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Palladium-catalyzed asymmetric carbamoyl-carbonylation of alkenes

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Science China Chemistry 2021年第8期64卷 1367-1371页

作者： Ziwen Feng qiuyu li Long Chen Hequan Yao Aijun lin State Key Laboratory of Natural Medicines(SKLNM)and Department of Medicinal Chemistry School of PharmacyChina Pharmaceutical UniversityNanjing210009China

An unprecedented palladium-catalyzed asymmetric carbamoyl-carbonylation of tethered alkenes with CO and alcohols has been *** reaction provided an efficient route to access oxindoles andγ-lactams bearingβ-carbonyl substituted quaternary carbons in good yields with excellent chemo-,regio-and ***-scale synthetic capability and facile transformations of the products to chiral spirooxindole and other functional molecules further illustrated the practicability of this reaction.

关键词： carbonylation oxindoles γ-lactams asymmetric catalytic synthesis quaternary carbon stereocenters

Assessment and prediction of the effect of ageing on the adsorption of nonylphenol in black carbon-sediment systems

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Journal of Environmental Sciences 2021年第4期33卷 216-225页

作者： Guanghuan Cheng Han liu Tailu Dong qiuyu li Mingyang Sun liping Lou Environmental Science College of EngineeringChina Pharmaceutical UniversityNanjing 211198China Department of Environmental Engineering Zhejiang UniversityHangzhou 310058China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control(AEMPC) Collaborative Innovation Center of Atmospheric Environment and Equipment Technology(AEET)School of Environmental Science and EngineeringNanjing University of Information Science&Technology(NUIST)Nanjing 210044China Key Laboratory of Water Pollution Control and Environmental Safety of Zhejiang Province Hangzhou 310058China

Black carbon(BC)is a promising sediment amendment,as proven by its considerable adsorption capacity for hydrophobic organic pollutants and accessibility,but its reliability when used for the removal of pollutants in natural sediments still needs to be *** example,the ageing process,resulting in changing of surface physicochemical properties of BC,will decrease the adsorption capacity and performance of BC when applied to sediment pollution *** this study,how the ageing process and BC proportion affect the adsorption capacity of BC-sediment systems was modelled and quantitatively investigated to predict their adsorption capacity under different ageing times and BC *** results showed that the ageing process decreased the adsorption capacity of both BC-sediment systems,due to the blockage of the non-linear adsorption sites of *** adsorption capacity of rice straw black carbon(RC)-sediment systems was higher than that of fly ash black carbon(FC)-sediment systems,indicating that RC is more efficient than FC for nonylphenol(NP)pollution control in *** newly established model for the prediction of adsorption capacity fits the experimental data appropriately and yields acceptable predictions,especially when based on parameters from the Freundlich ***,to fully reflect the influence of the ageing process on BC-sediment systems and make more precise predictions,it is recommended that future work considering more factors and conditions,such as modelling of the correlation between the adsorption capacity and the pore volume or specific surface area of BC,be applied to build an accurate and sound model.

关键词： Black carbon(BC) Nonylphenol(NP) Ageing Sorption Sediment

Fabrication of 3D hollow acorn-shell-like PtBi intermetallics via a surfactant-free pathway for efficient ethylene glycol electrooxidation

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Nano Research 2023年第5期16卷 6560-6567页

作者： Tingting Wan Xin Huang Sichen li qiuyu li Xianlong Yang Zhenjie Sun Dong Xiang Kun Wang Peng li Manzhou Zhu Department of Chemistry and Center for Atomic Engineering of Advanced Materials School of Materials Science and EngineeringAnhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized MaterialsAnhui UniversityHefei 230601China Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of EducationAnhui UniversityHefei 230601China

The synthesis of atomically ordered Pt-based intermetallic electrocatalysts for the direct alcohol fuel cells generally requires the addition of surfactants or the high-temperature ***,some residual surfactants on the surface of the assynthesized catalysts would prevent the exposure of catalytic active sites,the high-temperature annealing process is easy to accelerate the sintering of the metal,which both lead to the decline of electrocatalytic ***,we construct the atomically ordered bimetallic PtBi intermetallics with clean surfaces and unique three-dimensional hollow acorn-shell-like structure(3D PtBi HASL)by a simple,low-temperature,surfactant-free one-pot synthetic *** from the special hollow structures,the obtained 3D PtBi HASL intermetallics expose abundant accessible active ***,the introduction of oxophilic metal Bi can enhance adsorption of OHads,thereby significantly facilitating removal of poisoned *** functional theory(DFT)simulations further indicate that formation of the PtBi intermetallic phase with the downshift of the Pt d-band center endows 3D Pt49.4Bi50.6 HASL intermetallics with significantly attenuated COads and enhanced OHads adsorption,bringing about the boosting electrocatalytic *** mass activity of the 3D Pt49.4Bi50.6 HASL intermetallics for ethylene glycol oxidation reaction is as high as 24.67 A·mgPt^(−1),which is 12.98 times higher than that of commercial Pt/C(1.90 A·mgPt^(−1)).This work may inspire the design of Pt-based intermetallics as high-efficiency anode electrocatalysts for fuel cell applications.

关键词： surfactant-free strategy PtBi intermetallic three-dimensional hollow structure electrocatalyst ethylene glycol oxidation reaction

Immune microenvironment-reshaping Au@Bi_(2)Te_(3) nanoparticles for spectral computed tomography/photoacoustic imaging-guided synergetic photo/radio/immunotherapy

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Nano Research 2023年第1期16卷 771-781页

作者： Kai Zhu Zede Wu qiuyu li Meirong Hou Honglei Hu Shuting Zheng li Qi Yikai Xu Chenggong Yan Bingxia Zhao Department of Medical Imaging Center Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Guangzhou Key Laboratory of Tumor Immunology Research Cancer Research InstituteSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key Laboratory of Medical Image Processing Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic TechnologySchool of Biomedical EngineeringSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key Laboratory of Shock and Microcirculation Guangzhou 510515China Experimental Education/Administration Center School of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510515China

Radiotherapy(RT)mediated tumor immunogenicity offers an opportunity for simultaneous RT and immunotherapy via immunogenic cell death(ICD),which releases damaged-associated molecular patterns and generates“eat me”signals for the innate immune system to modulate the ***,tumor hypoxia significantly reduces the therapeutic efficacy of RT and hampers its mediation of ICD ***,Au@Bi_(2)Te_(3)-polyethylene glycol(PEG)was rationally constructed as theranostic nanozymes for mild photothermal therapy,tumor hypoxia modulation,and RT adjuvant cancer *** tumor-specific production of oxygen could not only augment the effects of RT by enhanced reactive oxygen species(ROS)generation,but also reduce hypoxia-related cytokines and downregulate programmed cell death-ligand 1(PD-L1)to unleash immune-enhancing T ***,Au@Bi_(2)Te_(3)-PEG could act as an immune-blocking inhibitor by efficient ICD induction with the combination of mild-photothermal therapy+RT to inhibit the tumor immune escape and improve antitumor immune *** amounts of CD^(4+) and CD^(8+) Tcells and elevated levels of cytokines could be observed that eventually led to effective post-medication inhibition of primary and abscopal *** computed tomography/photoacoustic imaging allowed noninvasive and real-time tracking of nanoparticle(NP)accumulation and oxygenation status at tumor ***,Au@Bi_(2)Te_(3)-PEG NPs could serve as effective theranostic nanoregulators with remarkable synergistic mildphotothermal/RT/immunotherapy effects that helped reshape the immune microenvironment and had remarkable molecular imaging properties.

关键词： radioresistance immunotherapy immunogenic cell death hypoxia programmed cell death-ligand 1(PD-L1) spectral computed tomography(CT)

A Novel Location Method for Interline Power Flow Controllers Based on Entropy Theory

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Protection and Control of Modern Power Systems 2024年第3期9卷 70-81页

作者： qiuyu li Baohong li Qin Jiang Tianqi liu Yin Yue Yingmin Zhang Sichuan University the School of Electrical Engineering Sichuan UniversityChengdu 610065China the College of Electrical Engineering and Information Technology Sichuan University

As one of the new generation flexible AC transmission systems(FACTS)devices,the interline power flow controller(IPFC)has the significant advantage of simultaneously regulating the power flow of multiple ***,how to choose the appropriate location for the IPFC converters has not been discussed *** solve this problem,this paper proposes a novel location method for IPFC using entropy *** clarify IPFC’s impact on system power flow,its operation mechanism and control strategies of different types of serial converters are ***,to clarify the system power flow characteristic suitable for device location analysis,the entropy concept is *** this process,the power flow distribution entropy index is used as an optimization *** this index as a foundation,the power flow transfer entropy index is also generated and proposed for the IPFC location determination ***,electromechanical electromagnetic hybrid simulations based on ADPSS are implemented for *** are tested in a practical power grid with over 800 nodes.A modular multilevel converter(MMC)-based IPFC electromagnetic model is also established for precise *** results show that the proposed method can quickly and efficiently complete optimized IPFC location and support IPFC to determine an optimal adjustment in the N-1 fault cases.

关键词： Flexible alternative current transmission systems interline power flow controller modular multi-level converter optimized location method power flow transfer entropy

Site-Selective Palladium-Catalyzed 1,1-Arylamination of Terminal Alkenes

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CCS Chemistry 2022年第2期4卷 616-624页

作者： Chunhua Han libo Cai Dongquan Zhang Rui Pan qiuyu li Aijun lin Hequan Yao State Key Laboratory of Natural Medicines(SKLNM) Department of Medicinal ChemistrySchool of PharmacyChina Pharmaceutical UniversityNanjing 210009

Many of the commonly used pharmaceuticals and biologically active natural products are nitrogencontaining ***,the transitionmetal-catalyzed or the radical-mediated 1,2-carboamination of alkenes has been well explored to access amine ***,synthetic strategies toward the 1,1-carboamination of alkenes are severely ***,we describe a method to achieve the 1,1-arylamination using readily available building blocks enabled by palladium *** sequential three step-Heck arylation,metal migration,followed by aza-1,6-Micheal addition process exhibits excellent chemo-and *** showcase the potential as a method for diversity-oriented drug discovery,the modification of numerous structurally complex bioactive molecules was also successfully performed.

关键词： alkene 1,1-arylamination palladium-catalyzed site-selective nitrogen-containing molecules

Morphology controllable urchin-shaped bimetallic nickel-cobalt oxide/carbon composites with enhanced electromagnetic wave absorption performance

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Journal of Materials Science & Technology 2023年第17期148卷 250-259页

作者： Fushan li qiuyu li Hideo Kimura Xiubo Xie Xiaoyu Zhang Nannan Wu Xueqin Sun Ben Bin Xu Hassan Algadi Rami Adel Pashameah Abdullah K.Alanazi Eman Alzahrani Handong li Wei Du Zhanhu Guo Chuanxin Hou School of Environmental and Material Engineering Yantai UniversityYantai 264005China Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing Yantai 264005China School of Material Science and Engineering Shandong University of Science and TechnologyQingdao 266590China Mechanical and Construction Engineering Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle Upon Tyne NE18STUK College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Department of Electrical Engineering Faculty of EngineeringNajran UniversityNajran 11001Saudi Arabia Department of Chemistry Faculty of Applied ScienceUmm Al-Qura UniversityMakkah 24230Saudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Integrated Composites Laboratory(ICL) Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK Department of Chemical and Bimolecular Engineering University of TennesseeKnoxvilleTN 37996United States

The microscopic morphology of electromagnetic wave absorbers influences the multiple reflections of electromagnetic waves and impedance matching,determining the absorption ***,the urchin-shaped bimetallic nickel-cobalt oxide/carbon(NiCo_(2)O_(4)/C)composites are prepared via a hy-drothermal route,whose absorption properties are investigated by different morphologies regulated by changing calcination temperature.A minimum reflection loss(RL_(min))of-75.26 dB is achieved at a match-ing thickness of 1.5 mm,and the effective absorption bandwidth(EAB)of 8.96 GHz is achieved at 2 ***-advantages of the synthesized NiCo_(2)O_(4)/C composites contribute to satisfactory absorption ***,the interweaving of the needle-like structures increases the opportunities for scattering and multiple reflections of incident electromagnetic waves,and builds up a conductive network to facilitate the enhancement of conductive ***,the carbon component in the NiCo_(2)O_(4)/C composites en-hances the interfacial polarization and reduces the density of the ***,generous oxygen va-cancy defects are introduced into the NiCo_(2)O_(4)/C composites,which induces defect polarization and dipole *** summary,the ternary coordination of components,defects and morphology led to out-standing electromagnetic wave absorption,which lightened the path for improving the electromagnetic wave absorption property and enriching the family of NiCo_(2)O_(4) absorbers with excellent performance.

关键词： NiCo_(2)O_(4)/C Oxygen vacancies Interfacial polarization Electromagnetic wave absorber

Multifaceted Rasch Model in Competition Assessment An Empirical Study Based on Counselors’ Professional Ability Competition

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Multifaceted Rasch Model in Competition Assessment An Empiri...

Studying Alzheimer’s Disease Using Drosophila melanogaster as a Powerful Tool

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作者： Siyuan Huang Yuanyuan Wang qiuyu li Tian Yu College of Science Wuhan University of Science and Technology

In the event of large-scale competitions, various factors such as the criterion of judges, the characteristic level of competitors and the testing mechanism affect the assessments on the practical capacity of competitors, making an unfair result. This paper introduces a Multifaceted Rasch Model which is based on Item Characteristic function. From the aspects of judges, competitors and testing mechanism, Facets Statistics Software is used in this model to analyze the consistency and deviation of the competitors’ scores, so that the three aspects can fall into the same evaluation scale. According to empirical analysis, to introduce an intermediate value as a parameter based on the model to further comprehensively correct the scores can obtain a good fitting result, which to some extent reduces the error of the assessment results brought by the subjective factors from the judges from different groups, and improves the fairness of the competition, providing a new way for the competition assessment.

关键词： Multifaceted Rasch model Grouping assessment Item Characteristic function Score correction

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Advances in Alzheimer's Disease 2022年第3期11卷 23-37页

作者： Jacob Kasanin Xingjun Wang Wanting Jiao qiuyu li Bingwei Lu Palo Alto High School Palo Alto USA Department of Pathology Stanford University School of Medicine Stanford USA School of life Science and Technology Tongji University Shanghai China

Background: Alzheimer’s disease (AD) is an increasingly prevalent neurodegenerative disease characterized by protein aggregation in the form of amyloid plaques containing beta-amyloid peptides and neurofibrillary tangles containing hyperphosphorylated tau protein. The central molecular events underlying AD pathogenesis remain controversial and poorly defined. Drosophila melanogaster has emerged as an important genetic resource for studying the pathology of AD. Many AD models have been created using Drosophila, taking advantage of its short generation times, sophisticated genetic tools, and abundance of homologs to human genes. Purpose: This review summarizes different models for studying AD in Drosophila melanogaster, including the full-length APP, C99, Aβ42 and Tau models, explaining how the models were built and what we have learned from them. Conclusion: Four main AD Drosophila models are introduced in this review, which can serve as a future method to investigate genes and drugs that can modify symptoms.

关键词： Drosophila Alzheimer’s Disease APP C99 Aβ42 Tau