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阿尔茨海默病脑白质葡萄糖代谢异常分析

中国神经精神疾病杂志 2007年第9期33卷 540-543页

作者：曹秋云郭万华杨海龙沈迪文赵鹏江开达张明园肖世富南京大学医学院附属鼓楼医院医学心理科南京210008 南京大学医学院附属鼓楼医院医学核医学科上海市精神卫生中心

目的探讨阿尔茨海默病(AD)脑白质葡萄糖代谢异常的意义。方法纳入33例符合美国精神障碍诊断与统计手册-第四版(DSM-IV)AD诊断标准的患者和健康对照20名,进行脑正电子发射断层成像(PET)检查。应用SPM软件对PET图像进行分析。结果①与健... 详细信息

目的探讨阿尔茨海默病(AD)脑白质葡萄糖代谢异常的意义。方法纳入33例符合美国精神障碍诊断与统计手册-第四版(DSM-IV)AD诊断标准的患者和健康对照20名,进行脑正电子发射断层成像(PET)检查。应用SPM软件对PET图像进行分析。结果①与健康对照相比,AD患者有广泛的白质葡萄糖代谢减低,减低较为明显的区域有右侧额叶皮质下白质、左侧额叶上中回皮质下白质(P<0.001);另外,AD患者左侧额叶内侧回皮质下白质、左侧枕叶楔回皮质下白质葡萄糖代谢增强(P<0.001);②与不伴有精神行为症状(BPS)的AD患者(16例)相比,伴有BPS的AD患者(17例)在左右枕叶中回、右侧枕叶楔回、右侧顶下小叶、左侧颞叶梭形回、左侧额叶内侧回等脑区的皮质下白质葡萄糖代谢增强(P<0.001);而左右额叶中央旁回、右侧额叶上回和中回、左侧颞叶上回等脑区的皮质下白质葡萄糖代谢减低(P<0.001)。结论AD有广泛的白质脑葡萄糖代谢异常,有无BPS的AD白质代谢异常不同。

关键词：阿尔茨海默病精神行为症状正电子发射计算机断层显像 SPM软件

Direct synthesis of ordered mesoporous ZSM-5 zeolites from in situ crystallization of carbonaceous SBA-15

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Science China Chemistry 2017年第12期60卷 1588-1595页

作者： Fangfang Wei qiuyun Zhang Hong Wu Changyan cao Weiguo Song School of Chemistry and Chemical Engineering Anshun UniversityAnshun 561000China Key Laboratory of Functional Materials and Resource Chemistry of Guizhou Provincial Education Department Anshun UniversityAnshun 561000China College of Chemistry and Material Engineering Liupanshui Normal UniversityLiupanshui 553004China Beijing National Laboratory of Molecular Sciences Laboratory of Molecular Nanostructure and NanotechnologyInstitute of ChemistryChinese Academy of SciencesBeijing 100190China

Two types of ordered mesoporous ZSM-5 zeolites with different mesopores were synthesized by a two-step method. First, carbonaceous SBA- 15 was produced by in situ carbonization of SBA- 15/P 123 composite. Then the obtained SBA- 15/C composite was transformed into crystallized mesoporous ZSM-5 by impregnation TPAOH followed by steam-assisted crystallization. The final calcined samples synthesized with typical SBA-15/P 123 precursor showed a wormlike morphology with the mean mesopore size of 4.6 nm, while samples synthesized with the addition of trimethylbenzene as swelling agent in the precursor exhibited the morphology of microsphere with the mesopore size of about 9.5 nm. Both two types of mesoporous ZSM-5 zeolites exhibited large surface area and mesopore structure. The steam-assisted crystallization （SAC） was performed with lower consumption of solvents. This two-step method may also be suitable for synthesizing other ordered mesoporous zeolites used as catalysts in some catatytic processes.

关键词： mesoporous zeolites ZSM-5 in situ carbonization steam-assistant crystallization

Atorvastatin protects against cerebral ischemia/ reperfusion injury through anti-inflammatory and antioxidant effects

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Neural Regeneration Research 2014年第3期9卷 268-275页

作者： qiuyun Tu Hui cao Wei Zhong Binrong Ding Xiangqi Tang Department of Geriatrics Third Xiangya Hospital of Central South University Department of Neurology Second Xiangya Hospital of Central South University

In addition to its lipid-lowering effect, atorvastatin exerts anti-inflammatory and antioxidant effects as well. In this study, we hypothesized that atorvastatin could protect against cerebral isch-emia/reperfusion injury. The middle cerebral artery ischemia/reperfusion model was established, and atorvastatin, 6.5 mg/kg, was administered by gavage. We found that, after cerebral ischemia/ reperfusion injury, levels of the inflammation-related factors E-selectin and myeloperoxidase were upregulated, the oxidative stress-related marker malondialdehyde was increased, and super- oxide dismutase activity was decreased in the ischemic cerebral cortex. Atorvastatin pretreatment significantly inhibited these changes. Our findings indicate that atorvastatin protects against ce-rebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects.

关键词： nerve regeneration brain injury cerebral ischemia/reperfusion atorvastatin E-selectin myeloperoxidase superoxide dismutase malondialdehyde inflammation free radicals blood-brainbarrier stroke NSFC grant neural regeneration

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临床医师的情感耗竭与家庭-工作冲突

中国心理卫生杂志 2021年第7期35卷 558-563页

作者：刘军军袁心崧余志波朱晓敏张文瑄沈迪文杨海龙曹秋云张向荣张宁南京梅山医院医学心理科南京210041 苏州大学附属苏州广济医院精神科江苏苏州215137 东南大学附属中大医院心理精神科南京210009 南京大学附属南京鼓楼医院医学心理科南京210008 南京医科大学附属南京脑科医院精神心理科南京210029

目的:探讨临床医师情感耗竭与家庭-工作冲突之间的关系。方法:2010年共招募临床医师2530名,采用自编问卷收集社会人口学和工作相关资料,采用中文版Maslach职业倦怠量表(CMBI)的情感耗竭维度(EE)、工作影响家庭和家庭影响工作量表(WFCS)... 详细信息

目的:探讨临床医师情感耗竭与家庭-工作冲突之间的关系。方法:2010年共招募临床医师2530名,采用自编问卷收集社会人口学和工作相关资料,采用中文版Maslach职业倦怠量表(CMBI)的情感耗竭维度(EE)、工作影响家庭和家庭影响工作量表(WFCS)的家庭-工作冲突维度(FWC)、简易应对方式问卷(SCSQ)评估情感耗竭、家庭-工作冲突及应对方式。结果:多因素线性回归分析显示,EE得分与FWC得分正向关联(β=0.39,95%CI:0.33~0.46)。广义相加混合模型曲线拟合结果显示,EE得分与FWC得分之间为“J”型非线性关系,存在1个拐点。以拐点分段进行多因素线性回归分析显示,当FWC得分<6.0时,EE得分随FWC得分升高而降低(β=-1.82,95%CI:-3.02~-0.63);当FWC得分≥6.0时,EE得分随FWC得分升高而升高(β=0.41,95%CI:0.34~0.48)。结论:本研究显示,中国临床医师的情感耗竭水平与家庭-工作冲突呈非线性关系,过高或过低水平的家庭-工作冲突可能对情感耗竭有不利影响。

关键词：情感耗竭家庭-工作冲突非线性关系临床医师

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综合医院心理门诊患者躯体化症状的临床分析

精神医学杂志 2010年第2期23卷 103-105页

作者：杨海龙曹秋云赵鹏沈迪文南京大学医学院附属鼓楼医院医学心理科南京210008

目的探讨综合性医院医学心理科门诊患者躯体化症状的临床特征以及抗抑郁药物对伴发躯体化症状的抑郁症的临床疗效。方法以躯体化症状为主诉至南京大学医学院附属鼓楼医院医学心理科门诊就诊的188例患者,分析其症状分布的特征、精神障碍... 详细信息

目的探讨综合性医院医学心理科门诊患者躯体化症状的临床特征以及抗抑郁药物对伴发躯体化症状的抑郁症的临床疗效。方法以躯体化症状为主诉至南京大学医学院附属鼓楼医院医学心理科门诊就诊的188例患者,分析其症状分布的特征、精神障碍的诊断构成,并对被诊断为抑郁症的患者中的39例给以帕罗西汀治疗,应用17项汉密尔顿抑郁量表(HAMD17)、汉密尔顿焦虑量表(HAMA)进行评分,在治疗前后进行比较。结果睡眠障碍、心、肺部不适、头部不适以及胃肠道不适为最常见的躯体化症状,而临床上常常会被诊断为抑郁症、焦虑障碍、躯体形式障碍以及精神分裂症等其他精神障碍。其中39例以躯体化症状就诊的被诊断为抑郁症的患者在给予帕罗西汀治疗四周以后,HAMD17、HAMA的平均分在治疗后较治疗前显著降低(P<0.01)。结论躯体化症状临床表现多种多样,可涉及全身各个系统,几乎所有的精神障碍都有可能伴发躯体化症状,帕罗西汀对以躯体化症状为主诉的抑郁症患者的疗效肯定。

关键词：综合性医院躯体化症状抑郁症

综合医院心理门诊双相障碍诊断现状的调查及筛查方法

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精神医学杂志 2010年第6期23卷 410-412页

作者：沈迪文曹秋云杨海龙赵鹏南京大学医学院附属鼓楼医院医学心理科 210008

目的探讨综合性医院医学心理科门诊患者双相障碍的诊断现状及如何提高双相障碍识别。方法 2005年7月～2009年7月以各种情绪问题为主诉至南京大学医学院附属鼓楼医院医学心理科门诊就诊的989例患者及在本院内科住院因情绪问题经心理科会... 详细信息

目的探讨综合性医院医学心理科门诊患者双相障碍的诊断现状及如何提高双相障碍识别。方法 2005年7月～2009年7月以各种情绪问题为主诉至南京大学医学院附属鼓楼医院医学心理科门诊就诊的989例患者及在本院内科住院因情绪问题经心理科会诊的285例患者,共1274例,分析其中确诊双相障碍的102例患者首诊时的诊断构成和现状分析及对其中637例患者给予MDQ(中文版心境障碍问卷)测评和另637例未给予MDQ测评的患者比较其诊断率。结果双相障碍首诊时的诊断包括抑郁症、躁狂症、双相障碍、精神分裂症、广泛性焦虑、惊恐障碍、社交恐惧症、应激相关障碍、强迫症、其他疾病等。双相障碍的确诊率只有11.8%,误诊率和漏诊率达88.2%。且运用MDQ测评后诊断率明显高于未测评者(P<0.01)。结论双相障碍常被临床医生忽视,尤其被综合医院临床医生忽视,疾病特点是难确诊,目前的双相障碍的诊断现状是误诊率和漏诊率高。MDQ可以作为一种简单方便的双相情感障碍辨识工具,帮助临床医生提高确诊率。

关键词：综合性医院双相障碍诊断现状筛查方法

Regulation of impedance matching feature and electronic structure of nitrogen-doped carbon nanotubes for high-performance electromagnetic wave absorption

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Journal of Materials Science & Technology 2022年第13期108卷 1-9页

作者： Fenghui cao Jia Xu Minjie Liu Feng Yan qiuyun Ouyang Xitian Zhang Xiaoli Zhang Yujin Chen Key Laboratory of In-Fiber Integrated Optics College of Physics and Optoelectronic EngineeringHarbin Engineering UniversityHarbin 150001China School of Mechatronic Engineering Daqing Normal UniversityDaqing 163712China Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of Educationand School of Physics and Electronic EngineeringHarbin Normal UniversityHarbin 150025China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China

In this study,we developed a facile method to fabricate three-dimensional(3D)structures composed of FeNi alloy nanoparticles encapsulated in N-doped carbon nanotubes that grafted on the SiO_(2) spheres(Fe_(x)Ni_(y)@NCNT@SiO_(2))for electromagnetic wave(EMW)*** experimental results suggest that the impedance matching characteristic can be tuned by the introduction of SiO_(2) spheres in the 3D *** functional theory(DFT)calculations showed that the introduction of Ni improved the polarization and conductive losses of the Fe_(x)Ni_(y)@NCNT@SiO_(2).As a result,the optimal 3D structure exhibits excellent EMW absorption property with a reflection loss and effective absorption bandwidth are-49.39 dB and 4.32 GHz,respectively,even though the matching thickness is only 1.6 mm,superior to most magnetic carbon-based ***,our current approach opens up an effective way to the development of low-cost,high-performance EMW absorbers.

关键词： FeNi alloy CNTs Silica Nitrogen doping Electromagnetic wave absorption

Lipopolysaccharide/Toll-like receptor 4 signaling pathway involved Qingdu decoction treating severe liver injury merging with endotoxemia

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Journal of Traditional Chinese Medicine 2017年第3期37卷 371-377页

作者： cao Wubing Du Yuqiong Gao Lianyin Che Niancong Zhang qiuyun Fu Xiuwen Luo Jiajia Wang Rongbing Beijing Key Laboratory of Traditional Chinese Medicine Collateral Disease Theory Research Department of Clinical Foundation of Chinese MedicineSchool of Traditional Chinese MedicineCapital Medical UniversityBeijing 100069China Department of Traditional Chinese Medicine Longyou County People's HospitalZhejiang 324400China Department of Traditional Chinese Medicine Campus Hospital of Capital Medical UniversityBeijing 100069China Department of Integrated Traditional and Western Medicine Beijing Ditan Hospital Affiliated to Capital Medical UniversityBeijing 100015China

OBJECTIVE: To investigate the protective effects and underlying mechanism of Qingdu decoction(QDD) on experimental rats with severe liver injury induced by thioacetamide(TAA).METHODS: A total of 40 Wistar rats were randomly divided into normal group(n = 10) and experimental group(n = 30). Rats were administrated the same content of saline in normal group. The rats inthe experimental group were pretreated with TAA at dose of 12 mg/kg lasting 8 weeks, and from 9th week to 12 th week, with TAA at concentration of 36mg/kg. During the 9th week to 12 th week period,the rats were randomly divided into three subgroups(n = 10 each) simultaneously based on the treatment categories: model group, lactulose(LA,3.5 m L/kg) group and QDD(5.95 g/kg) group, orally once per day respectively. At the 12 th week, the content of serum alanine transaminase(ALT), aspartate transaminase(AST), total bilirubin(TBIL), endotoxin(ET) and tumor necrosis factor α(TNF-α) was detected by automatic biochemical analyzer. The plasma prothrombin time(PT), prothrombin time-international normalized ratio(PTR) and prothrombin time activity(PTA) were measured by automatic coagulation analyzer. The level of lipopolysaccharide(LPS)-binding protein(LBP), cluster differentiation 14(CD14) and Toll-like receptor 4(TLR4) expressions was measured by both western blot(WB) and real-time polymerase chain reaction(real-time PCR).RESULTS: Compared with the model group, hepatic morphology in the QDD group was improved under light microscope and transmission electron microscope; at the same time, the contents of serum ALT, AST, TBIL, ET and TNF-α, and level of LBP, CD14 and TLR4 expressions in liver tissues were significantly decreased compared with the model group(P < 0.05), while PTA in the QDD group was enhanced(P < 0.05).CONCLUSION: QDD has the functional effect on improving the injured liver through inhibiting the LPS/TLR4 signaling pathway thus decreasing the level of the inflammatory medicators.

关键词： Thioacetamide Lipopolysaccharides,Antigens, CD14 Toll-like receptor 4, Endotoxin

Experimental and DFT Studies of Au Deposition Over WO_(3)/g-C_(3)N_(4) Z-Scheme Heterojunction

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Nano-Micro Letters 2020年第1期12卷 75-92页

作者： Muhammad Humayun Habib Ullah Junhao cao Wenbo Pi Yang Yuan Sher Ali Asif Ali Tahir Pang Yue Abbas Khan Zhiping Zheng qiuyun Fu Wei Luo Engineering Research Center for Functional Ceramics of the Ministry of Education School of Optical and Electronic InformationHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China China‑EU Institute for Clean and Renewable Energy Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Environment and Sustainability Institute(ESI) University of ExeterPenryn CampusPenrynCornwall TR109FEUK College of Engineering and Applied Sciences Nanjing UniversityNanjing 210093People’s Republic of China Department of Chemistry Abdul Wali Khan UniversityMardanKhyber Pakhtunkhwa 23200Pakistan

A typical Z-scheme system is composed of two photocatalysts which generate two sets of charge carriers and split water into H2 and O2 at different *** are struggling to enhance the efficiencies of these systems by maximizing their light absorption,engineering more stable redox couples,and discovering new O2 and H2 evolutions *** this work,Au decorated WO3/g-C3N4 Z-scheme nanocomposites are fabricated via wet-chemical and photo-deposition *** nanocomposites are utilized in photocatalysis for H2 production and 2,4-dichlorophenol(2,4-DCP)*** is investigated that the optimized 4Au/6%WO3/CN nanocomposite is highly efficient for production of 69.9 and 307.3μmol h−1 g−1 H2 gas,respectively,under visible-light(λ>420 nm)and UV–visible ***,the fabricated 4Au/6%WO3/CN nanocomposite is significant(i.e.,100%degradation in 2 h)for 2,4-DCP degradation under visible light and highly stable in photocatalysis.A significant 4.17%quantum efficiency is recorded for H2 production at wavelength 420 *** enhanced performance is attributed to the improved charge separation and the surface plasmon resonance effect of Au ***-state density functional theory simulations are performed to countercheck and validate our experimental *** surface formation energy,high charge transfer,and strong non-bonding interaction via electrostatic forces confirm the stability of 4Au/6%WO3/CN interface.

关键词： Polymeric g-C_(3)N_(4) Plasmonic Au Charge separation Solar H_(2) production DFT calculations