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Global trends in publications regarding macrophages-related diabetic foot ulcers in the last two decades

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World Journal of Diabetes 2024年第7期15卷 1627-1644页

作者： Jian-Ping Wen Shuan-Ji Ou Jia-Bao Liu Wei Zhang yu-Dun qu Jia-Xuan Li Chang-Liang Xia Yang Yang Yong Qi Chang-Peng Xu Department of Orthopaedics The Affiliated Guangdong Second Provincial General Hospital of Jinan UniversityGuangzhou 510000Guangdong ProvinceChina The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Diabetic foot ulcers(DFUs)are one of the most severe and popular complications of *** persistent non-healing of DFUs is the leading cause of amputation,which causes significant mental and financial stress to patients and their *** are critical cells in wound healing and perform essential roles in all phases of wound ***,no studies have been carried out to systematically illustrate this area from a scientometric point of *** there have been some bibliometric studies on diabetes,reports focusing on the investigation of macrophages in DFUs are *** To perform a bibliometric analysis to systematically assess the current state of research on macrophage-related *** The publications of macrophage-related DFUs from January 1,2004,to December 31,2023,were retrieved from the Web of Science Core Collection on January 9,*** different analytical tools:VOSviewer(v1.6.19),CiteSpace(v6.2.R4),HistCite(v12.03.07),and Excel 2021 were used for the scientometric *** A total of 330 articles on macrophage-related DFUs were *** most published countries,institutions,journals,and authors in this field were China,Shanghai Jiao Tong University of China,Wound Repair and Regeneration,and Aristidis *** the analysis of keyword co-occurrence networks,historical direct citation networks,thematic maps,and trend topics maps,we synthesized the prevailing research hotspots and emerging trends in this *** Our bibliometric analysis provides a comprehensive overview of macrophage-related DFUs research and insights into promising upcoming research.

关键词： Diabetic foot ulcers Macrophage Macrophage polarization Bibliometrics Wound healing Inflammation

Thiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2132-2142页

作者： Xinglong Han Lina qu Miao yu Lingqun Ye Liujia Shi Guangfu Ye Jingsi Yang Yaning Wang Hao Fan Yong Wang Yingjun Tan Chunyan Wang Qi Li Wei Lei Jianghai Chen Zhaoxia Liu Zhenya Shen Yinghui Li Shijun Hu Department of Cardiovascular Surgery of the First Affiliated Hospital&Institute for Cardiovascular Science State Key Laboratory of Radiation Medicine and ProtectionSuzhou Medical CollegeSoochow UniversitySuzhouChina State Key Laboratory of Space Medicine China Astronaut Research and Training CenterBeijingChina Department of Hand Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

During spaceflight,the cardiovascular system undergoes remarkable adaptation to microgravity and faces the risk of cardiac ***,the effects and mechanisms of microgravity on cardiac morphology,physiology,metabolism,and cellular biology need to be further *** China started constructing the China Space Station(CSS)in 2021,we have taken advantage of the Shenzhou-13 capsule to send human pluripotent stem cell-derived cardiomyocytes(hPSC-CMs)to the Tianhe core module of the *** this study,hPSC-CMs subjected to space microgravity showed decreased beating rate and abnormal intracellular calcium *** and transcriptomic analyses revealed a battery of metabolic remodeling of hPSC-CMs in spaceflight,especially thiamine *** microgravity condition blocked the thiamine intake in *** decline of thiamine utilization under microgravity or by its antagonistic analog amprolium affected the process of the tricarboxylic acid *** decreased ATP production,which led to cytoskeletal remodeling and calcium homeostasis imbalance in *** importantly,in vitro and in vivo studies suggest that thiamine supplementation could reverse the adaptive changes induced by simulated *** study represents the first astrobiological study on the China Space Station and lays a solid foundation for further aerospace biomedical *** data indicate that intervention of thiamine-modified metabolic reprogramming in human cardiomyocytes during spaceflight might be a feasible countermeasure against microgravity.

关键词： programming battery modified

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贷款受托支付与企业短贷长投

金融论坛 2024年第7期 26-36页

作者：王禹曹以伦南开大学经济学院天津300071 内蒙古大学经济管理学院

本文以2010年《流动资金贷款管理暂行办法》的出台为外生冲击,利用中国A股上市公司数据研究贷款受托支付对企业短贷长投的影响。研究发现:贷款受托支付抑制了企业短贷长投;贷款受托支付通过促使企业增加长期融资并回归稳健经营的渠道抑... 详细信息

本文以2010年《流动资金贷款管理暂行办法》的出台为外生冲击,利用中国A股上市公司数据研究贷款受托支付对企业短贷长投的影响。研究发现:贷款受托支付抑制了企业短贷长投;贷款受托支付通过促使企业增加长期融资并回归稳健经营的渠道抑制了企业短贷长投,而固定资产投资渠道则并不显著;企业关联交易、高管金融背景和区域银行业竞争会削弱贷款受托支付的政策效果;贷款受托支付降低了企业破产风险。

关键词：贷款受托支付短贷长投贷中支付监管监管套利

Graphdiyne scaffold anchored highly dispersed ruthenium nanoparticles as an efficient cathode catalyst for rechargeable Li-CO_(2) battery

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Chinese Chemical Letters 2024年第1期35卷 552-557页

作者： Yiru Ma Huiqi qu Wenna Wang Ziyang Guo yueqin yu Feng Liu Bin yu Minge Tian Zhenjiang Li Bin Li Lei Wang College of Chemistry and Molecular Engineering State Key Laboratory Base of Eco-Chemical EngineeringInternational Science and Technology Cooperation Base of Eco-Chemical Engineering and Green ManufacturingQingdao University of Science and TechnologyQingdao 266042China College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042China College of Environment and Safety Engineering Qingdao University of Science and TechnologyQingdao 266042China College of Chemical Engineering Qingdao University of Science and TechnologyQingdao 266042China Biomedical Sensing Engineering Technology Research Center Shandong UniversityJi'nan 250100China Scientific Green(Shandong)Environmental Technology Co. Ltd.Jining Economic Development ZoneJining 272499China

Lithium (Li)-CO_(2) battery is rising as an attractive energy-storage system with the competence of CO_(2) conversion/fixation. However, its practical development is seriously hindered by the high overpotential. Herein, a rational design on a highly catalytic Li-CO_(2) battery electrode built by graphdiyne powder as a multi-functional laminar scaffold with anchored highly dispersed Ru nanoparticles is explored. The strong interaction between the abundant acetylenic bond sites of graphdiyne scaffold and Ru nanoparticles can effectively promote the electrochemical progress and reduce the voltage polarization. The unique channels architecture of the cathodic catalyst with enough space not only accelerates CO_(2) diffusion and electrons/Li+ transport, but also allows a large amount of accommodation for discharged product (Li2CO3) to assure an advanced capacity. The corresponding Li-CO_(2) battery displays an advanced discharged capacity of 15,030 mAh/g at 500 mA/g, great capacity retention of 8873 mAh/g at 2 A/g, high coulombic efficiency of 97.6% at 500 mA/g and superior life span for 120 cycles with voltage gap of 1.67 V under a restricted capacity of 1000 mAh/g at 500 mA/g. Ex/in-situ studies prove that synergy between Ru nanoparticles and acetylene bonds of GDY can boost the round-trip CO_(2)RR and CO_(2)ER kinetics.

关键词： Nanopores Li-CO_(2)battery Anchored Ru nanoparticles Graphdiyne Synergistic effect

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基于选区激光熔化镍基单晶高温合金的修复

中国有色金属学报 2024年第4期34卷 1376-1392页

作者：张宇沈超张鹏章林曲选辉北京科技大学新材料技术研究院北京100083 北京科技大学北京材料基因组高精尖创新中心北京100083 辽宁材料实验室材料智能技术研究所沈阳110000

选区激光熔化技术光斑和热影响区小,成形精度高,可对镍基单晶高温合金叶片进行有效的修复以延长使用寿命。本工作选用了一种具有中等体积分数γ′相的合金粉末,研究了在单晶CM247LC基板上进行外延生长过程中该合金粉末的显微组织演变规... 详细信息

选区激光熔化技术光斑和热影响区小,成形精度高,可对镍基单晶高温合金叶片进行有效的修复以延长使用寿命。本工作选用了一种具有中等体积分数γ′相的合金粉末,研究了在单晶CM247LC基板上进行外延生长过程中该合金粉末的显微组织演变规律以及力学性能。结果表明:修复界面的熔池宽深比大于4时,沉积区与基体能形成良好的结合界面以及较小的晶粒取向差。通过增大扫描速率和降低激光功率可以有效减小沉积区裂纹密度,沉积组织以沿沉积方向生长的柱状枝晶为主,沉积层越高,冷却速率越小,枝晶间距和晶粒取向差越大。通过打印参数优化,最终得到了裂纹密度低、晶粒取向单一、且与单晶基板结合优异的镍基单晶高温合金沉积层,其抗拉强度为1094 MPa,伸长率为21%。

关键词：镍基单晶高温合金选区激光熔化显微组织晶粒取向力学性能

YKL40 potentially via activating the P38 pathway in decreasing atherosclerotic plaque stability

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Chinese Medical Journal 2024年第8期137卷 1003-1005页

作者： Chao Wang Yandong Liu Wei Huan Jianjin Wu Jie Jin Sili Zou yu Chen Lefeng qu Department of Vascular and Endovascular Surgery Changzheng Hospital Affiliated to the Naval Medical UniversityShanghai 200003China Department of Emergency Navy 905th HospitalShanghai 200050China Clinical Research Institute of Integrative Medicine Yueyang HospitalShanghai University of Traditional Chinese MedicineShanghai 200437China

To the Editor:Atherosclerosis is the main pathological feature of ischemic stroke,which remains a major cause of disability and death worldwide.[1]Vulnerable plaque,was characterized by ulceration,platelet activation,and thrombosis,potentially leading to emboli detachment and stroke.[2]Vascular smooth muscle cells(VSMCs),a major cellular component within lesions,can display pleiotropic phenotypes,including osteogenic or inammatory phenotypes,which may be harmful in maintaining advanced atherosclerotic plaque stability.[3]The modulation of the function of VSMCs,including proliferation,migration,and synthesizing the extracellular matrix(ECM)and matrix metalloproteinase(MMP),is thought to markedly affect plaque formation and vulnerability.[4]Therefore,it is of considerable signicance to drive harmful VSMCs toward VSMCs having benecial properties to strengthen plaque stability and retard plaque development.

关键词： YKL40 markedly stability

Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3286-3290页

作者： Miao Zheng Bo Feng yumin Zhang Xin Liu NaZhao Hui Liu Zichao Xu Xinheng He Zhiyan qu ShizhaoChen Zhidong Jiang Xi Cheng Hong Liu Yi Zang Linxiang Zhao Jie Zheng Leike Zhang Jia Li yu Zhou Key Laboratory of Structure-Based Drugs Design&Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyang 110016China School of Life Sciences and Biopharmaceuticals Shenyang Pharmaceutical UniversityShenyang 110016China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203and University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Chemical Biology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203and University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China Lingang Laboratory Shanghai 200031China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Hubei Jiangxia Laboratory Wuhan 430200China

To the Editor:The papain-like protease(PL^(pro)),as one of the most important proteases of SARS-CoV-2,has emerged as a highly promising target protein,its inhibitor probably holds dual potentials,namely blocking the cleavage of viral polyprotein and intercepting the deubiquitination and deISGylation functions to restore antiviral immunity1.

关键词： Non-covalent PL^(pro)inhibitors Antiviral activity Structural-based drug design Imidazo[4,5-b]pyridine scaffold

对象随型粗糙面近红外单目视觉测量与基准图像自愈

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红外与毫米波学报 2024年第1期43卷 134-142页

作者：侯旺屈也频刘坚强吕余海海军研究院上海200436

针对复杂应用环境中近红外单目视觉位姿测量系统偏离预置合作目标对象后,无法完成位姿测量的特殊情况,提出一种以合作目标周边随型粗糙面图像为测量对象的单目视觉测量方法,以及图像受损后的动态自愈方法。通过将实时获取的随型粗糙面... 详细信息

针对复杂应用环境中近红外单目视觉位姿测量系统偏离预置合作目标对象后,无法完成位姿测量的特殊情况,提出一种以合作目标周边随型粗糙面图像为测量对象的单目视觉测量方法,以及图像受损后的动态自愈方法。通过将实时获取的随型粗糙面图像特征与预存基准图像特征进行匹配计算,完成特殊情况下的应急测量。同时,为减少随型粗糙面图像污染或受损后对位姿测量精度的影响,实时计算污染或受损程度并动态自愈基准图像特征。实验结果表明,以随型粗糙面为对象的位姿测量精度稍低于合作目标对象,但能够满足特殊情况下的应急使用需求,提高了测量系统的鲁棒性;当随型粗糙面图像污染或受损达到70%时,采用自愈处理与未做自愈处理相比,方位角测量误差减少72%以上,验证了基准图像自愈方法的有效性。

关键词：对象随型粗糙面近红外单目视觉测量基准图像自愈基准图像特征特征匹配

High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia

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Science China(Life Sciences) 2024年第8期67卷 1635-1647页

作者： Feng-Qi Liu Qing-yuan qu Ying Lei Qi Chen yu-Xiu Chen Meng-Lin Li Xue-Yan Sun Ye-Jun Wu Qiu-Sha Huang Hai-Xia Fu yuan Kong yue-Ying Li Qian-Fei Wang Xiao-Jun Huang Xiao-Hui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Collaborative Innovation Centre of Hematology Peking UniversityBeijing 100044China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100074China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China

To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight(CyTOF).Thirtysix patients with ITP and nine healthy volunteers were enrolled in the *** soluble immunomodulatory molecules,more sCD25 and sGalectin-9 were detected in ITP *** the cell surface,co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T *** contrast,co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1 and Th17 cell *** a platelet count of 30×10^(9)L^(−1)as the cutoff value,ITP patients with high and low platelet counts showed different T cell immune ***-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions,respectively,and participate in the pathogenesis of *** conclusion,the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of *** may offer novel targets to develop personalized immunotherapies.

关键词： immune thrombocytopenia autoimmune diseases co-stimulatory co-inhibitory immune checkpoint CTLA4 Cytometry by Time of Flight bone marrow