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基于真实世界数据探讨中医药治疗慢性支气管炎用药规律

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中国中医药信息杂志 2024年第2期31卷 50-58页

作者：曲蒙蒙许宁周玲屈云艳王伟张婷婷高梅吉郡珠严镓文余海滨河南中医药大学河南郑州450000 河南中医药大学第一附属医院河南郑州450000

目的归纳总结中医药治疗慢性支气管炎(CB)的用药规律,为临床用药提供参考。方法基于健康信息系统(HIS)电子病历数据提取2016年1月1日-2021年12月31日于河南中医药大学第一附属医院呼吸科住院的CB患者病历资料。经筛选后,将处方中药录入E... 详细信息

目的归纳总结中医药治疗慢性支气管炎(CB)的用药规律,为临床用药提供参考。方法基于健康信息系统(HIS)电子病历数据提取2016年1月1日-2021年12月31日于河南中医药大学第一附属医院呼吸科住院的CB患者病历资料。经筛选后,将处方中药录入Excel 2019建立数据库。基于Lantern5.0软件对频率>6%的中药进行隐结构模型学习,得到隐变量及显变量,对模型进行诠释。利用SPSS Modeler 18.0软件将频率>6%的中药用Apriori算法建立模点,得到药物之间的关联规则,分析中医药治疗CB的用药规律。结果共纳入病例3410例,涉及中药423味,累计用药82766次,其中频率>6%的中药109味,累计频次为69845,频次前5位中药依次为川贝母、茯苓、白术、紫菀、陈皮,以化痰止咳平喘药、补虚药、清热药、解表药、活血化瘀药为主。药性偏温、寒、平,药味以苦、甘、辛为主,主归肺经、脾经、肝经、胃经。隐结构模型分析得到隐变量49个、隐类149个,结合专业知识推断得到10个综合聚类模型,21个核心方剂,如桑白皮汤、血府逐瘀汤、小青龙汤、二陈汤、沙参麦冬汤、六味地黄丸、银翘散、止嗽散、玉屏风散、血府逐瘀汤合导痰汤等,推断CB证候有痰热郁肺证、气滞血瘀证、寒饮射肺证、痰湿蕴肺证、肺气阴两虚证、肾阴虚证、风热犯肺证、风寒袭肺证、肺脾气虚证、痰瘀互结证。关联规则分析共得到强关联规则41条,其中二项强关联规则5条,三项强关联规则36条,置信度较高的为防风+黄芪→白术、防风+党参→白术、党参+陈皮→白术等,提升度较高的为柴胡+桑白皮→黄芩、紫苏子+射干→川贝母、苦杏仁+清半夏→陈皮等。结论中医药治疗CB以化痰止咳平喘为主,且常用活血化瘀法以助化痰,并注重补肺固表、健脾益气等法的应用。

关键词：慢性支气管炎中医药隐结构模型关联规则用药规律

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HIV整合酶抑制剂临床应用研究进展

中华实验和临床病毒学杂志 2024年第2期38卷 202-208页

作者：张艺宋兵史炎泽余敏睿郭鑫屈蒙蒙焦艳梅王福生解放军总医院第五医学中心感染病医学部、国家感染性疾病临床研究中心北京100039 蚌埠医科大学研究生院蚌埠233030

整合酶抑制剂(integrase inhibitors,INSTIs)是治疗人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染者的最新一类药物。自2007年以来,已经有5种INSTIs上市:拉替拉韦(Raltegravir,RAL)、艾维雷韦(Elvitegravir,EVG)、多替拉韦(Dolutegravir,DTG)、比克替拉韦(Bictegravir,BIC)和卡博特韦(Cabotegravir,CAB),这些药物均获得美国食品药品监督管理局(Food and Drug Administration,FDA)批准用于HIV感染者的起始抗逆转录病毒治疗(antiretroviral therapy,ART)。与其他类型抗病毒药物相比,INSTIs具有更好的疗效性及耐受性,因此全球众多国家把包含INSTIs的治疗方案列为HIV抗病毒治疗的优选方案。近年来,随着INSTIs的广泛使用,一些研究数据表明,INSTIs可能存在一些不良反应,比如出现中枢神经系统症状、血脂代谢异常、体重增加、肝肾功能异常等。本综述总结了目前用于成人HIV感染者的INSTIs,强调了5种INSTIs的临床疗效及其不良反应。

关键词：整合酶抑制剂人类免疫缺陷病毒抗逆转录病毒治疗临床疗效不良反应

Enhancing multifunctional photocatalysis with acetate-assisted cesium doping and unlocking the potential of Z-scheme solar water splitting

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Carbon Energy 2024年第3期6卷 178-195页

作者： mengmeng Ma Jingzhen Li Xiaogang Zhu Kong Liu Kaige Huang Guodong Yuan Shizhong Yue Zhijie Wang Shengchun qu Key Laboratory of Semiconductor Materials Science Beijing Key Laboratory of Low Dimensional Semiconductor Materials and DevicesInstitute of SemiconductorsChinese Academy of SciencesBeijingChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina Department of Physics College of Physical Science and TechnologyXiamen UniversityXiamenChina State Key Laboratory for Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijingChina

Graphitic carbon nitride(g-C_(3)N_(4))has been extensively doped with alkali metals to enlarge photocatalytic output,in which cesium(Cs)doping is predicted to be the most ***,the sluggish diffusion and doping kinetics of precursors with high melting points,along with imprecise regulation,have raised the debate on whether Cs doping could make *** this matter,we attempt to confirm the positive effects of Cs doping on multifunctional photocatalysis by first using cesium acetate with the character of easy *** optimized Csdoped g-C_(3)N_(4)(CCN)shows a 41.6-fold increase in visible-light-driven hydrogen evolution reaction(HER)compared to pure g-C_(3)N_(4) and impressive degradation capability,especially with 77%refractory tetracycline and almost 100%rhodamine B degradedwithin an *** penetration ofCs+is demonstrated to be a mode of interlayer doping,and Cs–N bonds(especially with sp^(2) pyridine N in C═N–C),along with robust chemical interaction and electron exchange,are *** atomic configuration triggers the broadened spectral response,the improved charge migration,and the activated photocatalytic ***,we evaluate the CCN/cadmium sulfide hybrid as a Z-scheme configuration,promoting the visible HER yield to 9.02 mmol g^(−1) h^(−1),which is the highest ever reported among all CCN *** work adds to the rapidly expanding field of manipulation strategies and supports further development of mediating served for photocatalysis.

关键词： acetate-assisted cesium doping multifunctional photocatalysis Z-scheme

LjaFGD:Lonicera japonica functional genomicsdatabase

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Journal of Integrative Plant Biology 2021年第8期63卷 1422-1436页

作者： Qiaoqiao Xiao Zhongqiu Li mengmeng qu Wenying Xu Zhen Su Jiaotong Yang Guizhou University of Traditional Chinese Medicine Guizhou550025 China State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing100193 China Research Center for Clinical&Translational Medicine Fifth Medical Center for General Hospital of PLABeijing100039 China

Lonicera japonica Thunb.,a traditional Chinese herb,has been used for treating human diseases for thousands of ***,the genome of *** has been decoded,providing valuable information for research into gene ***,no comprehensive database for gene functional analysis and mining is available for *** therefore constructed LjaFGD(***/LjaFGD and ***/LjaFGD),a database for analyzing and comparing gene function in *** constructed a gene co-expression network based on 77 RNA-seq samples,and then annotated genes of *** by alignment against protein sequences from public *** also introduced several tools for gene functional analysis,including Blast,motif analysis,gene set enrichment analysis,heatmap analysis,and *** co-expression network revealed that MYB and WRKY transcription factor family genes were co-expressed with genes encoding key enzymes in the biosynthesis of chlorogenic acid and luteolin in *** used flavonol synthase 1(LjFLS1)as an example to show the reliability and applicability of our *** and its various associated tools will provide researchers with an accessible platform for retrieving functional information on *** genes to further biological discovery.

关键词： co-expression network functional annotation functional analysis tools Lonicera japonica

Genotoxicity evaluation of drinking water sources in human peripheral blood lymphocytes using the comet assay

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Journal of Environmental Sciences 2008年第4期20卷 487-491页

作者： WU Yulin CHEN Haigang LI Zhaoli SUN Liwei qu mengmeng LI Mei KONG Zhiming State Key Laboratory of Pollution Control and Resource Reuse School of the Environment Nanjing University Nanjing 210093 China Jiangsu Institute of Planned Parenthood Research Nanjing 210036 China

The potential harm of organic pollutants in drinking water to human health is widely focused on in the wodd; more and more pollutants with genotoxic substances are released into the aquatic environment. Water source samples were collected from 7 different localities of Nanjing City. The potential genotoxicity of organic extracts from drinking water sources were investigated by means of the comet assay in human peripheral lymphocytes. The results showed that all the organic extracts from all the water source samples could induce DNA damages of human peripheral blood lymphocytes at different levels. A significant difference （P 〈 0.01） was observed when compared with the solvent control, The DNA damage increased with the increase of the dosage of the original water source. Significant differences of DNA damage were observed in different drinking water sources, as shown by the multiple comparisons analysis at the dosage of 100x; the degree of DNA damage treated by Hushu waterworks （at town level） was the most serious, the arbitrary units （AU） was 141.62±6.96, however, that of Shangyuanmen waterworks （at city level） was only 109.64±2.97. The analysis also revealed that the genotoxicity of town＇s water sources was higher than that of the city. The results demonstrated that the comet assay can be successfully applied to the genotoxicity monitoring programs of drinking water sources.

关键词： comet assay drinking water sources genotoxicity human peripheral blood lymphocyte

中国履行斯德哥尔摩公约农药领域的主要举措与成效

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农药科学与管理 2024年第5期45卷 11-14页

作者：武丽辉曲甍甍陶传江张文君王晓军黄心禾高歆越宗伏霖李敏农业农村部农药检定所北京100125

2004年5月,《关于持久性有机污染物的斯德哥尔摩公约》全球生效。我国同年正式加入该公约,全面履行公约各项义务,淘汰、消减和控制所涉及的各类POPs物质。今年正值公约全球生效以及我国履约20周年,本文从参与公约谈判、制定管理政策、... 详细信息

2004年5月,《关于持久性有机污染物的斯德哥尔摩公约》全球生效。我国同年正式加入该公约,全面履行公约各项义务,淘汰、消减和控制所涉及的各类POPs物质。今年正值公约全球生效以及我国履约20周年,本文从参与公约谈判、制定管理政策、完善国家标准、开发替代技术、开展履约调研、完成履约目标等多方面分享了20年来我国农药履约的主要举措与成效,并介绍了3个典型案例,提出了下一步工作重点和未来展望。

关键词：斯德哥尔摩公约农药履约举措成效典型案例

Time-Periodic Solutions to quasilinear Hyperbolic Systems on General Networks

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 41-72页

作者： Peng qu School of Mathematical Sciences Fudan UniversityShanghai 200433China

For quasilinear hyperbolic systems on general networks with time-periodic boundary-interface conditions with a dissipative structure,the existence and stability of the time-periodic classical solutions are discussed.

关键词： Time-periodic solution quasilinear hyperbolic system General net-work Classical solution Asymptotic stability

Flat jet electrochemical milling of TC4 alloy with tailoring backward parallel flow

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Chinese Journal of Aeronautics 2024年第4期37卷 574-592页

作者： Huanghai KONG Ningsong qu College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

In flat jet electrochemical milling, the electrolyte forms a backward parallel flow after impacting the workpiece, resulting in a weak current density distribution on the workpiece. Poor surface quality usually occurs on the machined titanium alloy surface because it inevitably suffers from the weak current density. In this study, a method of flat jet electrochemical milling with tailoring the backward parallel flow was proposed to eliminate the negative effects caused by the weak current density. Multiphysics simulations are carried out to comprehend the mechanism of flat jetEC milling with tailoring backward parallel flow and better construct the novel tool *** on flat jet electrochemical milling of TC4 alloy with and without tailoring backward parallel flow are conducted. The results reveal that, compared with flat jet electrochemical milling without tailoring backward parallel flow, the recommended tool reduces the surface roughness by86% to 93%, and improves the material removal rate by 93% to 163% with different feed ***, the recommended tool is more conducive to maintaining the inherent hardness of the material. Finally, a surface with low Sa of 0.37 μm is obtained.

关键词： Flat jet electrochemical milling TC4 alloy Surface roughness Micro-hardness Material removal rate

Pathways toward a pollution-free planet and challenges

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 3-8页

作者： Jiuhui qu Jiaping Chen School of Environment Tsinghua UniversityBeijing 100084China College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China

The mission of“Establishment of Zero-Pollution Earth”defined by United Nations Environment Programme aims at creation of a clean,safe and prosperous home for all human *** is of rational choice from each individual to protect our environment and demonstrates our great ambition to achieve our *** key message given in this article is that,zero pollution does not mean no discharge of pollutants and instead it can be achievable through optimizing and controlling a sound balance between pollutants discharge and capacities of decontamination through treatment and natural environmental accumulation,which can be termed as“Principle of Equilibrium”between pollution and *** on this principle,we propose and illustrate several key factors and synergistic pathways toward a pollution-free planet:quantitative determination on purification and wastewater;source control through green measures;minimization of negative side-effects;precise management through digitalized systems;and keeping sound balance between pollutants and natural *** should be noted that we would face a series of difficulties and challenges in moving forward to“Zero-Pollution Earth”.We should further develop theories,principles and tools to achieve the balance between quantity of pollutants and decontamination *** should work together to break through the bottleneck limited by“Principle of equilibrium”to establish new environmental remediation systems leading to“Zero-Pollution Earth”.

关键词： Wastewater treatment Resources Recovery Greenhouse gases Energy Pollution-free