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Nanoparticles for the treatment of spinal cord injury

Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： qiwei yang Di Lu Jiuping Wu Fuming Liang Huayi Wang Junjie yang Ganggang Zhang Chen Wang Yanlian yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

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Boosting xenon adsorption with record capacity in microporous carbon molecular sieves

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Science China Chemistry 2023年第2期66卷 601-610页

作者： Fuqiang Chen Xinlei Huang Liu yang Zhiguo Zhang qiwei yang Yiwei yang Dan Zhao Qilong Ren Zongbi Bao Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China Division of Electronic Chemicals Institute of Zhejiang University-QuzhouQuzhou324000China Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore117585Singapore

Xenon/krypton(Xe/Kr)separation is an important task in industry,yet it remains challenging to develop adsorbents with high Xe/Kr selectivity and adsorption capacity of Xe,especially at low partial ***,we report a series of microporous carbon molecular sieves(CMSs)for Xe/Kr *** materials have ideal bimodal pore size distributions that not only provide substantial space for the accommodation of gas molecules,but also allow selective diffusion of gas ***,the carbon frameworks decorated with polar oxygen-containing functional groups afford higher affinity for Xe than Kr,which is proven by density functional theory(DFT)calculations and charge density difference *** optimal CPVDC-700 exhibits a high selectivity of Xe/Kr and,more importantly,a record-high uptake of Xe(2.93 mmol g^(-1))at 0.2 bar and298 K,which is the highest among all the reported carbon *** experiments confirm the excellent performance of such CMSs for Xe/Kr separation,and the dynamic adsorption uptake of Xe and productivity of high-purity Kr are calculated to be 2.91 mmol g^(-1)and 208 m L g^(-1)(9.29 mmol g^(-1)),respectively,which also set up a new benchmark for Xe/Kr separation of carbon adsorbents.

关键词： adsorption separation xenon krypton carbon molecular sieve bimodal pore size distributions

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Hybridization of metal–organic framework and monodisperse spherical silica for chromatographic separation of xylene isomers

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Chinese Journal of Chemical Engineering 2019年第4期27卷 818-826页

作者： Bixuan Gao Minhui Huang Zhiguo Zhang qiwei yang Baogen Su Yiwen yang Qilong Ren Zongbi Bao Key Laboratory of Biomass Chemical Engineering of the Ministry of Education College of Chemical and Biological EngineeringZhejiang University

Metal–organic frameworks(MOFs) packed in the column have been a promising candidate as the stationary phase for high performance liquid chromatography(HPLC). However, the direct packing of irregular MOF powder could raise some problems like high back pressure and low column efficiency in the HPLC separation. In this work, UiO-66 capable of separating xylenes was supported effectively on the surface of the monodisperse spherical silica microspheres by one-pot method. The hybridization of Ui O-66 and silica microspheres(termed UiO-66@SiO2 shell–core composite) was prepared by stirring the suspension of the precursors of Ui O-66 and\\COOH terminated silica in the N,N-dimethylformamide with heating. The shell–core composite material UiO66@SiO2 was characterized by SEM, TEM, PXRD and FTIR. Then, it was used as a packing material for the chromatographic separation of xylene isomers. Xylene isomers including o-xylene, m-xylene and p-xylene were efficiently separated on the column with high resolution and good reproducibility. Moreover, the Ui O-66@SiO2 shell–core composites packed column still remained reverse shape selectivity as Ui O-66 possessed, and the retention of xylenes was probably ascribed to the hydrophobic effect between analytes and the aromatic rings of the Ui O-66 shell. The Ui O-66@SiO2 shell–core composites obtained in this study have some potential for the separation of structural isomers in HPLC.

关键词： Adsorption Chromatography Separation Hybridization Metal–organic framework Silica

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A robust ethane-trapping metal-organic framework for efficient purification of ethylene

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Science China Chemistry 2021年第4期64卷 666-672页

作者： Sisi Jiang Liangying Li Lidong Guo Changhua Song qiwei yang Zhiguo Zhang Yiwen yang Qilong Ren Zongbi Bao Key Laboratory of Biomass Chemical Engineering of the Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Institute of Zhejiang University-Quzhou Quzhou 324000China

Owing to the similar physicochemical properties between ethane(C_(2)H_(6))and ethylene(C_(2)H_(4)),obtaining polymerization-grade C_(2)H_(4)(≥99.95%pure)is still a tricky problem in the petrochemical ***,we report a robust scandium-based metalorganic framework(Sc BPDC),which is connected by oxygen-rich phenyl ligand with exceptionally high thermal stability(up to873 K)and capacity of C_(2)H_(6)(4.94 mmol/g at 100 k Pa and 283 K),exhibiting superior separation performance of C_(2)H_(6)/C_(2)H_(4) mixture(the IAST selectivity is up to 1.7 at 283 K).Importantly,Sc BPDC can produce 8.96 L/kg C_(2)H_(4) with≥99.99%purity while the C_(2)H_(4)/C_(2)H_(6)(50:50,v/v)as the mixture injection and the low isosteric heat of Sc BPDC(16.4 k J/mol for C_(2)H_(6))validates the facility of adsorbent ***,theoretical calculations demonstrate the C_(2)H_(6) molecules are trapped in the nonpolar pore surface via C–H···πand C–H···O interactions between multiple hydrogen atoms of C_(2)H_(6) and the host framework.

关键词： metal-organic frameworks adsorption separation ethane ethylene

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Hydrogen-bonded metal-nucleobase frameworks for highly selective capture of ethane/propane from methane and methane/nitrogen separation

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Nano Research 2022年第8期15卷 7695-7702页

作者： Ying Liu Qianqian Xu Lihang Chen Changhua Song qiwei yang Zhiguo Zhang Dan Lu Yiwen yang Qilong Ren Zongbi Bao Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Institute of Zhejiang University-Quzhou Quzhou 324000China

The separation of light hydrocarbons,including C_(2)H_(6)and C_(3)H_(8),is essential to natural gas ***,N_(2)removal from CH_(4)is also crucial to concentrating low-quality coalbed methane,but the adsorption process is challenging because of the close kinetic *** work reports two hydrogen-bonded metal-nucleobase frameworks(HOF-ZJU-201 and HOF-ZJU202)capable of efficiently separating C_(3)H_(8)/CH_(4),C_(2)H_(6)/CH_(4),and CH_(4)/N_(2).Due to strong affinity for C_(3)H_(8)and C_(2)H_(6),the lowpressure capacity for C_(3)H_(8)(5 kPa)and C_(2)H_(6)(10 kPa)of HOF-ZJU-201a exceeds most *** ideal adsorbed solution theory(IAST)selectivity of C_(3)H_(8)/CH_(4)and C_(2)H_(6)/CH_(4)is 119 and 45 at ambient *** to density functional theory calculations,surface polarization environments formed by electron-rich anions and electron-deficient purine heterocyclic rings contribute to the selective capture of C_(3)H_(8)and C_(2)H_(6)with greater ***,the high CH_(4)adsorption capacity(1.73 mmol/g for HOF-ZJU-201a and 1.50 mmol/g for HOF-ZJU-202a at 298 K and 1.0 bar)and excellent CH_(4)/N_(2)selectivity(6.0 for HOF-ZJU-201 at 298 K),as well as dynamic breakthrough experiments of binary CH_(4)/N_(2)gas mixture implied their efficacy in the concentration of low-quality coalbed methane.

关键词： hydrogen-bonded frameworks methane natural gas adsorption separation

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Temperature-dependent solubility of Rebaudioside A in methanol/ethanol and ethyl acetate mixtures:Experimental measurements and thermodynamic modeling

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Chinese Journal of Chemical Engineering 2024年第8期72卷 164-176页

作者： Zhenguang Liu Zexiang Ding Yifeng Cao Baojian Liu qiwei yang Zhiguo Zhang Qilong Ren Zongbi Bao Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China Institute of Zhejiang University-Quzhou Quzhou 324000China

The equilibrium solubility of Rebaudioside A(Reb A)FormⅡin binary mixtures of methanol/ethanol and ethyl acetate was quantitatively determined within the temperature range of 283.15—328.15 K at ambient *** experimental findings indicate a positive correlation between the solubility of Reb A(FormⅡ)and both the temperature and the methanol/ethanol content in the solvent *** describe the solubility data,six distinct models were employed:the modified Apelblat equation,theλh model,the combined nearly ideal binary solvent/Redlich—Kister(CNIBS/R—K)model,the van't HoffJouyban-Acree(VJA)model,the Apelblat-Jouyban-Acree(AJA)model,and the non-random two-liquid(NRTL)*** combined nearly ideal binary solvent/Redlich—Kister model exhibited the most precise fit for solubility in methanol+ethyl acetate mixtures,reflected by an average relative deviation(ARD)of 0.0011 and a root mean square deviation(RMSD)of 12×10^(-7).Conversely,for ethanol+ethyl acetate mixtures,the modified Apelblat equation provided a superior correlation(ARD=0.0014,RMSD=4×10^(-7)).Furthermore,thermodynamic parameters associated with the dissolution of Reb A(FormⅡ),including enthalpy,entropy,and the Gibbs energy change,were inferred from the *** findings underscore that the dissolution process is predominantly endothermic across the solvent systems ***,the entropy changes appear to have a significant influence on the Gibbs free energy associated with the dissolution of Reb A(FormⅡ),suggesting that entropic factors may play a pivotal role in the studied systems.

关键词： Rebaudioside A Solubility Thermodynamic modeling Dissolution Binary solvent

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Migration and transformation of Pb,Cu,and Zn during co-combustion of high-chlorine-alkaline coal and Si/Al dominated coal

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Journal of Environmental Sciences 2024年第7期141卷 26-39页

作者： Jiangze Luo qiwei yang Jianqiao Wang Boxiong Shen Zhuozhi Wang Qiqi Shi Zhong Zhao Chao Huang Jie Xu Tianjin Key Laboratory of Clean Energy and Pollution Control School of Energy and Environmental EngineeringHebei University of TechnologyTianjin 300103China School of Chemical Engineering Hebei University of TechnologyTianjin 300103China

Shaerhu(SEH)coal is abundant in Xinjiang,*** utilization of SEH suffers from severe ash deposition,slagging,and fouling problems due to its high-chlorine-alkaline *** co-combustion of high-alkaline coal and other type coals containing high Si/Al oxides has been proven to be a simple and effective method that will alleviate ash-related problems,but the risk of heavy metals(HMs)contamination in this process is ***,the volatilization rates and chemical speciation of Pb,Cu,and Zn in co-combusting SEH and a high Si/Al oxides coal,i.e.,Yuanbaoshan(YBS)coal were investigated in this *** results showed that the addition of SEH increased the volatilization rates of Pb,Cu,and Zn during the co-combustion at 800℃from 23.70%,23.97%,and 34.98%to 82.31%,30.01%,and 44.03%,respectively,and promoted the extractable state of Cu and *** addition,the interaction between SEH and YBS inhibited the formation of the Pb residue ***-EDS mapping results showed that compared to Zn and Cu,the signal intensity of Pb was extremely weak in regions where some of the Si and Al signal distributions *** DFT results indicated that the O atoms of the metakaolin(Al_(2)O_(3)·2SiO_(2))(001)surface were better bound to the Zn and Cu than Pb atoms after adsorption of the chlorinated *** results contribute to a better understanding of the effects of high-alkaline coal blending combustion on Pb,Cu,and Zn migration and transformation.

关键词： Heavy metals High-chlorine-alkaline coal Coal blending combustion Density functional theory

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Room-temperature hydrogenation of halogenated nitrobenzenes over metal-organic-framework-derived ultra-dispersed Ni stabilized by N-doped carbon nanoneedles

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Frontiers of Chemical Science and Engineering 2022年第12期16卷 1782-1792页

作者： Yuemin Lin Yuanyuan Zhang Renfeng Nie Kai Zhou Yao Ma Mingjie Liu Dan Lu Zongbi Bao qiwei yang Yiwen yang Qilong Ren Zhiguo Zhang Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China School of Chemical Engineering Henan Center for Outstanding Overseas ScientistsZhengzhou UniversityZhengzhou 450001China Institute of Zhejiang University—Quzhou Quzhou 324000China

Ultra-dispersed Ni nanoparticles(7.5 nm)on nitrogen-doped carbon nanoneedles(Ni@NCNs)were prepared by simple pyrolysis of Ni-based metal–organic-framework for selective hydrogenation of halogenated nitrobenzenes to corresponding *** different crystallization methods(stirring and static)were compared and the optimal pyrolysis temperature was ***@NCNs were systematically characterized by wide analytical *** the hydrogenation of p-chloronitrobenzene,Ni@NCNs-600(pyrolyzed at 600°C)exhibited extraordinarily high performance with 77.9 h^(–1)catalytic productivity and>99%p-chloroaniline selectivity at full p-chloronitrobenzene conversion under mild conditions(90°C,1.5 MPa H2),showing obvious superiority compared with reported Ni-based ***,the reaction smoothly proceeded at room temperature with full conversion and>99%***,Ni@NCNs-600 afforded good tolerance to various nitroarenes substituted by sensitive groups(halogen,nitrile,keto,carboxylic,etc.),and could be easily recycled by magnetic separation and reused for 5 times without *** adsorption tests showed that the preferential adsorption of–NO2 on the catalyst can restrain the dehalogenation of p-chloronitrobenzene,thus achieving high p-chloroaniline *** the high activity can be attributed to high Ni dispersion,special morphology,and rich pore structure of the catalyst.

关键词： halogenated nitrobenzenes room-temperature hydrogenation Ni nanoparticles nitrogen-doped carbon nanoneedles metal–organic-framework

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Porous Hydrogen-Bonded Frameworks Assembled from Metal-Nucleobase Entities for Xe/Kr Separation

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CCS Chemistry 2022年第1期4卷 381-388页

作者： Ying Liu Juanjuan Dai Lidong Guo Zhiguo Zhang Yiwen yang qiwei yang Qilong Ren Zongbi Bao Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027 Institute of Zhejiang University-Quzhou Quzhou 324000

It is challenging to obtain high-purity xenon(Xe)and krypton(Kr)from the by-products of the air separation process due to their similar atom size and physical *** using porous materials such as metal–organic frameworks(MOFs)has been considered a promising technology to separate Xe/***,we report two novel isostructural ionic supramolecular MOFs(SMOFs;SMOF-PFSIX-1 and SMOF-AsFSIX-1),in which inorganic anions(PF_(6)^(−)or AsF_(6)^(−))and cationic metal–organic entities have self-assembled through hydrogen bonds to give three-dimensional pore *** two kinds of SMOFs can efficiently separate Xe/Kr with ideal adsorbed solution theory(IAST)selectivity values of 6.9 and 6.7 under 298 K and 1.0 bar,*** breakthrough experiments further confirm their industrial application *** grand canonical Monte Carlo(GCMC)and density functional theory(DFT)calculations revealed that there are multiple adsorptive sites to capture the Xe atom,and the affinity between Xe and frameworks can be attributed to the inorganic anions and amino groups on the *** the best of our knowledge,this was the first report of using SMOFs for Xe/Kr separation,and we proposed a new strategy for Xe/Kr separation based on the synergistic effect of amino and inorganic anions.

关键词： supramolecular metal-organic frameworks gas separation adsorption xenon krypton

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Nickel single atom overcoordinated active sites to accelerate the electrochemical reaction kinetics for Li-S cathode

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Journal of Energy Chemistry 2023年第3期78卷 203-210,I0006页

作者： Juan Zhu Xinyue Wang Tian Ke Mingji Jia Biyu Jin Yuanyuan Li qiwei yang Lanhui Ren Yongyuan Ren Dangguo Cheng Jianguo Lu Xiang Gao Qinggang He yang Hou Xiaoli Zhan Qinghua Zhang School of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310027ZhejiangChina Institute of Zhejiang University-Quzhou Quzhou 324000ZhejiangChina School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027ZhejiangChina

Lithium-sulfur(Li-S)batteries with high theoretical energy density are promising advanced energy storage ***,shuttling of dissolute lithium polysulfide(LiPSs)and sluggish conversion kinetics impede their ***,single nickel(Ni)atoms on two-dimensional(2D)nitrogen(N)-doped carbon with Ni-N_(4)-O overcoordinated structure(SANi-N_(4)-O/NC)are prepared and firstly used as a sulfur host of Li-S *** to the efficient polysulfides traps and highly LiPSs conversion effect of SANi-N_(4)-O/NC,the electrochemical performance of Li-S batteries obviously *** batteries can well operate even under high sulfur loading(5.8 mg cm^(-2))and lean electrolyte(6.1μL mg^(-1))***,density functional theory(DFT)calculations demonstrate that Ni single atom’s active sites decrease the energy barriers of conversion reactions from Li_(2)S_(8)to Li2S due to the strong interaction between SANi-N_(4)-O/NC and ***,the kinetic conversion of LiPSs was accelerated and the shuttle effect is suppressed on SANi-N_(4)-O/NC *** study provides a new design strategy for a 2D structure with single-atom overcoordinated active sites to facilitate the fast kinetic conversion of LiPSs for Li-S cathode.

关键词： Nickel single atom catalyst Ni-N_(4)-O sites 2D N-doped carbon Li-S batteries Shuttle effect

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