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New Schizolepis Fossils from the Early Cretaceous in Inner Mongolia, China and its Phylogenetic Position

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Acta Geologica Sinica(English Edition) 2013年第5期87卷 1250-1263页

作者： XU Xiaohui li Ruiyun DONG Chong WANG qiujun JIN Peihong SUN Bainian School of Earth Sciences&Key Laboratory of Mineral Resources in Western China (Gansu Province) Lanzhou University

Three Schizolepis species collected from the Lower Cretaceous layer of the Huolinhe Basin, Inner Mongolia, China are described. These fossils are Schizolepis longipetiolus Xu XH et Sun BN sp. nov., which is a new species, Schizolepis cf. heilongjiangensis Zheng et Zhang, and Schizolepis neimengensis Deng. The new species is a well-preserved female cone, slender and cylindrical in shape. The seed-scale complexes have long petioles and are arranged on the cone axis loosely and helically. The seed scales are divided into two lobes from the base. Each lobe is semicircular or elongate ligulate in shape, widest at the middle or the lower middle part, with an obtuse or bluntly pointed apex. The inner margin is almost straight and the outer margin is strongly arched. On the surface of the lobe, there are longitudinal and somewhat radial striations from the base to the margin. The seed is borne on the adaxial surface at the base or middle of each lobe. Schizolepis was estabfished in 1847, and, although more than twenty species have been discovered and reported, its phylogenetic position is controversial because of the imperfection of fossils. Most authors have considered there to be a close evolutionary relationship between Schizolepis and extant Pinaceae. Here, we analyze characteristics and compare Schizolepis with Picea crassifolia Kom, which is morphologically most similar to Schizolepis. The results indicate that the genus probably has a distant evolutionary relationship with extant Pinaceae. A detailed statistical analysis of the global paleogeographic distribution of Schizolepis showed that all the fossils of this genus appeared in strata ranging from the Upper Triassic to the Lower Cretaceous in the North Hemisphere, being rare in the Upper Triassic and Lower Jurassic, but being very common from the Middle Jurassic to the Lower Cretaceous, and particularly abundant in the Lower Cretaceous. According to the statistical results, we speculate that the genus originated i

关键词： Schizolepis systematic evolution paleogeographic distribution Early Cretaceous cause of extinction Inner Mongolia

Anion competition for li^(+)solvated coordination environments in poly(1,3 dioxolane)electrolyte to enable high-voltage lithium metal solid-state batteries

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Journal of Energy Chemistry 2024年第9期96卷 633-641页

作者： qiujun Wang Yanqiang Ma Xiaomeng Jia Di Zhang Zhaojin li Huilan Sun Qujiang Sun Bo Wang li-Zhen Fan Hebei Key Laboratory of Flexible Functional Materials School of Materials Science and EngineeringHebei University of Science and TechnologyShijiazhuang 050000HebeiChina Beijing Advanced Innovation Center for Materials Genome Engineering Institute of Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China

Gel-based polymer electrolytes are limited by the polarity of the residual solvent,which restricts the coupling-breaking behaviour during li^(+)conduction,resulting in the li^(+)transport kinetics being greatly ***,we designed anion competitive gel polymer electrolyte(ACPE)by introducing lithium difluoro(oxalato)borate(liDFOB)anion into the 1,3-dioxolane(DOL)in situ polymerisation *** enhances the ionic dipole interaction between li^(+)and the solvent molecules and synergizes with li^(+)across the solvation site of the polymer ethylene oxide(EO)unit,combination that greatly improves the li^(+)transport *** a result,ACPE exhibits 1.12 mS cm^(−1)ionic conductivity and 0.75 li^(+)transfer number at room ***,this intra-polymer solvation sheath allows preferential desolvation of DFOB−,which contributes to the formation of kinetically stable anion-derived interphase and effectively mitigates side *** results demonstrate that the assembled li||NCM622 solid-state battery exhibits lifespan of over 300 cycles with average Coulombic efficiency of 98.8%and capacity retention of 80.3%.This study introduces a novel approach for ion migration and interface design,paving the way for high-safety and high-energy-density batteries.

关键词： li-metal batteries Poly(1,3-dioxolane) In situ polymerization Solid-state polymer electrolytes Anion competition

Selective ischemic-hemisphere targeting Ginkgolide B liposomes with improved solubility and therapeutic efficacy for cerebral ischemia-reperfusion injury

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Asian Journal of Pharmaceutical Sciences 2023年第2期18卷 76-93页

作者： Yang li Miaomiao Zhang Shiyi li Longlong Zhang Jisu Kim qiujun Qiu Weigen Lu Jianxin Wang Department of Pharmaceutics School of PharmacyFudan University&Key Laboratory of Smart Drug DeliveryMinistry of EducationShanghai201203China National Pharmaceutical Engineering and Research Center China State Institute of Pharmaceutical IndustryShanghai 201203China

Cerebral ischemia-reperfusion injury(CI/RI)remains the main cause of disability and death in stroke patients due to lack of effective therapeutic *** of the main issues related to CI/RI treatment is the presence of the blood-brain barrier(BBB),which affects the intracerebral delivery of *** B(GB),a major bioactive component in commercially available products of Ginkgo biloba,has been shown significance in CI/RI treatment by regulating inflammatory pathways,oxidative damage,and metabolic disturbance,and seems to be a candidate for stroke ***,limited by its poor hydrophilicity and lipophilicity,the development of GB preparations with good solubility,stability,and the ability to cross the BBB remains a ***,we propose a combinatorial strategy by conjugating GB with highly lipophilic docosahexaenoic acid(DHA)to obtain a covalent complex GB-DHA,which can not only enhance the pharmacological effect of GB,but can also be encapsulated in liposomes *** amount of finally constructed lipo@GB-DHA targeting to ischemic hemisphere was validated 2.2 times that of free solution in middle cerebral artery occlusion(MCAO)*** to the marketed ginkgolide injection,lipo@GB-DHA significantly reduced infarct volume with better neurobehavioral recovery in MCAO rats after being intravenously administered both at 2 h and 6 h *** levels of reactive oxygen species(ROS)and high neuron survival in vitro was maintained via lipo@GB-DHA treatment,while microglia in the ischemic brain were polarized from the pro-inflammatory M1 phenotype to the tissue-repairing M2 phenotype,which modulate neuroinflammatory and *** addition,lipo@GB-DHA inhibited neuronal apoptosis via regulating the apoptotic pathway and maintained homeostasis by activating the autophagy ***,transforming GB into a lipophilic complex and loading it into liposomes provides a promising nanomedicine strategy with excellent CI/RI therapeu

关键词： Ginkgolide B Cerebral ischemia reperfusion injury(CI/RI) Docosahexaenoic acid liposomes Brain targeting Microglia

Exploring the role of solvents in structural regulation during ultrasonic synthesis of Co/Ni-layered double hydroxide for oxygen evolution reaction

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Materials Reports(Energy) 2024年第4期4卷 48-56,I0002页

作者： Zhaojin li Qian Ma Zezhao li Di Zhang Qujiang Sun qiujun Wang Huilan Sun Bo Wang Key Laboratory of Flexible Functional Materials School of Materials Science and EngineeringHebei University of Science and TechnologyHebei050018PR China

Cobalt-based layered double hydroxides(LDHs)are highly sought after by researchers due to their low-cost,high efficiency and stability for oxygen evolution reaction(OER)in water *** OER performance of these LDHs is closely related to their morphology and electronic ***,there is a lack of theory on how to control reaction conditions to regulate the *** this paper,the growth mechanism of LDH prepared in different solvents is thoroughly ***,the Co/Ni-LDHs exhibiting a 3D hierarchical flower-like structure were synthesized with normal alcohol as a solvent,meanwhile,the thickness of the LDHs can be controlled by the molecular weight of the normal *** adjusting the suitable Co/Ni ratio and solvent,the Co/Ni0.050-LDH-Me was synthesized and exhibited excellent OER *** 10 mA cm^(-2),the overpotential of Co/Ni0.050-LDH-Me is 307 mV,and the Tafel slope is 76.5 mV dec^(-1).

关键词： Oxygen evolution reaction Electrocatalysts Layered double hydroxide Transition metal

Synergistically enabling the interface stability of lithium metal batteries with soft ionic gel and garnet-type li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)ceramic filler

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Journal of Materiomics 2023年第3期9卷 568-576页

作者： qiujun Wang Weiqi Zhu Ya Su Di Zhang Zhaojin li Huan Wang Huilan Sun Bo Wang Dan Zhou li-Zhen Fan Hebei Key Laboratory of Flexible Functional Materials School of Materials Science and EngineeringHebei University of Science and TechnologyShijiazhuang050000China Beijing Advanced Innovation Center for Materials Genome Engineering Institute of Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing100083China

lithium metal batteries based on solid electrolytes are considered as promising candidates with high energy density and ***,the weak solid-solid contact between electrolyte and electrode can easily lead to interface instability and lithium ions discontinuous migration,which seriously reduces the electrochemical performance of the ***,we construct a soft gel interfacial layer to improve the stability of the solid-solid interface between electrolyte and electrode by means of polyester-based monomers and imidazole-based ionic *** on this,garnet-type li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO)particles as inorganic ceramic filler were introduced in the layer to obtain composite electrolytes with high ionic conductivity(up to 1.1×10^(-3)S/cm at 25℃).As a result,the assembled lithium symmetric battery of li|THCE-15%LLZTO|li suggests excellent cycling stability with 700 h at 0.1 mA/cm^(2)at 50℃,and the lithium metal batteries of LFP|THCE-15%LLZTO|li delivers high initial discharge capacity of 128.2 mA·h/g with capacity retain of 75.48%after 150 cycles at 2 *** work paves a new route to build safe and stable lithium metal batteries with synergistic introduction of composite electrolytes between electrolyte and electrode using soft gel interfacial layer and inorganic filler.

关键词： lithium metal batteries Ionic liquid In-situ polymerization Soft interfacial layer Composite electrolyte

Bamboo Leaf and Pollen Fossils from the Late Miocene of Eastern Zhejiang,China and their Phytogeological Significance

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Acta Geologica Sinica(English Edition) 2014年第4期88卷 1066-1083页

作者： WANG qiujun MA Fujun YANG Yi DONG Junling WANG Haofei li Ruiyun XU Xiaohui SUN Bainian School of Earth Sciences & Key Laboratory of Mineral Resources in Western China (Gansu Province) Lanzhou University

Fossil bamboo leaves and pollen from Upper Miocene deposits of the Shengxian Formation in Tiantai and Ninghai counties, eastern Zhejiang, China represent a rare record in Asia. The distinctive pseudopetiole and parallel venation of the leaf blades and the clearly thickened annulus of the pollen aperture place them in the subfamily Bambusoideae. Morphological analysis supports the determination of these fossil leaves as belonging to the genus Bambusium and two new species are described. Bambusium latipseudopetiolus Q.J. Wang et B.N. Sun sp. nov. has a distinctly wide pseudopetiole of 0.23 cm in width and 0.40 cm in length, several vascular bundles on parallel veins, and 5-8 lateral veins on both sides of the midrib. Bambusium longipseudopetiolus Q.J. Wang et B.N. Sun sp. nov. has a distinctly long pseudopetiole of 0.60 cm in length and 0.10 cm in width, several vascular bundles on the pseudopetiole, and 6 lateral veins on both sides of the midrib. Pollen grains from the same layer provide additional evidence of bamboos. They are characterized by 32.0-51.0 μm in diameter, a round pore 3.0-4.0 μm in diameter with a broad thickened annulus 2.5-3.5 μm around, and several conspicuous secondary folds on the exine surface. The morphological analysis leads to their assignment to Graminidites bambusoides Stuchlik. These fossils are important for the study of bamboo phytogeography in China. They demonstrate that there were bamboos growing in southeastern China during the Late Miocene and that bamboos in Zhejiang begin to diversify no later than the Late Miocene. In combination with bamboo fossils from other places, it seems that bamboos had a wide distribution across southern China during the Miocene, ranging from southwestern Yun＇nan to southeastern Zhejiang.

关键词： Paleobotany Palynology Phytogeography Bambusoideae Late Miocene Zhejiang province

A two-step strategy for constructing stable gel polymer electrolyte interfaces for long-life cycle lithium metal batteries

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Journal of Materiomics 2022年第5期8卷 1048-1057页

作者： qiujun Wang Pin Zhang Weiqi Zhu Di Zhang Zhaojin li Huan Wang Huilan Sun Bo Wang li-Zhen Fan Hebei Key Laboratory of Flexible Functional Materials School of Materials Science and EngineeringHebei University of Science and TechnologyShijiazhuang050018China Beijing Advanced Innovation Center for Materials Genome Engineering Institute of Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing100083China

Due to the high reactivity between the lithium metal and traditional organic liquid electrolyte,the reaction of lithium metal electrode is usually uneven and there are also unexpected side ***,construction of a stable solid electrolyte interface(SEI)is highly essential to improve the performance of lithium metal ***,a sandwich-like gel polymer electrolyte(GPE)is accurately prepared by in-situ polymerization of Polyacrylonitrile(PAN)nanofiber membrane with trihydroxymethylpropyl trimethylacrylate(TMPTMA)and 1,6-hexanediol diacrylate(HDDA).The resulting GPE with a tightly cross-linked gel skeleton exhibits high ionic conductivity and electrochemical window of 5.6 V versus li/li^(+).In particular,the pretreatment of li metal anode can improve the interfacial wettability,and the synergy of the chemically pretreated li metal anode surface and the GPE can electrochemically in situ generate SEI with compositionally stable and fluorine-rich inorganic *** to these unique advantages,the interfacial compatibility between the GPE and lithium metal is greatly ***,the formed SEI can inhibit the formation of lithium dendrites,and decomposition of GPE would be *** assembled li-FEC|GPE|liFePO_(4) full cell shows a high initial discharge capacity of 157.1 mA h g^(-1),and maintains a capacity retention of 92.3%after 100 cycles at 0.2C.

关键词： Gel polymer electrolyte Pre-lithiation lithium-metal batteries In-situ polymerization

人类白细胞抗原相合同胞新鲜脐血移植治疗儿童β重型地中海贫血

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中国组织工程研究 2025年第23期29卷 4899-4906页

作者：温建芸陈丽白何岳林冯晓勤刘璇徐肖肖李秀刘秋君吴学东南方医科大学南方医院儿科广东省广州市510515

背景:异基因造血干细胞移植是目前根治重型地中海贫血最有效的方法,然而仅有不到一半的患者能找到相合的骨髓或外周血干细胞。同胞来源脐血干细胞与骨髓和外周血干细胞具有不同的特征,是重型地中海贫血患者移植治疗的一种潜在造血干细... 详细信息

背景:异基因造血干细胞移植是目前根治重型地中海贫血最有效的方法,然而仅有不到一半的患者能找到相合的骨髓或外周血干细胞。同胞来源脐血干细胞与骨髓和外周血干细胞具有不同的特征,是重型地中海贫血患者移植治疗的一种潜在造血干细胞替代来源。目的:探讨应用人类白细胞抗原相合同胞新鲜脐血移植治疗儿童β重型地中海贫血的疗效。方法:选择2010年6月至2020年6月南方医科大学南方医院收治的β重型地中海贫血患儿48例,男28例,女20例,中位年龄4岁,均接受人类白细胞抗原相合同胞新鲜脐血移植治疗,脐血移植前均采用清髓性不含抗胸腺细胞球蛋白的预处理方案,脐血移植后均采用环孢素A+吗替麦考酚酯+/-短程甲氨蝶呤预防移植物抗宿主病。结果与结论:(1)48例患儿输注的总有核细胞中位数为8.17×10^(7)/kg,输注的CD34^(+)细胞中位数为2.40×10^(5)/kg,脐血移植后中位随访时间98个月,44例植入成功,粒细胞和血小板植入中位时间分别为28 d和31 d,其中37例移植后植入证据检测为供者型完全嵌合,7例移植后早期检测为供受者稳定混合嵌合;(2)44例植入成功患儿中,4例发生急性移植物抗宿主病,分别为Ⅰ级(n=2)和Ⅱ级(n=2),受累器官均为皮肤,均未发生慢性移植物抗宿主病;(3)脐血移植后,48例患儿中5例发生巨细胞病毒感染及激活,12例发生败血症,3例发生侵袭性真菌病,21例发生口腔炎,8例发生出血性膀胱炎,1例发生肝静脉闭塞;(4)48例患儿中,47例存活,1例在移植后28 d因重症肺炎合并急性心力衰竭死亡,43例无病存活,3例发生原发性植入失败,1例发生移植后全血细胞减少,5年总生存率和无病生存率分别为98%和89%,1年时移植相关死亡的累计发病率为2.1%;(5)结果显示,人类白细胞抗原相合同胞新鲜脐血移植治疗儿童β重型地中海贫血的效果良好,移植物抗宿主病的发生风险低。

关键词：异基因造血干细胞移植新鲜脐血移植 β重型地中海贫血移植物抗宿主病儿童

Effect of Kupffer cells depletion on ABC phenomenon induced by Kupffer cells-targeted liposomes

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Asian Journal of Pharmaceutical Sciences 2019年第4期14卷 455-464页

作者： Chaoyang Lai Cong li Mengyang liu qiujun Qiu Xiang Luo Xinrong liu ling Hu Yihui Deng Yanzhi Song Shenyang Pharmaceutical University

Accelerated blood clearance(ABC) phenomenon is common in many PEGylated nanocarriers, whose mechanism has not been completely elucidated yet. In this study, the correlation between Kupffer cells(KCs) and ABC phenomenon has been studied by KCs-targeted liposomes inducing ABC phenomenon and KCs depletion. In other words, the 4-aminophenyl-α-D-mannopyranoside(APM) lipid derivative DSPE-PEG 2000-APM(DPM), and 4-aminophenyl-β-L-fucopyranoside(APF) lipid derivative DSPE-PEG 2000-APF(DPF) were conjugated and modified on alendronate sodium(AD) liposomes to specifically target and deplete KCs. The dualligand modified PEGylated liposomes(MFPL) showed stronger ability to damage KCs in vitro and in vivo, which also could indirectly illustrate that dual-ligand modification could better target KCs. Besides, the hepatic biodistribution and pharmacokinetics could directly prove that MFPL had a stronger targeting ability to KCs. In addition, in depletion rats, plasma concentration and splenic biodistribution of MFPL and PEGylated liposomes(PL) were significantly elevated and hepatic biodistribution was significantly reduced, which demonstrated that KCs played an important role on elimination of nanoparticles. What’s more, ABC phenomenon of the secondary injection of PL was stronger in KCs depletion rats than that in normal rats, which indicated that depletion of KCs prolonged the circulation of PL in the first injection repeatedly stimulating B-cells in the marginal region of the spleen and causing it to secrete more IgM antibodies. This could also illustrate that anti-PEG IgM takes up a major station compared with KCs. Most important of all, KCs-targeted liposomes could induce a stronger ABC phenomenon than PL in normal rats, which declared that based on the same IgM concentration, the more the KCs were stimulated, the stronger ABC phenomenon was induced. However, in depletion rats, this difference of ABC phenomenon between PL and MFPL could no more exist, further demonstrating tha

关键词： Accelerated blood clearance (ABC) phenomenon Kupffer cells Depletion liposomes Bio-distribution