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The Crop Journal 2024年第2期12卷 401-410页

作者： Wenyu Li Han Wang qiuyue Xu long Zhang Yan Wang Yongbiao Yu Xiangkun Guo Zhiwei Zhang Yongbin Dong Yuling Li State Key Laboratory of Wheat and Maize Crop Science Collaborative Innovation Center of Henan Grain CropsCollege of AgronomyHenan Agricultural UniversityLongzi Lake CampusZhengzhou 450046HenanChina

Triosephosphate isomerase(TPI)is an enzyme that functions in plant energy production,accumulation,and *** understand its function in maize,we characterized a maize TPI mutant,*** comparison to the wild type,zmtpi4 mutants showed altered ear development,reduced kernel weight and starch content,modified starch granule morphology,and altered amylose and amylopectin ***,ATP,and pyruvate contents were reduced,indicating ZmTPI4 was involved in *** subcellular localization confirmed ZmTPI4 as a cytosolic rather than a plastid isoform of TPI,the zmtpi4 mutant showed reduced leaf size and chlorophyll *** of ZmTPI4 in Arabidopsis led to enlarged leaves and increased seed weight,suggesting a positive regulatory role of ZmTPI4 in kernel weight and starch *** conclude that ZmTPI4 functions in maize kernel development,starch synthesis,glycolysis,and photosynthesis.

关键词： Maize Kernel Starch Weight Photosynthesis

Comprehensive Humoral and Cellular Immune Responses to SARS-CoV-2 Variants in Diverse Chinese Population

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Research 2022年第2期2022卷 61-69页

作者： Jiwei Li Jing Wu qiuyue long Yan'an Wu Xiaoyi Hu Yukun He Mingzheng Jiang Jia Li Lili Zhao Shuoqi Yang Xiaoyong Chen Minghui Wang Jianshi Zheng Fangfang Wu Ruiliang Wu Lihong Ren Liang Bu Houzhao Wang Ke Li Lijuan Fu Guojun Zhang Yali Zheng Zhancheng Gao Department of Respiratory Crilical Care and Sleep MedicineXiang'an Hospial of Xiamen UniersityXiamenFujianChina School of Medicine Xiamen University.XiamenFujianChina Department of Cimical Laboratory Xiang'an Hospial of Xiamen UniversityXiamenFuijianChina Department of Respiratory and Critical Care Medicine Peking University People's HospitalBejingChina Department of Thoracic Surgery Xiang an Hospital of Xiamen University.Xiamen FujianChina Department of Pediatrics Xiang'an Haspital of Xiamen UniversityXiamenFujianChina Department of Crical Care Medicine Xiang'an Hospial of Xiamen UriversityXiamenFujanChina Deparment of Infecious Diseases Xiang'an Hospital of Xiamen UniversiyXiamenFujianChina Cancer Research Center and The Department of Breast Thyroid Surgery Xiang'an Hospital of Xiamen UntiversityXiamenFujianChina

The SARS-CoV-2 variants have been emerging and have made great challenges to current vaccine and pandemic control *** is urgent to understand the current immune status of various Chinese populations given that the preexisting immunity has been established by national vaccination or ex posure to past *** sera from 85 individuals(including 21 convalescents of natural infection,15 cases which suffered a breakthrough infection after being fully vaccinated,and 49 healthy vaccinees),we showed signifcantly enhanced neutralizing activities against SRAS-CoV-2 variants in convalescent sera,especially those who had been fully *** neut ralizing antibodies against Omicron were detectable in 75%of convalescents and 4.9%of healthy vaccinees(p=0.006),with a GMT of 289.5,180.9-463.3,and 42.6,31.3-59,***,the neutralizing activities were weaker in young convalescents(aged<18y),with a detectable rate of 50%and a GMT of 46.4 against *** also examined and found no *** neutralizing activities in vaccinated SARS-CoV-I survivors.A booster dose could further increase the breadth and magnitude of neutralization against WT and variants of concern(VOCs)to different *** addition,we showed that COVID-19-inactivated vaccines can elicit Omicron-specific T-cell *** positive rates of ELISpot reactions were 26.7%(4/15)and 43.8%(7/16)in the full vaccination group and the booster vaccination group,respectively,although without statistically significant *** neutralizing antibody titers declined while T-cell responses remain consistent over 6 *** findings will inform the optimization of public health vaccination and intervention strategies to protect diverse populations against SARS-CoV-2 *** infection significantly boosted neutralizing activities against SARS-CoV-2 variants a compared to booster immunization with inaclivated ***-induced vir us-specific T-cell imm

关键词： immunity vaccine protective

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新型冠状病毒检测技术研究进展

中华结核和呼吸杂志 2022年第8期45卷 819-825页

作者：龙秋月郑雅莉高占成厦门大学附属翔安医院呼吸与危重症和睡眠医学科厦门361102 北京大学人民医院呼吸与危重症医学科北京100044

尽管自然感染或疫苗接种已经初步建立了群体保护屏障,但随着多种新冠病毒变异体的持续出现,突破性感染仍然无法完全避免,新冠病毒检测仍是发现传染源和中断传播链的关键。目前,以核酸、抗原、抗体检测为基础的新冠病毒检测形式呈多元化... 详细信息

尽管自然感染或疫苗接种已经初步建立了群体保护屏障,但随着多种新冠病毒变异体的持续出现,突破性感染仍然无法完全避免,新冠病毒检测仍是发现传染源和中断传播链的关键。目前,以核酸、抗原、抗体检测为基础的新冠病毒检测形式呈多元化发展。在相对疫情早期的后新冠时代,复工复产和疫情防控常态化,需要我们根据不同场景的防控需求选择合适的检测手段。本文总结了现有新冠病毒检测技术的原理及其适用特征,以期为临床及公共卫生人员提供精准化决策依据。

关键词：疫苗接种病毒检测技术保护屏障病毒变异抗体检测疫情防控自然感染传播链

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成渝城市群城市土地利用效率评价

绿色科技 2022年第19期24卷 190-194页

作者：龙秋月重庆数字城市科技有限公司重庆401121

为探究成渝城市群城市土地利用效率时空特征,构建了成渝城市群城市土地利用效率评价指标体系,采用超效率DEA模型、Malmquist指数等方法,进行了2010~2020年成渝城市群城市土地利用效率评价。结果表明:①2010~2020年成渝城市群城市土地利... 详细信息

为探究成渝城市群城市土地利用效率时空特征,构建了成渝城市群城市土地利用效率评价指标体系,采用超效率DEA模型、Malmquist指数等方法,进行了2010~2020年成渝城市群城市土地利用效率评价。结果表明:①2010~2020年成渝城市群城市土地利用效率整体处于较高水平,全要素土地利用效率呈上升趋势且波动幅度较小;②2010~2020年成渝城市群各城市土地利用效率平均值极差为0.633,空间差异较大,自贡市、重庆市、成都市、德阳市、南充市城市土地利用效率较高,达州市效率最低;③成渝城市群土地利用效率呈现以成渝为核心向周边递减的格局;④2010~2020年间各城市全要素土地利用效率变化不显著,其中87.50%的城市呈小幅上升趋势。

关键词：成渝城市群土地利用效率超效率DEA模型 Malmquist指数

社区获得性肺炎流行病学与病原学及其治疗进展

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中华预防医学杂志 2023年第1期57卷 91-99页

作者：姜宁龙秋月郑雅莉高占成北京大学人民医院呼吸与危重症医学科北京100044 厦门大学附属翔安医院呼吸与危重症和睡眠医学科厦门大学医学院厦门361102

社区获得性肺炎(CAP)是全球第三大致死原因,是最常见的感染性疾病之一。其流行病学特征因宿主和免疫状况而异,病原谱也随时间和空间分布而迁移;与此同时,随新冠疫情突发,一些非传统治疗策略正在兴起。本文对我国近年来CAP的流行病学特... 详细信息

社区获得性肺炎(CAP)是全球第三大致死原因,是最常见的感染性疾病之一。其流行病学特征因宿主和免疫状况而异,病原谱也随时间和空间分布而迁移;与此同时,随新冠疫情突发,一些非传统治疗策略正在兴起。本文对我国近年来CAP的流行病学特征、病原谱变迁及治疗方向转变进行阐述,以期为CAP的诊疗提供参考。

关键词：肺炎社区获得性感染流行病学治疗病原学

T2T-YAO: A Telomere-to-telomere Assembled Diploid Reference Genome for Han Chinese

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Genomics, Proteomics & Bioinformatics 2023年第6期21卷 1085-1100页

作者： Yukun He Yanan Chu Shuming Guo Jiang Hu Ran Li Yali Zheng Xinqian Ma Zhenglin Du Lili Zhao Wenyi Yu Jianbo Xue Wenjie Bian Feifei Yang Xi Chen Pingan Zhang Rihan Wu Yifan Ma Changjun Shao Jing Chen Jian Wang Jiwei Li Jing Wu Xiaoyi Hu qiuyue long Mingzheng Jiang Hongli Ye Shixu Song Guangyao Li Yue Wei Yu Xu Yanliang Ma Yanwen Chen Keqiang Wang Jing Bao Wen Xi Fang Wang Wentao Ni Moqin Zhang Yan Yu Shengnan Li Yu Kang Zhancheng Gao Department of Respiratory and Critical Care Medicine Peking University People’s HospitalBeijing 100044China CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Linfen Clinical Medicine Research Center Linfen 041000China Institute of Chest and Lung Diseases Shanxi Medical UniversityTaiyuan 030001China GrandOmics Biosciences Co. LtdWuhan 430076China Beijing Key Laboratory of Genome and Precision Medicine Technologies Beijing 100101China Department of Respiratory Critical Care and Sleep MedicineXiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361101China Institute of PSI Genomics Wenzhou 325024China Beijing Jishuitan Hospital Capital Medical UniversityBeijing 100035China University of Chinese Academy of Sciences Beijing 100490China

Since its initial release in 2001,the human reference genome has undergone continuous improvement in quality,and the recently released telomere-to-telomere(T2T)version-T2T-CHM13—reaches its highest level of continuity and accuracy after 20 years of effort by working on a simplified,nearly homozygous genome of a hydatidiform mole cell ***,to provide an authentic complete diploid human genome reference for the Han Chinese,the largest population in the world,we assembled the genome of a male Han Chinese individual,T2T-YAO,which includes T2T assemblies of all the 22+X+M and 22+Y chromosomes in both *** quality of T2T-YAO is much better than those of all currently available diploid assemblies,and its haploid version,T2T-YAO-hp,generated by selecting the better assembly for each autosome,reaches the top quality of fewer than one error per 29.5 Mb,even higher than that of *** from an individual living in the aboriginal region of the Han population,T2T-YAO shows clear ancestry and potential genetic continuity from the ancient *** haplotype of T2TYAO possesses330-Mb exclusive sequences,3100 unique genes,and tens of thousands of nucleotide and structural variations as compared with CHM13,highlighting the necessity of a population-stratified reference *** construction of T2T-YAO,an accurate and authentic representative of the Chinese population,would enable precise delineation of genomic variations and advance our understandings in the hereditability of diseases and phenotypes,especially within the context of the unique variations of the Chinese population.

关键词： Referencegenome Telomere-to-telomere assembly Han Chinese Haplotype-resolved assembly Diploid

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透析人体内葡萄糖的跨膜转运方式

生物学教学 2020年第4期45卷 68-70页

作者：龙秋月赵辉广东省深圳市宝安区新安中学深圳518101 广东省深圳大学师范学院附属中学深圳518054

本文对葡萄糖跨膜运输方式进行了系统梳理、概括,为高中生物学一线教师对“物质跨膜运输方式”一节内容的教学提供参考。

关键词：葡萄糖跨膜转运分类机制

基于科技论文创设真实问题情境的试题命制与评价

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生物学通报 2023年第12期58卷 68-71页

作者：赵辉龙秋月连圣强深圳大学附属中学广东深圳518054 深圳市新安中学高中部广东深圳518101 陕西师范大学教育学院陕西西安710061 深圳市宝安区教育科学研究院广东深圳518101

以一道原创试题的命制与评价为例,阐述如何基于科技论文创设真实问题情境,展开层次清晰、逻辑严谨的设问,达到有效测评生物学学科核心素养的目的,为提升试题命制的科学性提供借鉴。

关键词：试题命制评价科技论文核心素养

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“分解纤维素的微生物的分离”疑点探讨

生物学教学 2019年第11期44卷 74-75页

作者：赵辉龙秋月广东省深圳大学附属中学深圳518054 广东省深圳市宝安区新安中学深圳518101

本文针对“分解纤维素的微生物的分离”实验中常见的四点疑问进行探讨,为该实验教学的顺利开展提供参考.

关键词：纤维素分解菌培养基分离实验教学

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新型冠状病毒再感染病例临床特点汇总分析

中华结核和呼吸杂志 2021年第9期44卷 793-799页

作者：龙秋月郑雅莉高占成厦门大学附属翔安医院呼吸与危重症和睡眠医学科 361102 北京大学人民医院呼吸与危重症医学科 100044

目的回顾性分析已发表的新型冠状病毒(简称新冠病毒)再感染病例,了解其在人群中的发病情况并寻找再感染高风险因素,以期为临床诊疗和防疫工作提供参考。方法在电子数据库中检索已发表的新冠病毒再感染病例,并分别提取入选病例的相关数... 详细信息

目的回顾性分析已发表的新型冠状病毒(简称新冠病毒)再感染病例,了解其在人群中的发病情况并寻找再感染高风险因素,以期为临床诊疗和防疫工作提供参考。方法在电子数据库中检索已发表的新冠病毒再感染病例,并分别提取入选病例的相关数据和信息,包括患者基础疾病、抗体检测结果和病毒株基因组测序结果等。结果纳入来自14个国家20篇文献中的29例再感染病例。再感染患者年龄为21~90岁(中位年龄53岁),性别分布无明显差异。在29例患者中,11例患者为医护人员;6例患者使用了包括糖皮质激素在内的免疫抑制药物;17例患者症状表现较初次感染更重;其中5例患者死亡且其年龄均超过80岁。同一病毒株再次感染者,其感染时间间隔多<60 d;不同病毒株再感染者,其时间间隔大多较长(中位时间78.5 d)。再感染确诊时有9例患者抗体检测结果为阴性或抗体滴度低,其中5例在初次感染期间抗体检测结果也为阴性。结论病毒特异性抗体可为绝大多数人群提供保护作用,但随着时间延长保护水平下降。职业暴露、体内抗体水平低下甚或不能产生抗体,可能为再感染的主要危险因素。高龄为预后不良的主要危险因素。做好个人防护和保持有效社交距离仍不容懈怠。

关键词：新型冠状病毒再感染抗体危险因素预防