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Alleviative effects of Bacillus coagulans strains on irritable bowel syndrome-unraveling strain specificity through physiological and genomic analysis

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Food Science and Human Wellness 2024年第4期13卷 1845-1855页

作者： Jiang Cao Leilei Yu Jianxin zhao Hao Zhang Wei Chen Yuzheng Xue qixiao Zhai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch Wuxi 214122China Department of Gastroenterology Affiliated Hospital of Jiangnan UniversityWuxi 214122China

The high intraspecies heterogeneity of Baciillus coagulans leads to significant phenotypic differences among different ***,6 *** strains were tested in the present study using an irritable bowel syndrome(IBS)animal model to determine whether the IBS-alleviating effects of *** strains are *** results of this study showed that the ingestion of *** GBI-30,6086,and *** CCFM1041 significantly alleviated IBS symptoms in *** contrast,other *** strains showed no or limited alleviating effects on IBS *** to our experimental results,the two main common features of these strains were as follows:1)The resistance of vegetative cells to bile salts,and 2)ability to synthesize specific lipids and secondary *** strains based on these two indicators may greatly reduce costs and provide a basis for mining new functional *** *** results also suggest that administration of *** could significantly regulate microbiota dysbiosis in animal ***,the close relationships between the gut microbiota,gut microbiota metabolites,and IBS were further confirmed in this study.

关键词： Baciillus coagulans Irritable bowel syndrome Resistance to bile salts Comparative genomic analysis Gut microbiota

Akkermansia muciniphila-directed polyphenol chlorogenic acid intervention for obesity in mice

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Food Science and Human Wellness 2024年第1期13卷 90-100页

作者： Xiaoxiang Gao Chenbo Yue Ruocen Tian Leilei Yu Fengwei Tian Jianxin zhao Wei Chen qixiao Zhai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

Akkermansia muciniphila play an important in ameliorating obesity but is not allowed for direct consumption in most *** date,microbiota-directed foods selectively promote the targeted human gut microbes,providing a strategy for *** *** studies have indicated the potential regulation of the polyphenol on ***,a polyphenol screening based on *** upregulation was performed in *** acid(CGA)exhibited a greater response to *** ***,we found that CGA did not directly promote *** growth or mucin *** and metabolomics revealed that the increased abundance of *** resulted from the inhibition of CGA on Desulfovibrio and Alistipes and the influence of docosahexaenoic acid,β-hydroxybutyrate,and ***,to confirm the regulation of CGA on *** under disease conditions,high-fat diet-fed mice were *** results showed CGA promoted *** growth,and we expectedly found that CGA suppressed the augment in body weight of mice,significantly attenuated adipose tissue abnormality,provided liver protection and improved gut barrier *** results suggest that CGA inhibits the development of ***,our results indicate that microbiota-directed food is a promising approach for the treatment of obesity.

关键词： Akkermansia muciniphila polyphenol chlorogenic acid obesity

2’-Fucosyllactose alleviate immune checkpoint blockade-associated colitis by reshaping gut microbiota and activating AHR pathway

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Food Science and Human Wellness 2024年第5期13卷 2543-2561页

作者： Shikai Yan Leilei Yu Fengwei Tian Jianxin zhao Wei Chen qixiao Zhai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

Immune checkpoint blockade(ICB)therapeutics are highly effective in cancer immunotherapy,but gastrointestinal toxicity limited the *** microbiota plays a crucial role in ICB-associated colitis.2’-Fucosyllactose(2’FL)is most abundance prebiotic in human milk that can reshape gut microbiota and exert immune regulatory *** study aimed to determine the effects of 2’FL on ICB-associated colitis and to uncover the mediating ***-associated colitis was induced by the ipilimumab and dextran sulfate *** administration of 2’FL(0.6 g/(kg∙day))ameliorated ICB-induced colitis by enhancing regulatory T cells(Treg)and the M2/M1 ratio of macrophages in colon.2’FL treatment also increased the expression of tight junction proteins(zonula occludens-1(ZO-1)and mucin 2(MUC2))and antioxidant stress indicators(superoxide dismutase(SOD)and catalase(CAT)).In addition,administration of 2’FL increased the abundance of Bifidobacterium and Lactobacillus,and elevated the levels of microbial metabolites,such as indole-3-lactic acid(ILA),which activated the aryl hydrocarbon receptor ligands(AHR)*** protective effect of 2’FL was abolished upon depletion of gut microbiota,and ILA treatment partially simulated the protective effect of 2’***,2’FL did not exhibit inhibition of antitumor *** findings suggest that 2’FL could serve as a potential protective strategy for ICB-associated colitis by modulating the intestinal microbiota and bacterial metabolites.

关键词： 2’-Fucosyllactose Immune checkpoint blockade-associated colitis Gut microbiota Metabolomics Regulatory T cells(Treg)

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Graphene/MoS_(2-x)O_(x)/graphene photomemristor with tunable non-volatile responsivities for neuromorphic vision processing

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Light(Science & Applications) 2023年第2期12卷 284-293页

作者： Xiao Fu Tangxin Li Bin Cai Jinshui Miao Gennady NPanin Xinyu Ma jinjin Wang Xiaoyong Jiang Qing Li Yi Dong Chunhui Hao Juyi Sun Hangyu Xu qixiao zhao Mengjia Xia Bo Song Fansheng Chen Xiaoshuang Chen Wei Lu Weida Hu School of Physics and Optoelectronic Engineering Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China University of Chinese Academy of Sciences 100049 BeijingChina Institute of Intelligent Machines HFiPSChinese Academy of SciencesHefei 230031China Jianghuai Frontier Technology Coordination and Innovation Center Hefei 230088China Institute of Microelectronics Technology and High-Purity Materials Russian Academy of SciencesChernogolovkaMoscow district142432Russia

Conventional artificial intelligence(Al)machine vision technology,based on the von Neumann architecture,uses separate sensing,computing,and storage units to process huge amounts of vision data generated in sensory *** frequent movement of redundant data between sensors,processors and memory,however,results in high-power consumption and latency.A more efficient approach is to offload some of the memory and computational tasks to sensor elements that can perceive and process the optical signal ***,we proposed a non-volatile photomemristor,in which the reconfigurable responsivity can be modulated by the charge and/or photon flux through it and further stored in the *** non-volatile photomemristor has a simple two-terminal architecture,in which photoexcited carriers and oxygen-related ions are coupled,leading to a displaced and pinched hysteresis in the current-voltage *** the frst time,non-volatile photomemristors implement computationally complete logic with photoresponse-stateful operations,for which the same photomemristor serves as both a logic gate and memory,using photoresponse as a physical state variable instead of light,voltage and *** polarity reversal of photomemristors shows great potential for in-memory sensing and computing with feature extraction and image recognition for neuromorphic vision.

关键词： tunable operations hysteresis

Rational protein engineering of thermostable heparinase I from Bacteroides thetaiotaomicron for highly efficient heparin degradation

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Food Science and Human Wellness 2024年

作者： Chuan Zhang Ruohan zhao Leilei Yu qixiao Zhai Jianxin zhao Hao Zhang Xuegang Luo Fengwei Tian Wei Chen State Key Laboratory of Food Science and Technology， Jiangnan University School of Food Science and Technology， Jiangnan University Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education & Tianjin Key Lab of Industrial Microbiology， College of Biotechnology， Tianjin University of Science and Technology National Engineering Research Center for Functional Food， Jiangnan University

Heparin， a glycosaminoglycan， is a stable source of carbon that supports the growth of microorganisms in the human intestine. It is also a commonly used anticoagulant drug in clinical practice， with significant therapeutic effects. Low molecular weight heparin （LMWH） is a highly active low molecular weight fragment obtained via enzymatic reaction or the chemical degradation of heparin. LMWH has been applied globally in the prevention and treatment of venous thromboembolism in thrombosis patients. Simultaneously， as a potential prebiotic， because of its low molecular weight， LMWH can be well degraded by the gut microbiota to maintain intestinal balance. Enzymatic heparin degradation has recently emerged as a viable disposal method for LMWH preparation; however， only very few benchmark enzymes have been thoroughly described and subjected to protein engineering to improve their properties over the past few years. The commercialization of enzymes will require the development of robustly engineered enzymes that meet the demands of industrial processes. Herein， we report a rational protein engineering strategy that includes molecular dynamic simulations of flexible amino acid mutations and disulfide bond screening. Several Bt-HepI mutants were obtained and screened for high thermal stability. We obtained the Bt-HepID204C/K208C/H189W/Q198Rvariant， which features a stabilized protein surface structure， with a 1.3-fold increase in kcat/Km， a 2.44-fold increase in thermal stability at 50℃， and a 1.8-fold decrease in the average molecular weight of LMWH produced at 40℃ compared with that seen with Bt-HepIWT. Our study establishes a strategy to engineer thermostable HepI to underpin its industrial applications.

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Hyaluronic acid modulates gut microbiota and metabolites relieving inflammation:A molecular weight-dependent study

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Science Bulletin 2024年第17期69卷 2683-2687页

作者： Chuan Zhang Botao Wang Leilei Yu Ruohan zhao Qingsong Zhang Chengcheng Zhang Shumao Cui Jianxin zhao Arjan Narbad Wei Chen Fengwei Tian qixiao Zhai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122 China School of Food Science and Technology Jiangnan UniversityWuxi 214122 China Bloomage Biotechnology Co. Ltd.Jinan 250000 China International Joint Research Laboratory for Probiotics Jiangnan UniversityWuxi 214122 China Gut Health and Microbiome Institute Strategic Programme Quadram Institute BioscienceNorwich NR47UAUK

Hyaluronic acid(HA),a linear glycosaminoglycan polymer,is an inherent carbon source for gut microbiota and is capable of mitigating host inflammation by modulating gut *** length of hyaluronan can range from an oligomer to an extremely long-form up to millions of Daltons,and its biological functions depend on its molecular mass[1,2].Presently,the precise mechanisms through which HA of varying molecular weights alleviates inflammation by modulating the gut microbiota remain unclear[3].

关键词： inflammation precise weights

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双向二维快速伺服刀架的前馈控制研究

压电与声光 2022年第2期44卷 327-332页

作者：武志士李国平邓益民赵琪啸徐少岩杨依领宁波大学机械工程与力学学院浙江宁波315211

以压电陶瓷驱动器作为动力输入的快速伺服刀架具有输出力大和高频率响应的优点。压电陶瓷驱动器固有的迟滞现象严重影响了快速伺服刀架的输出定位精度。为解决此问题,通过引入归一化Bouc-Wen模型建立前馈控制补偿器,归一化Bouc-Wen模型... 详细信息

以压电陶瓷驱动器作为动力输入的快速伺服刀架具有输出力大和高频率响应的优点。压电陶瓷驱动器固有的迟滞现象严重影响了快速伺服刀架的输出定位精度。为解决此问题,通过引入归一化Bouc-Wen模型建立前馈控制补偿器,归一化Bouc-Wen模型解决了经典Bouc-Wen模型中存在的参数冗余问题。获得模型参数后,基于其逆模型搭建了前馈补偿器,并在搭建的实验平台上进行了单/双自由度轨迹跟踪性能测试。实验结果表明,对于等幅正弦波信号,经前馈控制环节补偿下快速伺服刀架的最大轨迹跟踪误差为1.18%,最大轨迹跟踪偏差为2.61%,证明该文所提出的前馈控制补偿器能提高快速伺服刀架的定位精度。

关键词：快速伺服刀架 Bouc-Wen模型迟滞特性前馈控制压电陶瓷驱动器

Principle and Experimental Verification of Caudal-fin-type Piezoelectric-stack Pump with Variable-cross-section Oscillating Vibrator

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Chinese Journal of Mechanical Engineering 2012年第1期25卷 128-136页

作者： HU Xiaoqi ZHANG Jianhui HUANG Yi XIA qixiao HUANG Weiqing zhao Chunsheng State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of Mechanical&Electronic Engineering Beijing Union UniversityBeijing 100020China

In the traditional flow-resistance-differential (FRD) type valve-less piezoelectric pump, the generated outflow and pressure are discontinuous because of the inherent periodicity and fluctuation of the pump. To overcome these drawbacks, utilizing the bending vibration of piezoelectric bimorph to drive fluid was conducted. However, our investigation on the current status of this piezoelectric bimorph pump shows that larger driving force and vibration amplitude are required for fluid pumping; the pumping can be realized through the centrifugal force; and the mechanism of fluid pumping is no longer further studied. Based on these cases, the paper designed a piezoelectric-stack pump with variable-cross-section oscillating (VCSO) vibrator by imitating the swing of the caudal-fin of tuna, and the pump is neither the rotating type nor the volumetric type according to the taxonomy. The interaction between the oscillating vibrator and the fluid parcel is firstly analyzed from the viewpoint of momentum conservation, and the analytical expression of pump flow rate is obtained. Then the modal and harmonic response analyses on the vibrator immerged in water are carried out. From the analyses the first two orders resonance frequencies are 832 Hz and 1 939 Hz, respectively, and the peak value of the tip amplitude is 0.6 mm. Laser Doppler vibrometer is used to measure both the frequency and vibration amplitude, and the determined first two orders resonance frequencies are 617 Hz and 1 356 Hz, respectively. The measured tip amplitude reaches to the peak value of 0.3 mm. At last, experimental measurement for the flow rates with different driving frequencies is conducted. The results show that the flow rate can reach 560 mL/min at 1 370 Hz when the pump runs under the backpressure of 30 mm water column. And the flow rate is as much as 560% of that of experiment results carried out by researchers from Brazil. The proposed pump innovates in both theory and taxonomy; in addition, the pum

关键词： caudal-fin-type variable-cross-section piezoelectric-stack valve-less pump

Theoretical Analysis and Experimental Verification on Valve-less Piezoelectric Pump with Hemisphere-segment Bluff-body

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Chinese Journal of Mechanical Engineering 2014年第3期27卷 595-605页

作者： JI Jing ZHANG Jianhui XIA qixiao WANG Shouyin HUANG Jun zhao Chunsheng State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and Astronautics College of Mechanical and Electrical Engineering Qingdao Agricultural University College of Mechanical and Electronic Engineer Beijing Union University Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences

Existing researches on no-moving part valves in valve-less piezoelectric pumps mainly concentrate on pipeline valves and chamber bottom valves, which leads to the complex structure and manufacturing process of pump channel and chamber bottom. Furthermore, position fixed valves with respect to the inlet and outlet also makes the adjustability and controllability of flow rate worse. In order to overcome these shortcomings, this paper puts forward a novel implantable structure of valve-less piezoelectric pump with hemisphere-segments in the pump chamber. Based on the theory of flow around bluff-body, the flow resistance on the spherical and round surface of hemisphere-segment is different when fluid flows through, and the macroscopic flow resistance differences thus formed are also different. A novel valve-less piezoelectric pump with hemisphere-segment bluff-body （HSBB） is presented and designed. HSBB is the no-moving part valve. By the method of volume and momentum comparison, the stress on the bluff-body in the pump chamber is analyzed. The essential reason of unidirectional fluid pumping is expounded, and the flow rate formula is obtained. To verify the theory, a prototype is produced. By using the prototype, experimental research on the relationship between flow rate, pressure difference, voltage, and frequency has been carried out, which proves the correctness of the above theory. This prototype has six hemisphere-segments in the chamber filled with water, and the effective diameter of the piezoelectric bimorph is 30mm. The experiment result shows that the flow rate can reach 0.50 mL/s at the frequency of 6 Hz and the voltage of 110 V. Besides, the pressure difference can reach 26.2 mm H20 at the frequency of 6 Hz and the voltage of 160 V. This research proposes a valve-less piezoelectric pump with hemisphere-segment bluff-body, and its validity and feasibility is verified through theoretical analysis and experiment.

关键词： valve-less piezoelectric pump hemisphere-segment bluff-body flow resistance