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Mitochondria-targeted nanoparticles overcome chemoresistance via downregulating BACH1/CD47 axis in ovarian carcinoma

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Chinese Chemical Letters 2024年第5期35卷 344-350页

作者： Ke Gong Jinghan Liao Jiangtao Lin quan wang Zhihua Wu Liting wang Jiali Zhang Yi Dong Yourong Duan Jianhua Chen State Key Laboratory of Systems Medicine for Cancer Shanghai Cancer InstituteRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200032China Department of Ultrasound Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China Department of Oncology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

The platinum-based chemotherapy is a routine strategy for the treatment of ovarian cancer,while it is prone to chemoresistance in clinical,which hinders the treatment.Therefore,it is urgently needed to elucidate the underlying mechanism of drug resistance and form the appropriate strategy.The sequencing results showed that cisplatin(DDP)resistant ovarian cancer overexpressed BTB and CNC homology 1(BACH1),and up-regulated the“don’t eat me”signal CD47.We identified that hemin,a BACH1 inhibitor,could effectively down-regulate BACH1 and simultaneously inhibit CD47.Moreover,hemin has a synergistic effect with DDP.We designed a pH-responsive nanoparticle(H/D@FA-CaP-NPs)in which folic acid(FA)ensured targeting of ovarian cancer cells,while hemin inhibited BACH1 as well as down-regulated CD47,achieving the promotion of apoptosis of tumor cells and inducing phagocytosis of tumors by macrophages.Moreover,hemin has a synergistic effect with DDP to promote apoptosis of tumor cells.Structurally,hemin and DDP was encapsulated within hydrophobic 1,2-distearoyl-sn-glycero-3-phosphoethanolamine(DSPE)to form a tight core,and hydrophilic polyethylene glycol 2000(PEG2000)and calcium phosphate(CaP)formed the outside shell,and FA was modified on the surface of nanoparticles.In terms of function,(a)FA enhanced the active targeting of nanoparticles to tumors;(b)NPs targeted mitochondria to induce reactive oxygen species(ROS)production;(c)hemin encapsulated in nanoparticles could specifically target BACH1,thereby down regulating CD47;(d)hemin had a synergistic effect with DDP,thus augmenting the chemotherapy.Altogether,mitochondria-targeted nanoparticles H/D@FA-CaP-NPs promoted tumor apoptosis and mobilized phagocytosis to treat tumor,providing a novel scheme for clinical treatment of cisplatin-resistant ovarian carcinoma.

关键词： Cisplatin-resistant Hemin BACH1 CD47 Phagocytosis ROS Synergistic effect

Noteworthy impacts of COVID-19 pandemic on cancer screening:A systematic review

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Fundamental Research 2024年第3期4卷 484-494页

作者： Huilin wang Min Yang Wei Xiong quan wang Bobo Zheng Yang Bai Kaiyong Zou Jibin Li Jiansong Ren Wanqing Chen Jingbo Zhai Jiang Li Office for Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Comprehensive Intervention National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Gynecology Endocrine&Reproductive Center National Clinical Research Center for Obstetric&Gynecologic Diseases Department of Obstetrics and GynecologyPeking Union Medical College HospitalPeking Union Medical College/Chinese Academy of Medical SciencesBeijing 100005China Ambulatory Surgery Center of Xijing Hospital Fourth Military Medical UniversityXi'an 710068China Department of General Surgery Shaanxi Provincial People’s HospitalXi'an 710068China College of Clinical Medicine Capital Medical UniversityBeijing 100069China School of Public Health Tianjin University of Traditional Chinese MedicineTianjin 301617China

The sudden onset of the coronavirus disease 2019(COVID-19)in January 2020 has affected essential global health services.Cancer-screening services that can reduce cancer mortality are strongly affected.However,the specific role of COVID-19 in cancer screening is not fully understood.This study aimed to assess the efficiency of global cancer screening programs before and during the COVID-19 pandemic and to promote potential cancer-screening strategies for the next pandemic.Electronic searches in PubMed,Embase,and Web of Science,and manual searches were performed between January 1,2020 and March 1,2023.Cohort studies that reported the number of participants who underwent cancer screening before and during the COVID-19 pandemic were included.The methodological quality of the included studies was assessed using the Newcastle-Ottawa Scale.Differences in cancer-screening rates were estimated using the incidence rate ratio(IRR).Fifty-five cohort studies were included in this meta-analysis.The screening rates of colorectal cancer using invasive screening methods(Pooled IRR=0.52,95%CI:0.42 to 0.65,p<0.01),cervical cancer(Pooled IRR=0.56,95%CI:0.47 to 0.67,p<0.01),breast cancer(Pooled IRR=0.57,95%CI:0.49 to 0.66,p<0.01)and prostate cancer(Pooled IRR=0.71,95%CI:0.56 to 0.90,p<0.01)during the COVID-19 pandemic were significantly lower than those before the COVID-19 pandemic.The screening rates of lung cancer(Pooled IRR=0.77,95%CI:0.58 to 1.03,p=0.08)and colorectal cancer using noninvasive screening methods(Pooled IRR=0.74,95%CI:0.50 to 1.09,p=0.13)were reduced with no statistical differences.The subgroup analyses revealed that the reduction in cancer-screening rates varied across economies.Our results suggest that the COVID-19 pandemic has had a noteworthy impact on colorectal,cervical,breast,and prostate cancer screening.Developing innovative cancer-screening technologies is important to promote the efficiency of cancer-screening services in the post-COVID-19 era and prepare for the next pandemic.

关键词： Cancer screening COVID-19 pandemic Cohort study Incidence rate ratio Meta-analysis

Lossless Compression Method for the Magnetic and Helioseismic Imager(MHI)Payload

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Research in Astronomy and Astrophysics 2024年第4期24卷 214-221页

作者： Li-Yue Tong Jia-Ben Lin Yuan-Yong Deng Kai-Fan Ji Jun-Feng Hou quan wang Xiao Yang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Key Laboratory of Solar Activity and Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Yunnan Observatories Chinese Academy of SciencesKunming 650216China

The Solar Polar-orbit Observatory(SPO),proposed by Chinese scientists,is designed to observe the solar polar regions in an unprecedented way with a spacecraft traveling in a large solar inclination angle and a small ellipticity.However,one of the most significant challenges lies in ultra-long-distance data transmission,particularly for the Magnetic and Helioseismic Imager(MHI),which is the most important payload and generates the largest volume of data in SPO.In this paper,we propose a tailored lossless data compression method based on the measurement mode and characteristics of MHI data.The background out of the solar disk is removed to decrease the pixel number of an image under compression.Multiple predictive coding methods are combined to eliminate the redundancy utilizing the correlation(space,spectrum,and polarization)in data set,improving the compression ratio.Experimental results demonstrate that our method achieves an average compression ratio of 3.67.The compression time is also less than the general observation period.The method exhibits strong feasibility and can be easily adapted to MHI.

关键词： methods:data analysis techniques:image processing Sun:magnetic fields Sun:photosphere

A survey on facial image deblurring

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Computational Visual Media 2024年第1期10卷 3-25页

作者： Bingnan wang Fanjiang Xu quan Zheng Institute of Software Chinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China

When a facial image is blurred,it significantly affects high-level vision tasks such as face recognition.The purpose of facial image deblurring is to recover a clear image from a blurry input image,which can improve the recognition accuracy,etc.However,general deblurring methods do not perform well on facial images.Therefore,some face deblurring methods have been proposed to improve performance by adding semantic or structural information as specific priors according to the characteristics of the facial images.In this paper,we survey and summarize recently published methods for facial image deblurring,most of which are based on deep learning.First,we provide a brief introduction to the modeling of image blurring.Next,we summarize face deblurring methods into two categories:model-based methods and deep learning-based methods.Furthermore,we summarize the datasets,loss functions,and performance evaluation metrics commonly used in the neural network training process.We show the performance of classical methods on these datasets and metrics and provide a brief discussion on the differences between model-based and learning-based methods.Finally,we discuss the current challenges and possible future research directions.

关键词： facial image deblurring model-based deep learning-based semantic or structural prior

Strong shock propagation for the finite-source circular blast in a confined domain

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 1071-1084页

作者： Qihang MA Kaileong CHONG Bofu wang quan ZHOU Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200072China Shanghai Institute of Aircraft Mechanics and Control Shanghai 200092China

The circular explosion wave produced by the abrupt discharge of gas from a high-temperature heat source serves as a crucial model for addressing explosion phenomena in compressible flow.The reflection of the primary shock and its propagation within a confined domain are studied both theoretically and numerically in this research.Under the assumption of strong shock,the scaling law governing propagation of the main shock is proposed.The dimensionless frequency of reflected shock propagation is associated with the confined distance.The numerical simulation for the circular explosion problem in a confined domain is performed for validation.Under the influence of confinement,the principal shock wave systematically undergoes reflection within the domain until it weakens,leading to the non-monotonic attenuation of kinetic energy in the explosion fireball and periodic oscillations of the fireball volume with a certain frequency.The simulation results indicate that the frequency of kinetic energy attenuation and the volume oscillation of the explosive fireball align consistently with the scaling law.

关键词： explosion confinement main shock frequency

Rheological Behaviors of Polymers with Nanoparticles Tethered at Each End

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Chinese Journal of Polymer Science 2024年第3期42卷 400-406,I0009页

作者： Song-Qi Zhang Wen-Qing wang Jia-Ping Lin Li-quan wang Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

The polymer with nanoparticles tethered at each end is a unique model for unraveling the effect of chain ends on the polymer dynamics. We investigated the rheological behavior of this kind of polymer by using nonequilibrium molecular dynamics simulation. The effect of polymer lengths and nanoparticle radii on the complex moduli and viscosity was examined. The dependence of complex moduli on the frequency becomes less pronounced as the polymer is short or the nanoparticle is large. The shear thinning behavior was revealed for these systems, and the scaling exponent of complex viscosity with respect to the frequency was found to change from-1/2 to-3/4 as the polymer shortens or the nanoparticle enlarges. The rheological behavior was further explained by analyzing the mean square distance of nanoparticles. The simulation results were compared with the existing experimental finding, showing an agreement. The work provides information for understanding the chain end effect on polymer rheology.

关键词： Polymer rheology Modulus Viscosity Molecular dynamics

State Estimation of Drive-by-Wire Chassis Vehicle Based on Dual Unscented Particle Filter Algorithm

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 99-113页

作者： Zixu wang Chaoning Chen quan Jiang Hongyu Zheng Chuyo Kaku State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun 130022China Jiangsu Chaoli Electric Co.Ltd. Zhenjiang 212321China

Accurate vehicle dynamic information plays an important role in vehicle driving safety.However,due to the characteristics of high mobility and multiple controllable degrees of freedom of drive-by-wire chassis vehicles,the current mature application of traditional vehicle state estimation algorithms can not meet the requirements of drive-by-wire chassis vehicle state estimation.This paper proposes a state estimation method for drive-by-wire chassis vehicle based on the dual unscented particle filter algorithm,which make full use of the known advantages of the four-wheel drive torque and steer angle parameters of the drive-by-wire chassis vehicle.In the dual unscented particle filter algorithm,two unscented particle filter transfer information to each other,observe the vehicle state information and the tire force parameter information of the four wheels respectively,which reduce the influence of parameter uncertainty and model parameter changes on the estimation accuracy during driving.The performance with the dual unscented particle filter algorithm,which is analyzed in terms of the time-average square error,is superior of the unscented Kalman filter algorithm.The effectiveness of the algorithm is further verified by driving simulator test.In this paper,a vehicle state estimator based on dual unscented particle filter algorithm was proposed for the first time to improve the estimation accuracy of vehicle parameters and states.

关键词： Drive-by-wire chassis vehicle Vehicle state estimation Dual unscented particle filter Tire force estimation Unscented particle filter

Peer-to-Peer Trading in Distribution Systems with the Utility's Operation

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 629-638页

作者： Xuanyi Xiao Feng wang Mohammad Shahidehpour Yujia Zhai quan Zhou Department of Electrical and Information Engineering Hunan UniversityChangshaChina Robert W.Galvin Center for Electricity Innovation Ilinois Institute of TechnologyChicagoIL60616USA

To realize a liberalized peer-to-peer (P2P) electricity market in distribution systems with network security, this paper develops a general framework for P2P trading in distribution systems with the utility's operation. The model is formulated as a bi-level programming. The utility's operation is an upper level problem, where a calculation method of network usage charges for P2P trading is also proposed. Peers' P2P trading is a lower level problem. An iterative algorithm based on analytical target cascading (ATC) is proposed to solve the model, where the interactions between utility and peers are presented. Numerical results on the IEEE 33-bus system demonstrate that the proposed method realizes a liberalized P2P market and ensures network security in distribution systems.

关键词： Distribution system peer-to-peer trading electricitymarket distributed energyresources(DERs) analytical target cascading(ATC)

Relationship of Retinal Nerve Fiber Layer Thickness and Retinal Vessel Calibers with Cognitive Impairment in the Asymptomatic Polyvascular Abnormalities Population

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Biomedical and Environmental Sciences 2024年第2期37卷 196-203页

作者： wang Dan Dan wang An Xin ZHANG Xiao Li WEI Wen Bin WU Shou Ling ZHAO Xing quan Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China China National Clinical Research Center for Neurological Diseases Beijing 100070China Beijing Tongren Eye Center Beijing Key Laboratory of Ophthalmology and Visual ScienceBeijing Tongren HospitalCapital Medical UniversityBeijing 100005China Department of Cardiology Kailuan HospitalTangshan 063001HebeiChina

Objective Cognitive impairment(CI)in older individuals has a high morbidity rate worldwide,with poor diagnostic methods and susceptible population identification.This study aimed to investigate the relationship between different retinal metrics and CI in a particular population,emphasizing polyvascular status.Methods We collected information from the Asymptomatic Polyvascular Abnormalities Community Study on retinal vessel calibers,retinal nerve fiber layer(RNFL)thickness,and cognitive function of 3,785participants,aged 40 years or older.Logistic regression was used to analyze the relationship between retinal metrics and cognitive function.Subgroups stratified by different vascular statuses were also analyzed.Results RNFL thickness was significantly thinner in the CI group(odds ratio:0.973,95%confidence interval:0.953–0.994).In the subgroup analysis,the difference still existed in the non-intracranial arterial stenosis,non-extracranial carotid arterial stenosis,and peripheral arterial disease subgroups(P<0.05).Conclusion A thin RNFL is associated with CI,especially in people with non-large vessel stenosis.The underlying small vessel change in RNFL and CI should be investigated in the future.

关键词： Retinal nerve fiber layer Cognitive impairment Polyvascular abnormality