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Radiofrequency ablation micro-dissecting of eyelid nevus with XL-RFA device under operating microscope

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International Journal of Ophthalmology(English edition) 2019年第7期12卷 1116-1121页

作者： jing-Xin Wang Yi-Lan Li Yue-ming Gao Li-Ning Zhang Li-Ping Huang Qing-Hua He Hui-min Xie Tian-Yu Jiang Zi-Shan Jia Xing-Lin Wang Medical School of Chinese PLA Beijing 100853China Department of Rehabilitation Zhengzhou Central Hospital Affiliated to Zhengzhou University Zhengzhou 100853Henan ProvinceChina Rehabilitation Medicine Center the 1st Medical Center Chinese PLA General Hospital Beijing 100853China Department of Ophthalmo-center Chinese PLA General Hospital Beijing 100853China

AIM: To study the effect of an innovative micro-dissection procedure by radiofrequency ablation (MRA) in removing eyelid ***: Fifty-six consecutive outpatients with eyelid nevus were treated with MRA using a monopolar device. The effect of MRA was determined after following-up for 6mo to ***: Fifty-two cases (52 eyes, 92.9%) were cured once, and 4 cases (4 eyes, 7.1%) received second treatment for small residual. All cases healed well after surgery, with no pigmentation, no scars, no loss of eyelashes, no deformation of eyelid margin. There was no visual impairment after ***: MRA of eyelid nevus using the XL-RFA device is highly efficient without significant complications.

关键词： radiofrequency ablation micro-dissecting eyelid nevus

豨莶草提取物对脑缺血/再灌注大鼠的神经保护作用

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中国药理学通报 2024年第1期40卷 70-75页

作者：吴慧玲吴青青陈景泉周彬彬余正双杨泽霖赖文芳洪桂祝福建中医药大学药学院福建福州350122

目的研究豨莶草提取物对脑缺血/再灌注大鼠的神经保护作用,并探讨其作用机制。方法 SD大鼠60只,线栓法制备大脑中动脉闭塞(middle cerebral artery occlusion, MCAO)模型,实验分为假手术(Sham)组,模型(MCAO)组,豨莶草低剂量(XXC-L)、... 详细信息

目的研究豨莶草提取物对脑缺血/再灌注大鼠的神经保护作用,并探讨其作用机制。方法 SD大鼠60只,线栓法制备大脑中动脉闭塞(middle cerebral artery occlusion, MCAO)模型,实验分为假手术(Sham)组,模型(MCAO)组,豨莶草低剂量(XXC-L)、中剂量(XXC-M)、高剂量(XXC-H)组,连续给药7天。mNSS评估大鼠神经功能损伤,MRI检测大鼠缺血侧脑梗死体积,Nissl染色检测Nissl阳性细胞数;Western blot检测Bax、Bcl-2、NeuN蛋白表达;免疫荧光染色检测Tunel、NeuN;RT-qPCR检测IL-1β、TNF-α、IL-6 mRNA表达。结果豨莶草提取物能显著降低MCAO大鼠mNSS评分和缺血侧脑梗死体积(P<0.05,P<0.01),促进缺血侧脑组织Nissl阳性细胞数和NeuN表达、抑制Tunel阳性细胞数(P<0.01);同时,豨莶草提取物能抑制IL-1β、TNF-α、IL-6mRNA及Bax蛋白,促进Bcl-2、NeuN蛋白(P<0.01)。结论豨莶草提取物对MCAO大鼠具有神经保护作用。

关键词：豨莶草提取物脑缺血/再灌注凋亡 NeuN mNSS评分神经保护

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不均衡数据下基于阴性免疫的过抽样新算法

控制与决策 2010年第6期25卷 867-872,878页

作者：陶新民徐晶童智靖刘玉哈尔滨工程大学信息与通信工程学院哈尔滨150001 黑龙江省科技学院数力系哈尔滨150027

为提高不均衡数据集下算法分类性能,提出一种基于阴性免疫的过抽样算法.该算法利用阴性免疫实现少数类样本空间覆盖,以生成的检测器中心为人工生成的少数类样本.由于该算法利用的是多数类样本信息生成少数类样本,避免了人工少数类过抽... 详细信息

为提高不均衡数据集下算法分类性能,提出一种基于阴性免疫的过抽样算法.该算法利用阴性免疫实现少数类样本空间覆盖,以生成的检测器中心为人工生成的少数类样本.由于该算法利用的是多数类样本信息生成少数类样本,避免了人工少数类过抽样技术(SMOTE)生成的人工样本缺乏空间代表性的不足.通过实验将此算法与SMOTE算法及其改进算法进行比较,结果表明,该算法不仅有效提高了少数类样本的分类性能,而且总体分类性能也有了显著提高.

关键词：不均衡数据阴性免疫过抽样算法人工少数类过抽样技术

Identification of bioactive anti-angiogenic constitutes targeting tumor endothelial cells in Shenmai Injection using multidimensional pharmacokinetics

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中国药理学与毒理学杂志 2019年第9期33卷 681-682页

作者： ZHONG Chong-jin JIANG Chao NI Sui-ying WANG Qi-zhi CHENG Ling-ge WANG Huan ZHANG Qi-xiang LIU Wen-yue ZHANG jing-wei LIU Jia-li WANG Mu-lan JIN min SHEN Pei-qiang YAO Xue-quan WANG Guang-ji ZHOU Fang Key Laboratory of Drug Metabolism and Pharmacokinetics State Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjing 210009China Department of Digestive Tumor Surgery Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China Chiatai QingChunbao Pharmaceutical Co.Ltd. Hangzhou 310023China

OBJECTIVE To identify the bioactive anti-angiogenic constitutes targeting tumor endothelial cells(TECs)in Shenmai Injection(SMI).METHEODS For pharmacokinetic(PK)studies,Balb/c mice harboring human colorectal cancer(LoVo)xenografts were treated with SMI 10 mL·kg^-1 daily for 1 or 8 *** PK profiles of ginsenosides in plasma,subcutaneous tumors,and TECs were *** PD studies,the tumor-bearing mice Intravital multi-photon imaging and CD31 immunofluorescence staining were used to evaluate the number of microves⁃sels and *** staining of CD31 and α-SMA was performed to evaluate pericytes coverage ratios around *** was performed to determine the concentrations of VEGF and FGF in tumor *** synergistic anti-tumor study,the tumor-bearing mice were treated with SMI 10 mL·kg^-1 daily,Rd 5 mg·kg^-1 daily with or without 5-FU 15 mg·kg^-1 every 3 d for 20 ***-MS/MS was used to determine the concentrations of 5-FU in plasma and tumor *** SMI decreased the number of microvessels(P<0.05)and vessel branches(P<0.05)and improved vascular pericytes coverage(P<0.05).PK studies showed that the concentrations of protopanaxadiol-type(PPD)ginsenosides(Rb1,Rb2/Rb3,Rc,and Rd)in both,plasma and tumors,were higher than those of protopanaxatriol-type(Rg1 and Re)and oleanane-type(Ro)*** PPD ginsenosides,Rd exhibited the greatest concentrations in tumors and TECs after repeated *** fact,the proportion of Rd in the detectable components of SMI gradually increased in the following order:SMI formula(2.8%),plasma(16.0%),tumor tissues(34.3%),and TECs(40.3%).In vivo bioactivity results showed that Rd 5 mg·kg^-1 daily significantly decreased the number of microvessels(P<0.05)and vessel branches(P<0.05)and increased pericytes coverage(P<0.05)while Rd 0.5 mg·kg^-1 daily,Rb1 and Rg1 had no significant effect on *** 5 mg·kg^-1 suppressed the expression of VEGF and FGF *** 5 mg·kg^-1 enhanced the antit

关键词： Shenmai Injection multidimensional pharmacokinetics ginsenoside Rd anti-angiogenic tumor endo⁃thelial cell

A New Ionic Trimolybdenum Cluster Compound:〔Mo_3S_7(S_2P(iprO)_2)_3〕〔S_2P(iprO)_2〕

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Chinese Journal of Structural Chemistry 1998年第2期17卷 137-141页

作者： YU Rong-min LU Shao-Fang HUANG Xiao-Ying WU Qiang-Jin HUANG Jian-quan(State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structureof Matter, Chinese Academy Of Sciences, Fuzhou, 350002, China) State Key Lab. of Struct. Chemistry Fujian Inst. Res. Struct. of Matter Chinese Academy of Sciences Fuzhou 350002 China Fuzhou University China

The title compound ttris-(diisopropyldithiophosphato)tris-μ-disulfidoμ3,-sulfido-cvclo-trimolybdenumj (3Mo-Mo) [diisopropyldithiophosphate], [Mo3S7 (S2P(iprO)2)3] [S2P(iprO)2] (Mr=1365. 39) is an ionic species which consists of a discretecluster cation [Mo3S7 (S2P (iprO)2)3] + (ipr = isopropyl) and an anion [S2P (iprO)2]-It was synthesized from the reaction of (NH4)2MoS4 with HS2P (iprO)2. Crystallo-graphic data for its crystal: space group for 7356 independent reflec-'tions with The structure analysis reveals that the cation contains a typical(Mo3 (μ3,-S) (μ-S2)3]+ cluster core in which three molybdenum atoms form an isoscelestriangle;the structure of the free diisopropyldithiophosphate anion [S2P (iprO)2]- isdifferent obviously from the coordinated one.

关键词： Mo-S cluster ionic cluster structure

Hepatoid adenocarcinoma of the stomach: A report of three cases

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World Journal of Gastroenterology 2013年第27期19卷 4437-4442页

作者： min-Feng Ye Feng Tao Fang Liu Ai-jing Sun Department of Gastrointestinal Surgery Shaoxing People's Hospital Shaoxing Hospital of Zhejiang University Department of Pathology Shaoxing People's Hospital

Hepatoid adenocarcinoma of the stomach (HAS) is a rare form of gastric cancer that has unique clinicopathological features and an extremely poor prognosis. Here, we report on three patients with suspected gastric cancer who were referred to our hospital. Gastrointestinal fiberscopy on the three patients revealed two lesions in the antrum and a third lesion in the gastroesophageal junction. The alpha fetoprotein (AFP) serum levels were markedly elevated in all cases. At the time of diagnosis, two cases were advanced stages with lymph nodes and/or liver metastases. Two patients underwent exploratory laparotomy. A total gastrectomy was performed on the operable lesion, and an expanded gastrectomy was completed in the case with hepatic metastases. Histopathological analysis revealed that the tumors displayed two pathological changes:hepatoid-like foci and adenocarcinomatous. Furthermore, the tumor cells were immunohistochemically positive for AFP, alpha-1 antitrypsin, and alpha-1 antichymotrypsin. All three patients received chemotherapy. The follow-up duration ranged from 8-36 mo. Our experience and previous published studies have suggested that HAS is an aggressive type of adenocarcinoma. However, radical surgery and chemotherapy may positively impact clinical outcomes.

关键词： Hepatic adenocarcinoma Gastric cancer Alpha fetoprotein Prognosis Stomach

弹性地基上输流管道主参数共振的主动振动控制

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振动与冲击 2016年第4期35卷 182-187页

作者：王忠民邹德志姜全友西安理工大学土木建筑工程学院西安710048

研究了弹性地基上输送脉动流管道主参数共振的主动振动控制问题。在管道上、下两侧对称的粘贴一对陶瓷压电片,利用压电效应使压电片对管道施加控制力矩。对运动微分方程中由控制力矩产生的Dirac Delta函数对轴向坐标的一阶导数,利用Four... 详细信息

研究了弹性地基上输送脉动流管道主参数共振的主动振动控制问题。在管道上、下两侧对称的粘贴一对陶瓷压电片,利用压电效应使压电片对管道施加控制力矩。对运动微分方程中由控制力矩产生的Dirac Delta函数对轴向坐标的一阶导数,利用Fourier级数进行展开,再采用微分求积法对控制微分方程和边界条件进行离散化处理,得到了时变系统的状态方程。以管道的横向振动变形和输入控制能量之和达到最小的最优控制原则,对简支输送脉动流管道的时变系统受控前后某些点的挠度响应进行了数值仿真。数值计算结果表明,采用的最优控制方案能有效地控制输送脉动流管道的主参数共振问题。

关键词：输送脉动流管道弹性地基微分求积法最优控制法压电效应

Gate tunable Rashba spin-orbit coupling at CaZrO_(3)/SrTiO_(3)heterointerface

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Chinese Physics B 2022年第6期31卷 615-619页

作者： Wei-min Jiang Qiang Zhao jing-Zhuo Ling Ting-Na Shao Zi-Tao Zhang ming-Rui Liu Chun-Li Yao Yu-Jie Qiao Mei-Hui Chen Xing-Yu Chen Rui-Fen Dou Chang-min Xiong Jia-Cai Nie Department of Physics Beijing Normal UniversityBeijing 100875China State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China

High mobility quasi two-dimensional electron gas(2DEG)found at the CaZrO_(3)/SrTiO_(3) nonpolar heterointerface is attractive and provides a platform for the development of functional devices and *** we report that the carrier density and mobility at low temperature can be tuned by gate voltage at the CaZrO_(3)/SrTiO_(3) ***,the magnitude of Rashba spin-orbit interaction can be modulated and increases with the gate ***,the diffusion constant and the spin-orbit relaxation time can be strongly tuned by gate *** diffusion constant increases by a factor of~19.98 and the relaxation time is reduced by a factor of over three orders of magnitude while the gate voltage is swept from-50 V to 100 *** findings not only lay a foundation for further understanding the underlying mechanism of Rashba spin-orbit coupling,but also have great significance in developing various oxide functional devices.

关键词： CaZrO_(3)/SrTiO_(3),2DEG Rashba spin-orbit coupling gate voltage

面向协同制造的分布式对象与虚拟设计环境研究

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通信学报 2006年第11期27卷 154-160页

作者：温泉何建敏曹杰刘波东南大学管理工程系北方民族大学计算机系宁夏银川750021 东南大学计算机工程系

针对分布式在协同设计与制造环境中的需求,提出了实体对象与分布式对象的映射模型和平台匹配方案。分析了协同虚拟制造(CVM,collaborative virtual manufacturing)的技术体系,给出了实体对象的分析方法,提出了分布式环境下的分布式对象... 详细信息

针对分布式在协同设计与制造环境中的需求,提出了实体对象与分布式对象的映射模型和平台匹配方案。分析了协同虚拟制造(CVM,collaborative virtual manufacturing)的技术体系,给出了实体对象的分析方法,提出了分布式环境下的分布式对象映射模型,并设计了CVM分布式支撑环境架构；引入单元匹配和平台匹配量化分析,改进了信息平台效率测度的评价方法。通过实例分析,得到了CVM系统结构拓展模型,对分布式虚拟设计与测试环节进行讨论,表明了应用协同与虚拟现实技术的改进效率。

关键词：协同虚拟制造分布式对象协同工作虚拟设计