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Chinese Medical Journal 2023年第21期136卷 2635-2637页

作者： Lijuan Zhong Yin Li Xiaohong He Subrata Kumar Dey quanfu zhang Santasree Banerjee Division of Maternal-Fetal Medicine Affiliated Shenzhen Bao’an Women’s and Children’s HospitalJinan UniversityShenzhenGuangdong 518102China Department of Oncology The First Affiliated Hospital of Jinan UniversityJinan UniversityGuangzhouGuangdong 510632China Department of Biotechnology Centre for Genetic StudiesSchool of Biotechnology and Biological SciencesMaulana Abul Kalam Azad University of Technology(Formerly West Bengal University of Technology)KolkataWest Bengal 700064India Department of Genetics College of Basic Medical SciencesJilin UniversityChangchunJilin 130021China

To the Editor:Alport syndrome(AS)is a rare hereditary progressive nephropathy manifested with hematuria,proteinuria,gradual renal failure leading to end-stage renal disease(ESRD),sensorineural hearing loss,and ocular abnormalities.^([1])Germline mutations in any of these collagen type IV genes(COL4A3,COL4A4,and COL4A5)cause AS.^([1])Here,we investigated a four-generation Chinese family with *** proband was clinically diagnosed with hematuria and proteinuria with an elevated level of plasma ***,the proband was diagnosed with ESRD and received renal *** other AS patients,the proband was identified with astigmatism.

关键词： elevated Alport astigmatism

Nd、Ca复合添加对铸态Mg-Gd-Zr合金组织及力学性能的影响

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有色金属工程 2024年第4期14卷 1-9页

作者：宋蕾刘彪彪李越王建张全福任乃栋武维康王红霞孝义市东义镁业有限公司山西孝义032308 太原理工大学材料科学与工程学院太原030024

采用金属型铸造法制备了Mg-6Gd-0.5Zr合金(GK60)、Mg-4Gd-2Nd-0.5Zr(GNK420)合金和Mg-4Gd-1Nd-1Ca-0.5Zr(GNXK4110)合金,研究了Mg-6Gd-0.5Zr合金中Nd替代Gd元素,Nd、Ca复合添加替代Gd元素对合金组织和力学性能的影响。结果表明:元素总量一定时,随着合金元素种类的增多,合金晶粒尺寸显著减小,平均晶粒尺寸从GK60合金的114.59μm减小到GNK420合金的102.69μm和GNXK4110合金的79.51μm;第二相由Mg5Gd相和Mg3Gd相演变到Mg5(Gd,Nd)相,再到Mg7(Gd,Nd,Ca)相,第二相数量显著增多。由于晶粒细化及第二相的强化作用使得三种合金的屈服强度和抗拉强度逐渐提高,而伸长率先降后升,GNXK4110合金力学性能最好,屈服强度和抗拉强度分别达到98.36 MPa和162.5 MPa,伸长率达到7.97%。

关键词：镁合金复合添加晶粒尺寸第二相力学性能

坦桑尼亚PL10451金矿地质特征及找矿方向

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中国锰业 2024年第3期42卷 73-78页

作者：周亚丽罗清威王昊张全傅尹润森王良河南省有色金属矿产探测工程技术研究中心河南郑州450016 河南省有色金属地质矿产局第七地质大队河南郑州450016

PL10451金矿区位于坦桑尼亚环维多利亚湖太古宙绿岩带型金矿成矿区的Ⅱ级成矿带-恩泽加成矿带上,该成矿带构造发育,岩浆活动强烈,成矿环境优越,找矿潜力巨大。通过大比例尺地质、物化探和深部钻孔验证等方法手段,在研究区内共发现4条含... 详细信息

PL10451金矿区位于坦桑尼亚环维多利亚湖太古宙绿岩带型金矿成矿区的Ⅱ级成矿带-恩泽加成矿带上,该成矿带构造发育,岩浆活动强烈,成矿环境优越,找矿潜力巨大。通过大比例尺地质、物化探和深部钻孔验证等方法手段,在研究区内共发现4条含矿构造蚀变带,圈定4条金矿体。初步研究成果表明:研究区金矿成矿类型为受剪切带控制的构造蚀变岩型金矿,矿(化)体围岩蚀变特征明显,其中硅化、绿泥石化、黄铁矿化、褐铁矿化与金矿化关系最为密切,矿石矿物共生组合以自然金+黄铁矿+石英+绿泥石为主,金矿(化)体具有“中低阻-相对高极化”的激电异常特征。初步认为区内近南北向构造带、物化探异常结合部位等是成矿有利部位,可以作为下步主要找矿方向。

关键词：地质特征找矿方向金矿坦桑尼亚

Hyperbranched polymer hollow-fiber-composite membranes for pervaporation separation of aromatic/aliphatic hydrocarbon mixtures

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Chinese Journal of Chemical Engineering 2024年第5期69卷 13-22页

作者： Tong Liu Hao Sun Xiangqiong Wang Jie Li Zhanquan zhang Pei Wu Naixin Wang quanfu An Beijing Key Laboratory for Green Catalysis and Separation Department of Chemical EngineeringCollege of Materials Science and EngineeringBeijing University of TechnologyBeijing 100124China Petrochemical Research Institute CNPCBeijing 102206China

The separation of aromatic/aliphatic hydrocarbon mixtures is crucial in the petrochemical *** is regarded as a promising approach for the separation of aromatic compounds from alkanes. Developing membrane materials with efficient separation performance is still the main task since the membrane should provide chemical stability, high permeation flux, and selectivity. In this study, the hyperbranched polymer(HBP) was deposited on the outer surface of a polyvinylidene fluoride(PVDF)hollow-fiber ultrafiltration membrane by a facile dip-coating method. The dip-coating rate, HBP concentration, and thermal cross-linking temperature were regulated to optimize the membrane *** obtained HBP/PVDF hollow-fiber-composite membrane had a good separation performance for aromatic/aliphatic hydrocarbon mixtures. For the 50%/50%(mass) toluene/n-heptane mixture, the permeation flux of optimized composite membranes could reach 1766 g·m^(-2)·h^(-1), with a separation factor of 4.1 at 60℃. Therefore, the HBP/PVDF hollow-fiber-composite membrane has great application prospects in the pervaporation separation of aromatic/aliphatic hydrocarbon mixtures.

关键词： Aromatic/aliphatic hydrocarbons Hyperbranched polymer Pervaporation Hollow fiber membrane Dip-coating

SNX11 Identified as an Essential Host Factor for SFTS Virus Infection by CRISPR Knockout Screening

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Virologica Sinica 2019年第5期34卷 508-520页

作者： Tiezhu Liu Jiajia Li Yang Liu Yuanyuan Qu Aqian Li Chuan Li quanfu zhang Wei Wu Jiandong Li Yan Liu Dexin Li Shiwen Wang Mifang Liang Key Laboratory of Medical Virology and Viral Diseases Ministry of Health of People's Republic of ChinaNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China CDC-WIV Joint Research Center for Emerging Diseases and Biosafety Wuhan 430071China Department of Microbiology Anhui Medical UniversityHefei 230032China The First Affiliated Hospital of Anhui Medical University Hefei 230022China

Severe fever with thrombocytopenia syndrome virus(SFTSV)is a highly pathogenic tick-borne bunyavirus that causes lethal infectious disease and severe fever with thrombocytopenia syndrome(SFTS)in *** molecular mechanisms and host cellular factors required for SFTSV infection remain *** a genome-wide CRISPR-based screening strategy,we identified a host cellular protein,sorting nexin 11(SNX11)which is involved in the intracellular endosomal trafficking pathway,as an essential cell factor for SFTSV *** SNX11-KO HeLa cell line was established,and SFTSV replication was significantly *** glycoproteins of SFTSV were detected and remained in later endosomal compartments but were not detectable in the endoplasmic reticulum(ER)or Golgi *** values in the endosomal compartments of the SNX11-KO cells increased compared with the pH of normal HeLa cells,and lysosomal-associated membrane protein 1(LAMP1)expression was significantly elevated in the SNX11-KO ***,these results indicated that penetration of SFTSV from the endolysosomes into the cytoplasm of host cells was blocked in the cells lacking *** study for the first time provides insight into the important role of the SNX11 as an essential host factor in the intracellular trafficking and penetrating process of SFTSV infection via potential regulation of viral protein sorting,membrane fusion,and other endocytic machinery.

关键词： CRISPR screen Severe fever with thrombocytopenia syndrome virus(SFTSV) Host factor Sorting nexin 11(SNX11)

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高效凝胶渗透色谱法在粉末涂料中的应用

涂料工业 1989年第1期19卷 49-55页

作者：张泉福化工部涂料工业研究所

本文择例概述了高效凝胶渗透色谱法(HPGPC)在粉末涂料中的应用,包括:(1)供厂商作原料和成品的质量控制;(2)指导树脂的合成和加工;(3)改进树脂合成,以提高最终使用性能;(4)估测齐聚物和聚合物的分子量分布及其与最终使用性能的关系;(5)... 详细信息

本文择例概述了高效凝胶渗透色谱法(HPGPC)在粉末涂料中的应用,包括:(1)供厂商作原料和成品的质量控制;(2)指导树脂的合成和加工;(3)改进树脂合成,以提高最终使用性能;(4)估测齐聚物和聚合物的分子量分布及其与最终使用性能的关系;(5)单体、引发剂、表面活性剂等的纯度检验。

关键词：粉末涂料高效凝胶渗透色谱法质量控制树脂合成

Hemorrhagic Fever with Renal Syndrome — Liaoning Province, China, 1999−2018

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China CDC weekly 2020年第20期2卷 350-354页

作者： Cui Shang Yingwei Sun Qiangling Yin Xiaoxia Huang Xuesheng Liu quanfu zhang Lingling Mao Chuan Li Aqian Li Qin Wang Lina Sun Mifang Liang Shiwen Wang Dexin Li Jiandong Li Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Institute for prevention and control of infection and infectious diseases Center for Disease Control and Prevention of Liaoning ProvinceShenyangLiaoningChina

Summary What is already known on this topic?Hemorrhagic fever with renal syndrome(HFRS)is endemic in Liaoning *** Seoul and Hantaan virus are circulating in rodents,and epidemic outbreaks and sporadic cases have been ... 详细信息

关键词： Province. Liaoning Hemorrhagic

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对民办高校可持续发展的再思考:安徽为例

浙江树人大学学报 2013年第2期13卷 28-31页

作者：张全福安徽三联学院基础部安徽合肥230601

安徽省民办高职院校正在经历新一轮的优胜劣汰,而第三批次本科高校很快也要加入这一进程之中。基于不乐观的前景,民办高校应从自身查找存在的问题,探索可持续发展的有效路径。文章从内因着手,分析安徽省民办高校在办学水平、教学投入、... 详细信息

安徽省民办高职院校正在经历新一轮的优胜劣汰,而第三批次本科高校很快也要加入这一进程之中。基于不乐观的前景,民办高校应从自身查找存在的问题,探索可持续发展的有效路径。文章从内因着手,分析安徽省民办高校在办学水平、教学投入、服务水平、产品质量和执行法律的力度方面存在的问题,指出民办高校应突出做好依法办学、以人为本以及凸显办学特色等关乎存亡的大事。

关键词：民办高等教育民办高校可持续发展安徽省

浅析公路路基施工管理的4M1E模块及其管理对策

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山西建筑 2018年第21期44卷 243-244页

作者：张全富中交二公局第三工程有限公司陕西西安710016

在公路项目中,路基施工质量是直接影响公路质量和使用寿命的关键所在,通过具体公路路基项目施工管理,提出路基施工管理的4M1E控制方法,对路基施工管理和路基施工质量控制能起到重要作用。

关键词：路基施工 4M1E 施工管理施工质量

差异化视阈下高校思想政治理论课考试考核方式改革初探——以安徽四所新建本科高校为例

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齐鲁师范学院学报 2015年第1期30卷 15-19页

作者：张全福安徽三联学院思政部安徽合肥230601

高校思想政治理论课同质化倾向已受到较多关注,然而,作为思想政治理论课教学重要环节的考试考核,却很少有人以差异化为视角进行研究和实践。没有考试考核方式的差异化,就无法彻底克服思想政治理论课教学的同质化倾向。在对安徽省四所新... 详细信息

高校思想政治理论课同质化倾向已受到较多关注,然而,作为思想政治理论课教学重要环节的考试考核,却很少有人以差异化为视角进行研究和实践。没有考试考核方式的差异化,就无法彻底克服思想政治理论课教学的同质化倾向。在对安徽省四所新建本科高校调研后发现,学生有差异、学生对考试考核方式的要求有差异,思想政治理论课课程体系中的各门课程也有很大差异。因此,关注差异化成为思想政治理论课考试考核改革的切入点。

关键词：差异化新建本科高校思想政治理论课考试考核方式改革