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Traditional Chinese medicine is a resource for drug discovery against 2019 novel coronavirus(SARS-CoV-2)

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Journal of Integrative Medicine 2020年第2期18卷 87-88页

作者： chang-quan Ling School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China

Novel coronavirus pneumonia,named as COVID-19 by the World Health Organization,has spread widely since December 2019[1–3],with more than 40,000 confirmed cases in China and exportations to over 20 countries[4].On January 30,2020,the World Health Organization declared the epidemic to be a public health emergency of international concern in the second meeting of the Emergency Committee[5].It was recommended that potential vaccines and antiviral medicines should be ***,the development of these therapeutics will take months,even *** this specific indication,rapid performance of traditional Chinese medicine(TCM)can contribute as an alternative measure.

关键词： SARS-CoV-2 Traditional Chinese medicine drug discovery

Ca^(2+)-Calmodulin is Involved in Betacyanin Accumulation Induced by Dark in C_3 Halophyte Suaeda salsa

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Journal of Integrative Plant Biology 2007年第9期49卷 1378-1385页

作者： chang-quan Wang Bao-Shan Wang College of Life Sciences Shandong Normal University Jinan 250014 China College of Life Sciences Shandong University of Technology Zibo 255049 China

The C3 halophyte Suaeda salsa was used to investigate the roles of Ca^2＋, Ca^2＋ channels, and calmodulin （CAM） in betacyanin metabolism. Seeds of S. salsa were cultured in both the dark and light for 3 days. The fresh weight and betacyanin content were much higher in S. salsa seedlings formed in the dark than in seedlings formed in the light. The addition of Ca^2＋ to the half-strength MS nutrient solution promoted betacyanin accumulation in the dark, whereas Ca^2＋ depletion by EGTA suppressed the dark-induced betacyanin accumulation in shoots of S. salsa. The Ca^2＋ channel blocker LaCl3 also inhibited dark-induced betacyanin accumulation. The highest activity of CaM and the maximum betacyanin content decreased by 51% and 45%, respectively, in shoots of S. salsa seedlings treated with the potent CaM antagonist chlorpromazine in the dark. Furthermore, the other CaM antagonist N-（6-aminohexyl）-5-chloro-l-naphthalenesulfonamide （W-7） also inhibited the activity of CaM and dark-dependent betacyanin accumulation, whereas its less active structural analog N-（6-aminohexyl）- 1-naphthalenesulfonamide （W-5） had little effect on the responses to dark of S. salsa seedlings. These results suggest that Ca^2＋, Ca^2＋-regulated ion channels, and CaM play an important role in dark-induced betacyanin accumulation in the shoots of the C3 halophyte S. salsa.

关键词： betacyanin Ca^2+ calmodulin darkness Suaeda salsa.

ORA59 and EIN3 interaction couples jasmonate-ethylene synergistic action to antagonistic salicylic acid regulation of PDF expression

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Journal of Integrative Plant Biology 2017年第4期59卷 275-287页

作者： Xiang He Jishan Jiang chang-quan Wang Katayoon Dehesh Department of Botany and Plant Sciences and Institute of Integrative Genome Biology University of CaliforniaRiversideCalifornia 92506USA Rice Research Institute Sichuan Agricultural UniversityChengduSichuan 611130China Department of Ornamental Horticulture College of HorticultureNaniing Agricultural UniversityNanjing 210095China

Hormonal crosstalk is central for tailoring plant responses to the nature of challenges encountered. The role of antagonism between the two major defense hormones, salicylic acid （SA） and jasmonic acid （JA）, and modulation of this interplay by ethylene （ET） in favor of JA signaling pathway in plant stress responses is well recognized, but the underlying mechanism is not fully understood. Here, we show the opposing function of two transcription factors, ethylene insensitive3 （EIN3） and EIN3-Like1 （EIL1）, in SA-mediated suppression and JA- mediated activation of PLANT DEFENSINI.2 （PDFI.2）. This functional duality is mediated via their effect on protein, not transcript levels of the PDF1.2 transcriptional activator octadecanoid-responsive Arabidopsis59 （ORA59）. Specifically, JA induces ORA59 protein levels independently of EIN3/EIL1, whereas SA reduces the protein levels dependently of EIN3/EIL1. Co-infiltration assays revealed nuclear co-localization of ORA59 and EIN3, and split- luciferase together with yeast-two-hybrid assays established their physical interaction. The functional ramification of the physical interaction is EIN3-dependent degradation of ORA59 by the 26S proteasome. These findings allude to SA-responsive reduction of ORA59 levels mediated by EIN3 binding to and targeting of ORA59 for degrada4tion, thus nominating ORA59 pool as a coordination node for the antagonistic function of ET/JA and SA.

关键词： EIN ORA59 and EIN3 interaction couples jasmonate-ethylene synergistic action to antagonistic salicylic acid regulation of PDF expression PDF EIL acid

Differential expressions among five Waxy alleles and their effects on the eating and cooking qualities in specialty rice cultivars

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Journal of Integrative Agriculture 2015年第6期14卷 1153-1162页

作者： ZHOU Li-jie SHENG Wen-tao WU Jun ZHANG chang-quan LIU Qiao-quan DENG Qi-yun Longping Branch of Graduate School Central South University State Key Laboratory of Hybrid Rice Hunan Hybrid Rice Research Center Key Laboratories of Crop Genetics and Physiology of Jiangsu Province/Key Laboratory of Plant Functional Genomics Ministry of Education/Agricultural College Yangzhou University

Eating and cooking qualities（ECQs） of rice are important attributes due to its major influence on consumer acceptability. To better understand the molecular mechanism of the variation in ECQs, we investigated and compared the expressions among different alleles of the Waxy（Wx） gene and its effect on ECQs in specialty rice cultivars. The results showed that the accumulation of amylose was positively and significantly correlated to the level of mature Wx m RNA and granule-bound starch synthase I（GBSS I） in developing rice grain at 12 days after flowering. The amount of GBSS I and its activity together are the main factors controlling amylose synthesis. Differences in ECQs among five Wx allele types were investigated in samples from 15 rice varieties. The apparent amylose content（AAC） and gel consistency（GC） were similar in each type of Wx allele. The AAC followed the order, Wx^a type〉Wx^in type〉Wx^b type〉Wx^mq type〉wx. Contrary to this, the GC showed an opposite trend compared to AAC. There was a wide variation in rapid visco analyzer（RVA） profile among five Wx allele types, while varieties sharing a specified Wx allele had basically the similar RVA profile, although there was a slight difference in some RVA parameters, peak, hot paste and cool paste viscosities.

关键词： alleles cooking eating qualities GBSS starch specialty flowering mature paste

Prolonged milk provisioning and extended maternal care in the milking spider Toxeus magnus: biological implications and questions unresolved

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Zoological Research 2019年第4期40卷 241-243页

作者： Bing Dong Rui-chang quan Zhan-Qi Chen CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesXishuangbanna Yunnan 666303China Center for Integrative Conservation Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesXishuangbanna Yunnan 666303China University of Chinese Academy of Sciences Beijing 100049China

Prolonged milk provisioning and extended parental care for nutritionally independent offspring, previously considered to only co-occur in long-lived mammals (Clutton-Brock, 1991;Royle et al., 2012), were recently reported in the reproduction of the milking spider, Toxeus magnus (Chen et al. 2018). Newly hatched T. magnus spiderlings require 53 days to develop to maturity, with an average adult body length of 6.6 mm.

关键词： milking spider Toxeus magnus biological implications Prolonged milk provisioning

Preparation of Nicotinic Acid from Oxidation of 3-Picoline with Oxygen Under Catalysis of T(o-Cl)PPMn

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Chemical Research in Chinese Universities 2008年第6期24卷 743-746页

作者： BAI Jin-quan WANG Qi-chang HU Yun GUO Feng-yan Department of Chemistry and Chemical Engineering College of Environment and Energy Engineering Beijing University of Technology Beijing 100022 P. R. China

The oxidation of 3-picoline to nicotinic acid took place efficiently in an ethanol solution with 02 as the oxidant under the catalysis of T（o-Cl）PPMn at 40--150 ℃ and 0.5--3.0 MPa oxygen pressure. The influences of temperature, oxygen pressure, reaction time, concentration of 3-picoline, concentration of sodium hydroxide, and concentration of T（o-Cl）PPMn catalyst, etc. on the production of nicotinic acid were investigated. The results show that T（o-Cl）PPMn presented excellent catalytic activity in the oxidation Of 3-pieoiine to nicotinic acid and the yield of nicotinic acid varied greatly with the reaction temperature, oxygen pressure, T（o-Cl）PPMn concentration, etc.

关键词： Nicotinic acid 3-Picoline Metalloporphyrin Oxidation

New efficient synthesis of 2,5,6-trisubstituted oxazolo[5,4-d]pyrimidi-7(6H)-ones via an oxazolyliminophosphorane

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Chinese Chemical Letters 2015年第9期26卷 1158-1160页

作者： Guo-Ping Zeng chang-quan Cai Fen Tan Ming-Wu Ding Hubei Province Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients Hubei University of Education Key Laboratory of Pesticideε Chemical Biology of Ministry of Education Central China Normal University

A new efficient synthesis of 2,5,6-trisubstituted oxazolo（5,4-d]pyrimidi-7（6H）-ones by consecutive azaWittig reaction was *** sequential three-component reaction of oxazolyliminophosphorane4,isocyanates and amines produced 2,5,6-trisubstituted oxazolo[5,4-d]pyrimidi-7（6H）-ones 7 in good overall yields in the presence of catalytic amount of EtONa.

关键词： Oxazolo[5 4-d]pyrimidi-7( 6H)-one Aza-Wittig reaction Iminophosphorane Carbodiimide

Progress in research on the effects of traditional Chinese medicine on the tumor microenvironment

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Journal of Integrative Medicine 2017年第4期15卷 282-287页

作者： Wan-fu Lin Jian-ying Lu Bin-bin Cheng chang-quan Ling changhai Hospital of Traditional Chinese Medicine Second Military Medical University Department of Traditional Chinese Medicine Jing'an Hospital of Integrated Traditional Chinese and Western Medicine

Tumor microenvironment （TME） has received more and more attention as modern medical research has begun to understand its importance in tumorigenesis. The occurrence, development, metastasis and drug resistance of tumors are closely related to TME. TME is a complicated system, including nontumor cells, their secreted cytokines, extracellular matrix, among other components. The concepts of wholism and multitarget regulation in traditional Chinese medicine （TCM） make it well suited to the regulation of TME. in this paper, the authors reviewed the progress of TME research and the effect of TCM on TME, providing some views of Chinese medicine in antitumor research.

关键词： tumor microenvironment medicine, Chinese traditional Chinese medicine monomer Chinesemedicine compound research progress

Spatial variability of soil bulk density and its controlling factors in an agricultural intensive area of Chengdu Plain,Southwest China

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Journal of Integrative Agriculture 2019年第2期18卷 290-300页

作者： LI Shan LI Qi-quan WANG chang-quan LI Bing GAO Xue-song LI Yi-ding WU De-yong College of Resources Sichuan Agricultural UniversityChengdu 611130P.R.China

Soil bulk density is a basic but important physic soil property related to soil porosity,soil moisture and hydraulic conductivity,which is crucial to soil quality assessment and land use *** this study,we evaluated the spatial variability of soil bulk density in the 0–20,20–40,40–60 and 60–100 cm layers as well as its affecting factors in Southwest China’s agricultural intensive *** indicated the mean value of surface soil bulk density(0–20 cm)was 1.26 g cm^(–3),significantly lower than that of subsoil(20–100 cm).No statistical difference existed among the subsoil with a mean soil bulk density of 1.54 g cm^(–3).Spatially,soil bulk density played a similar spatial pattern in soil profile,whereas obvious differences were found in *** nugget effects for soil bulk density in the 0–20 and 20–40 cm layers were 27.22 and27.02%while 12.06 and 3.46%in the 40–60 and 60–100 cm layers,respectively,gradually decreasing in the soil profile,indicating that the spatial variability of soil bulk density above 40 cm was affected by structural and random factors while dominated by structural factors under 40 *** organic matter was the controlling factor on the spatial variability of soil bulk density in each *** use and elevation were another two dominated factor controlling the spatial variability of soil bulk density in the 0–20 and 40–60 cm layers,*** genus was one of the dominated factors controlling the spatial variability of soil bulk below 40 cm.

关键词： soil bulk density profile spatial variability controlling factors Chengdu Plain