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A New Diterpene Glycoside from Isodon forrestii

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Chinese Chemical Letters 2001年第2期12卷 145-146页

作者： Shuang Xi MEI Yun Xin DENG quan bin han Zhong Wen LIN han Dong SUN Laboratory of Phytochemistry Kunming Institute of BotanyAcademia SinicaKunming 650204 Department of Pharmacy Guiyang Medical CollegeGuiyang 550000

A new diterpene glycoside named 9(10-->20)-abeo-7 beta ,10 beta ,11,15-tetrahydroxy-8,11,13-abietatrien-12-O-beta -D-glucopyranoside was isolated from aerial parts of Isodon forrestii. Its structure was determined by ... 详细信息

关键词： Isodon forrestii, diterpene glycoside, abietanoid 9(10→20)-abeo-7β,10β,11,15-tetra-hydroxy-8,11,13-abietatrien-12-O-β-D-glucopyranoside

Two new ent-kaurane diterpenoids from Isodon henryi

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Chinese Chemical Letters 2008年第9期19卷 1096-1098页

作者： Yong Zhao Li bin Yang Sheng Xiong Huang Wei Lie Xiao Jian Xin Pu Li Mei Li quan bin han han Dong Sun State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China College of Chemistry and Engineering Yunnan Normal University Kunming 650092 China Graduate University of Chinese Academy of Sciences Beijing 100039 China

Two new ent-kaurane diterpenoids, minheryins H （1） and I （2）, were isolated from the leaves of Isodon henryi. Their structures were elucidated by means of spectroscopic analysis, including 2D NMR spectra.

关键词： lsodon henryi Labiatae ent-Kaurane diterpenoid

A Coumarin Isolated from Bupleurum malconense and Its Anti-inflammatory Effects through Inhibiting NF-κB Activation

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A Coumarin Isolated from Bupleurum malconense and Its Anti-i...

A Novel and Rapid HPGPC-based Strategy for Quality Control of Saccharide-dominant Herbal Materials:Dendrobium Officinale,A Case Study

第十四届全国中药和天然药物学术研讨会

作者： Huai-Xue Mu quan-bin han Zhao-Xiang Bian Hong Kong Baptist University

＜正＞Bioassay-guided fractionation using lipopolysaccharide（LPS）-stimulated mouse macrophage（RAW-Blue cells）led to discovery of a coumarin,which was identified to be（+）-3’-angeloyloxy-4’-keto-3’,4’-dihydroseselin（Pd-lb）by MS and NMR spectral ***-lb markedly suppressed the gene expression of interleukin（IL）-1β,tumor necrosis factor

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A Novel and Rapid HPGPC-based Strategy for Quality Control o...

A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

第十四届全国中药和天然药物学术研讨会

作者： Jun Xu Zhong-Zhen Zhao quan-bin han Hu-Biao Chen Hong Kong Baptist University China Academy of Chinese Medical Sciences

＜正＞Qualitative and quantitative characterization of natural saccharides,especially polysaccharides,in herb materials remains a challenge due to their complicated structures and high macro-molecular *** available methods,such as complete structural characterization,total sugar content determination and sugar composition analysis,involve

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan Ping Wang bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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孔洞型碳酸盐岩储层饱和度建模新方法及应用

天然气地球科学 2017年第8期28卷 1250-1256页

作者：姜黎明余春昊齐宝权朱涵斌王勇军中国石油集团测井有限公司技术中心陕西西安710077 中国石油天然气集团测井重点实验室陕西西安710077 川庆钻探工程公司测井公司重庆400021

碳酸岩复杂的孔隙结构和强烈的非均质性,导致传统的阿尔奇模型存在一定不适用性,主要体现在,m,n值的变化范围大。从岩石体积物理模型出发,设定n为常数,扩展m的含义并重新定义为孔隙结构指数,用它代替原Archie公式中胶结指数和饱和度指... 详细信息

碳酸岩复杂的孔隙结构和强烈的非均质性,导致传统的阿尔奇模型存在一定不适用性,主要体现在,m,n值的变化范围大。从岩石体积物理模型出发,设定n为常数,扩展m的含义并重新定义为孔隙结构指数,用它代替原Archie公式中胶结指数和饱和度指数对含水饱和度计算的影响。鉴于碳酸盐岩孔隙成因的复杂性和孔隙结构的复杂性,特别是裂缝型和溶蚀孔洞型碳酸盐岩储层取心困难,采用数值模拟手段考察碳酸盐岩孔隙结构指数m的影响因素及变化规律,主要包括孔隙结构特征参数孔喉比、孔隙度、泥质含量等因素对表征岩石导电性的F和岩石孔隙结构指数m的影响,又通过引入孔隙结构组分建立了变m的饱和度模型。应用效果表明新模型成功解决了四川磨溪溶蚀孔洞型碳酸岩储层水层段自由烃饱和度计算偏高的难题。

关键词：孔洞型碳酸盐岩数字岩心孔隙结构指数饱和度模型

Identification and Pharmacokinetics Study of Multiple Components Absorbed into Rat Plasma after Oral Administration of Ma-Zi-Ren-Wan Formula using UPLC-MS/MS

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Identification and Pharmacokinetics Study of Multiple Compon...

Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

第十四届全国中药和天然药物学术研讨会

作者： Dong-dong Hu quan-bin han Li-dan Zhong Hong-sheng Tan Yan-hong Li Cheng-yuan Lin Man Zhang Shu-hai Lin Ling Zhao Zhao-xiang Bian Hong-xi Xu Shanghai University of Traditional Chinese Medicine Hong Kong Baptist University

＜正＞Ma-Zi-Ren-Wan（MZRW）,also known as Hemp seed pills,a formula first recorded in a TCM classic"ShanhanLun",has been widely used for constipation for many ***,the constituents absorbed into blood after oral administration of MZRW remain *** this study,an ultra-performance liquid chromatography-eiectrospray ionization-quadruple-time-of

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali Chen Yiyang Li Xingping quan Jinfen Chen Yan han Li Yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

Inside-out dual-doping effects on tubular catalysts:Structural and chemical variation for advanced oxygen reduction performance

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Nano Research 2022年第1期15卷 361-367页

作者： Yang Gao Debin Kong Jiaxu Liang Daliang han bin Wang quan-Hong Yang Linjie Zhi CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China University of Chinese Academy of Sciences Beijing 100049China

Dual-doping of carbon,especially the combination of nitrogen and a secondary heteroatom,has been demonstrated efficient to optimize the oxygen reduction reaction(ORR)***,the optimum dual-doping is still not clear due to the lack of strong experimental proofs,which rely on a reliable method to prepare carbon materials that can rule out the interference factors and then emphasize only the doping *** this work,an inside-out doping method is reported to prepare carbon submicrotubes(CSTs)as a material to study the principles of designing dual-doping catalysts for *** interference factors including the metal impurities and doping gradient in the bulk phase are excluded,and the doping effects including the structural and chemical variation of carbon are studied.P-doping exhibited a higher pore-forming ability to perforate carbon and a lower doping content,but a higher ORR catalytic activity as compared with S-and B-doped N-CSTs,demonstrating the N,P co-doping is more efficient in making carbon-based catalysts for ***-principle calculations reveal that the edge C situated around the oxidized P site nearby a graphitic N atom is the active site that shows the lowest ORR overpotential comparable to Pt-based *** study suggests that the catalytic activity of dual-heteroatoms-doped carbons not only depends on the intrinsic chemical bonding between heteroatoms and carbon,but also is affected by the structural variation generated by introducing different atoms,which can be extended to the study of other kinds of functionalization of carbon and potential reactions besides ORR.

关键词： dual-doping phosphorus carbon tubes oxygen reduction metal-free catalysts