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Conformation and Counterion Distribution of Polyelectrolyte in Solution as Viewed from Dielectric Approach

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Chinese Journal of Polymer Science 2024年第9期42卷 1278-1301,I0005页

作者： Kong-Shuang zhao College of Chemistry Beijing Normal UniversityBeijing 100875China

Polyelectrolyte solutions are more variable than uncharged macromolecule due to electrical interaction between charged molecules and surrounding ***,the subject of polyelectrolyte solutions has attracted a wide range of interests in both basic and applied research,and has also been extensively ***,the understanding of the molecular dynamics and conformation of polyelectrolytes in solution remains to be deepened,and universal consensus on some key issues have not been *** methods have contributed to solving the above problems in different ways,including dielectric relaxation spectroscopy(DRS).In this perspective,we briefly reviewed the history of dielectric spectroscopic research on polyelectrolyte solution,with emphasis on summarizing our *** particular,we expound the characteristics of DRS and its ability to obtain the internal information of the system of ***,we evaluate the advantages and limitations of the dielectric method and discussed future prospects of this field.

关键词： Polyelectrolyte Dielectric relaxation spectroscopy Chain conformation Thermosensitive microgel PNIPAM microgel Spherical polyelectrolyte brushes

CRL2^(APPBP2)-mediated TSPYL2 degradation counteracts human mesenchymal stem cell senescence

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Science China(Life Sciences) 2024年第3期67卷 460-474页

作者： Daoyuan Huang Qian zhao Kuan Yang Jinghui Lei Ying Jing Hongyu Li Chen Zhang Shuai Ma Shuhui Sun Yusheng Cai Guibin Wang Jing qu Weiqi Zhang Si Wang Guang-Hui Liu Advanced Innovation Centerfor Human Brain Protection National Clinical Research Centerfor Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational MedicineCenter International Centerfor Aging and CancerBejing Municipal GeriatricMedical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Beijing Institute for Stem Cell and Regenerative Medicine Beijing100101China CAS Key Laboratory of Genomic and Precision Medicine Bejing Institute of Genomics and China National Center for BioinformationChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration CASBeijing 100101China The Fifth People's Hospital of Chongqing Chongqing 400062China Sino-Danish Cllege University of Chinese Academy of SciencesBeijing101408China National Laboratory of Biomacromolecules CAS Center for Excelence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing100101China State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China

Cullin-RING E3 ubiquitin ligases(CRLs),the largest family of multi-subunit E3 ubiquitin ligases in eukaryotic cells,represent core cellular machinery for executing protein degradation and maintaining ***,we asked what roles Cullin proteins play in human mesenchymal stem cell(hMSC)homeostasis and *** this end,we conducted a comparative aging phenotype analysis by individually knocking down Cullin members in three senescence models:replicative senescent hMSCs,Hutchinson-Gilford Progeria Syndrome hMSCs,and Werner syndrome *** all family members,we found that CUL2 deficiency rendered hMSCs the most susceptible to *** investigate CUL2-specific underlying mechanisms,we then applied CRISPR/Cas9-mediated gene editing technology to generate CUL2-deficient human embryonic stem cells(hESCs).When we differentiated these into h MSCs,we found that CUL2 deletion markedly accelerates hMSC ***,we identified that CUL2 targets and promotes ubiquitin proteasome-mediated degradation of TSPYL2(a known negative regulator of proliferation)through the substrate receptor protein APPBP2,which in turn downregulates one of the canonical aging marker-P21^(waf1/cip1),and thereby delays *** work provides important insights into how CRL2^(APPBP2)-mediated TSPYL2 degradation counteracts hMSC senescence,providing a molecular basis for directing intervention strategies against aging and aging-related diseases.

关键词： Cullins stem cell senescence aging proteostasis ubiquitination APPBP2 TSPYL2

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磁场调制电机的由来、发展与挑战

中国电机工程学报 2024年第18期44卷 7361-7380,I0021页

作者：曲荣海李大伟赵钰强电磁技术全国重点实验室(华中科技大学) 湖北省武汉市430074

得益于磁场调制效应,磁场调制电机具有高转矩密度优势,在风力发电、舰船推进、工业驱动等低速大转矩直驱领域具有广阔应用前景。该文首先介绍磁场调制电机的由来,并梳理该类电机基础理论和分析方法的发展与完善过程;进一步,对磁场调制... 详细信息

得益于磁场调制效应,磁场调制电机具有高转矩密度优势,在风力发电、舰船推进、工业驱动等低速大转矩直驱领域具有广阔应用前景。该文首先介绍磁场调制电机的由来,并梳理该类电机基础理论和分析方法的发展与完善过程;进一步,对磁场调制电机进行分类并介绍其工作原理;同时,归纳磁场调制电机转矩密度、功率因数等关键电磁性能的提升方法。最后,总结磁场调制电机领域取得的主要研究成果,并讨论该类电机所面临的技术挑战和未来发展方向。

关键词：磁场调制电机工作原理拓扑结构电磁性能

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Resilient control of flexible hypersonic vehicles against unmatched distributed faults

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Chinese Journal of Aeronautics 2024年第5期37卷 60-70页

作者： Dong zhao Wenjing REN School of Artificial Intelligence Anhui UniversityHefei 230601China Key Laboratory of System Control and Information Processing Ministry of EducationShanghai Jiao Tong UniversityShanghai 200240China School of Electrical Engineering and Automation Hefei University of TechnologyHefei 230009China

This paper studies a robust fault compensation and vibration suppression problem of flexible hypersonic *** controlled plant is represented by a cascade system composed of a nonlinear Ordinary Differential Equation(ODE)and an Euler-Bernoulli Beam Equation(EBBE),in which the vibration dynamics is coupled with the rigid dynamics and suffers from distributed faults.A state differential transformation is introduced to transfer distributed faults to an EBBE boundary and a longitudinal dynamics is refined by utilizing T-S fuzzy IF-THEN rules.A novel T-S fuzzy based fault-tolerant control algorithm is developed and related stability conditions are *** robust exponential stability and well-posedness are proved by using the modified l_(0)-semigroup based Lyapunov direct approach.A simulation study on the longitudinal dynamics of flexible hypersonic vehicles effectively verifies the validity of the developed theoretical results.

关键词： Flexible hypersonic vehicles ODE-EBBE cascade Robust exponential stability Unmatched distributed fault compensation Vibration suppression

H-and J-aggregation of conjugated small molecules in organic solar cells

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Journal of Energy Chemistry 2024年第6期93卷 174-192,I0005页

作者： Qiaoqiao zhao Feng He State Key Laboratory of Biobased Material and Green Papermaking Qilu University of TechnologyShandong Academy of SciencesJinan 250353ShangdongChina Shenzhen Grubbs Institute and Department of Chemistry Southern University of Science and TechnologyShenzhen 518055GuangdongChina Guangdong Provincial Key Laboratory of Catalysis Southern University of Science and TechnologyShenzhen 518055GuangdongChina

As H-and J-aggregation receive more and more attention in the research of organic solar cells(OSCs),especially in small molecular systems,deep understanding of aggregation behavior is needed to guide the design of conjugated small molecular structure and the fabrication process of OSC *** this end,this review is ***,the review firstly introduced the basic information about H-and J-aggregation of conjugated small molecules in ***,the characteristics of H-and J-aggregation and the methods to identify them were ***,it reviewed the research progress of H-and J-aggregation of conjugated small molecules in OSCs,including the factors influencing H-and J-aggregation in thin film and the effects of H-and J-aggregation on OPV performance.

关键词： H-aggregation J-aggregation Organic solar cells Small molecules Efficiency Stability

A novel Bayesian-based INS/GNSS integrated positioning method with both adaptability and robustness in urban environments

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Chinese Journal of Aeronautics 2024年第6期37卷 205-218页

作者： Zhe YANG Hongbo zhao School of Electronics and Information Engineering Beihang UniversityBeijing 100191China

Achieving higher accuracy positioning results in urban environments at a lower cost has been an important pursuit in areas such as autonomous driving and intelligent *** Inertial Navigation System and Global Navigation Satellite System(INS/GNSS)integrated navigation systems have been an important means of fulfilling the above quest due to the complementary error characteristics between INS and *** complex urban driving environment requires the system sufficiently adaptive to keep up with the time-varying measurement noise and sufficiently robust to cope with measurement outliers and prior ***,many efforts lack a balance between adaptability and *** this paper,a novel positioning method with both adaptability and robustness is proposed by coupling the Mahalanobis distance method,the Variational Bayesian method and the student’s t-distribution in one process(M-VBt method).This method is robust against non-Gaussian noise and priori uncertainties,plus adaptive against measurement noise uncertainty and time-varying *** field test results show that the M-VBt method(especially the Mahalanobis distance part)has significantly improved the system performance in the complex urban driving environment.

关键词： Urban environments Mahalanobis distance Adaptability Robustness Integrated navigation

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun zhao De-En Xu Ming-Lei Wu Ji-chuan Liu Zi-Ling Shi quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Cryogenian and Ediacaran integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 919-949页

作者： Lang SUN Malik Muhammad Saud Sajid KHAN chuan YANG Zhixin SUN Bing PAN Shehryar AHMED Lanyun MIAO Weichen SUN Chunlin HU Xiaojuan SUN Cui LUO Bo CHEN Zongjun YIN Fangchen zhao Guoxiang LI Maoyan ZHU State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

The complex evolutionary history of the Qinghai-Tibetan Plateau and its surrounding areas,including the continental blocks(Indian,Lhasa,South Qiangtang,Tarim,Olongbuluk,Central Qilian,Alxa,North China,Yangtze,Central Iran and Oman)and the orogenic belts between them,has long been the frontier in Earth science *** Cryogenian and Ediacaran strata are extensively distributed in these ***,relatively complete Cryogenian and Ediacaran successions have been discovered in Oman,Indian,Yangtze,and Tarim blocks,while only the Ediacaran successions have been reported in Iran,the South Qiangtang,Central Qilian,Alxa,and North China *** on previous studies together with the integration of new materials and advancement obtained through the Second Tibetan Plateau Scientific Expedition and Research,this review aims to synthesize a correlative stratigraphic framework of the representative Cryogenian and Ediacaran sequences from the Qinghai-Tibetan Plateau and its surrounding ***,the Cryogenian and Ediacaran biotas and major geological events in these areas are comprehensively discussed in aspects of current research *** results indicate that,in general,Ediacaran fossils of each area exhibit distinct features in preservation and assemblage composition,but the typical late Ediacaran fossils Cloudina and Shaanxilithes have been reported from most of these *** addition to the two global Cryogenian glaciations,late Ediacaran glaciogenic deposits are extensively recorded in the areas within and around the northern QinghaiTibetan Plateau(including the North China,Alxa,Central Qilian,Olongbuluk,and Tarim blocks,and the North Qilian Accretionary Belt),as well as central and southern ***,further research is required to determine the age,distribution,and origin of these late Ediacaran glaciogenic ***,the middle Ediacaran DOUNCE/Shuram Excursion is widely documented in the Qinghai-Tibetan Plateau and its surroundi

关键词： Qinghai-Tibetan Plateau Cryogenian Ediacaran Stratigraphy Palaeogeography Biota Gondwana

pyIFPNI:A package for querying and downloading plant fossil data from the IFPNI

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Plant Diversity 2024年第2期46卷 280-282页

作者： Bailong zhao State Key Laboratory of Plant Diversity and Specialty Crops Institute of BotanyChinese Academy of SciencesBeijing100093China University of Chinese Academy of Sciences Beijing100049China

The International Fossil Plant Names Index(IFPNI,2014-onwards)not only serves as an online gateway to the fossil plant name registry for the global scientific community,but also serves as a comprehensive and dynamic archive of fossil plants(Doweld,2016,2022).Since its establishment in 2014,the IFPNI has accumulated more than 80,000 entries of fossil plant names,along with information on over 10,000 documents and over 6000 paleobotanists,all supported by exhaustive data,demonstrating the scope of the IFPNI's work(IFPNI,2014-onwards).

关键词： plant fossil