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Echinatin inhibits tumor growth and synergizes with chemotherapeutic agents against human bladder cancer cells by activating p38 and suppressing Wnt/β-catenin pathways

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Genes & Diseases 2024年第2期11卷 1050-1065页

作者： Xiaoxuan Wang Lijuan Luo Jingtao Xu qiuping Lu Haichao Xia Yanran Huang Lulu Zhang Liping xie Habu Jiwa Shiqiong Liang Xiaoji Luo Jinyong Luo Key Laboratory of Diagnostic Medicine Designated By the Chinese Ministry of Education School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Department of Orthopedics The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China

Bladder cancer (BC) is one of the most common malignant tumors in the urinary *** to the poor prognosis and high mortality rate of the disease,it is urgent to develop new drugs with high efficacy and low toxicity to treat *** (Ecn) is a bioactive natural flavonoid oflicorice that has attracted special attention for its promising anti-tumor ***,we explored the inhibitory effects of Echinatin on BC cells and probed the possible molecular *** found that Ecnin vitro inhibited the proliferation,migration,and invasion,arrested the cell cycle at the G2/M phase,and promoted apoptosis in BC ***,Ecn had no notable cytotoxicity towards human normal *** subsequently confirmed that Ecn restrained xenograft tumor growth and metastasis of BC cells in vivo .Mechanistically,Ecn activated the p38 signaling pathway but inactivated the Wnt/β-catenin signaling pathway,while over-expression of β-catenin and the p38 inhibitor both attenuated the inhibitory effects of Ecn on BC ***,Ecn combined with cisplatin (DDP) or gemcitabine (Gem) had synergistic inhibitory effects on BC *** summary,our results validate that Ecn inhibits the tumor growth of human BC cells via p38 and Wnt/β-catenin signaling *** meaningfully,our results suggest a potential strategy to enhance DDP- or Gem-induced inhibitory effects on BC cells by combining with Ecn.

关键词： Bladder cancer Combination chemotherapy Echinatin p38 Wnt/β-catenin

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腔镜甲状腺手术入路的选择

中华耳鼻咽喉头颈外科杂志 2023年第9期58卷 926-929页

作者：王平马军杰谢秋萍浙江大学医学院附属第二医院甲状腺外科杭州310009

过去的几十年中,在全球范围内,甲状腺癌的发病率持续上升,甲状腺手术已经成为最常见的外科手术之一。随着经济社会的不断发展,腔镜甲状腺手术(endoscopic thyroid surgery,ETS)也越来越受到广大患者的青睐。本文结合相关文献及本中心经... 详细信息

过去的几十年中,在全球范围内,甲状腺癌的发病率持续上升,甲状腺手术已经成为最常见的外科手术之一。随着经济社会的不断发展,腔镜甲状腺手术(endoscopic thyroid surgery,ETS)也越来越受到广大患者的青睐。本文结合相关文献及本中心经验,重点对腔镜甲状腺入路的选择作以下综述。

关键词：腔镜甲状腺手术外科手术甲状腺癌全球范围 endoscopic 入路发病率

N-乙酰半胱氨酸的生理功能及其在畜禽生产中的应用

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动物营养学报 2022年第8期34卷 4857-4866页

作者：林芷昕谢秋萍王长康高玉云福建农林大学动物科学学院福州350002 福建省绿色食品发展中心福州350003

N-乙酰半胱氨酸(NAC)存在于青葱、大蒜、韭菜、洋葱等葱属植物中,是半胱氨酸的乙酰化前体,可参与机体内谷胱甘肽的合成,具有抗氧化、抗炎、抗菌以及调节脂肪代谢等作用。近年研究发现,NAC在维护畜禽肠道健康、缓解机体氧化应激、提高畜... 详细信息

N-乙酰半胱氨酸(NAC)存在于青葱、大蒜、韭菜、洋葱等葱属植物中,是半胱氨酸的乙酰化前体,可参与机体内谷胱甘肽的合成,具有抗氧化、抗炎、抗菌以及调节脂肪代谢等作用。近年研究发现,NAC在维护畜禽肠道健康、缓解机体氧化应激、提高畜禽繁殖性能等方面具有潜在作用。本文综述了NAC的主要生理功能及其作用机制,并探讨了NAC作为畜禽饲料添加剂的可行性,旨在为NAC作为新型饲料添加剂提供参考。

关键词： N-乙酰半胱氨酸生理功能畜禽应用

Scarless endoscopic thyroidectomy(SET) via anterior chest and breast approach to levelⅡ～Ⅳdissection for papillary thyroid carcinoma:is it feasible?

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Scarless endoscopic thyroidectomy(SET) via anterior chest an...

Scarless endoscopic total or near total thyroidectomy for patients with papillary thyroid carcinoma

2013年浙江省外科学学术年会

作者： Haichao Yan Yong Wang Ping Wang qiuping xie Qunzi Zhao Department of Thyroid Surgery Second Affiliated HospitalZhejiang University

Objective We applied scarless(in the neck) endoscopic thyroidectomy(SET) via anterior chest and breast approach to lateral neck dissection,including ipsilateral level 11,111 and IV dissection,for papillary thyroid carcinoma( PTC) and evaluated its feasibility and safety. Methods Between January 2011 and March 2013,12 PTC female patients with suspected lymph node metastasis at level II,III or IV were selected for this procedure.3 patients were performed with total thyroidectomy and 3 patients with near total *** accomplishing thyroidectomy and central compartment dissection, ipsilateral level 11,111 and IV dissection via anterior chest and breast approach was *** steps of endoscopic lateral neck dissection were similar to that of conventional surgery except that the lateral cervical compartment was exposed by splitting the sternocleidomastoid muscles(SCM) longitudinally. Results This procedure was carried out successfully in all 12 *** operative time was 243 min.9 patients(75%) had lymph node metastasis in lateral *** lymph node yield in the lateral compartment(including ipsilateral level II,III and IV dissection) was 21.8(range 5 - 42).5 patients(41.6%) had lymph node metastasis in the ipsilateral level *** lymph node yield in the ipsilateral level II was 6.7(range 1 - 14).Postoperative transient hypocalcemia occurred in 1 case.5 patients were treated with RAI postoperatively. No evidence of residual or recurrent disease was found at *** cosmetic results of this procedure were excellent. Conclusions Endoscopic lateral neck dissection,including level II,III and IV dissection,via anterior chest and breast approach is feasible and safe with excellent cosmetic results for selected cases of PTC.

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Scarless endoscopic total or near total thyroidectomy for pa...

复合酸化剂对伊拉兔空肠消化酶活性、免疫功能和紧密连接蛋白表达的影响

2013年浙江省外科学学术年会

作者： Haichao Yan Yong Wang Ping Wang qiuping xie Qunzi Zhao Department of Thyroid Surgery Second Affiliated HospitalZhejiang University

ObjectiVG To evaluate the feasibility of endoscopic total or near total thyroidectomy via anterior chest and breast approach for patients with papillary thyroid carcinoma(PTC). Methods From Januray 2011 to March 2013,45 female patients with PTC were included in this study. Bilateral total or near total thyroidectomy was performed for all patients.34 patients were performed with ipsilateral central neck dissection.11 patients were performed bilateral central neck dissection. Results This procedure was performed successfully in all 45 *** mean operative time were 167 min. 16 patients(35.6%) had lymph node metastasis in central *** lymph node yield in the central compartment was 8.38(range 1 - 32).Postoperative transient voice changes occurred in 9 *** transient hypocalcemia occurred in 18 cases(40%).No other complications were *** patients were satisfied with the cosmetic result of the procedure.12 patients were treated with RAI *** evidence of residual or recurrent disease was found at follow-up. Conclusions Endoscopic total or near total thyroidectomy via anterior chest and breast approach for patients with PTC is a technically feasible and safe procedure.

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动物营养学报 2023年第3期35卷 1948-1956页

作者：杨国峰贺佳仪狄斌谢秋萍钟辛悦王长康高玉云福建农林大学动物科学学院(蜂学学院) 福州350002 福建省绿色食品发展中心福州350002

本试验旨在研究复合酸化剂对伊拉兔空肠消化酶活性、免疫功能和紧密连接蛋白表达的影响。选取192只体重相近、健康的(35±2)日龄断奶商品代伊拉兔公兔,随机分为4组,每组6个重复,每个重复8只。4组分别为空白组(基础饲粮)、抗生素组(基础... 详细信息

本试验旨在研究复合酸化剂对伊拉兔空肠消化酶活性、免疫功能和紧密连接蛋白表达的影响。选取192只体重相近、健康的(35±2)日龄断奶商品代伊拉兔公兔,随机分为4组,每组6个重复,每个重复8只。4组分别为空白组(基础饲粮)、抗生素组(基础饲粮+60 mg/kg盐霉素)、试验Ⅰ组(基础饲粮+0.1%复合酸化剂)和试验Ⅱ组(基础饲粮+0.2%复合酸化剂),复合酸化剂的有效成分为甲酸和丙酸。试验期28 d。结果表明:1)与空白组相比,试验Ⅰ组空肠黏膜胰蛋白酶活性显著提高(P0.05)。2)与空白组相比,抗生素组、试验Ⅰ组和试验Ⅱ组空肠黏膜白细胞介素-6(IL-6)和白细胞介素-1β(IL-1β)含量显著降低(P0.05)。3)与空白组相比,抗生素组、试验Ⅰ组和试验Ⅱ组空肠黏膜IL-1βmRNA相对表达量显著降低(P0.05)。4)与空白组相比,抗生素组和试验Ⅰ组空肠黏膜闭合小环蛋白-1(ZO-1)和闭锁蛋白(occludin)的mRNA相对表达量显著提高(P0.05)。综上所述,饲粮添加0.1%复合酸化剂可提高伊拉兔空肠黏膜胰蛋白酶活性,增强免疫能力,促进紧密连接蛋白的表达,其效果与抗生素相似,具有良好的替抗潜力。

关键词：伊拉兔复合酸化剂空肠消化酶免疫紧密连接蛋白

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中国制造行业上市公司跨国并购的绩效评估

前沿 2011年第11期 115-118页

作者：邹琪谢秋平上海财经大学国际工商管理学院上海200433

制造行业是中国经济发展的支柱产业,通过跨国并购方式促进中国制造行业发展是一条重要的发展路径。本文主要通过对中国制造业上市公司跨国并购的财务绩效的深入研究,了解这些制造业企业跨国并购的效果,分析并购前后制造业企业的经营业... 详细信息

制造行业是中国经济发展的支柱产业,通过跨国并购方式促进中国制造行业发展是一条重要的发展路径。本文主要通过对中国制造业上市公司跨国并购的财务绩效的深入研究,了解这些制造业企业跨国并购的效果,分析并购前后制造业企业的经营业绩和财务状况的变化,为中国制造行业的可持续发展提供可行的方案,也为有意进行跨国并购的企业及政府的政策制定提供建议。

关键词：制造行业上市公司跨国并购经营绩效

Multifocality,together with total tumor diameter is of greater clinical significance than mltifocality itself as an independent factor for predicting nodal metastasis and local recurrence risks among patients with papillary thyroid carcinoma

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Multifocality,together with total tumor diameter is of great...

在桂越南留学生跨文化人际交往实证研究——以广西师范大学为个案

2014年浙江省外科学学术年会

作者： Yong Wang Chundi Miao Qunzi Zhao Xing Yu Wenjie Qing Jaiswal Sanjay Haichao Yan qiuping xie Ping Wang Department of Thyroid Surgery The Second Affiliated Hospital of Zhejiang University School of Medicine Department of Clinical Medicine Zhejiang University School of Medicine

Background:A recently published study proposed a novel concept called total tumor diameter(TTD)which was defined as the sum of the maximal diameter of each lesion in multifocal papillary thyroid microcarcinoma,and found that multifocality together with TTD can better predict LNM risk in papillary *** conducted this retrospective case-control study to further explore the clinical significance of TTD in multifocal papillary thyroid carcinoma(PTC).Methods:Six hundred and eighty four patients who underwent initial thyroid surgery and had a pathological diagnosis of PTC between 2011 and 2013 at The Second Affiliated Hospital Zhejiang University School ofMedicine were included in this *** lymph node metastasis(LNM)risk was analyzed according to the clinicopathological *** multifocal lesions,the greatest diameter was first used as previous studies,total tumor diameter(TTD)was calculated as the sum of the maximal diameter of each lesion for further ***:Multifocality occurred in 24.6%of PTCs,and 54.2%of them had *** were no significant differences in LNM risk between multifocal tumors with TTD≤1cm and unifocal tumors with diameter≤1cm(36.2%vs.29.6%,P=0.294),1≤multifocal PTC with TTD2cm and unifocal PTC with diameter>2cm(66.7%vs.79.5%,P=0.113).In the microcarcinoma subgroup,there were also no significant differences in LNM risk between multifocal and unifocal microcarcinomas within the same range of *** LNM risk was significantly increased in multifocal microcarcinoma with TTD>1cm than unifocal microcarcinoma(P<0.001).Conclusion:Multifocality,together with TTD is of more clinical significance than mltifocality itself as an independent factor for predicting nodal metastasis and local recurrence risks among patients with PTC.

关键词： Papillary thyroid carcinoma Lymph node metastasis Multifocality Total tumor diameter

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桂林师范高等专科学校学报 2015年第1期29卷 90-93页

作者：谢秋萍广西师范大学外国语学院广西桂林541000

越南留学生在桂的跨文化人际交往总体呈现出交往频度低、交往渠道有限、交往需求不强烈的交往特征,其影响因素有:刻板印象、高语境文化、休闲观念、饮食文化、文化认同感因素以及语言符号因素。

关键词：越南留学生跨文化人际交往交往特征影响因素