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Preferential depletion of CD2^(low) plasmacytoid dendritic cells in HIV-infected subjects

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Cellular & Molecular Immunology 2011年第5期8卷 441-444页

作者： qiumei du Yanmei Jiao Wei Hua Rui Wang Feili Wei Yunxia Ji Peishuang du Yong-Jun Liu Hao Wu Liguo Zhang Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijingChina Graduate University of Chinese Academy of Sciences BeijingChina Beijing You-An Hospital Affiliated to the Capital Medical UniversityBeijingChina Department of Immunology The University of TexasM.D.Anderson Cancer CenterHoustonTXUSA

Plasmacytoid dendritic cells(pDCs)are decreased in number and are functionally impaired in HIV act reasons for pDCs depletion are still *** was recently reported that pDCs can be divided into two functionally distinct populations based on their CD2 expression *** determine how the CD2high and CD2^(low) populations are affected by HIV infection,we analyzed their frequencies in the peripheral blood of HIV-infected subjects and healthy *** found that the CD2^(low) pDC subset was preferentially depleted in infected *** frequency of CD2^(low) pDCs correlated with the CD41 T-cell count but not with the plasma viral *** finding furthers our understanding of the causes and consequences of pDC depletion during HIV infection.

关键词： CD2 HIV immune activation plasmacytoid dendritic cells

Death receptor 6 is a novel plasmacytoid dendritic cell-specific receptor and modulates type I interferon production

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Protein & Cell 2016年第4期7卷 291-294页

作者： Jingyun Li qiumei du Rui Hu Yanbing Wang Xiangyun Yin Haisheng Yu Peishuang du Joel Plu-mas Laurence Chaperot Yong-jun Liu Liguo Zhang Key Laboratory of Immunity and Infection Institute of BiophysicsChinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049China Department of Research and Development Etablissement Franais du Sang RhOne-Alpes Grenoble 38701 La Tronche France Baylor Institute for Immunology Research Baylor ResearchInstitute Dallas TX 75204 USA

Dear Editor, Plasmacytoid dendritic cells （pDCs） are the professional type I interferon-producing cells of the immune system, which rapidly produce massive amounts of type I interferons （IFN-I） in response to viruses or other nucleic acids Iigands through selectively expressed toll-like receptor （TLR）-7 and TLR9 （Siegal et al., 1999）. The activation of pDCs not only inhibits virus replication, but also regulates the function of other immune cells and links the innate and adaptive immunity （Liu, 2005）. The local accumulation of pDCs has been reported in both suppressive and overactive immune status （Swiecki and Colonna, 2010）, which highlights the importance of characterizing the molecular mechanisms underlying the functional specialization of pDCs in IFN-I production.

关键词： Tumor Necrosis Factor Receptor Superfamily Human pDCs Axon Pruning Death Receptor Family Nucleic Acid Ligand

Effects of Flowering Mode and Pollinator Sharing on Reproductive Success in Natural Hybrid of Two Epimedium(Berberidaceae)Species

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Phyton-International Journal of Experimental Botany 2024年第3期93卷 551-566页

作者： Lanying Chen qiumei Quan Yunxiang Li College of Life Sciences China West Normal UniversityNanchong637000China School of Ecology and Environment Tibet UniversityLasha850000China College of Environment Science and Engineering China West Normal UniversityNanchong637000China

Mediated by pollenﬂow,natural hybridization is deemed a crucial factor that propels speciation inﬂoral *** the fact that the diversity of Epimedium species is concentrated mainly in Southwestern China,the poten-tial impact of interspeciﬁc pollination on natural hybridization has yet to be empirically *** explore this,we studied theﬂowering period and the visitors ofﬂowers in three frequently overlapping Epimedium species at Jinchengshan National Forest Park,located in Nanchong,Sichuan ***,we performed a ser-ies of pollination experiments to examine breeding systems and hybrid ***,Epime-dium pubescens and Epimedium wushanense are clearly distinct and easily recognizable byﬂower morphology,while the putative hybrid is morphologically intermediate between *** observation revealed that ***-escens and *** had 15 days of overlapping *** species are self-incompatible and require pol-linator services for successful *** their pollinators differ in quantity and species,Lasioglossum sp.(Hymenoptera:Halictidae)visited all three ***ﬁcial pollination revealed no breeding barriers among the three species,and the resulting hybrid seeds exhibited *** overlapping time ofﬂowering,commonﬂoral visitors,and compatibility of hybrids may be important factors contributing to successful interspeciﬁc pol-lination and speciation for natural hybrid species of *** and ***,the role of potential interspeciﬁc pollination is crucial for hybrid speciation and the evolutionary dynamics of Epimedium species.

关键词： Breeding system ﬂoral visitor medicinal plant species evolution

基于广义弹性理论的微梁固有频率及模态的尺寸效应

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应用数学和力学 2018年第9期39卷 999-1008页

作者：沈暗明陈锐杜丘美重庆大学航空航天学院重庆400044 机械传动国家重点实验室(重庆大学) 重庆400044

经典弹性理论在近代工程技术中得到广泛应用,但其本构关系中不包含任何与尺寸相关的参数,因此不适用于微观结构,不能预测和解释尺寸效应.广义弹性理论增加了偶应力及其对应的曲率张量,完善了对小变形的几何描述,适用于微结构的尺寸效应... 详细信息

经典弹性理论在近代工程技术中得到广泛应用,但其本构关系中不包含任何与尺寸相关的参数,因此不适用于微观结构,不能预测和解释尺寸效应.广义弹性理论增加了偶应力及其对应的曲率张量,完善了对小变形的几何描述,适用于微结构的尺寸效应研究.该文采用广义弹性理论,并结合Hamilton变分原理推导了悬臂微梁的振动微分方程,对微梁的固有频率及其模态进行了分析.结果表明,随着微梁厚度的不断减小,固有频率的尺寸效应与其对应的模态密切相关.扭转和弯曲模态包含了旋转变形,其对应的固有频率显著提高,表现出了显著的尺寸效应;而拉压模态不涉及旋转变形,固有频率未产生明显变化,没有尺寸效应.

关键词：尺寸效应广义弹性理论 Hamilton原理固有频率模态悬臂微梁

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乳康灵治疗乳腺小叶增生症120例

中国民间疗法 2006年第12期14卷 34-35页

作者：杜秋梅东北农业大学医院黑龙江哈尔滨150030

1996年以来,笔者以乳康灵(自拟方)治疗乳腺小叶增生症120例,效果满意,并与用逍遥丸治疗的120例进行对照,现报告如下.一般资料两组240例病人均符合(第2版)拟定的乳腺小叶增生症的诊断标准.治疗组120例,其中年龄在23～30岁者31例,31～40岁... 详细信息

1996年以来,笔者以乳康灵(自拟方)治疗乳腺小叶增生症120例,效果满意,并与用逍遥丸治疗的120例进行对照,现报告如下.一般资料两组240例病人均符合(第2版)拟定的乳腺小叶增生症的诊断标准.治疗组120例,其中年龄在23～30岁者31例,31～40岁者63例,41～50岁者26例;发病2～6个月者32例,7～12个月者40例,1～3年者38例,3年以上者10例;患于左侧乳房者53例,右侧乳房者26例,两侧乳房者41例;肿块位于外上方者43例,外下方者61例,内上方者16例.对照组120例,其中年龄在23～30岁者32例,31～40岁者65例,41～50岁者23例;发病2～6个月者34例,7～12个月者43例,1～3年者35例,3年以上者8例;患于左侧乳房者56例,右侧乳房者25例,两侧乳房者39例;肿块位于外上方者46例,外下方者59例,内上方者15例.两组肿块一般在2cm×3cm左右,最小约0.8cm×1cm,最大约4cm×5cm.两组患者临床资料无显著差异,具有可比性.

关键词：乳腺小叶增生症治疗康灵自拟方逍遥丸

Carrimycin ameliorates lipopolysaccharide and cecal ligation and puncture-induced sepsis in mice

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Chinese Journal of Natural Medicines 2024年第3期22卷 235-248页

作者： LAI Junzhong LIANG Jiadi CHEN Kunsen GUAN Biyun CHEN Zhirong CHEN Linqin FAN Jiqiang ZHANG Yong LI qiumei SU Jingqian CHEN Qi LIN Jizhen The Cancer Center Fujian Medical University Union HospitalFuzhou 350001China Fujian Key Laboratory of Innate Immune Biology Biomedical Research Center of South ChinaFujian Normal UniversityFuzhou 350117China The Department of Otolaryngology Head&Neck SurgeryUniversity of Minnesota Medical SchoolMinneapolisMN 55455USA

Carrimycin(CA),sanctioned by China’s National Medical Products Administration(NMPA)in 2019 for treating acute bronchitis and sinusitis,has recently been observed to exhibit multifaceted biological activities,encompassing anti-inflammatory,antiviral,and anti-tumor *** these applications,its efficacy in sepsis treatment remains *** study introduces a novel function of CA,demonstrating its capacity to mitigate sepsis induced by lipopolysaccharide(LPS)and cecal ligation and puncture(CLP)in mice *** research employed in vitro assays,real-time quantitative polymerase chain reaction(RT-qPCR),and RNA-seq analysis to establish that CA significantly reduces the levels of pro-inflammatory cytokines,namely tumor necrosis factor-alpha(TNF-α),interleukin 1 beta(IL-1β),and interleukin 6(IL-6),in response to LPS ***,Western blotting and immunofluorescence assays revealed that CA impedes Nuclear Factor Kappa B(NF-κB)activation in LPS-stimulated RAW264.7 *** these findings,in vivo experiments demonstrated that CA effectively alleviates LPS-and CLP-triggered organ inflammation in C57BL/6 *** insights were gained through 16S sequencing,highlighting CA’s pivotal role in enhancing gut microbiota diversity and modulating metabolic pathways,particularly by augmenting the production of short-chain fatty acids in mice subjected to ***,a comparative analysis revealed that CA’s anti-inflammatory efficacy surpasses that of equivalent doses of aspirin(ASP)and ***,these findings suggest that CA exhibits significant therapeutic potential in sepsis *** discovery provides a foundational theoretical basis for the clinical application of CA in sepsis management.

关键词： Carrimycin Inflammation Lipopolysaccharide Cecal ligation and puncture Sepsis Gut microbiota

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2 MW风电机组机舱内热流场数值模拟

重庆理工大学学报（自然科学） 2017年第12期31卷 111-115页

作者：杜丘美郭原刘健重庆大学航空航天学院重庆400044

大型风力发电机在使用过程中,会在机舱内产生大量的热量,如果没有合理的降温措施,可造成潜在火灾事故的隐患。针对该问题,使用某风电设备公司提供的2 MW风电机组机舱模型数据,利用通用流体力学分析软件,对风电机组机舱进行三维热流场数... 详细信息

大型风力发电机在使用过程中,会在机舱内产生大量的热量,如果没有合理的降温措施,可造成潜在火灾事故的隐患。针对该问题,使用某风电设备公司提供的2 MW风电机组机舱模型数据,利用通用流体力学分析软件,对风电机组机舱进行三维热流场数值模拟,通过控制进、出风口的风速,分析热流场与流场的特点,可为降低机舱内温度的方法提供理论指导。

关键词：风电机舱数值模拟能源 CFD

死亡受体6的胞内结构域对其亚细胞定位的调节

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生物物理学报 2014年第2期30卷 117-126页

作者：李靖云胡瑞杜秋妹尹相云王婷婷王东辉张立国中国科学院生物物理研究所感染与免疫院重点实验室北京100101 中国科学院大学北京100049 中国人民解放军沈阳军区总医院沈阳110015

死亡受体6(death receptor 6,DR6)是死亡受体家族的一员,在免疫系统和神经系统中发挥着重要功能,然而,其亚细胞定位和调节机制尚不清楚。作者研究发现DR6不仅能够定位在细胞质膜表面,同时也存在于细胞内体系统。膜表面的DR6可以发生内吞... 详细信息

死亡受体6(death receptor 6,DR6)是死亡受体家族的一员,在免疫系统和神经系统中发挥着重要功能,然而,其亚细胞定位和调节机制尚不清楚。作者研究发现DR6不仅能够定位在细胞质膜表面,同时也存在于细胞内体系统。膜表面的DR6可以发生内吞,功能性单克隆抗体能够加速其内吞。通过构建一系列胞内结构域的缺失突变体,结果显示单独缺失丝氨酸/脯氨酸富集结构域,DR6在细胞膜表面定位显著增加,在内体定位显著减少。而分别缺失另外三个胞内结构域,DR6主要定位在细胞内体。以上结果提示DR6的胞内不同结构域在调控DR6的亚细胞定位和功能中发挥着重要作用。

关键词：死亡受体6 亚细胞定位内吞作用

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基于病毒溯源优化思想的元启发式优化算法

统计与决策 2024年第3期40卷 40-45页

作者：汪勇白雪艾学轶蒲秋梅武汉科技大学管理学院武汉430065 中央民族大学信息工程学院北京100081

为提高当前元启发式算法的优化精度和收敛性能,模拟病毒溯源过程的优化思想,文章提出一种元启发式病毒溯源多目标优化算法。给出更早感染者、最早感染者、误差最优解和算法性能评价指标的定义,构造追踪方向、追踪指令和追踪范围启发式... 详细信息

为提高当前元启发式算法的优化精度和收敛性能,模拟病毒溯源过程的优化思想,文章提出一种元启发式病毒溯源多目标优化算法。给出更早感染者、最早感染者、误差最优解和算法性能评价指标的定义,构造追踪方向、追踪指令和追踪范围启发式更新算法,建立具有目标偏好的感染度函数,由此设计具有快速精准搜索能力的启发式追踪算子和筛查算子。通过17个单目标和多目标测试函数优化实验验证了所提算法在优化精度、优化速度和平均误差上均优于参与比较的其他6个元启发式算法,为复杂优化问题的求解提供了一种新的有效方法。

关键词：多目标优化元启发式算法病毒溯源追踪与筛查误差最优解