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The Effect of Xu’s Influenza Decoction Combined with Oseltamivir on Influenza A:A Propensity Score Matching Study

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 1-9页

作者： Tianxi Chen Shuyan Fu Fengyuan Tian qiushuang Li Hongyu Ling Yijie Lou Jun Tang Hong Zheng Basic Medical School Zhejiang Chinese Medical UniversityHangzhou 310053ZhejiangChina Department of Infectious Diseases First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 31006ZhejiangChina First School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053ZhejiangChina Center of Clinical Evaluation and Analysis First Affiliated Hospital of Zhejiang Chinese Medicine UniversityHangzhou 31006ZhejiangChina Department of General Practice First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 31006ZhejiangChina

Background:The resurgence of seasonal influenza virus circulation has been seen in 2021-2022 after the tempo-rary suppression in *** inhibitors(NAIs)are widely applied in the clinical treatment of influenza A despite several ***:To access the efficacy of Xu’s influenza decoction(XID)in combination therapy with oseltamivir for the treatment of influenza ***:In this retrospective cohort study,the eligible participants were diagnosed with influenza A between June 1,2018,and May 30,2022,in the First Affiliated Hospital of Zhejiang Chinese Medical *** to whether Xu’s influenza decoction was applied,patients were divided into two groups:treated with or without *** score matching(PSM)was used to further adjust the covariates between *** primary outcome was to compare time to defervescence via K-M curves,Breslow tests,and Cox regression *** Cox proportional hazards model,a univariate analysis was performed to obtain preliminary results,while a further multivariate analysis was conducted to study the independent factors that influence *** analysis was conducted according to body temperature and time from onset to *** secondary outcome consisted of routine blood and C-reactive protein(CRP),length of stay,and medical ***:A total of 336 patients with influenza A were enrolled in this study(i.e.,163 patients in the XID+oseltamivir group;173 patients in the oseltamivir group).After 1:1 matching via PSM,230 patients meeting the criteria were included in the analysis,with 115 in each *** XID+oseltamivir group had shorter time to defervescence(36 h vs 44 h,P=0.011),shorter length of stay(3 days vs 4 days,P=0.018),and higher defervescence possibility(HR=1.384,95%CI:1.054-1.818).Subgroup analysis indicated that for patients during non-window period(≥48 h)with medium-grade fever(38.1℃-39℃),the XID+oseltamivir combination therapy reduced time to defervescence

关键词： Influenza A Xu’s influenza decoction Oseltamivir Time to defervescence,Cox regression Propensity score matching Cohort study

Comparative analysis of small RNAs among three germplast of Brassica napus L. by deep sequencing

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Comparative analysis of small RNAs among three germplast of ...

The Expression and Significance of CyclinD2,MPGES-1,Bcl2 in Diffuse Large B-cell Lymphoma

江苏省遗传学会2013年学术研讨会

作者： Chengyi TANG Song CHEN qiushuang CHANG Jinliang QI Guihua LU Yonghua YANG State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University NJU–NJFU Joint Institute for Plant Molecular Biology College of life Sciences Nanjing University Institute of Industrial Crops Jiangsu Academy of Agricultural Sciences

Background: Small（～20–30 nucleotide[nt]） nocoding RNAs have emerged as critical regulators in the expression and function of eukaryotes. MicroRNAs（mi RNAs） and short interfering RNAs（siRNAs） have been identified as two major classes of endogenous small RNAs, and regulate gene expression at the posttranscriptional and transcriptional levels. The majority of plant miRNAs are 21 nucleotides in length and generated from hairpin-shaped precursors, but the majority of plant siRNAs are 24 nucleotides long and produced from long double-stranded RNA duplexes or transcripts derived from inverted repeat regions. up to now, there was very limited research on their population and abundance between different germplast of Brassica napus L., especially between acceptor and its transgenic germplast. Results: In this study, we made a comparative analysis of small RNAs（miRNAs especially） and their putative target genes among three westar germplast of Brassica napus L. by deep sequencing. The total RNA were extracted from new leaf of three germplast of Brassica napus L., westar（WA）, high-seed-oil-content transgenic westar（A82） and high-seed-oleic-acid-content transgenic westar（W4） respectively at late vegetative growth stage. Then three small RNA librarys were constructed from the total RNA respectively for deep sequencing by Illumina GA-II platform, and produced more than 3.07 million, 2.77 million and 2.58 million unique sequences respectively. The most abundant classes of unique sRNAs were represented by 24 nt in length, whereas the most abundant classes of total sRNAs were represented by 21 and 24 nt in length. All those unique sRNAs were mapped to miRNA/pre-miRNA in the miRbase（V20.0） and the pre-miRNAs were further mapped to the genome ＆ EST. A total of 89 among 90 conserved Brassica napus miRNAs（bna-miR） in the miRbase（V20.0） were identified in this study. A total of 85, 85 and 86 conserved bna-miRs were identified in the leaf of WA, A82 and W4 respectively. Expression analysis

关键词： Brassica napus L.westar small RNA miRNA siRNA high-seed-oleic-acid-content westar high-seed-oil-content westar

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Proceedings of Anticancer Research 2021年第2期5卷 53-56页

作者： qiushuang Ma Peng Lin Bingjuan Zhou Yafei Zhao Ling Li Jinku Zhang Jirui Sun Department of Pathology Baoding First Central HospitalBaoding 071000Hebei provinceChina Department of Hematology Baoding First Central HospitalBaoding 071000Hebei provinceChina Department of Orthopedics Baoding First Hospital of Traditional Chinese MedicineBaoding 071000Hebei provinceChina Department of Dermatology Baoding First Central HospitalBaoding 071000Hebei provinceChina

Objective:To study the expression and significance of cell cycle proteins CyclinD2,mPGES-1,Bcl2 in diffuse large B-cell ***:Choose lymphoma and sexually hyper-plastic lymphoid tissues as ***-hemical methods were used to detect the expression of CyclinD2,mPGES-1,and Bcl2,and to compare the positive expression rates of CyclinD2,MPGES-1 and Bcl2 in diffuse large B-cell lymphoma and reactive proliferative lymphoid tissues to compare their diffusion formation.B-cell lymphoma was analyzed for its clinicopathological ***:The positive expression rate of CyclinD2,mPGES-1 and Bcl2 in diffuse large B-cell lymphoma is higher than that in reactive proliferative lymphoid tissue,and the difference between the two is statistically *** was no statistical difference in CyclinD2,mPGES-1 and Bcl2 in diffuse large B-cell lymphoma between patients according to the age,sex,location,tissue type and degree of ***:CyclinD2,mPGES-1 and Bcl2 are highly expressed in patients with diffuse large B-cell lymphoma,and can be used as reference indicators for evaluating the malignant degree and efficacy of dysplasia.

关键词： CyclinD2 mPGES-1 Bcl2 Diffuse large B-cell lymphoma Clinicopathology

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季铵盐对碘代全氟烷烃的卤键吸附作用

高等学校化学学报 2018年第4期39卷 743-748页

作者：阎小青刘秋双刘云凤牛侨山西医科大学公共卫生学院太原030001

通过红外光谱、紫外光谱及核磁共振波谱表征了四丁基碘化铵盐对正己烷溶液中二碘四氟乙烷(C_2F_4I_2)的卤键吸附作用.结果表明,固液两相间卤键作用引起的光谱变化同溶液中形成卤键复合物的光谱变化一致;四丁基氯化铵的吸附作用强于四丁... 详细信息

通过红外光谱、紫外光谱及核磁共振波谱表征了四丁基碘化铵盐对正己烷溶液中二碘四氟乙烷(C_2F_4I_2)的卤键吸附作用.结果表明,固液两相间卤键作用引起的光谱变化同溶液中形成卤键复合物的光谱变化一致;四丁基氯化铵的吸附作用强于四丁基溴化铵和四丁基碘化铵,而具有较长烷烃链的季铵盐——十六烷基三甲基氯/溴化铵对C_2F_4I_2则完全没有吸附作用.对四丁基氯化铵与4种碘代全氟烷烃间卤键作用强度的测定结果显示,尽管溶液中一碘代全氟烷烃与氯阴离子间的卤键作用强于二碘代全氟烷烃,但在固液两相间四丁基氯化铵对二碘代全氟烷烃的吸附强于一碘代全氟烷烃.利用拉曼光谱研究该体系时,发现卤键的形成可增强碘代全氟烷烃的拉曼光谱.

关键词：卤键碘代全氟烷烃季铵盐卤阴离子吸附

景观感知和地方依恋对居民文化补偿认知的影响与分异

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经济地理 2020年第5期40卷 220-229页

作者：王兆峰向秋霜湖南师范大学旅游学院中国湖南长沙410081 张家界市武陵源区文化旅游广电体育局中国湖南张家界427400

居民对景观文化价值补偿的认知是推动文化遗产保护和传承的重要内容。基于认知情感系统理论,构建居民景观文化价值补偿认知结构方程模型,以湖南省西部的芙蓉镇和边城镇两个少数民族特色旅游村镇为案例地,通过验证性因子分析和多群组结... 详细信息

居民对景观文化价值补偿的认知是推动文化遗产保护和传承的重要内容。基于认知情感系统理论,构建居民景观文化价值补偿认知结构方程模型,以湖南省西部的芙蓉镇和边城镇两个少数民族特色旅游村镇为案例地,通过验证性因子分析和多群组结构方程对样本数据进行实证分析。结果表明:①居民的景观价值感知中存在地方依赖和认同,它们是文化补偿认知的重要驱动因素;②居民文化补偿意识的形成需要文化补偿相关知识、态度和行为的支撑;③不同年龄、职业、月收入和居住地子群体居民文化补偿认知存在差异,但月收入和居住地群组中存在文化补偿认知差异不显著的子群。研究结论丰富了文化遗产保护价值研究的内容和视角,也有利于文化补偿和文化保护传承的实践。

关键词：少数民族特色村镇景观价值文化补偿子群体地方依恋文化遗产保护

Liver transplantation for patients with hepatocellular carcinoma at the Liver Cancer Institute of Fudan University, China

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Chinese Medical Journal 2005年第8期118卷 654-659页

作者： ZHOUJian FANJia WUZhi-quan qiushuang-jian HUANGXiao-wu YUYao WANGZheng SUNJian XIAOYong-sheng HEYi-feng YANGGuo-huan SONGKang YUANZhou WANGYu-qi TANGZhao-you LiverCancerInstitute ZhongshanHospitalFudanUniversityShanghai200032China

Background Selection of patients with hepatocellular carcinoma (HCC) for orthotopic liver transplantation (OLT) remains controversial. Since there is a trend to expand the transplant criteria for HCC patients, we reviewed the data of patients with HCC who had received OLT at our institute to determine their survival and prognostic *** A total of 67 patients with HCC who had undergone OLT from April 2001 through December 2003 were reviewed retrospectively. Selection OLT candidates with HCC was dependent on the anatomical characteristics and/or the severity of underlying liver cirrhosis. The 67 patients were followed up for more than 6 months after transplantation. Their survival rate was calculated by the Kaplan-Meier method. Univariate and multivariate analyses using the Cox proportional hazards regression model were performed to reveal the factors affecting the survival *** No perioperative death occurred in this series. The 1- and 2-year cumulative survival rates were 90.0% and 65.6%, and the disease-free survival (DFS) rates were 77.5% and 62.5% respectively. Univariate analysis revealed the tumor size, portal vein tumor thrombus (PVTT), serum alpha-fetoprotein level, bilobular distribution of tumors, pTNM stage and histological differentiation were statistically significant factors affecting the DFS ( P <0.05). Multivariate analysis showed tumor size and PVTT were independent and statistically significant factors affecting the DFS ( P =0.005 and 0.010, respectively). In this series, all but 2 received systemic chemotherapy, among them 13 had tumor recurrence within 8 months after OLT. Conclusions OLT is indicated for patients with HCC, even for some patients with end-stage liver disease who may survive longer without tumor recurrence. Adjuvant chemotherapy may decrease the recurrence of HCC after OLT.

关键词： liver transplantation · carcinoma hepatocellular· prognosis

一种相关型模糊集合及其在模糊逻辑系统中的应用

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中南大学学报（自然科学版） 2014年第2期45卷 441-449页

作者：岳菊梅陈秋双陈增强南开大学信息技术科学学院控制优化与物流管理研究室天津300071 南开大学信息技术科学学院智能预测自适应研究室天津300071

基于t-范数和t-余范数的模糊推理无法将模糊规则中前件集与后件集的相关性信息引入到模糊推理过程,这在某些情况下会导致模糊推理结果与实际经验不符。针对此问题,首先引入模糊集合之间相关度的概念,使模糊概念之间彼此相关。然后,在模... 详细信息

基于t-范数和t-余范数的模糊推理无法将模糊规则中前件集与后件集的相关性信息引入到模糊推理过程,这在某些情况下会导致模糊推理结果与实际经验不符。针对此问题,首先引入模糊集合之间相关度的概念,使模糊概念之间彼此相关。然后,在模糊集合相互关联的环境下提出相关型模糊集合的概念,包括相关type-1、相关区间型type-2以及相关一般型type-2模糊集合,并在理论上把模糊集合的基本概念和运算性质放在相关型模糊集合的环境下进行讨论,同时定义其自身特有的一些运算。最后,对相关型模糊集合在2种模糊逻辑系统(T1 FLS和IT2 FLS)中的应用进行探索,提出面向后件集的模糊推理方法。仿真实例表明:该方法比传统的模糊推理方法能捕获到规则中更多的不确定性信息。

关键词：模糊控制模糊推理模糊逻辑系统区间型type 2FLS

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漫谈硝化作用

生物学教学 2019年第2期44卷 77-79页

作者：陈秋霜俞如旺福建师范大学生命科学学院福州350117

介绍经典硝化作用、单步硝化作用、异养硝化作用及相应的硝化微生物,并简述硝化作用对生物圈的影响。

关键词：经典硝化作用单步硝化作用异养硝化作用

Non-small cell lung cancers(NSCLCs)oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors

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Signal Transduction and Targeted Therapy 2023年第10期8卷 5069-5084页

作者： Bopei Cui Lifang Song Qian Wang Kelei Li Qian He Xing Wu Fan Gao Mingchen Liu Chaoqiang An qiushuang Gao Chaoying Hu Xiaotian Hao Fangyu Dong Jiuyue Zhou Dong Liu Ziyang Song Xujia Yan Jialu Zhang Yu Bai Qunying Mao Xiaoming Yang Zhenglun Liang Division of Hepatitis and Enterovirus Vaccines NHC Key Laboratory of Research on Quality and Standardization of Biotech ProductsNMPA Key Laboratory for Quality Research and Evaluation of Biological ProductsInstitute of Biological ProductsNational Institutes for Food and Drug ControlBejingChina National Engineering Technology Research Center for Combined Vaccines WuhanChina Beijing Minhai Biotechnology Co LtdBeijingChina Taibang Biologic Group BeijingChina Changchun Institute of Biological Products Co. LtdChangchunChina Shanghai Institute of Biological Products Co LtdShanghaiChina China National Biotec Group Company Limited BeijingChina

With the continuous in-depth study of the interaction mechanism between viruses and hosts,the virus has become a promising tool in cancer *** fact,many oncolytic viruses with selectivity and effectiveness have been used in cancer *** enterovirus is one of the most convenient sources to generate oncolytic viruses,however,the high seroprevalence of some enteroviruses limits its application which urges to exploit more oncolytic enteroviruses.

关键词： damage enterovirus cancer