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The processed C-terminus of AvrRps4 effector suppresses plant immunity via targeting multiple WRKYs

Journal of Integrative Plant Biology 2024年第8期66卷 1769-1787页

作者： quang-minh nguyen Arya Bagus Boedi Iswanto Hobin Kang Jiyun Moon Kieu Anh Thi Phan Geon Hui Son Mi Chung Suh Eui-Hwan Chung Walter Gassmann Sang Hee Kim Division of Applied Life Science(BK21 Four Program) Plant Molecular Biology and Biotechnology Research CenterGyeongsang National UniversityJinju 52828Korea Department of Life Science Sogang UniversitySeoul 04107Korea Department of Plant Biotechnology Korea UniversitySeoul 02841Korea Division of Plant Science and Technology Christopher S.Bond Life Sciences Center and Interdisciplinary Plant GroupUniversity of MissouriColumbiaMissouri 65211USA Division of Life Science and Research Institute of Molecular Alchemy Gyeongsang National UniversityJinju 52828Korea

Pathogens generate and secrete effector proteins to the host plant cells during pathogenesis to promote virulence and *** the plant carries resistance(R)proteins that recognize pathogen effectors,effector-triggered immunity(ETI)is activated,resulting in a robust immune response and hypersensitive response(HR).The bipartite effector AvrRps4 from Pseudomonas syringae *** has been well studied in terms of avirulence *** planta,AvrRps4 is processed into two *** Cterminal fragment of AvrRps4(AvrRps4^(C))induces HR in turnip and is recognized by the paired resistance proteins AtRRS1/AtRPS4 in ***,we show that AvrRps4^(C)targets a group of Arabidopsis WRKY,including WRKY46,WRKY53,WRKY54,and WRKY70,to induce its virulence ***,AvrRps4^(C)suppresses the general binding and transcriptional activities of immune-positive regulator WRKY54 and WRKY54-mediated ***4^(C)interferes with WRKY54's binding activity to target gene SARD1 in vitro,suggesting WRKY54 is sequestered from the SARD1 promoter by AvrRps4^(C).Through the interaction of Avr Rps4^(C)with four WRKYs,AvrRps4 enhances the formation of homo-/heterotypic complexes of four WRKYs and sequesters them in the cytoplasm,thus inhibiting their function in plant ***,our results provide a detailed virulence mechanism of AvrRps4 through its C-terminus.

关键词： AvrRps4 bacterial effector effector-triggered immunity immune response suppression transcription factor WRKY

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GLOBAL BOUND ON THE GRADIENT OF SOLUTIONS TO p-LAPLACE TYPE EQUATIONS WITH MIXED DATA

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Acta Mathematica Scientia 2024年第4期44卷 1394-1414页

作者： minh-Phuong TRAN The-quang TRAN Thanh-Nhan nguyen Applied Analysis Research Group Faculty of Mathematics and StatisticsTon Duc Thang UniversityHo Chi Minh CityVietnam nguyen Huu Huan High School Thu Duc CityVietnam Group of Analysis and Applied Mathematics Department of MathematicsHo Chi Minh City University of EducationVietnam

In this paper,the study of gradient regularity for solutions of a class of elliptic problems of p-Laplace type is *** particular,we prove a global result concerning Lorentz-Morrey regularity of the non-homogeneous boundary data problem:-div((s^(2)+|▽u|^(2)p-2/2)▽u)=-div(|f|^(p-2)f)+g inΩ,u=h in■Ω,with the(sub-elliptic)degeneracy condition s∈[0,1]and with mixed data f∈L^(p)(Q;R^(n)),g∈Lp/(p-1)(Ω;R^(n))for p∈(1,n).This problem naturally arises in various applications such as dynamics of non-Newtonian fluid theory,electro-rheology,radiation of heat,plastic moulding and many *** on the idea of level-set inequality on fractional maximal distribution functions,it enables us to carry out a global regularity result of the solution via fractional maximal *** to the significance of M_(α)and its relation with Riesz potential,estimates via fractional maximal functions allow us to bound oscillations not only for solution but also its fractional derivatives of orderα.Our approach therefore has its own interest.

关键词： gradient estimates p-Laplace quasilinear elliptic equation fractional maximal operators Lorentz-Morrey spaces

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An Enhanced Ensemble-Based Long Short-Term Memory Approach for Traffic Volume Prediction

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Computers, Materials & Continua 2024年第3期78卷 3585-3602页

作者： Duy quang Tran Huy Q.Tran minh Van nguyen Faculty of Civil Engineering Nha Trang UniversityNha Trang650000Vietnam Robotics and Mechatronics Research Group Faculty of Engineering and TechnologyNguyen Tat Thanh UniversityHo Chi Minh City700000Vietnam Department of Civil Engineering Ho Chi Minh City University of Technology and EducationHo Chi Minh City700000Vietnam

With the advancement of artificial intelligence,traffic forecasting is gaining more and more interest in optimizing route planning and enhancing service *** volume is an influential parameter for planning and operating traffic *** study proposed an improved ensemble-based deep learning method to solve traffic volume prediction problems.A set of optimal hyperparameters is also applied for the suggested approach to improve the performance of the learning *** fusion of these methodologies aims to harness ensemble empirical mode decomposition’s capacity to discern complex traffic patterns and long short-term memory’s proficiency in learning temporal ***,a dataset for automatic vehicle identification is obtained and utilized in the preprocessing stage of the ensemble empirical mode decomposition *** second aspect involves predicting traffic volume using the long short-term memory ***,the study employs a trial-and-error approach to select a set of optimal hyperparameters,including the lookback window,the number of neurons in the hidden layers,and the gradient descent ***,the fusion of the obtained results leads to a final traffic volume *** experimental results show that the proposed method outperforms other benchmarks regarding various evaluation measures,including mean absolute error,root mean squared error,mean absolute percentage error,and *** achieved R-squared value reaches an impressive 98%,while the other evaluation indices surpass the *** findings highlight the accuracy of traffic pattern ***,this offers promising prospects for enhancing transportation management systems and urban infrastructure planning.

关键词： Ensemble empirical mode decomposition traffic volume prediction long short-term memory optimal hyperparameters deep learning

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A comparative study on kinetics and dynamics of two dump truck lifting mechanisms using MATLAB simscape

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Theoretical & Applied Mechanics Letters 2024年第2期14卷 146-156页

作者： Thong Duc Hong minh quang Pham Son Cong Tran Lam quang Tran Truong Thanh nguyen Faculty of Transportation Engineering Ho Chi Minh City University of Technology(HCMUT)Ho Chi Minh City 700000Vietnam Vietnam National University Ho Chi minh City(VNU-HCM) Ho Chi Minh City 700000Vietnam Industrial Maintenance Training Center Ho Chi Minh City University of Technology(HCMUT)Ho Chi Minh City 700000Vietnam

In this paper,two lifting mechanism models with opposing placements,which use the same hydraulic hoist model and have the same angle of 50°,have been *** mechanical and hydraulic simulation models are established using MATLAB Simscape to analyze their kinetics and dynamics in the lifting and holding *** simulation findings are compared to the analytical calculation results in the steady state,and both methods show good *** the early lifting stage,Model 1 produces greater force and discharges goods in the container faster than Model ***,Model 2 reaches a higher force and ejects goods from the container cleaner than its counterpart at the end lifting *** established simulation models can consider the effects of dynamic loads due to inertial moments and forces generated during the system *** is crucial in studying,designing,and optimizing the structure of hydraulic-mechanical systems.

关键词： Dump truck Lifting mechanism Hydraulic MATLAB Simscape Kinetic dynamic analysis

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Machine learning based models for predicting compressive strength of geopolymer concrete

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 1028-1049页

作者： quang-Huy LE Duy-Hung nguyen Thanh SANG-TO Samir KHATIR Hoang LE-minh Amir H.GANDOMI Thanh CUONG-LE Center for Engineering Application and Technology Solutions Ho Chi Minh City Open UniversityHo Chi Minh 700000Vietnam Institute of Civil Engineering Ho Chi Minh City University of TransportHo Chi Minh 700000Vietnam Faculty of Engineering&Information Technology University of Technology SydneyUltimoNSW 2007Australia

Recently,great attention has been paid to geopolymer concrete due to its advantageous mechanical and environmentally friendly *** effort has been made in experimental studies to advance the understanding of geopolymer concrete,in which compressive strength is one of the most important *** facilitate engineering work on the material,an efficient predicting model is *** this study,three machine learning(ML)-based models,namely deep neural network(DNN),K-nearest neighbors(KNN),and support vector machines(SVM),are developed for forecasting the compressive strength of the geopolymer concrete.A total of 375 experimental samples are collected from the literature to build a database for the development of the predicting models.A careful procedure for data preprocessing is implemented,by which outliers are examined and removed from the database and input variables are standardized before feeding to the fitting *** standard K-fold cross-validation approach is applied for evaluating the performance of the models so that overfitting status is well managed,thus the generalizability of the models is *** effectiveness of the models is assessed via statistical metrics including root mean squared error(RMSE),mean absolute error(MAE),correlation coefficient(R),and the recently proposed performance index(PI).The basic mean square error(MSE)is used as the loss function to be minimized during the model fitting *** three ML-based models are successfully developed for estimating the compressive strength,for which good correlations between the predicted and the true values are obtained for DNN,KNN,and *** numerical results suggest that the DNN model generally outperforms the other two models.

关键词： geopolymer concrete compressive strength prediction machine-learning based model deep neural network K-nearest neighbor support vector machines

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Push forward LC-MS-based therapeutic drug monitoring and pharmacometabolomics for anti-tuberculosis precision dosing and comprehensive clinical management

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Journal of Pharmaceutical Analysis 2024年第1期14卷 16-38页

作者： nguyen quang Thu nguyen Tran Nam Tien nguyen Thi Hai Yen Thuc-Huy Duong nguyen Phuoc Long Huy Truong nguyen Department of Pharmacology and PharmacoGenomics Research Center Inje University College of MedicineBusan47392Republic of Korea Department of Chemistry University of EducationHo Chi Minh City700000Viet Nam Faculty of Pharmacy Ton Duc Thang UniversityHo Chi Minh City700000Viet Nam

The spread of tuberculosis(TB),especially multidrug-resistant TB and extensively drug-resistant TB,has strongly motivated the research and development of new anti-TB *** strategies to facilitate drug combinations,including pharmacokinetics-guided dose optimization and toxicology studies of first-and second-line anti-TB drugs have also been introduced and *** chromatography-mass spectrometry(LC-MS)has arguably become the gold standard in the analysis of both endo-and exo-genous *** technique has been applied successfully not only for therapeutic drug monitoring(TDM)but also for pharmacometabolomics *** improves the effectiveness of treatment,reduces adverse drug reactions,and the likelihood of drug resistance development in TB patients by determining dosage regimens that produce concentrations within the therapeutic target *** on TDM,the dose would be optimized individually to achieve favorable *** is essential in generating and validating hypotheses regarding the metabolism of anti-TB drugs,aiding in the discovery of potential biomarkers for TB diagnostics,treatment monitoring,and outcome *** article highlighted the current progresses in TDM of anti-TB drugs based on LC-MS bioassay in the last two ***,we discussed the advantages and disadvantages of this technique in practical *** pressing need for non-invasive sampling approaches and stability studies of anti-TB drugs was ***,we provided perspectives on the prospects of combining LC-MS-based TDM and pharmacometabolomics with other advanced strategies(pharmacometrics,drug and vaccine developments,machine learning/artificial intelligence,among others)to encapsulate in an all-inclusive approach to improve treatment outcomes of TB patients.

关键词： Tuberculosis Therapeutic drug monitoring LC-MS MIPD Pharmacometabolomics Precision medicine

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Tungsten-based nanocatalysts with different structures for visible light responsive photocatalytic degradation of bisphenol A

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Journal of Environmental Sciences 2024年第5期139卷 569-588页

作者： Hai Bang Truong Thi Thu Loan Doan nguyen Tien Hoang nguyen Van Tam minh Kim nguyen Le Gia Trung Jin Seog Gwag nguyen Tien Tran Optical Materials Research Group Science and Technology Advanced InstituteVan Lang UniversityHo Chi Minh CityViet Nam Faculty of Applied Technology School of TechnologyVan Lang UniversityHo Chi Minh CityViet Nam The University of Da Nang University of Science and Technology54 Nguyen Luong BangDa NangViet Nam The University of Da Nang University of Science and Education459 Ton Duc Thang St.Lien ChieuDa Nang 550000Viet Nam Institute of Veterinary Science and Technology 31ha zoneTrau QuyGia LamHa Noi 12400Viet Nam Department of Physics Yeungnam UniversityGyeongsanGyeongbuk 38541Republic of Korea Center for Advanced Chemistry Institute of Research and DevelopmentDuy Tan University03 Quang TrungDa Nang 550000Viet Nam Faculty of Natural Sciences Duy Tan University03 Quang TrungDa Nang 550000Viet Nam

Environmental pollution,such as water contamination,is a critical issue that must be absolutely ***,three different morphologies of tungsten-based photocatalysts(WO_(3)nanorods,WO_(3)/WS_(2)nanobricks,WO_(3)/WS_(2)nanorods)are made using a simple hydrothermal method by changing the solvents(H_(2)O,DMF,aqueous HCl solution).The as-prepared nanocatalysts have excellent thermal stability,large porosity,and high *** results show all materials have good photocatalytic activity in aqueous media,with WO_(3)/WS_(2)nanorods(NRs)having the best activity in the photodegradation of bisphenol A(BPA)under visible-light *** may originate from increased migration of charge carriers and effective prevention of electron–hole recombination in WO_(3)/WS_(2)NRs,whereby this photocatalyst is able to generate more reactive·OH and·O_(2)^(–)species,leading to greater photocatalytic *** 99.6% of BPA is photodegraded within 60 min when using 1.5 g/L WO_(3)/WS_(2)NRs and 5.0 mg/L BPA at pH ***,the optimal conditions(pH,catalyst dosage,initial BPA concentration)for WO_(3)/WS_(2)NRs are also elaborately *** rod-like heterostructures are expressed as potential catalysts with excellent photostability,efficient reusability,and highly active effectivity in different types of *** particular,the removal efficiency of BPA by WO_(3)/WS_(2)NRs reduces by only 1.5% after five recycling runs and even reaches 89.1%in contaminated lake *** study provides promising insights for the nearly complete removal of BPA from wastewater or different water resources,which is advantageous to various applications in environmental remediation.

关键词： Photodegradation Bisphenol A Tungsten-based nanocatalyst Structure Nanorod

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Is convenience really king? Comparative evaluation of catastrophic costs due to tuberculosis in the public and private healthcare sectors of Viet Nam: a longitudinal patient cost study

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贫困所致传染病(英文) 2024年第2期13卷 17-28页

作者： nguyen Hoa Binh quang Vo Luan nguyen Forse Rachel Jeanette Wiemers Anja Maria Christine Huynh Huy Ba Dong Thuy Thi Thu Phan Yen Thi Hoang Creswell Jacob Dang Thi minh Ha nguyen Lan Huu Shedrawy Jad L?nnroth Knut nguyen Tuan Dinh Van Dinh Luong Annerstedt Kristi Sidney Codlin Andrew James National Lung Hospital Ha Noi Viet Nam Friends for International TB Relief Ha Noi Viet Nam Department of Global Public Health WHO Collaboration Centre On Tuberculosis and Social Medicine Karolinska Institute Stockholm Sweden Stop TB Partnership Geneva Switzerland Pham Ngoc Thach Hospital Ho Chi Minh City Viet Nam

Background In Viet Nam, tuberculosis (TB) represents a devastating life-event with an exorbitant price tag, partly due to lost income from daily directly observed therapy in public sector care. Thus, persons with TB may seek care in the private sector for its flexibility, convenience, and privacy. Our study aimed to measure income changes, costs and catastrophic cost incurrence among TB-affected households in the public and private *** Between October 2020 and March 2022, we conducted 110 longitudinal patient cost interviews, among 50 patients privately treated for TB and 60 TB patients treated by the National TB Program (NTP) in Ha Noi, Hai Phong and Ho Chi minh City, Viet Nam. Using a local adaptation of the WHO TB patient cost survey tool, participants were interviewed during the intensive phase, continuation phase and post-treatment. We compared income levels, direct and indirect treatment costs, catastrophic costs using Wilcoxon rank-sum and chi-squared tests and associated risk factors between the two cohorts using multivariate *** The pre-treatment median monthly household income was significantly higher in the private sector versus NTP cohort (USD 868 vs USD 578;P=0.010). However, private sector treatment was also significantly costlier (USD 2075 vs USD 1313;P=0.005), driven by direct medical costs which were 4.6 times higher than costs reported by NTP participants (USD 754 vs USD 164;P<0.001). This resulted in no significant difference in catastrophic costs between the two cohorts (Private: 55% vs NTP: 52%;P=0.675). Factors associated with catastrophic cost included being a single-person household [adjusted odds ratio [(aOR=13.71; 95% confidence interval (CI): 1.36–138.14;P=0.026], unemployment during treatment (aOR=10.86; 95%CI: 2.64–44.60;P<0.001) and experiencing TB-related stigma (aOR=37.90; 95%CI: 1.72–831.73;P=0.021).Conclusions Persons with TB in Viet Nam face similarly high risk of catastrophic costs whether treated in the

关键词： Tuberculosis Patient cost Catastrophic cost Private sector Comparative analysis Viet Nam

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Photocatalytic degradation of antibiotic sulfamethizole by visible light activated perovskite LaZnO_(3)

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Journal of Environmental Sciences 2024年第10期144卷 212-224页

作者： Bui The Huy XCuong nguyen Vu Khac Hoang Bui nguyen Ngoc Tri Iqra Rabani Nhu Hoa Thi Tran quang Viet Ly Hai Bang Truong Major of Biomedical Engineering Division of Smart HealthcareCollege of Information Technology and ConvergencePukyong National UniversityBusan 48513Korea Center for Advanced Chemistry Institute of Research and DevelopmentDuy Tan UniversityDa Nang 550000Viet Nam Faculty of Environmental and Chemical Engineering Duy Tan UniversityDa Nang 550000Viet Nam Department of Environment and Energy Sejong UniversitySeoul 05006Korea Lab of Computational Chemistry and Modelling Department of ChemistryFaculty of Natural SciencesQuy Nhon UniversityQuy NhonViet Nam Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Korea Faculty of Materials Science and Technology University of ScienceHo Chi Minh City 700000Viet Nam Vietnam National University Ho Chi Minh City 700000Viet Nam Department of Environmental Engineering Seoul National University of Science and TechnologySeoul 01811Korea Optical Materials Research Group Science and Technology Advanced InstituteVan Lang UniversityHo Chi Minh CityViet Nam Faculty of Applied Technology School of TechnologyVan Lang UniversityHo Chi Minh CityViet Nam

In thiswork,the perovskite LaZnO_(3) was synthesized via sol-gel method and applied for photocatalytic treatment of sulfamethizole(SMZ)antibiotics under visible light *** was almost completely degraded(99.2%±0.3%)within 4 hr by photocatalyst LaZnO3 at the optimal dosage of 1.1 g/L,with amineralization proportion of 58.7%±0.4%.The efficient performance of LaZnO_(3) can be attributed to itswide-range light absorption and the appropriate energy band edge levels,which facilitate the formation of active agents such as·O_(2)^(−),h^(+),and·*** integration of RP-HPLC/Q-TOF-MS and DFT-based computational techniques revealed three degradation pathways of SMZ,which were initiated by the deamination reaction at the aniline ring,the breakdown of the sulfonamidemoieties,and a process known as Smile-type rearrangement and SO2 *** toxicity of SMZ and the intermediateswere analyzed by quantitative structure activity relationship(QSAR),indicating the effectiveness of LaZnO_(3)-based photocatalysis in preventing secondary pollution of the intermediates to the ecosystem during the degradation *** visible-light-activated photocatalyst LaZnO_(3) exhibited efficient performance in the occurrence of inorganic anions and maintained high durability across multiple recycling tests,making it a promising candidate for practical antibiotic treatment.

关键词： Perovskite Antibiotics Photocatalysis Density functional theory Toxicity

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Nonlocal isogeometric analysis for bidirectional functionally graded porous curved microbeams with arbitrary boundary conditions

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Acta Mechanica Sinica 2024年第8期40卷 194-218页

作者： Thu-Huong nguyen Thi Van Ke Tran Van-minh Phung Van Hai Trinh Quoc Hoa Pham Faculty of Mechanical Engineering Hanoi University of IndustryHanoi100000Vietnam Faculty of Mechanical Engineering Le Quy Don Technical UniversityHanoi100000Vietnam Institute of Vehicle and Energy Engineering Le Quy Don Technical UniversityHanoi100000Vietnam Faculty of Engineering and Technology Nguyen Tat Thanh UniversityHo Chi Minh City700000Vietnam

This research aims to analyze the static bending and free vibration behaviors of bidirectional functionally graded porous(BFGP)curved microbeams with elastic boundary conditions resting on a Pasternak’s elastic foundation in a hygro-thermal *** analysis based on non-uniform rational B-splines,first-order shear deformation theory,nonlocal elasticity theory combined with the modified strain gradient theories,modified Timoshenko beam theory are formulated to depict bending and shear deformations of BFGP curved ***,because using the modified Timoshenko beam theory,this study removes the requirement for a shear correction factor and describes shear stress by zero at the upper and lower cross-sectional sites of the BFGP curved *** from traditional boundary conditions,where the beginning and end positions of a curved beam are connected by an elastic system of straight and torsion *** allows for greater flexibility in controlling the stiffness of the springs to obtain arbitrary *** assess the accuracy and convergence of the proposed approach,validation numerical examples were conducted in the various examples.

关键词： Bidirectional functionally graded porous material Elastic boundary condition Isogeometric analysis Curved microbeams Nonlocal elasticity theory Modified strain gradient theory

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