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Metal nanoparticles for cancer therapy:Precision targeting of DNA damage

Acta Pharmaceutica Sinica B 2024年第3期14卷 1132-1149页

作者： Qian Chen Chunyan Fang Fan Xia qiyue wang Fangyuan Li Daishun Ling Institute of Pharmaceutics Hangzhou Institute of Innovative MedicineCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringNational Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China World Laureates Association(WLA)Laboratories Shanghai 201203China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Hangzhou 310009China

Cancer,a complex and heterogeneous disease,arises from genomic ***,DNA damage-based cancer treatments,including radiotherapy and chemotherapy,are employed in clinical ***,the efficacy and safety of these therapies are constrained by various factors,limiting their ability to meet current clinical *** nanoparticles present promising avenues for enhancing each critical aspect of DNA damage-based cancer *** customizable physicochemical properties enable the development of targeted and personalized treatment *** this review,we delve into the design principles and optimization strategies of metal *** shed light on the limitations of DNA damage-based therapy while highlighting the diverse strategies made possible by metal *** encompass targeted drug delivery,inhibition of DNA repair mechanisms,induction of cell death,and the cascading immune ***,we explore the pivotal role of physicochemical factors such as nanoparticle size,stimuli-responsiveness,and surface modification in shaping metal nanoparticle ***,we present insights into the challenges and future directions of metal nanoparticles in advancing DNA damage-based cancer therapy,paving the way for novel treatment paradigms.

关键词： DNA damage Metal nanoparticles Nucleus-targeting DNA repair inhibition Immune response Size optimization Stimuli-responsiveness Surface modification

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Flexible,efficient,and accurate tests for epidemics

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Science China Mathematics 2024年第8期67卷 1881-1898页

作者： Linjiajie Fang Bing-Yi Jing Shen Ling qiyue wang Qing Yang Data Science and Analytics Thrust The Hong Kong University of Science and TechnologyHong KongChina Department of Statistics and Data Science Southern University of Science and TechnologyShenzhen 518055China Department of Mathematics and Statistics Dalhousie UniversityHalifaxNS B 3H 4R 2Canada Department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina

Group testing involves discovering a small subset of distinguished subjects from a large population while efficiently reducing the total number of *** has been widely used for industrial testing,information technology,and biology,especially epidemic ***,in reality,are noisy for the presence of false *** tests are accurate but time-consuming,while others are cheaper but less *** which test to use is constrained by various considerations,such as availability,cost,accuracy,and *** this paper,we propose flexible,efficient,and accurate tests(FEATs).FEATs are based on group testing with simple but careful designs by incorporating ideas such as close contact cliques and repeated *** could dramatically improve the efficiency or accuracy of existing *** example,for accurate but slow tests,the FEAT can improve efficiency multiple times without compromising *** the other hand,for fast but inaccurate tests,the FEAT can sharply reduce the false-negative rate(FNR)and significantly increase *** justifications are *** point out some scenarios where the FEAT can be effectively employed.

关键词： epidemiology control blood testing testing efficiency testing accuracy

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Reversibly size-switchable polyion complex micelles for antiangiogenic cancer therapy

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Chinese Chemical Letters 2024年第7期35卷 377-382页

作者： Mengjuan Sun Muye Zhou Yifang Xiao Hailei Tang Jinhua Chen Ruitao Zhang Chunjiayu Li Qi Ya Qian Chen Jiasheng Tu qiyue wang Chunmeng Sun NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients China Pharmaceutical UniversityNanjing 210009China State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 211198China Department of Pharmaceutics School of PharmacyChina Pharmaceutical UniversityNanjing 211198China Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics China Pharmaceutical UniversityNanjing 210009China School of Pharmaceutical Science Nanjing Tech UniversityNanjing 211816China

Size is one of the most important characteristics of nanoparticles to influence their biodistribution and antitumoral *** with large sizes have difficulty in deep tumor penetration,while small particles are easily removed from tumor tissues due to the high tumor interstitial fluid *** address these issues,an intelligent core-crosslinked polyion complex micelle(cPCM)with a reversibly sizeswitchable feature was engineered in this *** micelles are consisting of methoxy poly(ethylene glycol)-poly(D,L-lactide)copolymer(mPEG-PLA),mPEG-PLA-(HE)6CC,and mPEG-PLA-(RG)6CC at an optimal mass ratio of 6:1:1 with an antiangiogenic compound,dabigatran etexilate(DE),*** net charge inside the micelles is switchable when exposed to different pH conditions,thereby leading to revisable size-change of ***-loaded micelles(DE@cPCM)can swell and release drugs at the tumor sites with a mildly acidic pH,while they shrink and protect the cargo from leaking into the blood circulation with a neutral *** indicated that DE@cPCM can inhibit tumor angiogenesis in vitro and in vivo,thereby efficiently restraining tumor growth in a 4T1-bearing mouse ***,the sizeswitchable cPCM is a promising nanoplatform for targeting delivery of anticarcinogens into the matrix of tumor tissues.

关键词： Polyion complex micelle Size-switchable Revisable size-change pH response Antiangiogenic cancer

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西夏文字构件中的区别性符号

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西夏研究 2024年第2期 25-35页

作者：段玉泉王启越宁夏大学西夏学研究院宁夏大学民族与历史学院

西夏文字构形过程中,参与构形的构件除常见的意符、声符之外,还有一类与音义皆无关联。其主要功能是起区别性作用,因之在前人研究基础上改称为区别性符号。在完整字形基础上通过添加而出现的同一形体构件不都是区别性符号,区别性符号的... 详细信息

西夏文字构形过程中,参与构形的构件除常见的意符、声符之外,还有一类与音义皆无关联。其主要功能是起区别性作用,因之在前人研究基础上改称为区别性符号。在完整字形基础上通过添加而出现的同一形体构件不都是区别性符号,区别性符号的判别必须放在每个字的形成过程中去分析,构意清晰、构形理据明确。区别性符号用于造同源字、同义词、复合词语中的关联字以及记录词性变化的字,它们可以出现在一个字的左、右、上、下以及中间部位,因位置的不同有一系列不同的构件。区别性符号的正确认识对于西夏文字构形研究以及探讨西夏文字的形成有重要意义。西夏文字中的区别性符号与汉字中的“记号”颇为相似,但只起区别性作用,而无替代功能。

关键词：西夏文字文字构形构件区别性符号记号

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点状热干扰源诱导的准各向同性高温超导股线失超特性

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电工技术学报 2024年第2期39卷 369-377页

作者：王起悦刘子秋孙梓源杨宇皮伟华北电力大学新能源电力系统国家重点实验室北京102206 国网山东省电力公司济南供电公司济南250000

第二代高温超导带材因其较高的临界电流密度以及良好的机械特性,近年来在超导研究领域得到极大关注。由REBCO带材组成的高温超导导体在液氮温度下的零电阻特性使其在超导输电领域具有巨大的潜力。从安全角度看,高温超导导体的失超保护... 详细信息

第二代高温超导带材因其较高的临界电流密度以及良好的机械特性,近年来在超导研究领域得到极大关注。由REBCO带材组成的高温超导导体在液氮温度下的零电阻特性使其在超导输电领域具有巨大的潜力。从安全角度看,高温超导导体的失超保护研究是其获得广泛应用的一个关键。该文建立了准各向同性超导股线的三维失超仿真模型,耦合了电场、磁场和温度场,模拟了不同运行电流以及不同点状热干扰能量下超导股线的失超行为,求解出股线的温度、电流密度以及磁场分布,得到了准各向同性高温超导股线的最小失超能(MQE)以及失超传播速度(QPV),对超导装置的失超保护具有重要意义。该文对准各向同性超导股线建立的三维失超模型,也可以应用到其他结构的高温超导导体的失超研究中。

关键词：准各向同性超导股线失超行为最小失超能失超传播速度

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Nature-inspired supramolecular assemblies for precise biomedical imaging and therapy

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Acta Pharmaceutica Sinica B 2022年第10期12卷 4008-4010页

作者： Yamin Liu qiyue wang Fangyuan Li Daishun Ling Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringNational Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200438China Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China

To the editor:The precise diagnosis and effective therapy of refractory diseases,such as neurodegenerative diseases,coronary heart diseases and cancers,is critical to increase the survival rate and improve the life quality of *** of the conventional small molecular medicines are heavily associated with the limitations of poor solubility,low targeting efficiency,inducing drug resistance and systemic toxicity,promoting scientists to develop new strategies for overcoming these limitations.

关键词： Supramolecular assembly Biomedical applications Diagnosis Therapy Nature-inspired

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Tumor-responsive dynamic nanoassemblies for boosted photoimmunotherapy

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Nano Research 2023年第8期16卷 11125-11138页

作者： Dao Shi Nan wang Jie Zhang Xi Hu qiyue wang Ruixue Xiao Baoyue Ding Fangyuan Li Daishun Ling Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringNational Center for Translational MedicineState Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong UniversityShanghai 200240China Institute of Pharmaceutics Hangzhou Institute of Innovative MedicineCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Pharmaceutics Jiaxing Key Laboratory for Photonanomedicine and Experimental TherapeuticsCollege of MedicineJiaxing UniversityJiaxing 314001China World Laureates Association(WLA)Laboratories Shanghai 201203China School of Pharmacy Anhui University of Chinese MedicineHefei 230012China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Hangzhou 310009China

Photoimmunotherapy(PIT)is an emerging therapeutic approach that integrates phototherapy and immunotherapy to eliminate primary tumors under an appropriate dosage of local light irradiation,while simultaneously preventing tumor metastasis and recurrence by activating the host antitumor immune ***-responsive dynamic nanoassemblies(TDNs)have evolved from being a mere curiosity to a promising platform for high-performance ***,the dynamic nano-bio interaction between TDNs and tumor microenvironment remains poorly understood,which shall be critical for precise control of TDNs assembling/disassembling behavior and superior PIT *** deepen the understanding of the structure–function relationship of TDNs,this review introduces the rational design,nano-bio interactions,and controllable functionalities of cutting-edge TDNs for enhanced ***,the synergetic mechanism between TDNs-based PIT and immunomodulatory agents-mediated immunomodulation is particularly ***,the challenges and future perspectives in this emerging field are assessed.

关键词： photoimmunotherapy tumor-responsive dynamic nanoassemblies immunosuppressive tumor microenvironment

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A novel deep learning framework with variational auto-encoder for indoor air quality prediction

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Frontiers of Environmental Science & Engineering 2024年第1期18卷 97-109页

作者： qiyue Wu Yun Geng Xinyuan wang Dongsheng wang ChangKyoo Yoo Hongbin Liu Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry UniversityNanjing 210037China College of Automation&College of Artificial Intelligence Nanjing University of Posts and TelecommunicationsNanjing 210023China Guangxi Key Laboratory of Clean Pulp&Papermaking and Pollution Control College of Light Industry and Food EngineeringGuangxi UniversityNanning 530004China Laboratory for Comprehensive Utilization of Paper Waste of Shandong Province Shandong Huatai Paper Co.Ltd.Dongying 257335China Department of Environmental Science and Engineering College of EngineeringKyung Hee UniversityYongin 446701Republic of Korea

Exposure to poor indoor air conditions poses significant risks to human health, increasing morbidity and mortality rates. Soft measurement modeling is suitable for stable and accurate monitoring of air pollutants and improving air quality. Based on partial least squares (PLS), we propose an indoor air quality prediction model that utilizes variational auto-encoder regression (VAER) algorithm. To reduce the negative effects of noise, latent variables in the original data are extracted by PLS in the first step. Then, the extracted variables are used as inputs to VAER, which improve the accuracy and robustness of the model. Through comparative analysis with traditional methods, we demonstrate the superior performance of our PLS-VAER model, which exhibits improved prediction performance and stability. The root mean square error (RMSE) of PLS-VAER is reduced by 14.71%, 26.47%, and 12.50% compared to single VAER, PLS-SVR, and PLS-ANN, respectively. Additionally, the coefficient of determination (R2) of PLS-VAER improves by 13.70%, 30.09%, and 11.25% compared to single VAER, PLS-SVR, and PLS-ANN, respectively. This research offers an innovative and environmentally-friendly approach to monitor and improve indoor air quality.

关键词： Indoor air quality PM_(2.5)concentration Variational auto-encoder Latent variable Soft measurement modeling

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基于离散元的颗粒性质标定及铺砂过程模拟

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河北工业大学学报 2024年第2期53卷 22-29页

作者：代福增杨伟东王杞月线洪萱王媛媛中捷职业技术学校机电工程学院河北沧州061108 河北工业大学机械工程学院天津300401 河北工业大学亚利桑那工业学院天津300401

喷墨打印中,砂床质量的高低直接影响最终打印零件的质量,在砂层铺设过程中砂粒的颗粒性质是影响砂床质量的关键因素之一。为研究喷墨打印中颗粒性质对砂床质量的影响,以原砂为研究对象,通过实验和离散元仿真相结合的方法完成了砂粒间接... 详细信息

喷墨打印中,砂床质量的高低直接影响最终打印零件的质量,在砂层铺设过程中砂粒的颗粒性质是影响砂床质量的关键因素之一。为研究喷墨打印中颗粒性质对砂床质量的影响,以原砂为研究对象,通过实验和离散元仿真相结合的方法完成了砂粒间接触参数进行标定,并对覆膜砂接触参数进行研究,使用颗粒间的表面能来描述砂粒流动性的变化,通过实验与仿真结合的方法得到了催化剂含量和表面能之间的关系。在砂粒颗粒性质确定的基础上,构建了喷墨打印工艺中砂床铺设过程的离散元模型,完成了颗粒性质对铺砂质量影响的仿真实验,结果表明:催化剂含量的增加会降低砂床质量,但过低的催化剂含量会导致制件的尺寸精度和力学强度变差。因此,为了平衡固化效率和砂床质量,可将催化剂含量控制在0.4%到0.6%之间;在层厚和落砂质量一定的条件下,粒径系数是影响砂床质量的主要参数,粒径系数的减小会导致砂床质量的下降。

关键词：喷墨打印离散元铺砂工艺砂床质量颗粒性质

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A K~+-sensitive AND-gate dual-mode probe for simultaneous tumor imaging and malignancy identification

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National Science Review 2022年第7期9卷 127-136页

作者： qiyue wang Fangyuan Li Zeyu Liang Hongwei Liao Bo Zhang Peihua Lin Xun Liu Shen Hu Jiyoung Lee Daishun Ling Institute of Pharmaceutics Hangzhou Institute of Innovative MedicineCollege of Pharmaceutical Sciences Zhejiang University World Laureates Association (WLA) Laboratories Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringNational Center for Translational Medicine Shanghai Jiao Tong University Department of Obstetrics The Second Affiliated Hospital of Zhejiang University School of Medicine

Although molecular imaging probes have the potential to non-invasively diagnose a tumor,imaging probes that can detect a tumor and simultaneously identify tumor malignancy remain ***,we demonstrate a potassium ion(K+) sensitive dual-mode nanoprobe(KDMN) for non-invasive tumor imaging and malignancy identification,which operates via a cascaded ’AND’ logic gate controlled by inputs of magnetic resonance imaging(MRI) and fluorescence imaging(FI) *** encapsulate commercial K~+ indicators into the hollow cavities of magnetic mesoporous silica nanoparticles,which are subsequently coated with a K+-selective membrane that exclusively permits the passage of K+while excluding other *** KDMN can readily accumulate in tumors and enhance the MRI contrast after systemic *** information of the tumor lesion is thus accessible via MRI and forms the first layer of the ’AND’ ***,the KDMN selectively captures K+and prevents interference from other cations,triggering a K~+-activated FI signal as the second layer of the ’AND’ gate in the case of a malignant tumor with a high extracellular K~+*** dual-mode imaging approach effectively eliminates false positive or negative diagnostic results and allows for non-invasive imaging of tumor malignancy with high sensitivity and accuracy.

关键词： dual-mode imaging probe fluorescence imaging MRI tumor malignancy identification potassium ion

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