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Bioactive Materials 2022年第5期7卷 300-316页

作者： Shuting Xu Peng Yang Kang Qian Yixian Li Qian Guo Pengzhen Wang Ran meng Jing Wu Jinxu Cao Yunlong Cheng Minjun Xu qizhi Zhang Key Laboratory of Smart Drug Delivery Ministry of EducationSchool of PharmacyFudan UniversityShanghai201203China

Compromised autophagy and defective lysosomal clearance significantly contribute to impaired neuronal proteostasis,which represents a hallmark of Alzheimer’s disease(AD)and other age-related neurodegenerative *** evidence has implicated that modulating autophagic flux,instead of inducing autophagosome formation alone,would be more reliable to rescue neuronal ***,selectively enhancing drug concentrations in the leision areas,instead of the whole brain,will maximize therapeutic efficacy while reduing non-selective autophagy ***,we design a ROS-responsive targeted micelle system(TT-NM/Rapa)to enhance the delivery efficiency of rapamycin to neurons in AD lesions guided by the fusion peptide TPL,and facilitate its intracellular release via ROS-mediated disassembly of micelles,thereby maximizing autophagic flux modulating efficacy of rapamycin in ***,it promotes the efficient clearance of intracellular neurotoxic proteins,β-amyloid and hyperphosphorylated tau proteins,and ameliorates memory defects and neuronal damage in 3×Tg-AD transgenic *** studies demonstrate a promising strategy to restore autophagic flux and improve neuronal proteostasis by rationally-engineered nano-systems for delaying the progression of AD.

关键词： Autophagic flux ROS-Responsive micelle system Brain-neuron targeting Rapamycin Alzheimer’s disease

A HYDRO-MECHANICAL-CHEMICAL COUPLING MODEL FOR GEOMATERIAL WITH BOTH MECHANICAL AND CHEMICAL DAMAGES CONSIDERED

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Acta Mechanica Solida Sinica 2012年第4期25卷 361-376页

作者： Dawei Hu Hui Zhou qizhi Hu Jianfu Shao Xiating Feng Haibin Xiao State Key Laboratory of Geomechanies and Geoteehnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China LML UMR8107CNRSUniversity of Lille IVilleneuve d'AscqFrance School of Civil Engineering and Architecture Hubei University of TechnologyWuhan 430068China Laneang River Hydropower Co. LtdKunming 650214China

A general framework of hydro-mechanical-chemical coupling model is proposed for geomaterial subjected to the dual effects of mechanical loading and chemical degradation. Mechanical damage due to microcracks in solid matrix and chemical damage induced by the increase of porosity due to dissolution of matrix minerals as well as their interactions are considered. A special model is proposed for sandstone. The reaction rate is formulated within the framework of mineral reaction kinetics and can thus take into account different dissolution mechanisms of three main mineral compositions under different pH values. The increase of porosity is physically defined by the dissolution of mineral composition and the chemical damage is related to the increase of porosity. The mechanical behavior is characterized by unified plastic damage and viscoplastic damage modeling. The effective stress is used for describing the effect of pore pressure. The elastic parameters and plastic evolution as well as viscoplastic evolution are dependent on chemical damage. The advection, which is coupled with mechanical damage and chemical damage, is considered as the dominant mechanism of mass transfer. The application of model proposed is from decoupled experiments to fully coupled experiment. The model offers a convenient approach to describing the hydro-mechanical-chemical coupled behavior of geomaterial.

关键词： hydro-mechanical-chemical coupling mechanical damage chemical damage sandstone chemical kinetics

Numerical simulation of temporal and spatial evolution of fold-thrust belts in the northern and northeastern margins of the Qinghai-Tibetan Plateau

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Earthquake Research Advances 2021年第S1期1卷 23-25页

作者： qizhi Chen Caibo Hu School of Earth and Planetary Sciences University of Chinese Academy of SciencesKey Laboratory of Computational GeodynamicsChinese Academy of SciencesBeijingChina

Fold-thrust belts are common structural styles under the background of long-term regional tectonic *** northern and northeastern margins of the Qinghai-Tibetan Plateau are located on the edge of the growth and expansion of the Qinghai-Tibetan *** nearly 10 Ma,some significant and typical fold thrust belt have been *** spatial-temporal evolution of these fold-thrust belts and the characteristics of surface deformations are significant issues in *** this paper,we use the elastoplastic finite element model with considering the contact nonlinearity to study the spatialtemporal evolution of the fold-thrust belts in the northern and northeastern margins of the Qinghai-Tibetan Plateau,with particular attention to the details of the relationship between the depth and the shallow,the spatialtemporal order,and the characteristics of the surface deformation,etc.,in order to make a relatively complete mechanical interpretation of the spatial-temporal evolution of the foldthrust belts in the northern and northeastern margins of the Qinghai-Tibetan Plateau from the perspective of geodynamics.

关键词： Fold-thrust belts Finite element model Elastoplasticity Northeastern margin of the Qinghai-Tibetan Plateau Frictonal contact

INTELLIGENT DECISION ALGORITHM FOR FAULT DETECTION AND ITS APPLICATION

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国防科技大学学报 1995年第3期17卷 33-40页

作者： Wu Jianjun Zhang Yulin Chen qizhi(Department of Aerospace Technology, NUDT,Changsha, 410073 )

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关键词：故障检测智能决策算法

Flexible lithium metal capacitors enabled by an in situ prepared gel polymer electrolyte

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Chinese Chemical Letters 2021年第11期32卷 3496-3500页

作者： qizhi Zhong Bao Liu Bingjun Yang Yali Li Junshuai Li Xingbin Yan Key Laboratoy of Special Function Materials Structure Design of the Ministry of Education and School of Materials&EnergyLanzhou UniversityLanzhou 730000China Laboratory of Clean Energy Chemistry and Materials State Key Laboratory of Solid LubricationLanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

The rapid development of next-generation flexible electronics stimulates the growing demand for flexible and wearable power sources with high energy *** metal capacitor(LMC),combining with a Li metal anode and an activated carbon cathode,exhibits extremely high energy density and high power density due to the unique energy storage mechanism,thus showing great potential for powering wearable electronic ***,a flexible LMC based on an in situ prepared PETEA-based gel polymer electrolyte(GPE)was reported for the first *** to the high ionic conductivity of PETEA-based GPE(5.75×10^(−3)S/cm at 20℃),the assembled flexible LMC delivers a high capacitance of 210 F/g at 0.1 A/g within the voltage range from 1.5 V to 4.3 V ***/Li^(+),a high energy density of 474 Wh/kg at 0.1 A/g and a high power density of 29 kW/kg at 10 A/*** importantly,PETEA-based GPE endows the LMC with excellent flexibility and safety,which could work normally under abuse tests,such as bending,nail penetration and *** in situ prepared PETEA-based GPE simplifies the fabrication process,avoids the risk of leakage and inhibits the growth of Li dendrite,making LMC a promising flexible energy storage device for the flexible electronic field.

关键词： Lithium metal capacitor In situ prepared gel polymer electrolyte Flexible Energy density Power density

Technology and application of pressure relief and permeability increase by jointly drilling and slotting coal

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International Journal of Mining Science and Technology 2012年第4期22卷 545-551页

作者： Lin Baiquan Zhang Jianguo Shen Chunming Zhang qizhi Sun Chen State Key Laboratory of Coal Resources and Mine Safety China University of Mining&TechnologyXuzhou 221008China School of Safety Engineering China University of Mining 6"TechnologyXuzhou 221008China Zhongping Energy Chemical Group Pingdingshan 467000China

Difficulties with soft coal seams having a high gas content and high stress levels can be addressed by a technology of pressure relief and permeability *** the seam by auxiliary drilling with a water jet that breaks the coal and slots the coal seam during the process of retreat drilling achieves pressure relief and permeability *** efficiency of gas extraction from a field test,high gas coal seam was *** the theory of pressure relief and permeability increase required analyzing the characteristics of the double power slotting process and the effects of coal pressure relief and permeability *** influence of confining pressure on coal physical properties was examined by using FLAC3D software code to simulate changes of coal stress within the tool destruction *** double power joint drilling method was *** experiments were performed and the effects are *** research shows that there is an ''islanding effect'' in front of the joint double power drill and slotting *** failure strength of the coal seam is substantially reduced within the tool destruction *** depths are increased by 72% and the diameter of the borehole is increased by 30%.The amount of powdered coal extracted from the drill head increases by 17 times when using the new method.A 30 day total flow measurement from the double power drilled and slotted bores showed that gas extraction increased by 1.3 times compared to the standard drilled *** concentrations increased from 30% to 60% and were more stable so the overall extraction efficiency increased by a factor of two times.

关键词： Collaborative drillingDouble powerSlottingPressure relief and permeability increase

Induced drill-spray during hydraulic slotting of a coal seam and its influence on gas extraction

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International Journal of Mining Science and Technology 2012年第6期22卷 785-791页

作者： Shen Chunming Lin Baiquan Zhang qizhi Yang Wei Zhang Lianjun School of Safety Engineering China University of Mining & Technology Hunan Provincial Key Laboratory of Safe Mining Techniques of Coal Mines Hunan University of Science and Technology

Hydraulic slotting can induce drill spray in a gassy,low permeability coal *** then influences subsequent gas *** paper describes the drill spray phenomenon from a mechanical perspective and analyzes the effects of water jet damage during slotting.A simulation of the stresses around the drill hole and slot was prepared using FLAC-3D *** helps explain the induction of drill spray during hydraulic *** stress concentration around the bore increases as the diameter of the hole *** the hole enlarges the variation in stress also increases,which introduces an instability into the *** allows easy breaking and removal of the *** of the coal structure by the water jet is the major factor causing drill *** stored as either strain or gas pressure is released by the water jet and this causes the coal to fracture and be expelled from the *** tests showed the effect on gas extraction after slotting with drill *** concentration of gas increases after *** to conventional techniques,the hydraulic slotted bore gives a gas concentration three times higher and has an effective range twice as *** makes the gas extraction process more efficient and allows reduced construction effort.

关键词： Slotted Drill-spray Water jet Pressure relief and permeability increase Gas extraction

Fact-condition statements and super relation extraction for geothermic knowledge graphs construction

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Geoscience Frontiers 2023年第5期14卷 384-395页

作者： qizhi Chen Hong Yao Shengwen Li Xinchuan Li Xiaojun Kang Wenwen Lai Jian Kuang School of Computer Science China University of GeosciencesWuhan 430074China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan 430074China School of Geography and Information Engineering China University of GeosciencesWuhan 430074China

Researchers utilize information from the geoscience literature to deduce the regional or global geological *** this process has relied on the labor of *** the number of papers continues to increase,acquiring domain-specific knowledge becomes a heavy *** Graph(KG)is proposed as a new knowledge representation technology to change this ***,the super relation is not considered in the previous KG,which bridges the geological phenomenon(fact)and its precondition(condition).For instance,in the statement(“the late Archean was a crucial transition period in the history of global geodynamics”),the condition statement(“crucial transition for global geodynamics”)works as the complementary fact statement(“the late Archean was a crucial transition period”),which defines the scale of crucial transition accurately in the late *** this study,fact-condition statement extraction is introduced to construct a geological knowledge graph.A rule-based multi-input multi-output model(R-MIMO)is proposed for information *** the R-MIMO,fact-condition statements and their super relation are considered and extracted for the first *** verify its performances,a GeothCF dataset with 1455 fact tuples and 789 condition tuples is *** experiments,the R-MIMO model achieves the best performance by using BERT as encoder and LSTM-d as decoder,achieving F180.24%in tuple extraction and F170.03%in tag prediction ***,the geothermic KG with super relation is automatically constructed for the first time by trained R-MIMO,which can provide structured data for further geothermic research.

关键词： Fact-condition statements Super relation Knowledge graph Rule-based multi-input multi-output model

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News in Brief

China City Planning Review 2019年第1期28卷 3-5页

作者： Qian Fang(译) Mao qizhi(校) 不详

China Celebrates 40th Anniversary of Reform and Opening-Up,*** Liangyong Awarded the Medal of Reform Pioneer China held a grand gathering on Dec.18,2018 to celebrate the 40th anniversary of the country’s reform and o... 详细信息

关键词： News in Brief Office

Experimental investigation on the macro-mechanical behavior and micromechanical damage model of Xiyu conglomerate with pores and inclusions under triaxial compression

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International Journal of Mining Science and Technology 2024年第11期34卷 1529-1549页

作者： Yajun Cao Xuelei Duan Wei Wang qizhi Zhu Dengfeng Zhao Long Jiang Qiang Zhang Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing 210024China Institute of Geotechnical Engineering Hohai UniversityNanjing 210024China Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Shenyang 110819China Momoke Water Conservancy Project Construction Management Bureau Kashgar 844900China Institute of Geotechnical Engineering China Institute of Water Resources and Hydropower ResearchBeijing 100048China

The complex and special mechanical properties of Xiyu conglomerate are of great significance to the construction of water conservancy and hydropower *** crack characteristic stress,dilatancy behavior,and failure mechanism of Xiyu conglomerate collected from Momoke Water Control Project,southwestern China,were analyzed and discussed based on the experimental results of triaxial compression test and 3D X-ray computed tomography *** results show that with increasing confining pressure,the deformation characteristics and all characteristic stresses increase monotonically,while the dilation angle and dilatancy index decrease,and exponential function model can accurately describe the evolution rule of dilatancy index with confining *** the porosity is negatively correlated with confining *** failure modes of Xiyu conglomerate include axial tensile cracks,shear cracks,local cross cracks and cracks around *** increasing confining pressure,the failure modes transform from tension cracks to shear cracks.A non-associated micromechanical damage model considering pressure dependent matrix presenting tension-compression asymmetry is proposed and applied to Xiyu conglomerate with pores and a large number of *** comparing numerical calculations and experimental results,the proposed micromechanical plastic damage model is able to describe the mechanical behavior of Xiyu conglomerate.

关键词： Xiyu conglomerate Crack characteristic stress Dilation behavior CT observation Micromechanical plastic damage model