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Indirect determination of cefradine with n-propyl alcohol-ammonium sulfate-water system by extraction-flotation of cuprous thiocyanate

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Chinese Chemical Letters 2008年第5期19卷 565-568页

作者： ling li Wu Wei Zhao quan min li College of Chemistry and Environmental Science Henan Normal UniversityThe Key Laboratory of Environmental Pollution Control Technology of Henan province Xinxiang 453007 China Henan Radio and Television University Zhengzhou 450008 China

A new method was developed for the determination of cefradine by extraction-flotation of CuSCN. The experiment indicated that in the presence of 0.20 mol/L NaOH the degradation of cefradine took place in water bath at 100 ℃. The thiol group （-SH） of the degradation product could reduce Cu（Ⅱ） to Cu（Ⅰ） for the formation of the emulsion CuSCN in the presence of NH4SCN at pH 4.0. By determining the residual amount of Cu（Ⅱ） in the solution and calculating the flotation yield of Cu（Ⅱ）, the indirect determination of cefradine can be obtained. This method has been applied to determine cefradine in capsules, human serum and urine samples, respectively.

关键词： Cefradine Copper(Ⅱ) n-Propyl alcohol Extraction-flotation

A novel method for the spectrophotometric determination of cefradine by using sodium nitroprusside as chromogenic reagent

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Chinese Chemical Letters 2008年第12期19卷 1470-1474页

作者： Hua Zhang ling li Wu quan min li Xin Zhen Du College of Chemistry and Environmental Science Henan Normal University Xinxiang 453007 China College of Chemistry and Chemical Engineering Northwest Normal University Lanzhou 730070 China Henan Radio and Television University Zhengzhou 453008 China

A novel method is developed for the determination of cefradine by using sodium nitroprusside as chromogenic reagent. The experiment indicates that a russety product is formed by the reaction of cefradine with sodium nitroprusside in basic solution, and the maximum absorption wavelength （λmax） of russety product is 505 rim. And the sensitization of tetradecyl benzyl dimethyl ammonium chloride for the reaction of cefradine with sodium nitroprusside is remarkable, The apparent molar absorption coefficient （5505） is 2.81 × 103 L/mol cm. The linear equation isA = 0.0657 ＋ 0.00804C （μg/mL） in the range of 1.50-55.0μg/mL of cefradine with a correlation coefficient r = 0.9992, and the detection limit is 1.38 p,g/mL. This method has been applied to determine cefradine in capsule and tablet samples.

关键词： Cefradine Sodium nitroprusside Chromogenic reagent Spectrophotometry

A randomized, open-label, multicentre study to evaluate plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus and arteriosclerosis obliterans when treated with Probucol and Cilostazol

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Journal of Geriatric Cardiology 2012年第3期9卷 228-236页

作者： Xiao-Wei Ma Xiao-Hui Guo Xin-Hua Xiao li-Xin Guo Xiao-Feng Lv quan-min li Yan Gao Department of Endocrinology Peking University First Hospital No. 7 of Xishiku Street Xicheng District Beijing 100034 China Department of Endocrinology Peking Union Medical College Hospital No.1 Shuaifuyuan Dongcheng District Beijing 100005 China Department of Endocrinology Peking Hospital No. 1 Dahua Road Dongdan Dongcheng District Beijing 100730 China Department of Endocrinology Military General Hospital of Peking PLA No.5 Nanmencang Dongsishitiao Dongcheng District Beifing 100070 China Department of Endocrinology Second Artillery Forces General Hospital of Peking PLA No.16 Xinjiekouwai Street Xicheng District Beijing 100088 China

Objectives To evaluate the plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus （T2DM） and arteriosclerosis obliteran （ASO） when treated with Probucol plus Cilostazol in combination and individually. Methods In this open-label study, patients aged 40-75 years were randomized to receive conventional therapy alone, or with Cilostazol 100 mg bid, or with Probucol 250 mg bid, or with both in combination. Endpoints included changes in plasma biomarker and safety at 12 weeks. Results Of the 200 randomized pati- ents, 165 for per-protocol and 160 for the safety （QTc intervals） were set, respectively. Probucol significantly reduced total cholesterol （P 〈 0.001）, low-density lipoprotein cholesterol （LDL-C）, （P = 0.01）, and high-density lipoprotein cholesterol （HDL-C）（P 〈 0.001） compared with conventional therapy. Cilostazol was effective in increasing HDL-C （P = 0.002） and reducing triglycerides levels （P 〈 0.01） compared with conventional therapy. A trend towards significance was observed for the difference between conventional therapy alone and Probucol plus Cilostazol group for the change in oxidized low-density lipoprotein （Ox-LDL, P = 0.065）. No significant effects on the majority of the remaining biomarkers were found across the treatment groups. Conclusions We have confirmed that Ox-LDL could be a possible plasma atherosclerotic biomarker among the evaluated biomarkers, which reflected the synergetic effect of Cilostazol plus Probucol in patients with T2DM and ASO shown previously in preclinical studies.

关键词： Cilostazol Probucol Combination treatment Atherosclerosis Biomarkers Synergetic effect

Coronary collateral circulation： Effects on outcomes of acute anterior myocardial infarction after primary percutaneous coronary intervention

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Journal of Geriatric Cardiology 2011年第2期8卷 93-98页

作者： Bin Wang Ya-ling Han Yi li quan-min Jing Shou-li Wang Ying-Yan Ma Geng Wang Bo Luan Xiao-Zeng Wang Department of Cardiology Shenyang North Hospital Shenyang 110016 Liao Ning Province China

Background To investigate the effects of collateral coronary circulation on the outcome of the patients with anterior myocardial infarction （MI） with left anterior desending artery occlusion abruptly. Methods Data of 189 patients with acute anterior MI who had a primary percutaneous coronary intervention （PCI） in the first 12 h from the onset of symptoms between January 2004 and December 2008 were retrospective analyzed. Left anterior descending arteries （LAD） of all patients were occluded. LADs were reopened with primary PCI. According to the collateral circulation, all patients were classified to two groups： no collateral group （n = 111）, patients without angiographic collateral filling of LAD or side branches （collateral index 0） and collateral group （n = 78）, and patients with angiographic collateral filling of LAD or side branches （collateral index 1, 2 or 3）. At one year＇ s follow-up, the occurrence of death, reinfarctlon, stent thrombosis （ST）, target vessel revascularization and readmission because of heart failure were observed. Results At one year, the mortality was lower in patients with collateral circulation compared with those without collateral circulation （1% vs. 8%, P = 0.049）, whereas there Were no differences in the occurrence of reinfarction, ST, target vessel revascularization and readmission because of heart failure. The occurrence of composite of endpoint was lower in patients with collateral circulation compared with those without collateral circulation （12% vs. 26%; P = 0.014）. Conclusions Pre-exist collateral circulation may prefigure the satisfactory prognosis to the patients with acute anterior MI after primary PCI in the first 12 h of MI onset.

关键词： collateral circulation myocardial infarction mortality left anterior descending artery

ROLE OF B LYMPHOCYTE AND ITS SUBPOPULATIONS IN PATHOGENESIS OF IMMUNORELATED PANCYTOPENIA

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Chinese Medical Sciences Journal 2007年第3期22卷 199-202页

作者： Rong Fu Zong-hong Shao Hong liu Yu-hong Wu Hua-quan Wang li-min Xing Department of Hematology and Oncology General Hospital of Tianjin Medical University Tianjin 300052

Objective To measure the quantities and apoptosis-related protein levels of B lymphocyte in the patients with immunorelated pancytopenia （IRP） and explore the action of B lymphocyte in the pathogenic mechanism of IRP. Methods quantifies of whole B lymphocytes and CD5^＋ B lymphocytes as well as the expressions of Fas and Bcl-2 in B lymphocytes in 35 patients with untreated IRP, 15 IRP patients in complete remission （CR）, and 10 normal controls were assayed by flow cytometry. The percentages of B lymphocyte and CD5^＋ B lymphocyte were significantly higher in untreated IRP patients than in CR IRP patients and normal controls （ P 〈 0. 05 ）, and there was no significant difference between the latter two groups （ P 〉 0. 05 ）. There was no significant difference of Fas expression in B lymphocyte among three groups （ P 〉 0. 05）. The expression of Bcl-2 in B lymphocyte was significantly higher in untreated patients than in CR patients or normal controls （ P 〈 0. 01 ）, and significantly higher in CR patients than in normal controls （ P 〈 0. 01 ）. The apoptosis. related index was significantly lower in untreated patients than in CR patients or normal controls （ P 〈 0. 05 ）, and signif. icantly lower in CR patients than in normal controls （ P 〈 0. 05 ）. The percentage of B lymphocyte was positively correlated with post-treated response time （ r = 0. 53, P 〈 0. 01 ）. Conclusion The production of auto-antibodies in IRP patients probably has some relationship with the abnormal quantifies of B lymphocyte and its subpopulations as well as with the inhibition of B lymphocyte apoptosis.

关键词： immunorelated pancytopenia B lymphocyte quantifies apoptosis

Percutaneous coronary intervention for chronic total occlusion in 1263 patients:a single-center report

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Chinese Medical Journal 2006年第14期119卷 1165-1170页

作者： HAN Ya-ling WANG Shou-li JING quan-min li Yi ZHANG Jian MA Ying-yan LUAN Bo Department of Cardiology Shenyang General Hospital of PLA Shenyang 110016 China

Background Coronary chronic total occlusion （CTO） remains one of the most challenging lesion subsets in interventional cardiology, even with the development of medical device and operator expertise. This study was conducted to examine the relationship between lesion characteristics and procedural success and the incidence of in-hospital major adverse cardiac events （MACE） after percutaneous coronary intervention （PCI） for CTO. Methods Clinical and coronary angiographic data of 1263 patients with CTO who underwent PCI between June 1995 and December 2005 in Shenyang General Hospital of PLA were retrospectively analyzed. Results There were 1625 CTO lesions located in 1596 vessels with a mean occlusion time of 48.9 months. A total of 1647 coronary stents were implanted to the target lesions. The overall patient and lesion success rates were 90.8 % （1147/1263） and 88.9 % （1445/1625）, respectively. The success rate of PCI was declined with long duration of occlusion, abrupt missing stump, bridging collaterals ≥15 mm in occluded length, moderate to severe calcification or tortuosity and ostial or distal location of CTO lesions （P〈 0.05）. Procedural failure occurred in 116 patients, caused by impossibility of guide-wire （81.0%） or balloon （19.0%） to pass through the occlusion. There was no death during procedure, but 2 patients suffered from acute stent thrombosis and other 9 patients had acute or late pericardial perforation. Those complications were all successfully treated. After procedure, 3 patients died, 4 experienced urgent target vessel revascularization because of subacute stent thrombosis and 1 underwent coronary bypass graft surgery due to coronary ftstula during in-hospital period. The overall in-hospital MACE rate was 0.6% （8/1263）. Drug-eluting stents were used in 198 patients without in-hospital MACE. Conclusions In an experienced heart center, it is possible to obtain a relatively high success rate of PCI and favorable clinical outcomes for patients with

关键词： coronary heart disease chronic total occlusion angioplasty, transluminal percutaneous coronary

Performance Study of Distributed Multi-Agent Intrusion Detection System

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Computer Aided Drafting,Design and Manufacturing 2005年第2期15卷 38-43页

作者： YIN Yong ZHOU Zu-de liU quan li Fang-min li Zhong-nan School of Information Engineering Wuhan University of Technology Wuhan 430070 China

Traditional Intrusion Detection System （IDS） based on hosts or networks no longer meets the security requirements in today＇s network environment due to the increasing complexity and distributivity. A multi-agent distributed IDS model, enhanced with a method of computing its statistical values of performance is presented. This model can accomplish not only distributed information collection, but also distributed intrusion detection and real-time reaction. Owing to prompt reaction and openness, it can detect intrusion behavior of both known and unknown sources. According to preliminary tests, the accuracy ratio of intrusion detection is higher than 92% on the average.

关键词： distributed intrusion detection system multi-agent intrusion detectionmethod information security

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数据驱动的溶解氧浓度在线自组织控制方法

自动化学报 2023年第12期49卷 2582-2593页

作者：权利敏杨翠丽乔俊飞北京工业大学信息学部智慧环保北京实验室计算智能与智能系统北京市重点实验室北京100124 青岛理工大学信息与控制工程学院青岛266520

针对城市污水处理过程的非线性、不确定性以及非高斯等特点,提出一种数据驱动的溶解氧(Dissolved oxygen,DO)浓度在线自组织控制方法.首先,设计一种基于相关熵的自组织模糊神经网络控制器(Correntropy-based self-organizing fuzzy neur... 详细信息

针对城市污水处理过程的非线性、不确定性以及非高斯等特点,提出一种数据驱动的溶解氧(Dissolved oxygen,DO)浓度在线自组织控制方法.首先,设计一种基于相关熵的自组织模糊神经网络控制器(Correntropy-based self-organizing fuzzy neural network,CSOFNN),采用相关熵与规则贡献度指标实现控制器结构与参数的自动构建或修剪.其次,设计基于相关熵诱导准则的补偿控制器及参数自适应律,充分利用相关熵抑制非高斯噪声的能力,能够有效地降低系统中的不确定性.然后,分析所提出的控制方法的稳定性,从而保证其在实际应用中的可靠性.最后,基于基准仿真1号模型(Benchmark simulation model No.1,BSM1)的实验验证了所提方法的有效性.

关键词：数据驱动控制相关熵在线自组织模糊神经网络溶解氧浓度稳定性分析

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Elective percutaneous intervention for unprotected left main coronary artery stenosis complicated with left anterior descending artery chronic total occlusive lesions

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Chinese Medical Journal 2010年第7期123卷 816-821页

作者： YANG Gui-tang HAN Ya-ling JING quan-min WANG Shou-li li Yi MA Ying-yan WANG Geng LUAN Bo WANG Xiao-zeng WANG Bin WANG Zu-lu WANG Dong-mei Department of Cardiology Shenyang Northern HospitalShenyang Liaoning 110840 China

Background The patients with unprotected left main coronary artery （ULMCA） stenosis and chronic total occlusion （CTO） lesions at the left anterior descending （LAD） artery are often recommended for bypass surgery. However, some of these patients are deemed inoperable or are at high risk for surgery. In this study, we explored strategies and evaluated the efficacy of percutaneous coronary intervention for the treatment of ULMCA stenosis complicated by LAD CTO. Methods From November 2001 to July 2009, 78 patients with ULMCA stenosis and LAD CTO lesions were selectively treated with stenting. Six patients （7.7%） refused surgery due to their young age （S40 years）, and the other 72 patients （92.3%） were unsuitable for surgery. Reasons for poor surgical candidacy included advanced age （〉80 years）, chronic obstructive pulmonary, unsuitable distal target vessels for bypass, EuroSCORE ≥6, and so on. Four different strategies were applied based on the degree of left main stenosis and the ostial diameter and involvement of the left circumflex. Results Total procedural success was achieved in 94.9%, there were no deaths or thromboses. Five patients （6.4%） experienced non-Q-wave myocardial infarction in hospital. At long-term follow-up （（52±28） months）, there were 3 cardiac deaths （3.8%） and 4 （5.1%） nonfatal myocardial infarctions. Angiographic follow-up was performed in 50 patients （64.1%）, and target vessel revascularizations were required in 10 patients （12.8%）, among which 4 nonfatal myocardial infarction patients included. The rate of major adverse cardiac events was 16.7% （13/78）.Conclusions This study indicates that percutaneous intervention can be performed safely in high risk surgical patients with ULMCA and LAD CTO lesions based on individual therapeutic strategies. It may be feasible to apply this technique in selected patients mentioned above.

关键词： percutaneous coronary intervention chronic total occlusion left main coronary artery disease strategy