week after ART to evaluate the impact of PDR on the efficacy of ***:Pretreatment drug resistance was detected in 125 cases(6.46%)from the 1936 enrolled participants,most of which were resistant to non-nucleoside reverse transcriptase inhibitors(64.00%,80/125).One hundred and eight of 125 completed the follow-up of 96 weeks(PDR arm).In this cohort,52 patients whose ART regimen containing the resistant drug were grouped as con-PDR arm,and the remaining 56 patients whose ART regimen did not contain the resistant drug were grouped as non-con-PDR arm.A total of 125 patients without PDR were randomly selected as the control group(non-PDR arm),112 of whom had completed the 96-week *** the 96th week after ART initiation,7 patients(6.5%,7/108)in the PDR arm and 1 patient(0.9%,1/112)in the non-PDR arm developed VF,exhibiting a significant difference(χ^(2)=4.901,P=0.029).Meanwhile,3 patients(5.8%,3/52)in the con-PDR arm developed VF;the rate was also higher than that in the non-PDR arm,but without a significant difference(χ^(2)=3.549,P=0.095).The CD4^(+)T-cell count in the non-PDR arm increased more than the PDR arm(386.6 vs.319.1 cells/μL,t=2.448,P=0.0

关键词： Prevalence Pretreatment drug resistance Antiretroviral therapy Virologic failure

Study of spectrophotometric method for determination of trace copper after the separation and enrichment with solid phase extractant-microcrystalline phenolphthalein

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Chinese Science Bulletin 2007年第1期52卷 65-70页

作者： li quanmin ZHAO XiaoHong JIANG Kai liU GuoGuang The Key Laboratory of Environmental Pollution Control Technology of Henan Province College of Chemistry and EnvironmentalScience Henan Normal University Xinxiang 453007 China

A new method of using phenolphthalein loaded with 1-(2-pyridylazo)-2-naphthol (PAN) as solid phase extractant to separate and enrich trace copper in diverse water samples has been developed. The ef- fects of different parameters, such as the amounts of PAN and phenolphthalein, stirring time, various salts and metal ions on the enrichment yield of Cu(II) have been investigated to select the experimental conditions. Under the optimum conditions, Cu(II) can be totally adsorbed on the surface of microcrys- talline phenolphthalein. By controlling appropriate acidity (pH=1.0), Cu(II) is completely separated from Cd(II), Pb(II), Mn(II), Co(II), Fe(III), Ni(II), Al(III), Zn(II) and Hg(II) in the solution. The possible reaction mechanism of the enrichment of copper is discussed in detail in this paper. The detection limit of this proposed method is found to be 0.03 μg·L-1 with the enrichment factor of 200. The recovery is in a range of 96.8%―105%. The standard deviation is less than 2.5%. The proposed method has been successfully applied to the determination of trace copper in different water samples with satisfactory results.

关键词：固态提取物微晶酚酞铜

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量子社会科学的兴起和挑战

学术前沿 2022年第3期 76-83页

作者：郦全民华东师范大学人文社会科学学院华东师范大学哲学系、知识与行动研究中心

量子社会科学是量子物理学与社会科学相交叉所产生的一门新兴学科,将属于现代物理学并且用于刻画微观现象的"量子"概念,与研究人类认知和行为的社会科学发生关联,用于解释人类社会的现象和人类行为。通过对量子社会科学的产生背景、研... 详细信息

量子社会科学是量子物理学与社会科学相交叉所产生的一门新兴学科,将属于现代物理学并且用于刻画微观现象的"量子"概念,与研究人类认知和行为的社会科学发生关联,用于解释人类社会的现象和人类行为。通过对量子社会科学的产生背景、研究进路和应用的简要考察,分析量子社会科学在当代社会的重要价值以及面临的诸多挑战,在此基础上展望量子社会科学的未来前景,有助于加深我们对这一门新兴学科的了解,从而提高在面对复杂的社会环境时分析和解决问题的能力和效率。

关键词：量子理论量子思维社会现象

2010—2021年广州市初治HIV感染者糖脂代谢异常患病趋势及其年龄-时期-队列模型分析

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华南预防医学 2024年第3期50卷 246-250,254页

作者：尚萌琳谢今朝王旭刘聪钟海丹杜佩珊李全敏蔡卫平李凌华顾菁中山大学公共卫生学院广东广州510000 广州市第八人民医院感染病中心

目的分析2010—2021年广州市初治HIV感染者糖脂代谢异常患病率的变化,探讨性别、年龄、时期、队列因素的影响。方法基于广州市第八人民医院2010—2021年16454例初治HIV感染者数据,采用Joinpoint回归模型分析糖代谢异常、甘油三酯代谢异... 详细信息

目的分析2010—2021年广州市初治HIV感染者糖脂代谢异常患病率的变化,探讨性别、年龄、时期、队列因素的影响。方法基于广州市第八人民医院2010—2021年16454例初治HIV感染者数据,采用Joinpoint回归模型分析糖代谢异常、甘油三酯代谢异常、胆固醇代谢异常的患病率变化趋势,采用年龄-时期-队列模型分析患病率变化的影响因素。结果16454例初治HIV感染者中,平均年龄(36.78±12.07)岁,男性13783例(83.8%)。2010—2021年期间初治HIV感染者糖代谢异常(AAPC=-2.4%,95%CI:-5.31%~0.50%,P=0.103)、甘油三酯代谢异常(APC=AAPC=-4.13%,95%CI:-7.59%~-0.54%,P=0.029)、胆固醇代谢异常(APC=AAPC=-13.47%,95%CI:-16.03%~-10.84%,P<0.001)患病率整体均呈下降趋势,女性脂代谢异常患病率高于男性。年龄-时期-队列模型结果显示,糖代谢异常、甘油三酯代谢异常的患病率在40~50岁最高,胆固醇代谢异常患病率随年龄增大逐渐下降;糖脂代谢异常的患病率随时期整体呈下降趋势;较早出生队列的人群糖脂代谢异常的患病率较高。结论近年来初治HIV感染者糖脂代谢异常负担整体降低,但仍应加强对糖代谢异常的防控。女性、中老年群体、较早的感染者是糖脂代谢异常的高危群体。

关键词：抗病毒治疗 HIV 糖脂代谢异常 Joinpoint回归模型年龄-时期-队列模型