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Progress,challenges,and prospects of spent lithium-ion batteries recycling:A review

Journal of Energy Chemistry 2024年第2期89卷 144-171,I0005页

作者： Pengwei Li Shaohua Luo Lin Zhang qiuyue liu Yikai Wang Yicheng Lin Can Xu Jia Guo Peam Cheali Xiaoning Xia School of Materials Science and Engineering Northeastern UniversityShenyang 110819LiaoningChina School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao 066004HebeiChina Department of Chemistry and Bioscience Aalborg UniversityAalborg 9220Denmark Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province Qinhuangdao 066004HebeiChina Department of Materials and Production Aalborg UniversityAalborg 9220Denmark School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

The recycling and reutilization of spent lithium-ion batteries(LIBs)have become an important measure to alleviate problems like resource scarcity and environmental *** some progress has been made,battery recycling technology still faces challenges in terms of efficiency,effectiveness and environmental *** review aims to systematically review and analyze the current status of spent LIB recycling,and conduct a detailed comparison and evaluation of different recycling *** addition,this review introduces emerging recycling techniques,including deep eutectic solvents,molten salt roasting,and direct regeneration,with the intent of enhancing recycling efficiency and diminishing environmental ***,to increase the added value of recycled materials,this review proposes the concept of upgrading recycled materials into high value-added functional materials,such as catalysts,adsorbents,and *** life cycle assessment,the paper also explores the economic and environmental impacts of current battery recycling and highlights the importance that future recycling technologies should achieve a balance between recycling efficiency,economics and environmental ***,this review outlines the opportunities and challenges of recycling key materials for next-generation batteries,and proposes relevant policy recommendations to promote the green and sustainable development of batteries,circular economy,and ecological civilization.

关键词： Spent li-ion batteries Recycle Direct regeneration High-value conversion Functional materials

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RIPK1 plays a crucial role in maintaining regulatory T-Cell homeostasis by inhibiting both RIPK3-and FADD-mediated cell death

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Cellular & Molecular Immunology 2024年第1期21卷 80-90页

作者： Xiaoxue Deng Lingxia Wang Yunze Zhai qiuyue liu Fengxue Du Yu Zhang Wenxing Zhao Tingtao Wu Yiwen Tao Jie Deng Yongbing Cao Pei Hao Jiazi Ren Yunli Shen Zuoren Yu Yuejuan Zheng Haibing Zhang Haikun Wang State Key Laboratory of Cardiology Shanghai East HospitalTongji University School of MedicineShanghai200120China CAS Key Laboratory of Molecular Virology and Immunology Shanghai Institute of Immunity and InfectionChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai200031China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthShanghai Institutes for Biological SciencesUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai200031China The Research Center for Traditional Chinese Medicine Shanghai Institute of Infectious Diseases and BiosecurityShanghai University of Traditional Chinese MedicineShanghai201203China Institute of Vascular Disease Shanghai TCM-Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai200433China

Regulatory T(T_(reg))cells play an essential role in maintaining immune balance across various physiological and pathological ***,the mechanisms underlying T_(reg)homeostasis remain incompletely ***,we report that RIPK1 is crucial for T_(reg) cell survival and *** generated mice with T_(reg) cell-specific ablation of Ripk1 and found that these mice developed fatal systemic autoimmunity due to a dramatic reduction in the Treg cell compartment caused by excessive cell *** conventional T cells,Treg cells with Ripk1 deficiency were only partially rescued from cell death by blocking FADD-dependent ***,simultaneous removal of both Fadd and Ripk3 completely restored the homeostasis of Ripk1-deficient Treg cells by blocking two cell death ***,our study highlights the critical role of RIPK1 in regulating Treg cell homeostasis by controlling both apoptosis and necroptosis,thereby providing novel insights into the mechanisms of Treg cell homeostasis.

关键词： Treg cell Homeostasis Apoptosis Necroptosis

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结核分枝杆菌膜囊泡RNA表达谱分析及功能研究

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中国医学前沿杂志（电子版） 2024年第3期16卷 28-33,I0002页

作者：吕翎娜刘秋月首都医科大学附属北京佑安医院肝病消化中心、首医基础-临床联合实验室北京100069 首都医科大学附属北京胸科医院重症医学科、北京市耐药结核病研究重点实验室北京101149

目的描绘结核分枝杆菌膜囊泡(mycobacterium tuberculosis membrane vesicles,MVs)的RNA特征表达谱,分析其主要的生物功能,初步探索其诱导巨噬细胞凋亡的作用。方法分离结核分枝杆菌MVs,提取总RNA,采用illumina Hiseq 2500-SE50平台... 详细信息

目的描绘结核分枝杆菌膜囊泡(mycobacterium tuberculosis membrane vesicles,MVs)的RNA特征表达谱,分析其主要的生物功能,初步探索其诱导巨噬细胞凋亡的作用。方法分离结核分枝杆菌MVs,提取总RNA,采用illumina Hiseq 2500-SE50平台进行双端测序。使用BWA软件进行序列比对,通过COG数据库对基因进行功能注释。通过MTT试验检测细胞存活率,采用Annexin-V联合PI染色法检测细胞凋亡。结果本研究通过RNA测序及生物信息学分析描绘了结核分枝杆菌MVs中RNA的种类及含量,COG数据库功能注释结果显示这些RNA主要富集的生物学功能包括脂质转运代谢、氨基酸转运代谢、能量产生与转化、次级代谢物合成转运与代谢和转录等。生物分析显示富集的主要功能包括脂质转运代谢、氨基酸转运代谢、能量产生与转化、次级代谢物合成转运与代谢和转录等。功能实验表明,结核分枝杆菌MVs可以降低THP-1源巨噬细胞的存活率,促进细胞凋亡。结论结核分枝杆菌MVs中含有丰富的短片段RNA,具有诱发细胞凋亡的作用。然而其具体作用机制仍需要更深入细致的研究。

关键词：结核分枝杆菌膜囊泡核糖核酸测序细胞凋亡

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预混煤油/空气两相旋转爆轰传播特性数值研究

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推进技术 2024年第9期45卷 118-128页

作者：刘秋月王放翁春生赵庆军南京理工大学瞬态物理国家重点实验室中国科学院工程热物理研究所轻型涡轮动力全国重点实验室中国科学院大学航空宇航学院分布式冷热电联供系统北京市重点实验室

为研究预混煤油/空气两相旋转爆轰波的传播特性，以煤油蒸气/液滴为燃料，空气为氧化剂，开展了二维旋转爆轰过程的数值模拟计算，研究了气态燃料当量比和液滴直径对气液两相旋转爆轰过程中流场结构、胞格形状和数目、爆轰分数以及传播... 详细信息

为研究预混煤油/空气两相旋转爆轰波的传播特性，以煤油蒸气/液滴为燃料，空气为氧化剂，开展了二维旋转爆轰过程的数值模拟计算，研究了气态燃料当量比和液滴直径对气液两相旋转爆轰过程中流场结构、胞格形状和数目、爆轰分数以及传播速度等特征的影响。结果表明：较高的气态燃料当量比和较小的液滴直径有利于旋转爆轰波的成功传播。气态燃料当量比为0.83时，可起爆的液滴直径增大至40μm。研究发现，爆轰波成功起爆的前提下，提高气态燃料当量比或减小液滴直径均利于胞格数目的增多和平均尺寸的减小，胞格数目为5.0～6.7，低于5.0爆轰波将无法维持传播；燃料的爆轰分数与气态燃料当量比和液滴直径有关，提高气态燃料当量比或减小液滴直径均促进燃料的爆轰分数以及爆轰波传播速度的提高，爆轰分数最高可达94.9%，爆轰波的传播速度为1 638.34～1 777.62 m/s，速度亏损在13%以内。

关键词：旋转爆轰波气态燃料当量比两相爆轰传播特性数值仿真

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颈部淋巴结结核超声检查表现及其预后分析

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医学影像学杂志 2024年第6期34卷 26-29,36页

作者：杨青张鸥权刘秋月首都医科大学附属北京胸科医院超声科北京101149 首都医科大学附属北京胸科医院重症医学科北京101149

目的探讨颈部淋巴结结核的超声特征,分析超声检查不同声像图表现与颈部淋巴结结核预后的关系。方法选取在北京胸科医院经病理确诊并接受规律抗结核治疗的109例颈部淋巴结结核患者超声检查不同声像图表现,根据液化情况分为两组:无液化及... 详细信息

目的探讨颈部淋巴结结核的超声特征,分析超声检查不同声像图表现与颈部淋巴结结核预后的关系。方法选取在北京胸科医院经病理确诊并接受规律抗结核治疗的109例颈部淋巴结结核患者超声检查不同声像图表现,根据液化情况分为两组:无液化及液化范围<50%的淋巴结作为A组(63例),液化范围≥50%的淋巴结作为B组(46例),停药时比较两组淋巴结的缩小率,分析两组的预后是否存在差异。结果规律抗结核至患者停药,两组病例中A组淋巴结缩小率大于B组,差异有统计学意义(P<0.001)。结论A组淋巴结抗结核治疗后预后更好,超声检查可以全程观察颈部淋巴结结核患者的淋巴结情况、对疾病的诊断及预后有指导价值。

关键词：淋巴结结核超声检查预后

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Current research trends of nanomedicines

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Acta Pharmaceutica Sinica B 2023年第11期13卷 4391-4416页

作者： qiuyue liu Jiahui Zou Zhongjian Chen Wei He Wei Wu Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China School of Pharmacy China Pharmaceutical UniversityNanjing 211198China Shanghai Pudong Hospital Fudan University Pudong Medical CenterShanghai 201399China Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China Fudan Zhangjiang Institute Shanghai 201203China

Owing to the inherent shortcomings of traditional therapeutic drugs in terms of inadequate therapeutic efficacy and toxicity in clinical treatment,nanomedicine designs have received widespread attention with significantly improved efficacy and reduced non-target side *** hold tremendous theranostic potential for treating,monitoring,diagnosing,and controlling various diseases and are attracting an unfathomable amount of input of research *** the backdrop of an exponentially growing number of publications,it is imperative to help the audience get a panorama image of the research activities in the field of ***,this review elaborates on the development trends of nanomedicines,emerging nanocarriers,in vivo fate and safety of nanomedicines,and their extensive ***,the potential challenges and the obstacles hindering the clinical translation of nanomedicines are also *** elaboration on various aspects of the research trends of nanomedicines may help enlighten the readers and set the route for future endeavors.

关键词： Nanomedicine Drug delivery Nanoparticles Nanocarriers Trigger-responsive In vivo fate Protein corona Clinical translation

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重组人促红细胞生长素联合维生素D治疗对腹膜透析肾性贫血患者的影响

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中外医学研究 2024年第16期22卷 17-20页

作者：王艳桥郑自力柳秋月晋江市医院(上海市第六人民医院福建医院) 福建晋江362200

目的:研究重组人促红细胞生长素联合维生素D治疗腹膜透析肾性贫血患者的影响。方法:选取2022年1月—2023年6月于晋江市医院进行诊治的120例腹膜透析肾性贫血患者,按照随机数表法分为观察组[活性维生素D(骨化三醇)+重组人促红细胞生长素... 详细信息

目的:研究重组人促红细胞生长素联合维生素D治疗腹膜透析肾性贫血患者的影响。方法:选取2022年1月—2023年6月于晋江市医院进行诊治的120例腹膜透析肾性贫血患者,按照随机数表法分为观察组[活性维生素D(骨化三醇)+重组人促红细胞生长素注射治疗]和对照组(应用重组人促红细胞生长素注射治疗),各60例。比较两组治疗前后血细胞情况[血红蛋白(Hb)、红细胞计数(RBC)、红细胞压积(HCT)]、铁代谢指标[血清铁调素、血清铁(SI)、血清铁蛋白(SF)]、甲状腺激素水平[血游离三碘甲状腺原氨酸(FT_(3))、血游离甲状腺素(FT_(4))、促甲状腺素(TSH)、全段甲状旁腺激素(PTH)]及不良反应发生情况。结果:治疗后,两组Hb、RBC和HCT水平均高于治疗前,且观察组Hb和RBC水平高于对照组,差异有统计学意义(P<0.05)。治疗后,两组血清铁调素、SF低于治疗前,SI高于治疗前,且观察组血清铁调素、SF低于对照组,SI高于对照组,差异有统计学意义(P<0.05)。治疗后,两组TSH、FT_(3)、FT_(4)高于治疗前,PTH低于治疗前,且观察组TSH、FT_(4)高于对照组,PTH低于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(χ^(2)=1.345,P=0.246)。结论:重组人促红细胞生长素联合维生素D治疗可显著改善腹膜透析肾性贫血患者血细胞指标,调节铁代谢及甲状腺激素水平,且未见明显不良反应。

关键词：维生素D 肾性贫血腹膜透析铁调素甲状腺激素

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“互联网+”背景下沙县小吃的品牌营销策略研究

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北方经贸 2024年第8期 77-81页

作者：余可欣程春廖嘉璇刘秋悦汤奕菲仰恩大学管理学院福建泉州362014

沙县小吃作为传统特色美食品牌,经过多年的发展取得了一定的成绩,但在发展过程中也遭遇瓶颈。在互联网+背景下,沙县小吃积极借助互联网平台开展营销,以提升品牌竞争力,推动产业实现转型升级。现基于“互联网+”背景下沙县小吃的品牌营... 详细信息

沙县小吃作为传统特色美食品牌,经过多年的发展取得了一定的成绩,但在发展过程中也遭遇瓶颈。在互联网+背景下,沙县小吃积极借助互联网平台开展营销,以提升品牌竞争力,推动产业实现转型升级。现基于“互联网+”背景下沙县小吃的品牌营销概况,对品牌营销开展情况进行问卷调查,根据存在问题提出品牌营销的对策,为沙县小吃品牌竞争力的提升提供参考和借鉴。

关键词：沙县小吃品牌营销策略

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Spatiotemporal Evolution of Urban Heat Islands and Optimization of Spatial Network Construction in the Central Urban Area of Fuzhou City, China

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Chinese Geographical Science 2024年第5期34卷 917-930页

作者： ZHAO qiuyue YU Kunyong GENG Jianwei LIN Jiqing AI Jingwen liu Jian College of Landscape Architecture Fujian Agriculture and Forestry UniversityFuzhou 350002China University Key Lab for Geomatics Technology and Optimize Resources Utilization in Fujian Province Fujian Agriculture and Forestry UniversityFuzhou 350002China

Although accelerated urbanization has led to economic prosperity,it has also resulted in urban heat island ***,identifying methods of using limited urban spaces to alleviate heat islands has become an urgent *** this study,we assessed the spatiotemporal evolution of urban heat islands within the central urban area of Fuzhou City,China from 2010 to *** assessment was based on a morphological spatial pattern analysis(MSPA)model and an urban thermal environment spatial network constructed us-ing the minimum cumulative resistance(MCR)*** measures for the spatial network were proposed to provide a theor-etical basis for alleviating urban heat *** results show that the heat island area within the study area gradually increased while that of urban cold island area gradually *** core area was the largest of the urban heat island patch landscape elements with a significant impact on other landscape elements,and represented an important factor underlying urban heat island network *** thermal environment network revealed a total of 197 thermal environment corridors and 93 heat island *** locations were then optimized according to the current land use,which maximized the potential of 1599.83 *** based on current land use led to an increase in climate resilience,with effective measures showing reduction in thermal environment spatial network structure and function,contributing to the mitigation of urban heat *** findings support the use of current land use patterns during urban heat island mitigation measure planning,thus providing an important reference basis for alleviating urban heat island effects.

关键词： urban heat island spatiotemporal analysis circuit theory post optimization evaluation climate mitigation Fuzhou City,China

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The m^(6)A reader YTHDC2 maintains visual function and retinal photoreceptor survival through modulating translation of PPEF2 and PDE6B

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Journal of Genetics and Genomics 2024年第2期51卷 208-221页

作者： Yeming Yang Xiaoyan Jiang Junyao Chen Lu liu Guo liu Kuanxiang Sun Wenjing liu Xianjun Zhu qiuyue Guan The Sichuan Provincial Key Laboratory for Human Disease Gene Study Center for Medical GeneticsSichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Department of Geriatrics Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical Sciences and Sichuan Provincial People's HospitalChengduSichuan 610072China Qinghai Key Laboratory of Qinghai Tibet Plateau Biological Resources Chinese Academy of Sciences and Qinghai Provincial Key Laboratory of Tibetan Medicine ResearchNorthwest Institute of Plateau BiologyXiningQinghai 810008China Henan Eye Institute Henan Eye HospitalPeople's Hospital of Zhengzhou UniversityHenan Provincial People's HospitalZhengzhouHenan 450003China

Inherited retinal dystrophies (IRDs) are major causes of visual impairment and irreversible blindness worldwide, while the precise molecular and genetic mechanisms are still elusive. N6-methyladenosine (m^(6)A) modification is the most prevalent internal modification in eukaryotic mRNA. YTH domain containing 2 (YTHDC2), an m^(6)A reader protein, has recently been identified as a key player in germline development and human cancer. However, its contribution to retinal function remains unknown. Here, we explore the role of YTHDC2 in the visual function of retinal rod photoreceptors by generating rod-specific Ythdc2 knockout mice. Results show that Ythdc2 deficiency in rods causes diminished scotopic ERG responses and progressive retinal degeneration. Multi-omics analysis further identifies Ppef2 and Pde6b as the potential targets of YTHDC2 in the retina. Specifically, via its YTH domain, YTHDC2 recognizes and binds m^(6)A-modified Ppef2 mRNA at the coding sequence and Pde6b mRNA at the 5′-UTR, resulting in enhanced translation efficiency without affecting mRNA levels. Compromised translation efficiency of Ppef2 and Pde6b after YTHDC2 depletion ultimately leads to decreased protein levels in the retina, impaired retinal function, and progressive rod death. Collectively, our finding highlights the importance of YTHDC2 in visual function and photoreceptor survival, which provides an unreported elucidation of IRD pathogenesis via epitranscriptomics.

关键词： Epitranscriptomics N^(6)-methyladenosine(m^(6)A) Inherited retinal dystrophies YTHDC2 Retina function Photoreceptor degeneration

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