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Chinese Chemical Letters 2023年第10期34卷 275-280页

作者： Xianyue Zhou qiuyang Liu Guangqiang Xu Rulin Yang Hongguang sun Qinggang Wang College of Polymer Science and Engineering Qingdao University of Science and TechnologyQingdao 266042China Key Laboratory of Biobased Materials Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Chemical upcycling of end-of-life poly(lactide) plastics to lactide,lactate ester and new poly(lactide)has been achieved by using magnesium bis[bis(trimethylsilyl)amide][Mg(HMDS)_(2)]as promoter.Mg(HMDS)2 showed high efficiency in L-lactide polymerization and poly(lactide) depolymerization.Mg(HMDS)_(2)/Ph_(2) CHOH catalytic system displayed high ring-opening selectivity and the characteristic of immortal polymerization.Taking advantage of transesterification,depolymerizations of end-oflife poly(lactide) plastics to lactate ester (polymer to value-added chemicals) and lactide (polymer to monomer) were achieved with high yields.Besides,a new“depolymerization-repolymerization”strategy was proposed to directly transform poly(lactide) into new poly(lactide).This work provides a theoretical basis for the design of polymerization and depolymerization catalysts and promotes the development of degradable polymers.

关键词： Upcycling Poly(lactide) Mg(HMDS)2 Polymerization Depolymerization

Dual-targeted lung cancer therapy via inhalation delivery of UCNP-siRNA-AS1411 nanocages

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Cancer Biology & Medicine 2022年第7期19卷 1047-1060页

作者： Yu Han Yuming Yang Qiuyang Sun Bin Li Caixia Yue Yanlei Liu Jesús M.de la Fuente Daxiang Cui Institute of Nano Biomedicine and Engineering Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of EducationShanghai Engineering Research Center for Intelligent Diagnosis and Treatment InstrumentDepartment of Instrument Science&EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China National Engineering Center for Nanotechnology Collaborative Innovational Center for System BiologyShanghai 200241China Department of Neurosurgery Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 200092China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Instituto de Nanociencia de Aragon(INA) Universidad de ZaragozaZaragoza 50018Spain

Objective:Although great progress has been made in the field of siRNA gene therapy,safe,efficient,and targeted delivery of siRNA are still major challenges in siRNA therapeutics.Methods:We developed an up-conversion nanoparticle-based nanocage system.This system protected the siRNA from being degraded by nucleases in organisms and selectively delivered the siRNAs to the tumor sites,due to modifications of targeted molecules on the surfaces of nanocages and local inhalation.Results:The siRNAs delivered by the up-conversion nanoparticle nanocages were protected from degradation in transit to the tumor sites,where they accumulated.Compared with the passive target and control groups,the up-conversion nanoparticles based on the nanocage system showed a tumor suppressive effect after approximately 3 weeks of treatment.Conclusions:The up-conversion nanoparticle nanocages efficiently delivered vascular endothelial growth factor siRNAs to tumor sites.Mice with lung tumors treated with tumors targeting up-conversion nanoparticle nanocages showed steady body weight changes,high tumor inhibition ratios,and longer survival times.

关键词： Nanomaterials VEGF siRNA lung cancer gene therapy siRNA delivery

Lithographic printing inspired in-situ transfer of MXene-based films with localized topo-electro tunability for high-performance flexible pressure sensors

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Nano Research 2023年第11期16卷 12670-12679页

作者： qiuyang Yan Yi Zhou Yin Cheng Liangjing Shi Ranran Wang Lian Gao Jing sun State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of ScienceShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

MXene-based films have been intensively explored for construction of piezoresistive flexible pressure sensors owing to their excellent mechanical and electrical properties.High pressure sensitivity relies on pre-molding a flexible substrate,or regulating the micromorphology of MXene sheets,to obtain a micro-structured surface.However,the two avenues usually require complicated and time-consuming microfabrication or wet chemical processing,and are limited to non-adjustable topographicelectrical(topo-electro)properties.Herein,we propose a lithographic printing inspired in-situ transfer(LIPIT)strategy to fabricate MXene-ink films(MIFs).In LIPIT,MIFs not only inherit ridge-and-valley microstructure from paper substrate,but also achieve localized topo-electro tunability by programming ink-writing patterns and cycles.The MIF-based flexible pressure sensor with periodical topo-electro gradient exhibits remarkably boosted sensitivity in a wide sensing range(low detection limit of 0.29 Pa and working range of 100 kPa).The MIF sensor demonstrates versatile applicability in both subtle and vigorous pressuresensing fields,ranging from pulse wave extraction and machine learning-assisted surface texture recognition to piano-training glove(PT-glove)for piano learning.The LIPIT is quick,low-cost,and compatible with free ink/substrate combinations,which promises a versatile toolbox for designing functional MXene films with tailored morphological-mechanical-electrical properties for extended application scenarios.

关键词： MXene film transfer printing surface tunability flexible pressure sensor

The most typical shape of oceanic mesoscale eddies from global satellite sea level observations

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Frontiers of Earth Science 2015年第2期9卷 202-208页

作者： Zifei WANG qiuyang LI Liang sun Song LI Yuanjian YANG Shanshan LIU Key Laboratory of the Atmospheric Composition and Optical Radiation CAS School of Earth and Space Sciences University of Science and Technology of China Hefei 230026 China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of Oceanography State Oceanic Administration HangZhou 310012 China Key Laboratory of Atmospheric Sciences and Satellite Remote Sensing of Anhui Province Anhui Institute of Meteorological Sciences Hefei 230031 China

In this research, we normalized the character- istics of ocean eddies by using satellite observation of the Sea Level Anomaly （SLA） data to determine the most typical shape of ocean eddies. This normalization is based on modified analytic functions with nonlinear optimal fitting. The most typical eddy is the Taylor vortex （~50%）, which exhibits a Gaussian-shaped exp（-r2） SLA and a vorticity distribution of （1-rZ）exp（-r2） as a function of the normalized radii r. The larger the amplitude of the eddy, the more likely the eddy is to be Gaussian-shaped. Furthermore, approximately 40% of ocean eddies are combinations of two Gaussian eddies with different parameters, but the composition of these types of eddies is more like a quadratic eddy than a Gaussian one. Only a small portion of oceanic eddies are pure quadratic eddies （〈 10%） with the same vorticity distribution as a Rankine vortex. We concluded that the Taylor vortex is a good approximation of the typical shape of ocean eddies.

关键词： sea level anomaly ocean eddies Taylorvortex typical shape

Mechanism and kinetics for methanol synthesis from CO_(2)/H_(2) over Cu and Cu/oxide surfaces:Recent investigations by firstprinciples-based simulation

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中国化学前沿:英文版 2011年第3期6卷 164-172页

作者： Qiuyang Sun Zhipan LIU Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Department of ChemistryKey Laboratory of Computational Physical Science(Ministry of Education)Fudan UniversityShanghai 200433China

The efficient fixation and utilization of CO_(2) has been consistently pursued by chemists for decades.Although Cu-based catalysts,e.g.,Cu/ZnO/Al_(2)O_(3),have been widely used in industry for methanol synthesis from CO_(2) hydrogenation(CO_(2)+3H_(2)→H_(3)COH+H_(2)O),many issues on the mechanism and the kinetics remain largely uncertain.For example,the surface site for CO_(2) activation and the synergetic effect between Cu and oxide have been hotly debated in literature.In the past few years,theoretical modeling on pure Cu surfaces and Cu/oxide interfaces has been utilized to provide insight into these important questions.Here we will review the recent theoretical advances on simulating this complex heterogeneous catalytic process with first principles density functional theory(DFT)calculations and kinetics modeling.The theoretical results on the mechanism and the kinetics are compared and summarized.

关键词： density functional theory calculation CO_(2)hydrogenation methanol synthesis Cu-based catalysts review

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供给侧改革视角下公共体育资源优化研究

当代体育科技 2020年第24期10卷 199-201页

作者：孙秋阳郑州升达经贸管理学院河南郑州451191

优化公共体育资源供给结构和解决公共体育资源供需矛盾是促进我国体育事业长足发展的关键所在。本文主要采用文献资料法、专家访谈法从公共体育设施资源配置与服务的现状出发,首先分析公共体育资源进行供给侧改革的现实意义,其次结合我... 详细信息

优化公共体育资源供给结构和解决公共体育资源供需矛盾是促进我国体育事业长足发展的关键所在。本文主要采用文献资料法、专家访谈法从公共体育设施资源配置与服务的现状出发,首先分析公共体育资源进行供给侧改革的现实意义,其次结合我国公共体育资源供给中存在现实困境,最后探讨总结供给侧改革视角下公共体育资源优化的主要路径。

关键词：供给侧改革公共体育资源供需矛盾优化

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胆囊癌转移至卵巢一例

中华病理学杂志 2020年第10期49卷 1071-1074页

作者：景秋洋陈琼孙亮四川大学华西二院病理科/出生缺陷与相关妇儿疾病教育部重点实验室成都610041 四川省成都市第二人民医院病理科 610021

女性生殖系统,尤其卵巢是易于发生消化道肿瘤转移的部位。部分转移性黏液性肿瘤可能形态非常温和,形似卵巢原发黏液性囊腺瘤或黏液性交界性肿瘤,使得卵巢肿瘤的鉴别诊断存在困难,黏液性肿瘤术中冷冻切片诊断尤其充满挑战。胃肠道肿瘤转... 详细信息

女性生殖系统,尤其卵巢是易于发生消化道肿瘤转移的部位。部分转移性黏液性肿瘤可能形态非常温和,形似卵巢原发黏液性囊腺瘤或黏液性交界性肿瘤,使得卵巢肿瘤的鉴别诊断存在困难,黏液性肿瘤术中冷冻切片诊断尤其充满挑战。胃肠道肿瘤转移至卵巢相对常见,胆囊癌转移至卵巢则较为罕见,本文报道一例65岁女性发生胆囊癌转移至卵巢,并广泛累及女性生殖系统。

关键词：女性生殖系统胆囊癌黏液性肿瘤黏液性囊腺瘤消化道肿瘤卵巢肿瘤胃肠道肿瘤鉴别诊断

石墨炔原子催化剂的崭新道路:基于自验证机器学习方法的筛选策略

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高等学校化学学报 2022年第5期43卷 134-146页

作者：黄汉浩卢湫阳孙明子黄勃龙香港理工大学生物及化学科技学系中国香港999077

近年来,原子催化剂(ACs)引起了广泛的研究关注.目前该领域的长足发展受限于贵金属的使用和单原子催化剂(SACs)的性能有限.本文总结了利用密度泛函理论(DFT)和机器学习(ML)方法筛选高效的基于石墨炔(GDY)的原子催化剂的工作.研究表明, Pd... 详细信息

近年来,原子催化剂(ACs)引起了广泛的研究关注.目前该领域的长足发展受限于贵金属的使用和单原子催化剂(SACs)的性能有限.本文总结了利用密度泛函理论(DFT)和机器学习(ML)方法筛选高效的基于石墨炔(GDY)的原子催化剂的工作.研究表明, Pd, Co, Pt和Hg可以形成稳定的零价过渡金属-石墨炔组合(TM-GDY),而镧系-过渡金属的双原子催化剂(Ln-TM DAC)组合通过f-d轨道耦合作用可以获得有效的催化性能提升.进一步分析表明,主族元素与过渡金属和镧系金属的结合可以通过p轨道耦合保持高电活性,从而构成高度稳定的GDY-DAC系统,机器学习算法也揭示了s,p轨道的作用.此外,理论算法技术在筛选催化水分解析氢反应(HER)的高效组合上也表现出了优越性,创新性地预测了石墨炔-原子催化剂在实际催化反应中的潜能.本综合评述可为未来设计新型原子催化剂提供新的思路与策略.

关键词：石墨炔原子电催化剂自验证机器学习密度泛函理论

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小学体育游戏的设计与价值研究

当代体育科技 2020年第23期10卷 135-136,139页

作者：孙秋阳郑州升达经贸管理学院河南郑州451191

游戏教学法是小学体育教学中重要且有效的形式之一。本文主要运用文献综述法、逻辑分析法等对小学体育教学游戏进行研究,探索体育游戏在小学体育教学中的价值,揭示小学体育教学游戏对体育教学的重要意义,并对在实践中如何设计体育游戏... 详细信息

游戏教学法是小学体育教学中重要且有效的形式之一。本文主要运用文献综述法、逻辑分析法等对小学体育教学游戏进行研究,探索体育游戏在小学体育教学中的价值,揭示小学体育教学游戏对体育教学的重要意义,并对在实践中如何设计体育游戏的原则、方法进行了简单的介绍,最后提出了提升体育游戏价值相应的意见和建议,以期为小学生身心健康发育提供有价值的参考。

关键词：小学体育游戏设计价值

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天然产物生物合成与微生物制造的挑战

中国生物工程杂志 2024年第1期44卷 72-87页

作者：李秋阳孙文涛秦磊吕波李春北京理工大学医药分子科学与制剂工程工信部重点实验室化学与化工学院生物化工研究所北京100081 清华大学化学工程系北京100084 中国医学科学院药物研究所天然药物活性物质与功能国家重点实验室北京100050 清华大学工业生物催化教育部重点实验室北京100084

天然产物是大自然赐予人类的资源宝库,与人类的生活质量和健康息息相关。利用传统方式获取天然产物存在含量低、提取工艺复杂耗时以及资源不可持续等问题,而化学合成步骤繁琐、成本高,这些都严重制约了天然产物的广泛应用。合成生物学... 详细信息

天然产物是大自然赐予人类的资源宝库,与人类的生活质量和健康息息相关。利用传统方式获取天然产物存在含量低、提取工艺复杂耗时以及资源不可持续等问题,而化学合成步骤繁琐、成本高,这些都严重制约了天然产物的广泛应用。合成生物学赋能的微生物细胞工厂通过变革天然产物的传统获取方式,实现高效、绿色及可持续的生物制造。分析天然产物传统获取方式面临的挑战,总结不同类型微生物细胞工厂的特点及天然产物合成案例。基于天然产物代谢通路的复杂性、底盘细胞的稳定性可能导致产物的结构和性质难以预测以及纯度和收率低等问题,从催化元件的局限、途径组装调控及底盘网络重塑的角度分析设计微生物细胞工厂的应对策略,并针对微生物制造产品的发展与应用提出政策建议。

关键词：天然产物生物制造微生物细胞工厂底盘细胞生物安全