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Low dispersion finite volume scheme based on reconstruction with minimized dispersion and controllable dissipation

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Science China(Physics,Mechanics & Astronomy) 2013年第2期56卷 423-431页

作者： wang qiuju REN YuXin SUN ZhenSheng SUN YuTao Department of Engineering Mechanics School of AerospaceTsinghua University Institute of Applied Physics and Computational Mathematics

The reconstruction with minimized dispersion and controllable dissipation(MDCD) optimizes dispersion and dissipation separately and shows desirable properties of both dispersion and dissipation.A low dispersion finite volume scheme based on MDCD reconstruction is proposed which is capable of handling flow discontinuities and resolving a broad range of length *** the proposed scheme is formally second order accurate,the optimized dispersion and dissipation make it very accurate and robust so that the rich flow features encountered in practical engineering applications can be handled properly.A number of test cases are computed to verify the performances of the proposed scheme.

关键词： low dispersion reconstruction finite volume scheme

ANIMAL BEHAVIORAL MODELS OF TINNITUS

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Journal of Otology 2014年第2期9卷 58-63页

作者： ZHANG Chao wang qiuju SUN Wei Department of Otolaryngology Chinese PLA General Hospital Center for Hearing & Deafness Department of Communicative Dis-orders and SciencesState University of New York at Buffalo 3435 Main StreetBuffaloNY 14214

The pathophysiology of tinnitus is poorly understood and treatments are often unsuccessful. A number of animal models have been developed in order to gain a better understanding of tinnitus. A great deal has been learned from these models re- garding the electrophysiological and neuroanatomical correlates of tinnitus following exposure to noise or ototoxic drugs. Re- liable behavioral data is important for determining whether such electrophysiological or neuroanatomical changes are indeed related to tinnitus. Of the many documented tinnitus animal behavioral paradigms, the acoustic startle reflex had been pro- posed as a simple method to identify the presence or absence of tinnitus. Several behavioral models based on conditioned re- sponse suppression paradigms have also been developed. In addition to determining the presence or absence of tinnitus, some of the behavioral paradigms have provided signs of the onset, frequency, and intensity of tinnitus in animals. Although none of these behavioral models have been proved to be a perfect model, these studies provide useful information on understanding the neural mechanisms underlying tinnitus.

关键词： Tinnitus Behavioral model Acoustic startle Noise exposure Salicylate

Molecular genetic studies of familial Meniere’s disease

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Science China(Life Sciences) 2019年第11期62卷 1557-1560页

作者： Jing Zhang Jing Guan Hongyang wang Dayong wang Lidong Zhao Huifang Zhou qiuju wang Chinese PLA Institute of Otolaryngology Chinese PLA General HospitalMedical School of Chinese PL ABeijing 100853China Department of Otolaryngology of Tianjin Medical University General Hospital Tianjin 300052China

Dear ***'s disease(MD,MIM 156000),a chronic clinical illness affecting the inner ear,presents as episodes of spontaneous vertigo,fluctuating sensorineural hearing loss,tinnitus,and aural *** hydrops in the cochlear duct and vestibular organs is considered the underlying histopathologic characteristic of *** MD cases are sporadic(sporadic Meniere's disease,SMD),and approximately 4%-20%of patients with MD have a familial history.

关键词： Meniere familial organs

Current trends and hotspots of etiology of auditory neuropathy in the past 30 years: A bibliometric analysis

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Journal of Otology 2024年第2期19卷 113-119页

作者： Danyang Li Hongyang wang Yiming Li Yang Cao Kaili Wu qiuju wang Department of Otolaryngology Head and Neck Surgery the 6th Medical Center of Chinese PLA General HospitalChinese PLA Medical SchoolBeijing100853China School of Medicine Nankai UniversityTianjin300000China National Clinical Research Center for Otolaryngologic Diseases Key Lab of Hearing ScienceMinistry of EducationBeijing Key Lab of Hearing Impairment Prevention and TreatmentBeijing100853China

Objective:To make an overview of global research trends in the etiology of auditory neuropathy(AN)over the past 30 years using a bibliometric ***:Bibliometric analyses were conducted by GraphPad Prism 9.0,Citespace 6.2.R2,and an online analysis platform to analyze and visualize publications related to etiology of AN from the Web of Science Core Collection(WoSCC)database from 1996 to ***,genetic factors in human AN were ***:In total,604 original articles and reviews related to the etiology of AN from the WoSCC were included for bibliometric *** results showed that annual publications and trend on etiology of AN increased linearly from *** them,the United States and China published nearly 400 records(40.32%).From the 604 records,a total of 752 keywords and 10 clustered network maps were extracted by Citespace,and‘mutations’was among the top 10 *** of genetic factors found that more than 30 genes were related to AN,and the latest burst occurred in ***:The bibliometric analysis mapped the global research trends and analyzed hotspots for *** results indicated that the annual publications increased linearly from ***,there was a burst in genetic factors in 2022,which identified that genetic factor would remain a focus of future research.

关键词： Bibliometric analysis Auditory neuropathy Etiology Citespace

Understanding auditory neuropathy spectrum disorder： a system- atic review in transgenic mouse models

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Science China(Life Sciences) 2016年第5期59卷 480-486页

作者： Li wang Jing Guan Hongyang wang Lan Lan Qiujing Zhang Liang Zong Wan Du Wenping Xiong Fengjiao Li Kaiwen Wu Dayong wang qiuju wang Institute of Otolaryngology Chinese PLA General Hospital Medical School of Chinese PLA Beijing 100853 China Medical College Nankai University Tianjin 300071 China

Auditory neuropathy spectrum disorder is a unique group of hearing dysfunctions characterized by preserved outer hair cell function and abnormal neural conduction of the auditory pathway. However, the pathogenic mechanism underlying this disorder is not clear. We therefore performed a systematic review of genetic mouse models with different gene mutations to provide a valuable tool for better understanding of the process and the possible molecular mechanisms. Of the 18 articles retrieved, nine met the required criteria. All biochemical, histological, and electrophysiological results were recorded for each of the mouse models, as was the transgenic technology. This review provides a summary of different mouse models that may play an important role in the diagnosis and management of auditory neuropathy spectrum disorder in the future.

关键词： auditory neuropathy spectrum disorder transgenic mouse models pathogenesis systematic review

A novel de novo mutation of ACTG1 in two sporadic non-syndromic hearing loss cases

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Science China(Life Sciences) 2018年第6期61卷 729-732页

作者： Hongyang wang Jing Guan Lan Lan Lan Yu Linyi Xie Xu Liu Ju Yang Cui Zhao Dayong wang qiuju wang Chinese PLA Institute of Otolaryngology Chinese PLA General Hospital Medical School of Chinese PLA Beijing 100853 China Beijing Centre for Physical and Chemical Analysis Beijing 100089 China

Dear Editor,Actins are a family of essential cytoskeletal proteins involved in nearly all cellular processes（Lambrechts et al.,2004）.Of the six human genes that encode actins,only ACTG1and ACTB are ubiquitously ***1（OMIM#604717）,which is linked to the DFNA20/26 locus,wasidentified in autosomal dominant, non-syndromic hearing loss （NSHL） cases （Baek et al., 2012; Liu et al., 2008; Park et al., 2013; Yuan et al., 2016）. In addition, some ACTG1 （OMIM #614583） mutations are associated with Baraitser-Winter syndrome, which is characterized by developmental delay, facial dysmorphologies, brain malformations, colobomas, and variable hearing loss （Riviere et al., 2012）.

关键词： A novel de novo mutation of ACTG1 in two sporadic non-syndromic hearing loss cases

Validation Study of LPDDR2 SDRAM Based on TD-LTE Baseband chip

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无线互联科技 2014年第10期11卷 128-134页

作者： wang ChengZhi wang qiuju Han Juan Collgeg of Computer and Information Guizhou University Institute of Computing Technology Chinese Academy of Sciences

In recent years,as China has finished the updating of the fourth generation of network,for guaranteeing the information security of the state,communication chip with complete independent intellectual property right must be possessed to support the advancement of such ***-LTE Baseband Chip is a super-large-scale integrated circuit designed basing on SOC,which needs to carry out coding,etc to the transmitted baseband signal,or carry out decoding,etc to the received baseband ***2 SDRAM is used in the chip design process due to its low power dissipation,high capacity and high *** PHY in the controller architecture of LPDDR2 SDRAM adopts hard core design,it cannot be achieved in Virtex-7 2000T prototype verification *** design mainly builds on such prototype verification platform to propose the verification scheme of LPDDR2 SDRAM controller in TD_LTE baseband chip,so as to guarantee that prototype verification in FPGA can be carried out by TD_LTE baseband system,and meanwhile high capacity storage space can be provided to the system.

关键词：无线互联网 TD-LTE 手机移动通信

Clue to a New Deafness Gene:A Large Chinese Nonsyndromic Hearing Loss Family Linked to DFNA4

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Journal of Genetics and Genomics 2012年第12期39卷 653-657页

作者： Liang Zong Chunye Lu Yali Zhao Qian Li Dongyi Han Weiyan Yang Yan Shen Qingyin Zheng qiuju wang Department of Otolaryngology Head and Neck SurgeryInstitute of OtolaryngologyChinese PLA General Hospital28 Fuxing RoadBeijing 100853China Chinese National Human Genome Centre Beijing 100176China Department of Biochemistry and Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100853China Department of Otolaryngology-HNS Case Western Reserve UniversityClevelandOH 44106USA

Hereditary hearing loss is one of the most common neurosensory defects in humans. Approximately 70% of cases are nonsyndromic and could be inherited in autosomal domi- nant, autosomal recessive, mitochondrial, X-linked, and Y-linked manners （wang et al., 2004; Alford, 2011）. The autosomal dominant type, comprising 15%-20% of non- syndromic hearing loss, is monogenic and genetically heterogeneous. Since the first dominant deafness locus （DFNA 1） was identified in 1992, a total of 64 DFNA loci have been mapped （DFNA1-DFNA64）,

关键词：巨口 gene 口口 Clue to a New Deafness Gene CAMI

Progression of KCNQ4 related genetic hearing loss:a narrative review

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Journal of Bio-X Research 2021年第4期4卷 151-157页

作者： Xiaolong Zhang Hongyang wang qiuju wang College of Otolaryngology-Head and Neck Surgery Department of Audio-Vestibular MedicineChinese PLA Institute of OtolaryngologyChinese PLAGeneral HospitalMedical School of Chinese PLA National Clinical Research Center for Otolaryngologic Diseases Chinese PLA General HospitalBeijingChina

KCNQ4 gene mutation can lead to deafness non-syndromic autosomal dominant 2A,which is a type of autosomal dominant non-syndromic hearing *** non-syndromic autosomal dominant 2A patients with KCNQ4 gene mutation usually present with symmetrical,delayed,progressive high-frequency-affected hearing loss,which eventually can involve all *** this article,we comprehensively reviewed the research on the role and function of KCNQ4 gene in genetic hearing *** discussed the pathological and physiological mechanisms of KCNQ4 gene and the related clinical phenotypes of KCNQ4 gene *** also reviewed the latest developments in the treatment of KCNQ4 gene mutation-related genetic hearing loss,including selective potassium channel activation drugs and gene therapy.

关键词： deafness non-syndromic autosomal dominant 2A genetic hearing loss gene mutation KCNQ4 potassium channel