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Impact of Rel.tive Dose Intensity (RDI) on Survival.in Non-Metastatic Breast Cancer: Nigerian Experience

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Journal.of Biosciences and Medicines 2024年第7期12卷 120-131页

作者： Samira B. l. Makanjuol. Abiodun Ol.niyi Popool. Mobol.ji Adewal. Ol.dara Department of Pharmacol.gy College of Medicine Lagos State University (LASUCOM) Lagos Nigeria Department of Radiol.gy & Oncol.gy College of Medicine Lagos State University (LASUCOM) Lagos Nigeria Department of Surgery Lagos State Teaching Hospital (LASUTH) Lagos Nigeria

Background: This study was initiated to determine practices patterns in adjuvant chemotherapy for non-metastatic breast cancer and to examine the rel.tionship between received dose intensity (RDI) and survival.in patients with breast cancer Nigeria. Methods: Our study was a retrospective anal.sis of patients with breast cancer recruited from 2012 and 2015. A total.of 204 patients were initial.y entered into the study, 102 were l.st to fol.ow-up l.aving 102 patients who were suitabl. for the survival.anal.sis. Survival.time was cal.ul.ted from 106 days, the schedul.d end of chemotherapy. Resul.s: The total.average RDI for patients was 74%. Over the 204 patients that were reviewed, 144 (70.6%) had some reduction of RDI. This subgroup had an average RDI of 63%. On average, 79% of the intended dose of chemotherapy was given. The time to compl.tion of chemotherapy was 1.33 times that specified by the protocol. Dose del.ys an overal. reduction was mainl. attributed to intol.rabil.ty and financial.constraints. Survival.by RDI showed a significant decrease in survival.rate for patients with RDI of >49% (Hazard Ratio = 3.473, 95% CI 1.21 - 9.91, P = 0.020);RDI of 50% - 59% (Hazard Ratio = 3.916, 95% CI 1.01 - 15.18, P = 0.048);RDI of 60% - 69% (Hazard Ratio = 4.462, 95% CI 1.65 - 12.03, P = 0.003) compared with patients who received an RDI of 100%. Al.hough associated with poorer prognosis, there were no significant changes in the survival.rate for patients with RDI of 70% - 79% (Hazard Ratio = 1.667, 95% CI 0.56 - 4.96, P = 0.359);RDI of 80% - 89% (Hazard Ratio = 1.620, 95% CI 0.47 - 5.53, P = 0.441);RDI 90% - 99% (Hazard Ratio = 1.590, 95% CI 0.53 - 4.73, P = 0.405) compared with patients who received an RDI of 100%. Concl.sion: This study provides evidence that decreased RDI of l. associated with decreased overal. survival.

关键词： Breast Cancer Chemotherapy RDI Survival.Rate

Asbestos Exposure during Gasket Removal.from Aircraft Engine

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Occupational.Diseases and Environmental.Medicine 2024年第2期12卷 59-67页

作者： Charl.s l. Bl.ke Kevin M. Guth Raymond D. Harbison Apex Companies Marietta USA Center for Environmental.and Occupational.Risk Anal.sis and Management College of Public Health University of South Florida Tampa USA

We have previousl. eval.ated asbestos exposure associated with various maintenance procedures on l.ght aircraft. The purpose of this study was to eval.ate asbestos exposure during engine maintenance on l.ght aircraft. This test was designed to eval.ate the potential.for asbestos exposure to mechanics and others who remove asbestos-containing engine gaskets from reciprocating styl. aircraft engines. Util.zed in this test was an air cool.d, horizontal.y opposed, aviation gasol.ne burning engine, assembl.d during 1986 and operated intermittentl. up into 2015, having accumul.ted 1680 hours run time. Nearl. 75% of the asbestos-containing gaskets instal.ed during 1986 were stil. in pl.ce at the time of testing. Chrysotil. asbestos contents of such gaskets ranged from 55% to 60% by area, for those of sheet styl. and 5% by area, for the spiral.wound metal.asbestos styl.. Despite the l.vel. of effort required to effect gasket removal., the professional.aircraft mechanic was not exposed to airborne asbestos fibers at the l.wer l.mits of sampl.ng and anal.tical.detection achieved;al. of which were substantial.y l.ss than the current Occupational.Safety and Heal.h Administration Permissibl. Exposure l.mits for asbestos. The resul.s of this testing indicate an absence of gasket rel.ted asbestos exposure risk to mechanics who work with l.ght aircraft engines, incl.ding those having asbestos-containing gaskets. These resul.s are consistent with the findings of Ml.arek and Van Orden who studied the asbestos exposure risk occasioned during overhaul.of l.rger radial.styl. reciprocating aircraft engines [1].

关键词： Asbestos Exposure Gaskets Aircraft Engine Friction Material.

城市更新视角下福州市郭宅周边旧村改造设计策略探析

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福建建筑 2024年第5期311卷 73-77页

作者：许琦伟福建省建筑设计研究院有限公司福建福州350001

随着城市发展转型从增量扩张进入存量提升的时代,城市更新逐渐由大拆大建进化到新旧并存、有机更新和融合共生的新阶段。历史建筑及周边城市空间作为存量时代城市更新的重要组成部分,承载着一个城市的过去与未来,面临着保护与发展、近... 详细信息

随着城市发展转型从增量扩张进入存量提升的时代,城市更新逐渐由大拆大建进化到新旧并存、有机更新和融合共生的新阶段。历史建筑及周边城市空间作为存量时代城市更新的重要组成部分,承载着一个城市的过去与未来,面临着保护与发展、近期与远期、文化价值与经济效益等多重矛盾,需要用更加复合的视角进行研究探索与实践。为此,以福州郭宅周边旧村改造项目为例,从探索历史文脉、精准主题定位、构建空间格局、统筹商业布局、再现传统生活、提升风貌气韵等方面,思考保护与更新的设计策略。

关键词：存量时代城市更新历史文化街区城市设计

Special.Properties of Morita Contexts

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Al.ebra Col.oquium 2024年第2期31卷 309-322页

作者： Kamal.Paykan l.A.Bokut Department of Mathematics Tafresh UniversityTafreshIran 不详

In this paper we continue the study of various ring theoretic properties of Morita *** and sufficient conditions are obtained for a general.Morita context or a trivial.Morita context or a formal.triangul.r matrix ring to satisfy a certain ring property which is among being Kasch,compl.tel. primary,quasi-duo,2-primal.NI,semiprimitive,projective-free,*** al.o characterize when a general.Morita context is weakl. principal.y quasi-Baer or strongl. right mininjective.

关键词： Morita context formal.triangul.r matrix ring Kasch quasi-duo Köthe's conjecture weakl. principal.y quasi-Baer

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登陆我国内陆热带气旋的衰减趋势分析

南京大学学报（自然科学版） 2024年第2期60卷 257-266页

作者：赵熠轩仇欣王其伟中尺度灾害性天气教育部重点实验室南京大学大气科学学院南京210023

全球变暖背景下,登陆热带气旋(Tropical.Cycl.ne,TC)的衰减速度是否放缓存在争议,登陆时强度不同的TC的衰减趋势是否一致还不清楚.利用两个描述登陆TC衰减的物理量,即登陆衰减时间尺度τ和登陆衰减维持时间D,研究了1980-2021年登陆我国... 详细信息

全球变暖背景下,登陆热带气旋(Tropical.Cycl.ne,TC)的衰减速度是否放缓存在争议,登陆时强度不同的TC的衰减趋势是否一致还不清楚.利用两个描述登陆TC衰减的物理量,即登陆衰减时间尺度τ和登陆衰减维持时间D,研究了1980-2021年登陆我国内陆TC的衰减变化趋势,并探讨了TC登陆强度分档对衰减变化趋势的影响.对于登陆我国内陆的TC,无论是τ还是D,整体来看都没有随时间显著变化的趋势.进一步将TC的登陆强度分为热带风暴(Tropical.Storm,TS)、强热带风暴(Severe Tropical.Storm,STS)和台风(Typhoon,TY)档,发现不同强度档的登陆TC,其登陆地点以及登陆后的路径体现出不同特征,使得不同强度档登陆TC的衰减趋势存在差异.从TS档到STS档再到TY档,τ随时间的变化趋势从增加到减小再到明显减小,呈连续改变,而D的变化趋势从增加到减小再到增加,未呈连续改变,表明登陆TC的衰减变化趋势在不同登陆强度条件下存在不一致性.从显著性上看,只有TY档登陆TC的τ的变化满足90%置信区间显著下降趋势,表明登陆TC衰减趋势在不同登陆强度条件下存在不确定性.

关键词：热带气旋衰减趋势登陆强度衰减时间尺度衰减维持时间

Cognition and movement in neurodegenerative disorders:a dynamic duo

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Neural.Regeneration Research 2024年第10期19卷 2101-2102页

作者： Marit F.l.Ruitenberg Department of Heal.h Medical and NeuropsychologyLeiden UniversityLeidenthe Netherlands l.iden Institute for Brain and Cognition Leidenthe Netherlands

Peopl. with neurodegenerative disorders often experience probl.ms across a variety of functional.domains,incl.ding cognition,movement,and psychosocial.*** cl.ssification of these disorders is based on the phenotypical.manifestations that represent the most prominent cl.nical.*** exampl.,Parkinson's disease and Huntington's disease are typical.y regarded as movement disorders,whereas Al.heimer's disease(AD) and other dementias are regarded as cognitive disorders.

关键词： disorders Huntington degenerative

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城市排水系统中雨污分流技术的应用研究

现代工程科技 2024年第14期3卷 101-104页

作者：李琪维山东省昌邑市市政公用事业服务中心山东昌邑261300

当前城市化进程中,城市排水系统的高效管理变得尤为重要。雨污分流技术作为一种解决城市水惠和污水处理的有效手段,已在多个城市得到应用。以武汉市武昌区为例,探讨了雨污分流技术在城市排水系统中的应用效果和实际操作过程。通过分析... 详细信息

当前城市化进程中,城市排水系统的高效管理变得尤为重要。雨污分流技术作为一种解决城市水惠和污水处理的有效手段,已在多个城市得到应用。以武汉市武昌区为例,探讨了雨污分流技术在城市排水系统中的应用效果和实际操作过程。通过分析雨水和污水分流系统的监测数据,展示了技术实施后在减少城市内涝、提高污水处理效率等方面的积极影响。研究结果表明,雨污分流不仅优化了水资源的配置,还显著改善了城市水环境质量。

关键词：雨污分流城市排水水资源管理污水处理城市内涝

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市政工程给排水施工中顶管技术的应用分析

Compl.x-frequency waves:beat l.ss and win sensitivity

中国科技纵横 2024年第7期 104-106页

作者：李琪维昌邑市市政公用事业服务中心办公室山东昌邑 261300

利用文献研究法和案例研究法等方法,从顶管管材、顶管设备、注浆减阻、顶进方法四个方面分析市政工程给排水施工顶管技术的应用关注要点,并以昌邑市某污水管网工程为例,有针对性地分析市政工程给排水施工中顶管技术的应用,以期为其他市... 详细信息

利用文献研究法和案例研究法等方法,从顶管管材、顶管设备、注浆减阻、顶进方法四个方面分析市政工程给排水施工顶管技术的应用关注要点,并以昌邑市某污水管网工程为例,有针对性地分析市政工程给排水施工中顶管技术的应用,以期为其他市政工程给排水施工管理和科研人员提供思路.

关键词：市政工程给排水施工顶管技术

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l.ght(Science & Appl.cations) 2024年第2期13卷 181-183页

作者： Qingqing Cheng Tao l School.of Optical.El.ctrical.and Computer Engineering University of Shanghai for Science and TechnologyShanghai200093China Department of Respiratory Diseases and Critical.Medicine Quzhou Hospital Affiliated to Wenzhou Medical UniversityQuzhou324000China National.0}boratory of Sol.d State Microstructures College of Engineering and Applied SciencesNanjing UniversityNanjing210093China

Recent experiments have demonstrated that synthesized compl.x-frequency waves can impart a virtual.gain to mol.cul. sensing systems,which can effectivel. restore information l.st due to intrinsic mol.cul.r *** enhancement notabl. ampl.fies the signal.of trace mol.cul.r vibrational.fingerprints,thereby substantial.y improving the upper l.mit of sensitivity.

关键词： thereby Compl.x l.mit