检索结果-南通市图书馆

1型糖尿病患者早期视觉诱发电位和视网膜电图分析

在线全文

学校读者我要写书评

暂无评论

国际眼科杂志 2016年第7期16卷 1316-1318页

作者：赵全良张春香菅宝芬内蒙古民族大学第二临床医学院眼科中国内蒙古自治区牙克石市022150 内蒙古民族大学第二临床医学院内分泌科中国内蒙古自治区牙克石市022150 中国吉林省长春市红星医院 130000

目的:探讨1型糖尿病患者早期的视觉电生理变化情况,分析糖尿病视网膜病变的早期与视觉诱发电位和视网膜电图改变的相关性。方法:观察组60例1型糖尿病患者,男女比例均等,平均年龄19.42±7.78岁,病程小于5a,矫正视力5.0,平均空腹血糖7.8±... 详细信息

目的:探讨1型糖尿病患者早期的视觉电生理变化情况,分析糖尿病视网膜病变的早期与视觉诱发电位和视网膜电图改变的相关性。方法:观察组60例1型糖尿病患者,男女比例均等,平均年龄19.42±7.78岁,病程小于5a,矫正视力5.0,平均空腹血糖7.8±3.6mmol/L。进行图形视觉诱发电位和闪光视网膜电图检查。对照组60例正常人,男女比例均等,平均年龄17.2±6.52岁,矫正视力5.0,进行图形视觉诱发电位和闪光视网膜电图检查;记录两组PVEP参数P100波潜伏期和P100波振幅值,FERG参数a波潜伏值、b波潜伏期、a波振幅值、b波振幅值。结果:观察组的参数P100波振幅值、P100波潜伏期与对照组比较,有显著统计学意义(P<0.01),均有振幅值降低,潜伏期延长;观察组的参数a波潜伏期、a波振幅值、b波潜伏期、b波振幅值与对照组比较差异有显著统计学意义(P<0.01);观察组平均空腹血糖控制稳定,PVEP P100的振幅值、FERG a、b波的振幅值与糖尿病程无关,而PVEP P100的潜伏值、FERG a、b波的潜伏值与糖尿病程有关。结论:图形视觉诱发电位提示糖尿病患者视神经元损伤较为敏感;闪光视网膜电图是早期发现糖尿病患者视网膜Müller细胞和双极细胞损害的理想手段;图形视觉诱发电位参数P100波振幅值、闪光视网膜电图参数b波振幅值可能是糖尿病视网膜临床前期最敏感的诊断指标。

关键词：视功能损害糖尿病视觉诱发电位视网膜电图

LiDAR-Visual SLAM with Integrated Semantic and Texture Information for Enhanced Ecological Monitoring Vehicle Localization

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2025年第1期82卷 1401-1416页

作者： Yiqing Lu Liutao zhao Qiankun zhao Foreign Environmental Cooperation Center Ministry of Ecology and Environment of PRCBeijing100035China Beijing Computing Center Co. Ltd.Beijing Academy of Science and TechnologyBeijing100083China Beijing Guyu Interactive Artificial Intelligence Application Co. Ltd.Beijing100024China

Ecological monitoring vehicles are equipped with a range of sensors and monitoring devices designed to gather data on ecological and environmental *** vehicles are crucial in various fields,including environmental science research,ecological and environmental monitoring projects,disaster response,and emergency management.A key method employed in these vehicles for achieving high-precision positioning is LiDAR(lightlaser detection and ranging)-Visual Simultaneous Localization and Mapping(SLAM).However,maintaining highprecision localization in complex scenarios,such as degraded environments or when dynamic objects are present,remains a significant *** address this issue,we integrate both semantic and texture information from LiDAR and cameras to enhance the robustness and efficiency of data ***,semantic information simplifies the modeling of scene elements,reducing the reliance on dense point clouds,which can be less ***,visual texture information complements LiDAR-Visual localization by providing additional contextual *** incorporating semantic and texture details frompaired images and point clouds,we significantly improve the quality of data association,thereby increasing the success rate of *** approach not only enhances the operational capabilities of ecological monitoring vehicles in complex environments but also contributes to improving the overall efficiency and effectiveness of ecological monitoring and environmental protection efforts.

关键词： LiDAR-Visual simultaneous localization and mapping integrated semantic texture information

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi Wang Mengke zhao Dong Fu Meina Wang Chao Han Zhongyue Lv liang Wang Jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

A versatile synthetic strategy towards rare earth based metal-organic frameworks

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： quan Shi Yun-Hao Xu Ming-Hui Chen Peng zhao Wen-Bo Deng Ji Xiong Kai Guo Ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

关键词：

Laser assisted phase transformation of carbon-based transition metal oxide electrode for high-performance supercapacitor application

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Mingzhen Xiu Jianghong Zhang Yu Lu Xun Cao Kang Huang Siyu Zhu Bowei Zhang Yu liang Chunwang zhao Junsheng Wu Yizhong Huang School of Materials Science and Engineering Nanyang Technological University Energy Research Institute Interdisciplinary Graduate Programme Nanyang Technological University Institute of Sustainability for Chemicals Energy and Environment Agency for Science Technology and ResearchSingapore Institute of Advanced Materials and Technology University of Science and Technology Beijing School of Materials Science and Technology Shenyang University of Chemical Technology School of Materials Science and Hydrogen Energy Foshan University

Transitional metal oxides have a wide range of applications due to their superior *** enhanced performance of metal oxide relies on their desirable oxidation states,which is challenging to achieve and requires complex *** study demonstrates a facile strategy enabling rapid phase transformation of transition metal *** approach involves synthesis of a tetragonal Mn3O4/carbon cloth composite using the liquid plasma discharge deposition （LPDD） technique,followed by laser irradiation with the presence of ethylene glycol under an N2gas *** resulting face-centered cubic MnO/carbon cloth electrode exhibits an excellent capacitance of 1,125 F g-1at 2 A g-1,with remarkable capacitance retention of 95%after10,000 *** approach can be extended to other transition metals including Co,Cu,Cr,Fe,Ni,and *** simulations reveal the significance of ethylene glycol and the underlying mechanism associated with the phase transformation of transition metal *** present study offers a powerful technique for the phase transformation of transition metal oxide which can guide the development of new electrode materials with enhanced electrochemical properties for high-performance energy storage applications.

关键词：

Decision making module based on stochastic magnetic tunnel junctions

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 202-209页

作者： Yifan Miao Li zhao Yajun Zhang Zhe Yuan Center for Advanced quantum Studies and Department of Physics Beijing Normal University Institute for Nanoelectric Devices and quantum Computing Fudan University Interdisciplinary Center for Theoretical Physics and Information Sciences Fudan University

In biological neural systems, noise is ubiquitous but does not affect the correct decisions made in the complex cognitive ***-making in biological neural system is typically achieved by accumulating input information over a period of *** by recent developments in neurosciences, we design a decision-making module based on spintronic devices, utilizing superparamagnetic tunnel junctions as artificial neurons. The feasibility of this decision-making module is verified through circuit simulations. Taking a multi-layer perceptron as an example, the module significantly improves the accuracy of the perceptron in the handwritten digit recognition task. Furthermore, the spintronic decision-making module offers advantages over the conventional pooling methods, such as adaptive decision time, high performance and the absence of analog-to-digital conversion. The decision-making module is flexible to be integrated into artificial neural networks and provides a general yet effective solution to enhance performance against device noise.

关键词： neuromorphic computing spintronics magnetic tunnel junction neural networks

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

分布式虚拟环境中的综合地面环境研究

系统仿真学报 2000年第4期12卷 343-347页

作者：何红梅吕良权赵沁平北京航空航天大学计算机科学与工程系!北京100083

详细阐述了分布式虚拟环境中综合地面环境研究的各个方面。首先介绍了采用多种地理数据生成综合地面环境数据库的过程 ;然后提出了一种大规模三维地形环境管理方法和一种通用的实时调度算法 ;最后给出了一种支持动态地形环境一致性的动... 详细信息

详细阐述了分布式虚拟环境中综合地面环境研究的各个方面。首先介绍了采用多种地理数据生成综合地面环境数据库的过程 ;然后提出了一种大规模三维地形环境管理方法和一种通用的实时调度算法 ;最后给出了一种支持动态地形环境一致性的动态地形环境体系结构

关键词：虚拟现实综合环境分布式虚拟环境分布交互仿真

A Generative Model-Based Network Framework for Ecological Data Reconstruction

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2025年第1期82卷 929-948页

作者： Shuqiao Liu zhao Zhang Hongyan Zhou Xuebo Chen School of Electronic and Information Engineering University of Science and Technology LiaoningAnshan114051China School of Computer Science and Software Engineering University of Science and Technology LiaoningAnshan114051China

This study examines the effectiveness of artificial intelligence techniques in generating high-quality environmental data for species introductory site selection *** Strengths,Weaknesses,Opportunities,Threats(SWOT)analysis data with Variation Autoencoder(VAE)and Generative AdversarialNetwork(GAN)the network framework model(SAE-GAN),is proposed for environmental data *** model combines two popular generative models,GAN and VAE,to generate features conditional on categorical data embedding after SWOT *** model is capable of generating features that resemble real feature distributions and adding sample factors to more accurately track individual sample *** data is used to retain more semantic information to generate *** model was applied to species in Southern California,USA,citing SWOT analysis data to train the *** show that the model is capable of integrating data from more comprehensive analyses than traditional methods and generating high-quality reconstructed data from them,effectively solving the problem of insufficient data collection in development *** model is further validated by the Technique for Order Preference by Similarity to an Ideal Solution(TOPSIS)classification assessment commonly used in the environmental data *** study provides a reliable and rich source of training data for species introduction site selection systems and makes a significant contribution to ecological and sustainable development.

关键词： Convolutional Neural Network(CNN) VAE GAN TOPSIS data reconstruction