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网络计算中间件

软件学报 2013年第1期24卷 67-76页

作者：吴泉源国防科学技术大学计算机学院湖南长沙410073

网络计算中间件是随着互联网的发展而于20世纪90年代兴起的一类基础软件.网络计算中间件为各种网络应用系统的开发、部署、运行和管理提供了有力支持.随着信息网络技术和软件服务工程的快速发展,网络计算中间件又被赋予了新的内涵.首先... 详细信息

网络计算中间件是随着互联网的发展而于20世纪90年代兴起的一类基础软件.网络计算中间件为各种网络应用系统的开发、部署、运行和管理提供了有力支持.随着信息网络技术和软件服务工程的快速发展,网络计算中间件又被赋予了新的内涵.首先从网络计算环境出发,就基础中间件、应用集成中间件和领域应用框架的基本概念和主要技术作较全面的诠释;然后聚焦于云计算和物联网等网络计算的热点研究方向,从中间件的角度指出当前值得关注的某些挑战性研究课题和需要深入探索的若干关键技术.

关键词：网络计算环境中间件云计算虚拟化服务化物联网

Metastatic infection caused by hypervirulent Klebsiella pneumonia and co-infection with Cryptococcus meningitis: A case report

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World Journal of Clinical Cases 2019年第22期7卷 3812-3820页

作者： Yun-Feng Shi Yu-Kai Wang Yan-Hong Wang Hui Liu Xiao-Han Shi Xiao-Jie Li Ben-quan wu Medical Intensive Care Unit Department of Respiratory and Critical Care MedicineThird Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina Institute of Respiratory Diseases Sun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Laboratory Medicine Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Klebsiella pneumoniae(***)used to affect mainly people with compromised immunity or weakened by other infections,but recent emergence of hypervirulent strains has increased infections even in healthy *** infections include liver abscess,pneumonia,bacteremia,meningitis,necrotizing fasciitis,and *** metastatic infection by hypervirulent ***(hvKP)is increasingly recognized,co-infection with Cryptococcus neoformans(***)meningitis in immunocompetent hosts is rare but ***,it is necessary to determine the risk factors,complications,and comorbidity of this *** SUMMARY This report describes a 58-year-old man with hvKP pulmonary abscess,bacteremia,and meningitis,accompanied by fatal Cryptococcus *** patient presented with fever for 1 wk and drowsiness for 3 *** findings revealed pulmonary abscess and bacteremia of *** was given intravenous antibiotic therapy,and the infection was under control for about 1 ***,his condition deteriorated rapidly because of metastatic purulent *** hvKP and *** were isolated and confirmed,the patient died of spontaneous respiratory and cardiac arrest caused by cerebral *** HvKP has emerged as a cause of metastatic infections in immunocompetent *** co-infections should be taken into consideration when metastatic infection is present.

关键词： Hypervirulent Klebsiella pneumoniae Metastatic infection Cryptococcusneoformans meningitis Comorbidity Case report

Sources of high-temperature water and gas inrush during tunnel excavation:A case of Bangfu tunnel in Southwest China

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第12期16卷 5027-5049页

作者： Guo-Hua Zhang Zhong-Zhi Xie Bo-Wen Zhang Yu-Yong Jiao Jun-Peng Zou Jin-quan wu Feng Xiong Zhi-Cheng Tang Factory of Engineering China University of GeosciencesWuhan430074China Key Laboratory of Geological Survey and Evaluation of Ministry of Education China University of GeosciencesWuhan430074China Lincang Transportation Bureau Lincang677099China

Cases of simultaneous inrush of high-temperature water and harmful gases are infrequently reported in areas without geothermal anomalies,hydrocarbon source rock,or coal *** this,we investigated the origin,development,and formation of the high-temperature water and harmful gases that rushed into Bangfu tunnel,Southwest *** excavation of the Bangfu tunnel through the F1-2 fault in sandstone,a significant incident occurred involving a sudden influx of high-temperature water(45.4℃)of NaeHCO_(3)type and harmful gases(CO_(2),H2S).An extensive geological examination uncovered a fault network extending from the crust to the mantle in the tunnel site *** site features a substantial presence of both surface water and ***,within the middle crust at depths ranging from 19 km to 23 km,there are high-temperature ductile melts enriched with fluids and *** and experiments conducted on the harmful gases reveal that the primary source is identified in the crust,with the mantle source being secondary,followed by the atmospheric source being a minimal *** hydrochemical and isotopic composition characteristics of the hightemperature rushed water indicate its evolution was formed through the infiltration of atmospheric precipitation from cold groundwater of the CaeHCO_(3)*** mechanism underlying the formation of the inrush high-temperature water and harmful gases can be outlined as *** fault network,spanning from the crust to the mantle,serves as a migration pathway for the inflow *** volatiles and high-temperature melts make heat energy facilitate the inrush activity,while groundwater contributes to heat transfer and acts as a medium for gas *** mantle-derived volatiles migrate towards the surface through the fault network,they mix with high-temperature melts and crust-derived gases,forming a crust-mantle mixed *** processes such as deep hydrothermal circulation,shallo

关键词： Tunnel construction Water and gas inrush Harmful gases High-temperature water Genetic mechanism

Conversion to sirolimus immunosuppression in liver transplantation recipients with hepatocellular carcinoma:Report of an initial experience

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World Journal of Gastroenterology 2006年第19期12卷 3114-3118页

作者： Jian Zhou Jia Fan Zheng Wang Zhi-quan wu Shuang-Jian Qiu Xiao-wu Huang Yao Yu Jian Sun Yong-Sheng Xiao Yi-Feng He Yu-Qi Wang Zhao-You Tang Liver Cancer Institute and Zhongshan Hospital Fudan University Shanghai 200032 China

AIM： To report a retrospective analysis of preliminary results of 36 patients who received sirolimus （SRL, Rapamune, rapamycin） in a consecutive cohort of 248 liver allograft recipients. METHODS： Thirty-six liver transplant patients with hepatocellular carcinoma （HCC） who were switched to SRL- based immunosuppression therapy from tacrolimus were enrolled in this study. The patients who were diagnosed as advanced HCC before orthotopic liver transplantation （OLT） were divided into group A （n = 11）, those who were found to have HCC recurrence and/or metastasis after OLT were assigned to group B （n = 18）, and those who developed renal insuffidency caused by caldneurin inhibitor （CNI） were assigned to group C （n = 7） after OLT. RESULTS： The patients were followed up for a median of 10.4 mo （range, 3.8-19.1 mo） after conversion to SRL therapy and 12.3 mo （range, 5.1-34.4 too） after OLT. Three patients developed mild acute cellular rejection 2 wk after initiating SRL therapy, which was fully reversed after prednisolone pulse therapy. In group A, only 1 patient was found to have HCC recurrence and metastasis 12 mo after OLT. In group B, 66.7% （12/18） patients （2 with progressive tumor, 7 with stable tumor and 3 without tumor） were still alive due to conversing to SRL and/ or resection for HCC recurrence at the end of a median follow-up of 6.8 mo post conversion and 10.7 mo posttransplant. In group C, no HCC recurrence was demonstrated in 7 patients, and renal function became normal after SRL therapy. Thrombocytopenia （n = 2）, anemia （n = 8）, and oral aphthous ulcers （n = 7） found in our cohort were easily manageable. CONCLUSION： The conversion to SRL-based immunosuppression may inhibit the recurrence and metastasis of HCC and improve CNI-induced renal insufficiency in OLT patients with HCC.

关键词： Sirolimus Orthotopic liver transplantation Hepatocellular carcinoma

Inhibitory effect of humanized anti-VEGFR-2 ScFv-As_2O_3-stealth nanoparticles conjugate on growth of human hepatocellular carcinoma:in vitro and in vivo studies

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Asian Pacific Journal of Tropical Medicine 2014年第5期7卷 337-343页

作者： Xiang-Bao Yin Lin-quan wu Hua-Qun Fu Ming-Wen Huang Kai Wang Fan Zhou Xin Yu Kai-Yang Wang Department of Hepatobiliary Surgery 2nd Affiliated Hospital of Nanchang University

Objective:To investigate the inhibitory effect of humanized anti-VEGFR-2 ScFv-As2O3-stealth nanoparticles conjugate on growth of human hepatocellular carcinoma both in vitro and in vivo,which may be a potential agents with sensitivity and targeting ability for human hepatocellular ***:Humanized anli-VECFR-2 ScFv-As2O3-stealth nanoparticles conjugate was previously constructed using ribosome display technology and antibody conjugate *** this combined in vitro and in vivo study,the inhibitory effects of anti-VEGFR-2 ScFv-As2O3-stealth nanoparticles conjugate on tumor growth,invasion,and metastasis was observed with human liver carcinoma cell line Bel7402 and normal cell L02 by MTT assay,Tanswell assay,Hochest33258 staining,and DNA ladder *** anticancer activity and distribution of anti-VEGFR-2 ScFv-As2O3-stealth nanoparticles was then verified in a mouse model of ***:Anti-VEGFR-2 ScFv-As2O3-stealth nanoparticles significantly inhibited the proliferation of Bel7402 in the 3-(4,5-dimethylthiazol-2-yh-2,5-diphenyltetrazolium bromide assay while had almost no effects on L02 *** the apoptosis inducing effects were proved by Hochest33258 staining and DNA ladder *** assay found that the drug also inhibited the metastasis ability of tumor ***,anti-VEGFR-2 ScFv-As^-stealth nanoparticles significantly delayed the growth of Bel7402 xenografts after administration（92.9%）,followed by As2O3-stealth nanoparticles,anti-VEGFR-2 ScFv,and As203（61.4%,58.8%,20.5%,P<0.05）.The concentration of As2O3 in anti-VEGFR-2 ScFv-As2O3-steallh nanoparticles group was more ***:Anti-VEGFR-2 ScFv-As2O3-stealth nanoparticles is a potent and selective anti-hepatocellular carcinoma agent which could inhibit the growth of liver cancer as a targeting agent both in vitro and in vivo and also significantly inhibit angiogenesis.

关键词： Anti-VEGFR-2 single-chain antibody conjugate As_2O_3 stealth nanoparticles Hepatocellular carcinoma

Diagnosis and treatment of hepatic angiomyolipoma in 26 cases

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World Journal of Gastroenterology 2003年第8期9卷 1856-1858页

作者： Ning Ren Lun-Xiu Qin Zhao-You Tang Zhi-quan wu Jia Fan, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai 200032, China Liver Cancer Institute Fudan University Shanghai 200032 China. ningren@***

AIM: To summarize the experience of the diagnosis and treatment of hepatic angiomyolipoma (HAML).METHODS: The clinical, imaging and pathological features,and treatment strategies of 26 patients with HAML treated at the authors′institute between October 1998 and January 2003 were retrospectively analyzed. All the patients received liver resection and were followed up till the *** assays were performed with a panel of ***: There was an obvious female predominance (21:5), and most of the patients (18/26) had no *** high echo was found in ultrasonography and punctiform or filiform vascular distribution pattern was found in color Doppler-sonography in most of the lesions (21/26).All of the 5 lesions further enhanced with Levovist showed early and prolonged enhancement. At contrast-enhanced spiral CT, the soft-tissue components of 24 lesions were markedly enhanced in the arterial phase and 18 lesions remained enhanced in the portal venous phase. MRI was performed in 9 patients, and showed hypointensity or hyperintensity on T1-weighted images and heterogeneous hyperintensity on T2-weighted images. Histopathologically,all lesions were composed of adipose tissues, smooth muscle and blood vessels with different proportions. Most lesions showed positive immunohistochemical staining for HMB45(26/26), A103 (24/26) and SMA (24/26). All of the 26 patients showed a benign course with no sign of ***: Preoperative radiological diagnosis of HAML is possible. The demonstration of intratumoral fat and central vessels is helpful in the diagnosis. HMB45, A103 and SMA are promising markers for pathologic diagnosis of HAML,and surgical resection is effective for the treatment of HAML.

关键词：肝血管肌脂瘤肝肿瘤 CT诊断手术治疗

Microstructure and properties of LZQT600-3 HCCDIBs for plunger pump cylinder

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China Foundry 2024年第2期21卷 197-204页

作者： Chun-jie Xu Yuan-ying Jin Dong Ma Zhen Zhao Jia-wei Qi Shang Sui Xiang-quan wu Can Guo Zhong-ming Zhang Yong-hui Liu Dan Shechtman School of Materials Science and Engineering Xi'an University of TechnologyXi'an 710048China Xi'an Shechtman Nobel Prize New Materials Institute Xi'an 710048China Tongchuan Huazhu Precision Technology Co. Ltd.Tongchuan 727100ShaanxiChina Faculty of Materials Science and Engineering Technion-Israel Insititue of TechnologyHaifa 3200003Israel

It is important to improve the comprehensive performance of the ductile iron bars(DIBs)for the cylinder block of the extra high pressure hydraulic plunger pump and accelerate the industrial *** this work,the LZQT600-3 DIBs with the diameter of 145 mm were prepared by the horizontal continuous casting(HCC)process,that is,LZQT600-3 *** microstructure and room temperature tensile properties of different sections[left-edge(surface layer),left-1/2R(left half of the radius),and the center of the HCCDIBs]were *** results show that the spheroidization of LZQT600-3 HCCDIBs matrix from the left-edge,left-1/2R to the center is at nodulizing grade II and *** the cooling rate gradually decreases from surface to the center of the HCCIBs,the number of spheroidized graphite is gradually reduced,the size is gradually increased,the shape factor is decreased,and the pearlite content and lamellate spacing are *** the horizontal direction of the section,the hardness of the material is distributed symmetrically around the center of the *** the vertical direction,the hardness distribution in the center of the HCCDIBs is asymmetrical due to the gravity during the solidification ***,the microstructure in the lower part of the section solidifies relatively *** left-edge has the best tensile mechanical properties,and the ultimate tensile strength,yield tensile strength and elongation are 597.3 MPa,418.5 MPa and 9.6%,*** tensile fracture belongs to the ductile-brittle hybrid *** comprehensive performances of LZQT600-3 HCCDIBs meet the actual application requirements of ultra-high pressure hydraulic plunger pump cylinder.

关键词： horizontal continuous casting(HCC) nodular cast iron ductile iron bars microstructure mechanical properties

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依达拉奉对脑缺血再灌注损伤的保护作用

中国药科大学学报 2005年第6期36卷 577-579页

作者：吴务权浙江省义乌市中心医院义乌322000

目的:研究依达拉奉对急性脑缺血再灌注损伤的保护作用。方法:将108只SD大鼠分成生理盐水组和依达拉奉高剂量组(1 mg)及低剂量组(0.5 mg),每组再各分为1 h,6 h及24 h组,每组12只。采用线栓法制造大鼠大脑中动脉再灌注模型,将依达拉奉生... 详细信息

目的:研究依达拉奉对急性脑缺血再灌注损伤的保护作用。方法:将108只SD大鼠分成生理盐水组和依达拉奉高剂量组(1 mg)及低剂量组(0.5 mg),每组再各分为1 h,6 h及24 h组,每组12只。采用线栓法制造大鼠大脑中动脉再灌注模型,将依达拉奉生理盐水溶液于造模后1,6,24 h注入大鼠股静脉中,1周后断头取脑,组织做病理切片并计算梗死体积。结果:依达拉奉高剂量组(1 mg)、依达拉奉低剂量组(0.5 mg)、对照组坏死体积依次明显减少。结论:依达拉奉对脑缺血再灌注损伤组织有明显保护作用。

关键词：依达拉奉脑缺血保护

Effect of fractures on mechanical behavior of sand powder 3D printing rock analogue under triaxial compression

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Journal of Central South University 2024年第8期31卷 2703-2716页

作者： LI Pi-mao JIANG Li-shuai WEN Zhi-jie wu Chao-lei YANG Yi-ming PENG Xiao-han wu quan-sen wu quan-lin State Key Laboratory of Mining Disaster Prevention and Control Shandong University of Science and TechnologyQingdao 266590China Mining College Guizhou UniversityGuiyang 550025China School of Engineering Jining UniversityQufu 273100China

In practical engineering applications,rock mass are often found to be subjected to a triaxial stress ***,defects like joints and fractures have a notable impact on the mechanical behavior of rock *** defects are identified as crucial contributors to the failure and instability of the surrounding rock,subsequently impacting the engineering *** study aimed to investigate the impact of fracture geometry and confining pressure on the deformation,failure characteristics,and strength of specimens using sand powder 3D printing technology and conventional triaxial compression *** results indicate that the number of fractures present considerably influences the peak strength,axial peak strain and elastic modulus of the *** pressure is an important factor affecting the failure pattern of the specimen,under which the specimen is more prone to shear failure,but the initiation,expansion and penetration processes of secondary cracks in different fracture specimens are *** study confirmed the feasibility of using sand powder 3D printing specimens as soft rock analogs for triaxial compression *** insights from this research are deemed essential for a deeper understanding of the mechanical behavior of fractured surrounding rocks when under triaxial stress state.

关键词： sand powder 3D printing triaxial compression confining pressure fracture geometry mechanical behavior