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Solid solution strategy modulated defects engineering of(Cr_(1-x)V_(x))_(2)AlC MAX phase toward superior electromagnetic wave absorption

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Rare Metals 2024年第7期43卷 3205-3219页

作者： Ji-Lin gou Yu-Kai Chang Shu Liu Peng-Hui Li Ping-Hao Cui Qian-Ku Hu Li-Bo Wang Xin Zhang Jun-Kai Wang Qi-Xun Xia Ai-Guo Zhou School of Materials Science and Engineering Henan Polytechnic UniversityJiaozuo 454003China Key Laboratory for Microstructural Material Physics of Hebei Province School of ScienceYanshan UniversityQinhuangdao 066004China State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004China

Defects engineering is an effective strategy for manipulating electromagnetic parameters and enhancing electromagnetic wave(EMW)absorption ***,the relationship between them is not clear,especially in solid solution *** this work,a series of(Cr_(1-x)V_(x))_(2)AlC MAX phase solid solutions with layered structure were prepared via tuning the ratio of Cr and V to explore their EMW absorption *** experimental results indicated that the doping of V atoms at the M-site could effectively regulate its impedance matching and EMW absorption properties by introducing appropriate numbers of defects in the crystal,such as twin boundaries,dislocations and lattice *** them,if Cr:V=3:1,Cr_(1.5)V_(0.5)AlC,as radar absorption materials,could reach a strong reflection loss of-51.8 dB at the frequency of 12.8 GHz under an ultra-thin thickness of 1.3 *** reflection loss value could attain-10 dB in a wide frequency range of 2.7-18 GHz and thickness range of 1-5 *** addition,after high temperature and acid-alkali immersion treatment,this sample still had good EMW absorption capability,and the effective absorption bandwidth was enhanced from 2.3 to 2.6 GHz after concentrated acid immersion or 3.1 GHz after concentrated alkali *** work has great reference significance for the research and development of high-performance MAX-based EMW absorption materials in harsh environments.

关键词： MAX phases Solid solution Defects engineering Electromagnetic wave absorption Harsh environments

A Case of Waldenström Macroglobulinemia with Acute Kidney Injury as the First Manifestation and Literature Review

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Proceedings of Anticancer Research 2024年第3期8卷 127-132页

作者： Yang Xu Shanshan Guo Yanli gou Xijie Zheng Department of Nephrology Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

Waldenström macroglobulinemia is a rare lymphoid tumor accounting for 2% of all hematological malignancies. Renal complications are less common compared to multiple myeloma, with the most frequent renal manifestations being microproteinuria and microhematuria. This paper presents a case of Waldenström macroglobulinemia with acute kidney injury as the initial manifestation. A 75-year-old male was admitted to the Affiliated Hospital of Hebei University after elevated blood creatinine levels were detected for one day. Upon admission, his blood creatinine was 255 μmol/L, urine protein was 1+, urine erythrocytes were negative, electrophoresis showed IgM positivity in the κ-region, and a bone marrow biopsy indicated a tendency towards lymphoplasmacytic lymphoma. The patient was discharged after receiving a treatment regimen of prednisone acetate, thalidomide, and cyclophosphamide, and continued oral medication outside the hospital. The patient returned two weeks later due to diarrhea and was found to have a blood creatinine level of 985 μmol/L, along with severe acidosis and hyperkalemia. The patient refused renal replacement therapy and was not followed up, resulting in a poor prognosis. Additionally, a review of the literature is provided to contextualize this case within the broader scope of existing research.

关键词： Waldenström macroglobulinemia Acute kidney injury Prognosis Literature review

Mechanically strong porous bioceramic tubes facilitate large segmental bone defect repair by providing long-term structurally stability and promoting osteogenesis

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Engineered Regeneration 2024年第1期5卷 1-10页

作者： Lijun Xie Jiahao Zhang Hangxiang Sun Zehao Chen Wangsiyuan Teng Xupeng Chai Cong Wang Xianyan Yang Yifan Li Sanzhong Xu Zhongru gou Zhaoming Ye Department of Orthopedic Surgery the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310000PR China Orthopedics Research Institute of Zhejiang University Hangzhou 310000PR China Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province Hangzhou 310000PR China Bio-nanomaterials and Regenerative Medicine Research Division Zhejiang-California International Nanosystem InstituteZhejiang UniversityHangzhou 310058PR China Department of Orthopedics the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003PR China

Mechanically strong magnesium-doped Ca-silicate bioceramic scaffolds have many advantages in repairing large segmental bone *** we combine β-TCP with 6 mol%magnesium-doped calcium silicate(Mg6)at three different ratios(TCP,TCP+15%Mg6,TCP+85%Mg6)to find an appropriate ratio which can exert considerable influence on bone *** this study,the bioceramic scaffolds were assessed for mechanical strength,bioactive ion release,biocompatibility,and osteogenic capacity through in vitro ***,the potential for promoting bone regeneration was investigated through in vivo implantation of porous tube-like *** results showed that the compressive strength increased with the augmentation of Mg6 *** the compressive strength of the TCP+85%Mg6 group reached 38.1±3.8 MPa,three times that of the other two ***,extensive in vivo investigations revealed that the TCP+85%Mg6 bioceramic scaffolds were particularly beneficial for the osteogenic capacity of critical-sized femoral defects(20 mm in length).Altogether,magnesium doping in bioceramic implants is a promising strategy to provide stronger mechanical support and enhance osteogenesis to accelerate the repair of large defects.

关键词： Bioceramic tubes Mg-doped calcium silicate Porous structural stability Large segmental bone defects Digital light processing

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村落空间图式与明清以来的京西文化意象

美术研究 2024年第5期 129-133页

作者：缑梦媛中国艺术研究院美术研究所 100029

界对空间图式的已有研究多从形式、结构等方面入手,强调空间图式的本体纯粹性和超越属性。本文在考察永定河流域传统村落的基础上,发现空间图式是基于特定区域文化意象语境下的社会实践产物,空间图式既是历史时期国家对地方社会自上而... 详细信息

界对空间图式的已有研究多从形式、结构等方面入手,强调空间图式的本体纯粹性和超越属性。本文在考察永定河流域传统村落的基础上,发现空间图式是基于特定区域文化意象语境下的社会实践产物,空间图式既是历史时期国家对地方社会自上而下影响的结果,也是地方社会中宗族、族商的价值观、文化观、世界观的体现。应对空间图式自身的实践性、社会性和整体性特征予以更多关注。

关键词：空间图式文化意象社会实践京西村落

细长潜器在内孤立波作用下大幅运动的轨迹和姿态

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兵工学报 2024年第6期45卷 1854-1865页

作者：刘忻丹勾莹滕斌大连理工大学海岸和近海工程国家重点实验室辽宁大连116024

海洋内部的大幅内孤立波可能会威胁到潜器的航行稳定性和安全性,为探究潜器迎面遭遇内孤立波时的运动特性,建立两层流中细长潜器结构在内孤立波作用下的大幅运动时域求解模型。考虑潜器各运动自由度耦合引起的非线性作用力,潜器受到的... 详细信息

海洋内部的大幅内孤立波可能会威胁到潜器的航行稳定性和安全性,为探究潜器迎面遭遇内孤立波时的运动特性,建立两层流中细长潜器结构在内孤立波作用下的大幅运动时域求解模型。考虑潜器各运动自由度耦合引起的非线性作用力,潜器受到的内孤立波力采用Morison方程和Froude-Krylov力计算,由内孤立波传播引起的静力变化通过对潜器表面静压强积分计算。通过与计算流体力学数值仿真结果和物理模型试验结果对比验证模型的精度,并计算SUBOFF潜器在两层流中不同潜深、不同航速时迎面遭遇KdV型内孤立波后的运动轨迹和姿态。数值仿真结果表明:内孤立波作用下,位于密度分层界面上方和分层界面处的潜器沿内孤立波传播方向运动,位于密度分层界面下方的潜器逆着内孤立波传播方向运动;垂向上潜器会发生大幅掉深,且先下沉再上浮;不同潜深、航速下潜器表现出不同的运动轨迹和姿态。

关键词：潜器内孤立波非线性作用力运动轨迹 Morison方程

In vivo evaluation of guide-free Cas9-induced safety risks in a pig model

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3493-3506页

作者： Weikai Ge Shixue gou Xiaozhu Zhao Qin Jin Zhenpeng Zhuang Yu Zhao Yanhui Liang Zhen Ouyang Xiaoyi Liul Fangbing Chen Hui Shi Haizhao Yan Han Wu Liangxue Lai Kepin Wang China-New Zealand Joint Laboratory on Biomedicine and Health CAS Key Laboratory of Regenerative BiologyGuangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineJoint School of Life SciencesGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou Medical UniversityGuangzhou 510530China Sanya institute of Swine resource Hainan Provincial Research Center of Laboratory AnimalsSanya 572000China Guangdong Provincial Key Laboratory of Large Animal models for Biomedicine Wuyi UniversityJiangmen 529020China Guangzhou National Laboratory Guangzhou 510005China SUniversity of Chinese Academy of Sciences 100049 BeijingChina Research Unit of Generation of Large Animal Disease Models Chinese Academy of Medical Sciences(2019RU015)Guangzhou 510530China

The CRISPR/Cas9 system has shown great potential for treating human genetic diseases through gene ***,there are concerns about the safety of this system,specifically related to the use of guide-free *** studies have shown that guidefree Cas9 can induce genomic instability in ***,the in vivo safety risks associated with guide-free Cas9 have not been evaluated,which is necessary for the development of gene therapy in clinical *** this study,we used doxycycline-inducible Cas9-expressing pigs to evaluate the safety risks of guide-free Cas9 in *** findings demonstrated that expression of guide-free Cas9 could induce genomic damages and transcriptome changes in *** severity of the genomic damages and transcriptome changes were correlate with the expression levels of Cas9 ***,prolonged expression of Cas9 in pigs led to abnormal phenotypes,including a significant decrease in body weight,which may be attributable to genomic damage-induced nutritional absorption and metabolic ***,we observed an increase in whole-genome and tumor driver gene mutations in pigs with long-term Cas9 expression,raising the risk of tumor *** in vivo evaluation of guide-free Cas9 in pigs highlights the necessity of considering and monitoring the detrimental effects of Cas9 alone as genome editing via the CRISPR/Cas9 system is implemented in clinical gene *** research emphasizes the importance of further study and implementation of safety measures to ensure the successful and safe application of the CRiSPR/Cas9 system in clinical practice.

关键词： CRISPR/Cas9 vivo alone

Study on IMF Emission in 30 MeV/u^(40)Ar Induced Reattions

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IMP & HIRFL Annual Report 1995年 12-12页

作者： Zhu Yongtai Xu Hushan Lu Jun Zhang Yuhu Wei Zhiyong Wang Qi Li Songlin Xie Yuanxiang Song Mingtao gou quanbu Zhao Qingzhong Wu Zhongli and Yin Suzhi

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Research on fault time prediction method for high speed rail BTM unit based on multi method interactive validation

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High-Speed Railway 2024年第3期2卷 164-171页

作者： Limin Fu Junqiang gou Chao Sun Hanrui Li Wei Liu School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China China Railway Signal and Communication Research and Design Institute Group Co Ltd. Beijing 100089China

The Balise Transmission Module(BTM)unit of the on-board train control system is a crucial *** to its unique installation position and complex environment,this unit has a higher fault rate within the on-board train control *** conduct fault prediction for the BTM unit based on actual fault data,this study proposes a prediction method combining reliability statistics and machine learning,and achieves the fusion of prediction results from different dimensions through multi-method interactive ***,a method for predicting equipment fault time targeting batch equipment is *** method utilizes reliability statistics to construct a model of the remaining faultless operating time distribution considering uncertainty,thereby predicting the remaining faultless operating probability of the BTM ***,considering the complexity of the BTM unit’s fault mechanism,the small sample size of fault cases,and the potential presence of multiple fault features in fault text records,an individual-oriented fault prediction method based on Bayesian-optimized Gradient Boosting Regression Tree(Bayes-GBRT)is *** method achieves better prediction results compared to linear regression algorithms and random forest regression algorithms,with an average absolute error of only 0.224 years for predicting the fault time of this type of ***,a multi-method interactive validation approach is proposed,enabling the fusion and validation of multi-dimensional *** results indicate that the predicted fault time and the actual fault time conform to a log-normal distribution,and the parameter estimation results are basically consistent,verifying the accuracy and effectiveness of the prediction *** above research findings can provide technical support for the maintenance and modification of BTM units,effectively reducing maintenance costs and ensuring the safe operation of high-speed railway,thus having practical engineering va

关键词： High speed rail BTM unit Remaining faultless operating time Machine learning Multi method interactive verification

“增量”是否“提质”:数字经济对灵活就业质量的影响

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财经科学 2024年第3期 118-133页

作者：郭露王峰江西财经大学统计学院

数字经济发展正推动我国就业市场发生新的变革,新就业形态加速涌现,灵活就业已经成为劳动力的主要选择之一,但“增量”的同时,如何提高灵活就业质量日益成为我国面临的重要现实问题。本文利用中国劳动力动态调查数据,基于灵活就业不同... 详细信息

数字经济发展正推动我国就业市场发生新的变革,新就业形态加速涌现,灵活就业已经成为劳动力的主要选择之一,但“增量”的同时,如何提高灵活就业质量日益成为我国面临的重要现实问题。本文利用中国劳动力动态调查数据,基于灵活就业不同于正规就业的独有特征,探索性地测度了灵活就业质量,并考察了数字经济对灵活就业质量的影响、分维度差异及作用机制。研究发现,灵活就业者多为男性、农村户籍、高龄以及低学历劳动者,且其工作收入低、工作强度大、工作得不到保障等问题广泛存在,就业质量普遍较低;基准回归发现,数字经济发展显著提高了灵活就业质量,这主要体现在数字经济发展对灵活就业工作收入以及工作自由度显著的正向影响中;异质性分析发现,数字经济发展对新生代、低人力资本、雇员型以及非农业户籍灵活就业者的就业质量提升作用更强;机制分析表明,数字经济发展可以通过培养灵活就业新业态与提高灵活就业者数字素养进而提高灵活就业质量。本文的结论有助于对政府进一步提升庞大的灵活就业群体就业质量,实现更高质量的发展与共同富裕。

关键词：数字经济灵活就业就业质量新业态