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我国涉外信托法律适用的困境及完善路径

太原学院学报（社会科学版） 2024年第2期25卷 30-40页

作者：吴雨伦兰州大学法学院甘肃兰州730000

涉外信托纠纷在国际司法领域频频发生,各国关于涉外信托的法律冲突现象普遍。我国涉外信托冲突法规则具有一定的局限性,无法妥善解决涉外信托存在的法律适用难题。《涉外民事关系法律适用法》第17条的规定主要存在最密切联系原则缺位、... 详细信息

涉外信托纠纷在国际司法领域频频发生,各国关于涉外信托的法律冲突现象普遍。我国涉外信托冲突法规则具有一定的局限性,无法妥善解决涉外信托存在的法律适用难题。《涉外民事关系法律适用法》第17条的规定主要存在最密切联系原则缺位、意思自治适用范围受限、连接点过少等问题。通过比较分析信托制度应用发达国家的立法、司法实践和《海牙信托公约》,从引入最密切联系原则、延伸意思自治原则适用范围、软化系属公式连接点、建立信托领域案例指导制度以及加强国际法治交流合作等五个方面入手,提出完善涉外信托法律适用的可行性建议。

关键词：涉外信托法律适用最密切联系原则连接点软化案例指导

基于内置式声发射装置的金刚滚轮磨损在线监测方法

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科学技术与工程 2024年第26期24卷 11253-11262页

作者：于光宁史慧楠迟杰迟玉伦中国航发哈尔滨轴承有限公司哈尔滨150027 上海理工大学机械工程学院上海200093

为解决金刚滚轮修整磨损情况难以准确在线判断难题。设计开发了一套内置式声发射在线监测金刚滚轮磨损装置。基于Shannon信息熵理论与小波包模型,提出了一种对金刚滚轮修整声发射信号处理方法。该方法计算每一层小波包系数的信息熵,并... 详细信息

为解决金刚滚轮修整磨损情况难以准确在线判断难题。设计开发了一套内置式声发射在线监测金刚滚轮磨损装置。基于Shannon信息熵理论与小波包模型,提出了一种对金刚滚轮修整声发射信号处理方法。该方法计算每一层小波包系数的信息熵,并根据信息熵变化规律可确定小波包最佳分解层数。然后,利用主成分分析对该小波包分解特征参数进行降维,提取出最能表征金刚滚轮磨损的特征参数。最后,基于该特征参数建立粒子群优化算法支持向量机(particle swarm optimization-support vector machin,PSO-SVM),对金刚滚轮磨损状态进行实验监测研究。结果表明PSO-SVM模型分类精度最高,平均正确率高达95.24%以上,并通过大量实验验证了PSO-SVM的有效性。

关键词：金刚滚轮信息熵小波包分解 PSO-SVM

N-acetylserotonin alleviates retinal ischemia-reperfusion injury via HMGB1/RAGE/NF-κB pathway in rats

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 228-238页

作者： yu-Ze Zhao Xue-Ning Zhang Yi Yin Pei-lun Xiao Meng Gao Lu-Ming Zhang Shuan-Hu Zhou Shu-Na yu Xiao-Li Wang Yan-Song Zhao Department of Ophthalmology Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina School of Medical Imaging Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Anatomy Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Departments of Orthopedic Surgery Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA

AIM:To observe the effects of N-acetylserotonin(NAS)administration on retinal ischemia-reperfusion(RIR)injury in rats and explore the underlying mechanisms involving the high mobility group box 1(HMGB1)/receptor for advanced glycation end-products(RAGE)/nuclear factor-kappa B(NF-κB)signaling ***:A rat model of RIR was developed by increasing the pressure of the anterior chamber of the *** male Sprague Dawley were randomly divided into five groups:sham group(n=8),RIR group(n=28),RIR+NAS group(n=28),RIR+FPS-ZM1 group(n=8)and RIR+NAS+FPS-ZM1 group(n=8).The therapeutic effects of NAS were examined by hematoxylin-eosin(H&E)staining,and retinal ganglion cells(RGCs)*** expression of interleukin 1 beta(IL-1β),HMGB1,RAGE,and nod-like receptor 3(NLRP3)proteins and the phosphorylation of nuclear factorkappa B(p-NF-κB)were analyzed by immunohistochemistry staining and Western blot *** expression of HMGB1 protein was also detected by enzyme-linked immunosorbent assay(ELISA).RESULTS:H&E staining results showed that NAS significantly reduced retinal edema and increased the number of RGCs in RIR *** NAS therapy,the HMGB1 and RAGE expression decreased significantly,and the activation of the NF-κB/NLRP3 pathway was antagonized along with the inhibition of p-NF-κB and NLRP3 protein ***,NAS exhibited an anti-inflammatory effect by reducing IL-1β*** inhibitory of RAGE binding to HMGB1 by RAGE inhibitor FPS-ZM1 led to a significant decrease of p-NF-κB and NLRP3 expression,so as to the IL-1βexpression and retinal edema,accompanied by an increase of RGCs in RIR ***:NAS may exhibit a neuroprotective effect against RIR via the HMGB1/RAGE/NF-κB signaling pathway,which may be a useful therapeutic target for retinal disease.

关键词： retinal diseases retinal ischemia—reperfusion injury N-acetylserotonin high mobility group box 1 receptor for advanced glycation end-products nuclear factor-κB rats

Effect of endometrial thickness on the risk of ectopic pregnancy for frozen embryo transfer

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Reproductive and Developmental Medicine 2024年第2期8卷 75-81页

作者： Li-Juan Huang qu Zheng Xue-Jiao Wang Zhao-Hui Zhong Li-Juan Fu Xing-yu Lv Li-Hong Geng Xiao-Jun Tang yu-Bin Ding Qi Wan Department of Obstetrics and Gynecology Women and Children’s Hospital of Chongqing Medical UniversityChongqing 401147China School of Public Health Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of ChinaChongqing 400016China The Reproductive Center Chengdu Xinan Gynecology HospitalChengdu 610011China School of Public Health Research Center for Medical and Social DevelopmentChongqing Medical UniversityChongqing 400016China Department of Pharmacology Academician WorkstationChangsha Medical UniversityChangsha 410119China Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengdu 610041China

Objective:Few studies have explored the suitability of endometrial thickness(EMT)as a predictor of ectopic pregnancy(EP)in frozen embryo transfer(FET)*** study aimed to investigate the association between EMT and EP and explore the cutoff value of EMT to predict ***:This retrospective cohort study included women aged 20-45 years undergoing FET between March 2015 and September *** primary outcomes and measured variables were EP and EMT,*** threshold effect of EMT on EP was calculated based on a constructed smooth curve *** patients were divided into two groups based on the threshold for comparison.A subgroup analysis was conducted to examine whether the relationship between EMT and EP remained consistent across the different ***,a generalized linear model was used to analyze the interactions between the treatment factors and EMT in ***:In total,27,549 FET cycles were included,with 27,086 intrauterine and 463 ectopic *** risk of EP in the EMT≤8.7 mm group was 3.36 times higher than that in the EMT>8.7 mm group(odds ratio[OR]:3.36,95%confidence interval[CI]:2.57-4.05).Subgroup analysis further indicated that a thin EMT was a risk factor for EP,independent of other *** also noted that diminished ovarian reserve,tubal factor infertility,transfer of two embryos,or transfer of cleavage-stage embryos may further enhance the risk of EP in patients with thin ***:Thin endometrium was associated with an increased risk of *** with EMT less than 8.7 mm need close medical observation and management after embryo *** addition,diminished ovarian reserve,tubal factor infertility,transfer of two embryos,or transfer of cleavage-stage embryos may significantly enhance the effect of a thin endometrium on the risk of EP.

关键词： Endometrial thickness Thin endometrium Ectopic pregnancy FET cycle Risk factors

Exploring the impact of non-small cell lung cancer tumor microbiome on the efficacy of chemotherapy and immune checkpoint inhibitors

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Cancer Advances 2024年第5期7卷 1-10页

作者： Yan Dong Tian-Hao qu Xi-yue Zhang Hai-yu Chen yu-Jun Li Bin Zhang Ping Gao Ling Wang Chun-Xia Zhang Jia Li Xiao-Nan Cui Department of Oncology The First Hospital of Dalian Medical UniversityDalian 116000China.

Background:This study aimed to investigate the potential of intratumoral microbiota,gut microbiome,peripheral blood T-cell subsets,and inflammatory markers as predictive biomarkers for antitumor efficacy in patients with non-small cell lung ***:This study observed patients with metastatic non-driver mutation non-small cell lung cancer who were initially diagnosed at the First Affiliated Hospital of Dalian Medical University’s Department of Oncology from August 2021 to July 2022 and completed at least four cycles of chemotherapy combined with immune checkpoint inhibitor *** biopsy tissues,fecal,and peripheral blood samples were collected from these *** on the efficacy of the combined chemotherapy and immunotherapy,patients were divided into an effective group and an ineffective *** tumor microbiota,gut microbiome,peripheral blood T-cell subsets,and inflammatory markers were compared between the two *** lung and fecal microbiota were analyzed using 16S rRNA high-throughput *** cytometry was used to detect T-cell subsets,and enzyme-linked immunosorbent assay was employed to measure inflammatory ***:A total of 21 patients were *** were significant differences in the tumor microbiota between the responsive and non-responsive groups,particularly the proportion of the genera Sphingomonas and *** gut microbiome composition changed after treatment,but there were no differences between the two groups before *** were no significant differences in T-cell subsets and inflammatory markers between the responsive and non-responsive ***:The composition of intratumoral microbiota in non-small cell lung cancer patients may serve as an indicator of response to chemotherapy combined with *** predictive value of gut microbiota,T-cell subsets,and inflammatory markers appears *** research should further validate the predictive role of changes in gu

关键词： NSCLC tumor microenvironment gut microbiota tumor-associated microbiota

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“双碳”目标下的乡村体育旅游低碳发展

体育文化导刊 2024年第3期 89-96页

作者：屈钰丰腊甜甜屈铭喆屈东华郑州旅游职业学院体育学院郑州451464 郑州西亚斯学院体育学院郑州451100 郑州大学体育学院运动训练系郑州450044

运用文献资料、实地调研等方法,探究“双碳”目标下乡村体育旅游低碳发展的意义、困境,并提出发展路径。意义:推进城乡绿色低碳发展,加快产业结构优化升级,推动供需两端良性互动,提升企业生态责任能力,加快培育绿色消费潜力。困境:政策... 详细信息

运用文献资料、实地调研等方法,探究“双碳”目标下乡村体育旅游低碳发展的意义、困境,并提出发展路径。意义:推进城乡绿色低碳发展,加快产业结构优化升级,推动供需两端良性互动,提升企业生态责任能力,加快培育绿色消费潜力。困境:政策机制供给乏力,产业融合深度有限,要素市场化配置效率偏低,企业低碳运营薄弱,低碳消费动能受阻。路径:优化政策保障体系,共建共享产业融合新格局,释放市场要素配置潜能,构建企业低碳运营新局面,促进消费方式绿色转型。

关键词：体育经济乡村体育旅游低碳发展 “双碳”目标

具有中点电压平衡与零序电流抑制的T型三电平逆变器供电六相PMSM-DTC

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电工技术学报 2024年第20期39卷 6371-6385页

作者：黄德猛周扬忠屈艾文禹春敏福州大学福建省新能源发电与电能变换重点实验室

在三电平六相电机驱动系统中，存在中点电压不平衡及零序电流导致定子电流畸变等问题。为此，该文针对T型三电平逆变器供电的六相永磁同步电机，提出一种具有中点电压平衡与零序电流抑制功能的直接转矩控制（DTC）策略。为实现DTC的快... 详细信息

在三电平六相电机驱动系统中，存在中点电压不平衡及零序电流导致定子电流畸变等问题。为此，该文针对T型三电平逆变器供电的六相永磁同步电机，提出一种具有中点电压平衡与零序电流抑制功能的直接转矩控制（DTC）策略。为实现DTC的快速构建，该策略基于两电平三相电机DTC结构，利用精简后的开关状态，在六相绕组轴线上分别合成满足控制要求的4个电压矢量，然后通过两个滞环比较器结合简单的扇区划分，确定最优电压矢量所在轴线，同时构建中点电压与零序电流控制平面，并对系统在控制平面所处扇区进行判断。在此基础上，根据最优电压矢量所在绕组的相电流iy的极性，实现最优电压矢量的选择，并进一步构建DTC最优开关矢量表。最后，通过实验结果验证了所提控制策略的可行性和有效性。

关键词： T型三电平逆变器六相永磁同步电机直接转矩控制中点电压平衡零序电流抑制

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稀燃条件下甲烷-空气预混射流的着火特性

同济大学学报（自然科学版） 2024年第5期52卷 815-821页

作者：于洋瞿宗举谢巍邓俊吴志军同济大学汽车学院上海201804

基于可控热氛围燃烧试验系统,探究射流当量比、射流速率和协流速率对甲烷-空气预混射流着火特性的影响。根据试验规律对天然气发动机稀薄燃烧的控制策略提出优化建议,以减少失火现象的发生。结果表明:随着协流温度的升高,甲烷-空气预混... 详细信息

基于可控热氛围燃烧试验系统,探究射流当量比、射流速率和协流速率对甲烷-空气预混射流着火特性的影响。根据试验规律对天然气发动机稀薄燃烧的控制策略提出优化建议,以减少失火现象的发生。结果表明:随着协流温度的升高,甲烷-空气预混射流的稀燃极限降低而富燃极限升高,符合大多数碳氢燃料预混合气的着火界限分布规律。不同的射流速率和协流速率下均存在临界当量比,当低于临界当量比时,着火温度随射流当量比的升高而显著降低,当高于临界当量比时,着火温度趋于稳定。在较低的射流当量比工况(0.20~0.62)下,提高射流速率可以降低着火温度从而优化着火性能。

关键词：动力机械工程天然气发动机稀薄燃烧着火温度失火

基于生理药动学模型的瑞舒伐他汀口服吸收及饮食影响分析

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中国现代应用药学 2024年第8期41卷 1021-1026页

作者：孙烨文屈昱晨潘杰俞蕴莉苏州大学药学院江苏苏州215127 苏州大学附属第二医院药学部江苏苏州215004

目的通过构建瑞舒伐他汀空腹状态下的生理药动学(physiologically based pharmacokinetic model,PBPK)模型,预测其餐后状态下的吸收,并探究其可能的食物效应机制,为服用他汀类药物的高脂血症患者提出合理的饮食建议,提高BCSⅢ类他汀类... 详细信息

目的通过构建瑞舒伐他汀空腹状态下的生理药动学(physiologically based pharmacokinetic model,PBPK)模型,预测其餐后状态下的吸收,并探究其可能的食物效应机制,为服用他汀类药物的高脂血症患者提出合理的饮食建议,提高BCSⅢ类他汀类药物的药物吸收。方法根据文献和已有研究获得瑞舒伐他汀建模的理化参数、生物药剂学参数以及药动学参数,利用Gastro Plus^(TM)软件建立瑞舒伐他汀餐后给药的PBPK预测模型,并结合实测的血药浓度数据验证模型,判断是否可以准确预测出瑞舒伐他汀餐后的药物吸收结果,并进行参数敏感性分析。结果通过构建瑞舒伐他汀PBPK模型预测其餐后吸收,计算得到模型预测数据与实测数据的平均折叠误差和绝对平均折叠误差<2,结合模型验证的拟合相关系数表明拟合效果较好,同时参数敏感性分析提示高热量饮食、药物的油水分配系数(Log D)和渗透性对瑞舒伐他汀的吸收影响较大。结论所建立的模型能够较好地预测瑞舒伐他汀餐后状态下的吸收,基于参数敏感性分析结果,为服用BCSⅢ类他汀类药物的高脂血症患者提出合理的饮食建议,包括适当增加饮食中蛋白质的比重、减少脂肪和水溶性膳食纤维的占比等,可提高BCSⅢ类他汀类药物的肠道吸收。

关键词：生理药动学模型瑞舒伐他汀饮食影响