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MR diffusion-weighted imaging of rabbit liver VX-2 tumor

World Journal of Gastroenterology 2005年第20期11卷 3070-3074页

作者： You-HongYuan En-HuaXiao JunXiang Ke-LiTang KeJin Shi-JianYi QiangYin Rong-HuaYan ZhongHe quan-liangshang Wei-ZhouHu Su-WenYuan DepartmentofRadiology theSecondXiangyaHospitalCentralSouthUniversityChangsha410011HunanProvinceChina

AIM: To investigate the implanting method of rabbit liver VX-2 tumor and its MR diffusion-weighted imaging (DWI) characteristics. METHODS: Thirty-five New Zealand rabbits were included in the study. VX-2 tumor was implanted subcutaneously in 14 rabbits and intrahepatically in 6 for pre-experiments. VX-2 tumor was implanted intrahepatically in 12 rabbits for experiment and three were used as the control group. DWI, T1- and T2-weighted of MRI were performed periodically in 15 rabbits for experiment before and after implantation. The distinction of VX-2 tumors on DWI was assessed by their apparent diffusion coefficient (ADC) values. The statistical significance was calculated by analysis of variance (ANOVA) of the randomized block design using SPSS10.0 software. RESULTS: The successful rate of subcutaneous implantation of VX-2 tumor was 29% (4/14) while that of intrahepatic implantation of it was 33% (2/6) in the preexperiment. The successful rate of intrahepatic implantation of VX-2 tumor in the experiment was 83% (10/12) and 15 tumors grew in 10 successfully implanted rabbits. The DWI signal of VX-2 tumor was high and became lower when the b value increased step by step. The signal of VX-2 tumor on the map of ADC was low. When the b value was 100 or 300 s/mm2, the ADC value of normal group and VX-2 tumor group was respectively 2.57±0.26, 1.73±0.31, 1.87±0.25 and 1.57±0.23 mm2/s. Their distinction was significant (F= 43.26, P<0.01), the tumor ADC value between b values 100 and 300 s/mm2 was significant (Tukey HSP,P<0.05) and the ADC value between VX-2 tumor and normal liver was also significant (Tukey HSP, P<0.01). VX-2 tumor developed quickly and metastasized early to all body, especially to the lung, liver, lymph nodes of mediastinum, etc. CONCLUSION: The DWI signal of rabbit VX-2 tumor has its characteristics on MR DWI and DWI plays an important role in diagnosing and discovering VX-2 tumor.

关键词： Magnetic resonance imaging Diffusion-weighted Liver VX-2 tumor Rabbits

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Multiparameter magnetic resonance imaging of liver fibrosis in a bile duct ligation mouse model

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World Journal of Gastroenterology 2021年第47期27卷 8156-8165页

作者： Jia-Yi Liu Zhu-Yuan Ding Zi-Yi Zhou Sheng-Zhen Dai Jie Zhang Hao Li Qiu Du Ye-Yu Cai quan-liangshang Yong-Heng Luo En-Hua Xiao Department of Radiology The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Department of Emergency Medicine First People's Hospital of Changde CityChangde 415000Hunan ProvinceChina Department of Urology Hunan Provincial People's HospitalFirst Affiliated Hospital of Hunan Normal UniversityChangsha 410005Hunan ProvinceChina

BACKGROUND Bile duct ligation(BDL)in animals is a classical method for mimicking cholestatic *** different surgical techniques have been described in rats and rabbits,mouse models can be more cost-effective and reproducible for investigating cholestatic *** resonance imaging(MRI)has made great advances for noninvasive assessment of liver *** comprehensive liver fibrotic features of BDL on MRI are ***,the utility of multiparameter MRI to detect liver fibrosis in a BDL mouse model has not been *** To evaluate the correlation between the pathological changes and multiparameter MRI characteristics of liver fibrosis in a BDL mouse *** Twenty-eight healthy adult male balb/c mice were randomly divided into four groups:sham,week 2 BDL,week 4 BDL,and week 6 *** MRI sequences,included magnetic resonance cholangiopancreatography,T1-weighted,T2-weighted,T2 mapping,and pre-and post-enhanced T1 mapping,were performed after sham and BDL *** blood and liver tissue were collected after *** statistical analysis,Student’s t-test and Pearson’s correlation coefficient were *** Four mice died after BDL surgery;seven,six,five and six mice were included separately from the four *** intensities of liver parenchyma showed no difference on TI-and T2-weighted *** duct volume,ΔT1 value,T2 value,and the rate of liver fibrosis increased steadily in week 2 BDL,week 4 BDL and week 6 BDL groups compared with those in the sham group(P<0.01).Alanine aminotransferase and aspartate transaminase levels initially surged after surgery,followed by a gradual decline over *** correlations were found between bile duct volume(r=0.84),T2 value(r=0.78),ΔT1 value(r=0.62),and hepatic fibrosis rate(all P<0.01)in the BDL *** The BDL mouse model induces changes that can be observed on *** MRI parameters correlate with the hepatic fibrosis rate and allow for detec

关键词： Liver Fibrosis Magnetic resonance imaging Pathology Animal model Bile duct ligation

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