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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-quan xu Jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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3D analysis for pit evolution and pit-to-crack transition during corrosion fatigue

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第4期14卷 292-299页

作者： Xiao-guang HUANG Jin-quan xu Department of Engineering Mechanics China University of Petroleum Department of Engineering Mechanics Shanghai Jiao Tong University

This paper presents a deterministic model to predict the pit evolving morphology and crack initiation life of corrosion *** on the semi-ellipsoidal pit assumption,the thermodynamic potential including elastic energy,surface energy and electrochemical energy of the cyclically stressed solid with an evolving pit is established,from which specific parameters that control the pit evolution are introduced and their influence on the pit evolution are *** critical pit size for crack nucleation is obtained from stress intensity factor criterion and the crack nucleation life is evaluated by Faraday's ***,this paper presents a numerical example to verify the proposed model and investigate the influence of cyclic load on the corrosion fatigue crack nucleation *** corrosion pit appears approximately as a hemisphere in its early formation,and it gradually transits from semicircle to *** strain energy accelerates the morphology evolution of the pit,while the surface energy decelerates *** higher the stress amplitude is,the smaller the critical pit size is and the shorter the crack initiation life is.

关键词： Pit Evolving morphology Thermodynamic potential Critical pit size Crack nucleation

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Two-Dimensional Breather Lattice Solutions and Compact-Like Discrete Breathers and Their Stability in Discrete Two-Dimensional Monatomic β-FPU Lattice

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Communications in Theoretical Physics 2009年第1期51卷 153-156页

作者： xu quan TIAN Qiang Department of Physics Daqing Normal University Daqing 163712 China Department of Physics Beijing Normal University Beijing 100875 China

We restrict our attention to the discrete two-dimensional monatomic β-FPU lattice. We look for two- dimensional breather lattice solutions and two-dimensional compact-like discrete breathers by using trying method and analyze their stability by using Aubry＇s linearly stable theory. We obtain the conditions of existence and stability of two-dimensional breather lattice solutions and two-dimensional compact-like discrete breathers in the discrete two- dimensional monatomic β-FPU lattice.

关键词： β-FPU lattice two-dimensional breather lattice solution two-dimensional compact-like discrete breather

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Novel Evidence for a Reversible Dissociation of Light-harvesting Complex II from Photosystem II Reaction Center Complex Induced by Saturating Light Illumination in Soybean Leaves

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Journal of Integrative Plant Biology 2007年第4期49卷 523-530页

作者： Yi Liao Da-quan xu Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences the Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences Shanghai 200032 China

After saturating light illumination for 3 h the potential photochemical efficiency of photosystem Ⅱ （PSII）（FJF,, the ratio of variable to maximal fluorescence） decreased markedly and recovered basically to the level before saturating light illumination after dark recovery for 3 h in both soybean and wheat leaves, indicating that the decline in FJ/Fm is a reversible down-regulation. Also, the saturating light illumination led to significant decreases in the low temperature （77 K） chlorophyll fluorescence parameters F685 （chlorophyll a fluorescence peaked at 685 nm） and F685/F735 （F735, chlorophyll a fluorescence peaked at 735 nm） in soybean leaves but not in wheat leaves. Moreover, trypsin （a protease） treatment resulted in a remarkable decrease in the amounts of PsbS protein （a nuclear gene psbS-encoded 22 kDa protein） in the thylakoids from saturating light-illuminated （SI）, but not in those from darkadapted （DT） and dark-recovered （DRT） soybean leaves. However, the treatment did not cause such a decrease in amounts of the PsbS protein in the thylakoids from saturating light-illuminated wheat leaves. These results support the conclusion that saturating light illumination induces a reversible dissociation of some light-harvesting complex Ⅱ （LHClI） from PSII reaction center complex in soybean leaf but not in wheat leaf.

关键词： chlorophyll fluorescence light-harvesting complex Ⅱ PsbS protein reversible dissociation soybean trypsin.

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Attention-Aware Heterogeneous Graph Neural Network

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Big Data Mining and Analytics 2021年第4期4卷 233-241页

作者： Jintao Zhang quan xu College of Sciences Northeastern UniversityShenyang 110004China State Key Laboratory of Synthetical Automation for Process Industries Northeastern UniversityShenyang 110819China

As a powerful tool for elucidating the embedding representation of graph-structured data,Graph Neural Networks(GNNs),which are a series of powerful tools built on homogeneous networks,have been widely used in various data mining *** is a huge challenge to apply a GNN to an embedding Heterogeneous Information Network(HIN).The main reason for this challenge is that HINs contain many different types of nodes and different types of relationships between *** contains rich semantic and structural information,which requires a specially designed graph neural ***,the existing HIN-based graph neural network models rarely consider the interactive information hidden between the meta-paths of HIN in the poor embedding of nodes in the *** this paper,we propose an Attention-aware Heterogeneous graph Neural Network(AHNN)model to effectively extract useful information from HIN and use it to learn the embedding representation of ***,we first use node-level attention to aggregate and update the embedding representation of nodes,and then concatenate the embedding representation of the nodes on different ***,the semantic-level neural network is proposed to extract the feature interaction relationships on different meta-paths and learn the final embedding of *** results on three widely used datasets showed that the AHNN model could significantly outperform the state-of-the-art models.

关键词： Graph Neural Network(GNN) Heterogeneous Information Network(HIN) embedding

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QFS-domains and Quasicontinuous Domains

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Acta Mathematica Sinica,English Series 2015年第2期31卷 295-304页

作者： Wen Feng ZHANG Xiao quan xu Department of Mathematics Sichuan University School of Mathematics and Computer Science Jiangxi Science & Technology Normal University Department of Mathematics Jiangxi Normal University

In this paper, we show that （1） for each QFS-domain L, L is an ωQFS-domain iff L has a countable base for the Scott topology; （2） the Scott-continuous retracts of QFS-domains are QFS- domains; （3） for a quasicontinuous domain L, L is Lawson compact iff L is a finitely generated upper set and for any x1, x2 ∈ L and finite G1, G2 C L with G1 〈〈 x1, G2 〈〈 x2, there is a finite subset F C L such that ↑ x1 x2 G2; （4） L is a QFS-d0main iff L is a quasicontinuous domain and given any finitely many pairs {（Fi, xi）： Fi is finite, xi ∈ L with Fi 〈〈 xi, 1 ≤i ≤n}, there is a quasi-finitely separating function 5 on L such that Fi 〈〈 δ（xi）〈〈 xi.

关键词： QFS-domain quasicontinuous domain Scott topology Lawson compact

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Decentralized Adaptive Strategies for Synchronization of Fractional-order Complex Networks

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IEEE/CAA Journal of Automatica Sinica 2017年第3期4卷 543-550页

作者： quan xu Shengxian Zhuang Yingfeng Zeng Jian Xiao School of Electrical Engineering Southwest Jiaotong University School of Technology Xihua University

This paper focuses on synchronization of fractionalorder complex dynamical networks with decentralized adaptive *** on local information among neighboring nodes,two fractional-order decentralized adaptive strategies are designed to tune all or only a small fraction of the coupling gains *** constructing quadratic Lyapunov functions and utilizing fractional inequality techniques,Mittag-Leffler function,and Laplace transform,two sufficient conditions are derived for reaching network synchronization by using the proposed adaptive ***,two numerical examples are given to verify the theoretical results.

关键词： Decentralized adaptive control fractional-order complex networks quadratic Lyapunov functions synchronization

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Carbon quantum dots: An innovative additive for water lubrication

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Science China(Technological Sciences) 2019年第4期62卷 587-596页

作者： XIAO HuaPing LIU ShuHai xu quan ZHANG Hang College of Mechanical and Transportation Engineering China University of Petroleum-Beijing Institute of New Energy China University of Petroleum-Beijing

Water soluble carbon quantum dots(CQDs) were prepared and used as lubricant additives in deionized(DI) water. The impacts of CQDs on the tribological properties of water were evaluated for both Si_3N_4-on-steel and Si_3N_4-on-Si_3N_4 contacts. Experimental results show that the coefficient of friction(COF) reduced in the two types of tribopairs after the addition of *** reductions in COF were found to be 30% and 14% for the Si_3N_4-steel and Si_3N_4-Si_3N_4 contacts, respectively. In terms of wear behaviors, the CQDs notably improved tribofilm formation on the Si_3N_4 disk surface for the Si_3N_4-Si_3N_4 contacts,confirming that the nanoparticles increase friction while providing better protection from wear. This research will help to expand the application of CQDs as promising additives in water-based lubricants.

关键词： carbon quantum dot water lubrication lubricant additives ceramic tribopairs

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A New Kind of Pilot Controlled Proportional Direction Valve with Internal Flow Feedback

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Chinese Journal of Mechanical Engineering 2010年第1期23卷 60-65页

作者： quan Long xu Xiaoqing YAN Zheng ZHANG Xiaojun Institute of Mechatronics Engineering Taiyuan University of Technology Taiyuan 030024 China

Proportional direction valve is one of the most fundamental elements in electronic-hydraulic control technique. Its function is to control the operating speed, direction, position, and strength of output force of the hydraulic actuator continuously. Considering the different application and the cost, the existing technique mainly includes the internal feedback valve used in open loop system, and the electronic closed loop controlled valve used in closed loop system. Because of their different mechanical structure and the gre at different in performance, it brings inconvenience for customer to select, also inconvenience for enterprise to produce. Aiming at this problem, the idea of combining the above two kinds of valves into one body is proposed first, and then the new valve＇s structure to realize this target is designed. The idea intends to apply the displacement pilot flow feedback control principle in present 2-position 2-way valve system to the proportional direction valve of 3-position 4-way system. Newly designed feed forward controller can decouple the interference between the internal feedback and the electronic closed loop. Redundant conversion is designed to electronic switch mode. Experiment on dynamic and static characteristic of new proportional direction valve in internal feedback control mode and electronic closed loop control mode is discussed to prove the new theory is correct. Although the new valve is of excellent dynamic response characteristic, its steady control characteristic in open loop control mode needs to be improved further. The research results prepare one new fundamental element for electronic-hydraulic control technology.

关键词： pilot flow feedback proportional direction valve working principle characteristic research

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Size Effects of the Properties in a Ferroelectric Bilayer Film with Surface Transition Layers

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Chinese Physics Letters 2012年第3期29卷 212-215页

作者： CUI Lian xu quan HAN Zhi-You xu xu Department of Physics Daqing Normal UniversityDaqing 163712

Using the transverse Ising model theory,a ferroelectric bilayer film,considering the surface transition layer within each constituent slab and an interracial coupling between two slabs,is investigated in the framework of the mean-field *** discuss in detail the thickness effects of the spontaneous polarization and dielectric susceptibility ofa ferroelectric bilayer film under two conditions of interracial coupling:ferroelectric and antiferroelectric *** results show some unexpected phenomena for a small thickness of a ferroelectric bilayer film.

关键词： film ferroelectric layer

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