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市政道路工程水泥混凝土材料抗冻耐久性分析

Inhibition of the Neddylation Pathway Suppresses Enterovirus Replication

建筑与装饰 2024年第10期 157-159页

作者：刘全亮青岛冠通市政建设有限公司山东青岛 266011

市政道路工程中的水泥混凝土材料是一种常用的路面材料,其抗冻耐久性是确保道路使用寿命和交通安全的重要指标之一.在寒冷地区或气候条件恶劣的地方,水泥混凝土材料的抗冻性能对路面的稳定性和耐久性尤为关键.基于此,本文简单讨论材料... 详细信息

市政道路工程中的水泥混凝土材料是一种常用的路面材料,其抗冻耐久性是确保道路使用寿命和交通安全的重要指标之一.在寒冷地区或气候条件恶劣的地方,水泥混凝土材料的抗冻性能对路面的稳定性和耐久性尤为关键.基于此,本文简单讨论材料抗冻耐久性的作用和影响因素,深入探讨分析方法,以供参考.

关键词：市政道路工程水泥混凝土材料抗冻耐久性

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Virologica Sinica 2021年第6期36卷 1664-1667页

作者： Zhe Zhang Haoran Guo Jing Wang Yan Li Yanhang Gao quan liu Junqi Niu Wei Wei Institute of Virology and AIDS Research First HospitalJilin UniversityChangchun 130021China Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education Institute of Translational MedicineFirst HospitalJilin UniversityChangchun 130021China Department of Hepatology First HospitalJilin UniversityChangchun 130021China Department of Emerging Infectious Diseases Institute of Translational MedicineFirst HospitalJilin UniversityChangchun 130021China

Dear Editor,Human enteroviruses(HEVs)comprise polioviruses,coxsackieviruses,echoviruses,rhinoviruses,and the enterovirus subgroups and belong to the genus Enterovirus in the family Picornaviridae(Baggen et al.2018).The HEV genome was thought to contain a single open reading frame(ORF)encoding one polyprotein,which was post-translationally processed into structural capsid proteins(VP1-4)and non-structural accessory proteins(2A,2B,2C,3A,3B,3C,3D)(Baggen et al.2018).Recently,we and others,have identified an additional upstream ORF(Guo et al.2019a;Lulla et al.2019)(ORF2/uORF).

关键词： ORF2 Replication upstream

2023年度国家自然科学基金联合基金项目申请受理、评审与资助情况综述

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中国科学基金 2024年第1期38卷 63-69页

作者：李志兰孟展董哲康刘权王岩国家自然科学基金委员会计划局北京100085 西南石油大学石油与天然气工程学院成都610500 杭州电子科技大学电子信息学院杭州310018

联合基金作为国家自然科学基金的重要组成部分,在引导和整合社会资源投入基础研究方面发挥了重要作用。2023年国家自然科学基金委员会稳步推进新时期联合基金改革,会同各联合资助方圆满完成了联合基金项目申请受理、评审与资助工作。本... 详细信息

联合基金作为国家自然科学基金的重要组成部分,在引导和整合社会资源投入基础研究方面发挥了重要作用。2023年国家自然科学基金委员会稳步推进新时期联合基金改革,会同各联合资助方圆满完成了联合基金项目申请受理、评审与资助工作。本文统计分析了2023年度国家自然科学基金联合基金项目申请、受理与资助数据,分别介绍了项目指南发布、项目申请及其特点、项目初审、评审与资助的情况,并对2024年度联合基金工作进行了展望。

关键词：联合基金新时期联合基金改革项目申请受理评审与资助

Anti-diabetes effects and mechanisms of a Chinese herbal medicine preparation JQ-R in diabetic KKAy mice and in vitro

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中国药理学与毒理学杂志 2018年第4期32卷 294-295页

作者： Shuai-nan liu quan liu Zhu-fang SHEN Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Key laboratory of Polymorphic Drugs of Beijing Diabetes Research Center of

OBJECTIVE To investigate the effects and mechanisms by which JQ-R regulated the glucose metabolism and improves insulin sensitivity in diabetic KKAy mice and insulin-resistant L6 myotubes.JQ-R is a mixture of refined extracts from Coptis chinensis,Astragalus membranaceus and Lonicera japonica,three major herbs of JinQi-JiangTang tablet.METHODS Diabetic KKAy mice were adminis.tered JQ-R(100 mg·kg^(-1) or 200 mg·kg^(-1) BW) for 10 weeks.Levels of fasting plasma glucose,lipids,insulin and hemoglobin A1c were monitored.Systemic insulin sensitivity was quantified using the eugly.cemic clamp.The effect of JQ-R on the expressions of the enzymes involved in insulin signaling,oxidative stress and inflammation(Akt,NFκB,IΚBα,JNK,Erk,p38 MAPK) were measured in L6 insulin-resis.tant myotubes.RESULTS JQ-R showed beneficial effects on glucose homeostasis and insulin sensi.tivity in diabetic KKAy mice after 10 weeks treatment.JQ-R also ameliorated the plasma lipid profiles.Moreover,JQ-R can directly reverse the decreased activity of SOD and increased MDA levels as well as activity of iNOS in insulin resistant L6 cell induced with palmitic acid(PA).The expressions of phos.phorylation of NF-κB p65,IκBα,JNK1/2 and Erk1/2 were also decreased after JQ-R treatment.It was also shown that the insulin-stimulated glucose uptake increased significantly after JQ-R treatment,with upregulated expression of phosphorylation of Akt.CONCLUSION JQ-R ameliorated the glucose and lipid metabolism and insulin sensitivity in diabetic KKAy mice.In vitro treatment with JQ-R directly enhanced insulin stimulated glucose uptake in insulin resistant myotubes with improved insulin signal.ling and inflammatory response and oxidative stress state.

关键词：糖尿病胰岛素治疗方法临床分析

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柴油机气缸套空化现象与空蚀机理分析

排灌机械工程学报 2024年第1期42卷 49-56,78页

作者：韩峰刘泉李宇寒李晨阳林杰威内燃机可靠性国家重点实验室山东潍坊261061 潍柴动力股份有限公司山东潍坊261061 天津大学先进内燃动力全国重点实验室天津300350

针对柴油机气缸套在工作过程中因冷却液的空化发生空蚀现象,文中在对单缸冷却水套进行空化流动数值模拟的基础上,结合近壁面多空泡溃灭过程的仿真,从宏观和介观上研究了柴油机气缸套的空化现象和空蚀机理.首先,基于单缸冷却水套的模拟发... 详细信息

针对柴油机气缸套在工作过程中因冷却液的空化发生空蚀现象,文中在对单缸冷却水套进行空化流动数值模拟的基础上,结合近壁面多空泡溃灭过程的仿真,从宏观和介观上研究了柴油机气缸套的空化现象和空蚀机理.首先,基于单缸冷却水套的模拟发现,缸套壁面的振动导致冷却液发生空化现象,生成大量空化气泡.然后,模拟了近壁面空泡的溃灭过程,并分析了空泡间距、空泡数量等因素对多空泡溃灭的影响.结果表明:空泡间距越小,溃灭时间越长,当泡心间距从0.050 mm减小至0.025 mm时,近壁面空泡的溃灭压力增大49.82%,产生的微射流速度增大10.56%;增加空泡数量,溃灭压力呈先增后减的趋势,当空泡数量由2个增至10个,微射流的速度增大44.93%.研究表明,空泡溃灭产生的微射流具有较高的水锤压力,该压力作用于缸套壁面,造成腐蚀破坏,是缸套发生空蚀的根本原因.

关键词：柴油机气缸套空化空蚀空泡

A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response

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Signal Transduction and Targeted Therapy 2021年第10期6卷 2995-3008页

作者： Yinghua Zhao Liyan Sui Ping Wu Wenfang Wang Zedong Wang Yang Yu Zhijun Hou Guangyun Tan quan liu Guoqing Wang Center for Pathogen Biology and Infectious Diseases Key Laboratory of Organ Regeneration and Transplantation of the Ministry of EducationThe First Hospital of Jilin UniversityState Key Laboratory of Human-Animal Zoonotic infectious DiseasesChangchunChina College of Wildlife and Protected Area Northeast Forestry UniversityHarbinChina Department of Pathogenbiology The Key Laboratory of ZoonosisChinese Ministry of EducationCollege of Basic MedicineJilin UniversityChangchunChina Hospital of Stomatology Jilin UniversityChangchunChina School of Life Sciences and Engineering Foshan UniversityFoshanChina Institute of Animal Health Guangdong Academy of Agricultural SciencesGuangzhouChina

The recently emerged severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which is the causative agent of ongoing global pan demic of COVID-19,may trigger imm uno suppression in the early stage and overactive immune resp onse in the late stage of infection;However,the un derlying mecha nisms are not well understood.Here we dem on strated that the SARS-CoV-2 nucleocapsid(N)protein dually regulated innate immune responses,i.e.,the low-dose N protein suppressed type I interferon(IFN-I)signaling and inflammatory cytokines,whereas high-dose N protein promoted IFN-I signaling and inflammatory cytokines.Mechanistically,the SARS-CoV-2 N protein dually regulated the phosphorylation and nuclear translocation of IRF3,STAT1,and STAT2.Additi on ally,low-dose N protein combined with TRIM25 could suppress the ubiquitination and activatio n of retinoic acidinducible gene I(RIG-I).Our findings revealed a regulatory mechanism of innate immune responses by the SARS-CoV-2 N protein,which would contribute to understanding the pathogenesis of SARS-CoV-2 and other SARS-like coronaviruses,and development of more effective strategies for controlling COVID-19.

关键词： interferon respiratory acute

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蛋白质组学推动慢性鼻窦炎异质性图谱构建

中华耳鼻咽喉头颈外科杂志 2024年第6期59卷 636-643页

作者：叶方舟王丽李光耀史俊峰刘全余洪猛复旦大学附属眼耳鼻喉科医院耳鼻咽喉科上海200031 中国医学科学院内镜下鼻颅底肿瘤外科治疗技术创新单元(2018RU003) 上海200031

慢性鼻窦炎(CRS)是一类累及鼻和鼻窦的慢性炎性疾病,患病率高,显著影响人群生活质量。而CRS异质性强,临床诊疗策略却趋于同质,其治疗策略亟待个体化、精准化发展。近年,生物大数据蓬勃发展,高通量测序技术更是推动着组学研究不断深入,... 详细信息

慢性鼻窦炎(CRS)是一类累及鼻和鼻窦的慢性炎性疾病,患病率高,显著影响人群生活质量。而CRS异质性强,临床诊疗策略却趋于同质,其治疗策略亟待个体化、精准化发展。近年,生物大数据蓬勃发展,高通量测序技术更是推动着组学研究不断深入,其中蛋白质组学在探索疾病异质性方面已初露头角,是研究CRS病因机制、表型特征、疗效预测的良好工具。随着蛋白质组学技术不断进展,以此为依托的CRS研究也将逐步深入。本文将针对近年CRS相关蛋白质组学研究展开综述,阐明蛋白质组学技术在推动构建CRS异质性图谱中的潜在优势及未来前景。

关键词：慢性鼻窦炎病因机制蛋白质组学诊疗策略疗效预测治疗策略高通量测序技术未来前景

MiRNA-122 Promotes Ischemia-Reperfusion Injury after Lung Transplantation via the Toll-like Receptor Signaling Pathway

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Current Medical Science 2021年第6期41卷 1231-1238页

作者： Yuan LU Ya-li WANG quan liu Peng ZHOU Pei-yuan MEI Jin-song LI Zhi-kun ZHENG Department of Thoracic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Pediatric Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective:MiRNAs have been recently implicated in the pathogenesis of ischemia-reperfusion(IR)injury.This study aimed to investigate the miRNA expression profiles,in the early stages after lung transplantation(LT)and to study the involvement of the Toll-like receptor(TLR)signaling pathway in lung IR injury following LT.Methods:We established the left LT model in mice and selected the miRNA-122 as a research target.The mice were injected with a miRNA-122-specific inhibitor,following which pathological changes in the lung tissue were studied using different lung injury indicators.In addition,we performed deep sequencing of transplanted lung tissues to identify differentially expressed(DE)miRNAs and their target genes.These target genes were used to further perform gene ontology(GO)enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis.Results:A total of 12 DE miRNAs were selected,and 2476 target genes were identified.The GO enrichment analysis predicted 6063 terms,and the KEGG analysis predicted 1554 biological pathways.Compared with the control group,inhibiting the expression of miRNA-122 significantly reduced the lung injury and lung wet/dry ratio(P<0.05).In addition,the activity of myeloperoxidase and the expression levels of tumor necrosis factor-alpha and TLR2/4 were decreased(P<0.05);whereas the expression of interleukin-10 was increased(P<0.05).Furthermore,the inhibition of miRNA-122 suppressed the IR injury-induced activation of the TLR signaling pathway.Conclusion:Our findings showed the differential expression of several miRNAs in the early inflammatory response following LT.Of these,miRNA-122 promoted IR injury following LT,whereas its inhibition prevented IR injury in a TLR-dependent manner.

关键词： miRNAs miRNA-122 lung transplantation Toll-like receptor signaling pathway

收缩抑或拓展——无人驾驶汽车影响下的路权重构与街道演变

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规划师 2024年第5期40卷 154-160页

作者：刘泉李昊陈瑶瑶洪晓苇赖亚妮深圳市蕾奥规划设计咨询股份有限公司中规院(北京)规划设计有限公司深圳大学建设管理与房地产系

无人驾驶汽车技术正在快速发展,无人驾驶环境下路权的变化对街道形态的演变具有重要的影响。研究发现,关于面向未来的智慧街道空间设计及研究更多倾向于汽车路权会收缩,街道空间被归还给行人,建设充满活力的街道空间似乎成为一种普遍的... 详细信息

无人驾驶汽车技术正在快速发展,无人驾驶环境下路权的变化对街道形态的演变具有重要的影响。研究发现,关于面向未来的智慧街道空间设计及研究更多倾向于汽车路权会收缩,街道空间被归还给行人,建设充满活力的街道空间似乎成为一种普遍的共识和设计原则。基于已有研究提出,汽车路权收缩并不是一种全面的认知,收缩与拓展并存才是无人驾驶环境下街道路权的真实变化,未来街道空间的规划设计不仅要关注传统汽车路权的收缩,还要关注无人驾驶汽车路权的拓展,兼顾人行与车行需求,并构建街道空间演变的新模式。

关键词：无人驾驶自动驾驶汽车智慧街道路权智慧城市

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