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A human-specific insertio. pro.o.es cell pro.iferatio. and migratio. by enhancing TBC1D8B expressio.

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Science china(Life sciences) 2024年第4期67卷 765-777页

作者： Hui Zhao.Lin-Lin Liu Jian Sun Lian Jin Hai-Bing Xie Jian-Bo.Li Hui Xu Do.g-Do.g Wu Xiao.Lin Zhuang Min-sheng peng Ya-Jun guo.Wei-Zhu Qian Newto. o.tecko.Wei-Jie Sun Liang-Hu Qu Jie He Zhao.Li Chen ro.g Liu Ce-Shi Chen Ya-ping Zhang State Key Labo.ato.y fo. Co.servatio. and Utilizatio. o. Bio.reso.rce School of Life SciencesSchool of Ecology and Environmental ScienceYunnan UniversityKunming 650091China Scho.l o. Fo.ensic Medicine Kunming Medical UniversityKunming 650500China academy o. Bio.edical Engineering Kunming Medical UniversityKunming 650500China The Third Affiliated Ho.pital Kunming Medical UniversityKunming 650118China Key Labo.ato.y o. Animal Mo.els and Human Disease Mechanisms o. the Chinese academy o. sciences and Yunnan pro.ince Kunming Institute of ZoologyChinese Academy of SciencesKunming 650201China State Key Labo.ato.y o. genetic reso.rces and Evo.utio. Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of SciencesKunming 650201China The Key Labo.ato.y o. gene Engineering o. the Ministry o. Educatio. State Key Laboratory for BiocontrolSun Yat-sen UniversityGuangzhou 510275China Natio.al Engineering research Center fo. Antibo.y Medicine and Shanghai Key Labo.ato.y o. Cell Engineering and Antibo.y Shanghai 201203China Department o. Tho.acic Surgery Cancer Institute and HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Human-specific insertio.s play impo.tant ro.es in human pheno.ypes and *** we repo.ted a 446-bp insertio.(Insert-446)in intro. 11 o. the TBC1D8B gene,lo.ated o. chro.o.o.e X,and traced its o.igin to.a po.tio. o. intro. 6 o. the EBF1 gene o. chro.o.o.e ***,Insert-446 was present in the human Neanderthal and Deniso.ans geno.es,and was fixed in humans after human-chimpanzee *** have demo.strated that Insert-446 acts as an enhancer thro.gh binding transcript facto.s that pro.o.es a higher expressio. o. human TBC1D8B gene as co.pared with o.tho.o.s in *** additio.,o.er-expressio. TBC1D8B pro.o.ed cell pro.iferatio. and migratio. thro.gh“a dual finger”catalytic mechanism(Arg53. and gln573.in the TBC do.ain in vitro.and kno.kdo.n o. TBC1D8B attenuated tumo.igenesis in *** o. Insert-446 prevented cell pro.iferatio. and migratio. in cancer and no.mal *** results reveal that the human-specific Insert-446 pro.o.es cell pro.iferatio. and migratio. by upregulating the expressio. o. TBC1D8B *** findings pro.ide a significant insight into.the effects o. human-specific insertio.s o. evo.utio..

关键词： human-specific insertio. enhancer gene expressio. cell pro.iferatio. and migratio.

正电子湮没符合多普勒展宽技术的材料学研究进展

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物理学报 2024年第7期73卷 62-81页

作者：叶凤娇张鹏张红强况鹏于润升王宝义曹兴忠中国科学院高能物理研究所多学科研究中心北京100049

正电子湮没技术是研究材料微观结构的一种原子尺度表征方法,通过分析正电子湮没行为可以得到湮没位点处局域电子密度和原子结构信息.近年来,正电子湮没谱学技术已经发展成为优于常规手段的特色表征技术,其中符合多普勒展宽技术在研究缺... 详细信息

正电子湮没技术是研究材料微观结构的一种原子尺度表征方法,通过分析正电子湮没行为可以得到湮没位点处局域电子密度和原子结构信息.近年来,正电子湮没谱学技术已经发展成为优于常规手段的特色表征技术,其中符合多普勒展宽技术在研究缺陷附近的电子和原子结构方面具有独特优势,商谱曲线中高动量区域形状的变化反映了正电子湮没位点周围的元素信息.在常规符合多普勒展宽技术发展基础上,能量可调的慢正电子束流符合多普勒展宽技术在获取表面微观结构的深度分布信息上展示出独特的作用,同时也弥补了常规符合多普勒展宽技术只能表征体材料中缺陷环境的不足.本文结合国内外相关进展,综述了符合多普勒展宽技术在各类材料中的研究进展:1)合金中空位型缺陷和纳米沉淀的演化行为;2)半导体中晶格空位与杂质原子的相互作用;3.氧化物中氧空位和金属阳离子浓度的变化.除此之外,在聚合物中自由体积孔洞的大小、数量及分布的估算表征领域中,符合多普勒展宽技术也逐步得到应用.

关键词：符合多普勒电子动量元素分布微观缺陷

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信息能源融合发展策略和体系架构

电信科学 2024年第2期40卷 116-123页

作者：高鹏肖子玉张晟中国移动通信集团设计院有限公司北京100080 中国移动通信集团有限公司北京100032

深度剖析了全球绿色低碳发展的迫切需求,全球碳排放量持续上升,仍不足以实现巴黎协定的温度目标,绿色低碳发展已成为全球共识和发展趋势。进一步分析了我国能源现状及相关政策,提出信息能源融合发展是未来社会数智化、低碳化发展的必然... 详细信息

深度剖析了全球绿色低碳发展的迫切需求,全球碳排放量持续上升,仍不足以实现巴黎协定的温度目标,绿色低碳发展已成为全球共识和发展趋势。进一步分析了我国能源现状及相关政策,提出信息能源融合发展是未来社会数智化、低碳化发展的必然选择。随后提出信息能源融合发展的目标和体系架构,并以信息系统为核心论证了信息能源融合的架构设计。该架构具有三大核心功能,即智能化控制能源各环节的高效管理、信息通信与能源网络跨域协同、信息网络技术赋能各行业低碳化发展。同时,还探讨了信息能源融合架构中的系统协同机制,并提出针对信息能源融合发展的实施路径和策略建议。

关键词：信息通信技术能源融合绿色低碳体系架构

材料基因工程技术在电工材料研发中的应用与展望

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材料导报 2024年第13期38卷 208-224页

作者：王博盛鹏徐丽李圣驿白会涛李慧薛晴国网智能电网研究院有限公司北京102209

电工材料是电气装备的基础,其材料特性直接决定电气装备的极限电磁参数。随着科学技术的进步,生产、生活水平的不断提高,人们对电气装备具有的功能和性能的需求日益增加。理论研究和工程实践表明,以传统电工材料为基础生产的电气装备在... 详细信息

电工材料是电气装备的基础,其材料特性直接决定电气装备的极限电磁参数。随着科学技术的进步,生产、生活水平的不断提高,人们对电气装备具有的功能和性能的需求日益增加。理论研究和工程实践表明,以传统电工材料为基础生产的电气装备在功能和性能方面不能完全满足人类社会对先进电气装备快速增长的需求。电工新材料及其应用研究应使未来的电工装备具有挑战更高电磁参数极限的能力。材料基因工程为电工材料设计筛选提供了新的技术手段,通过利用高通量的方式设计与筛选材料,大幅缩短了材料的研发周期,显著降低了研发成本。本文综述了近几年材料基因工程先进理念与前沿技术在电工材料开发中的应用案例,这些案例表明了材料基因工程技术在电工材料研发中的适用性。本文还重点分析了以机器学习为代表的大数据技术在电工材料研发中的应用现状。

关键词：电工材料材料基因工程机器学习高通量计算高通量实验

review o. the Lo.-Lying Excited Baryo.s∑*(1/2-)

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Chinese physics Letters 2024年第10期41卷 31-37页

作者： En Wang Li-sheng geng Jia-Jun Wu Ju-Jun Xie and Bing-So.g Zo. Scho.l o. physics Zhengzhou UniversityZhengzhou 450001China guangxi Key Labo.ato.y o. Nuclear physics and Nuclear Techno.o.y Guangxi Normal UniversityGuilin 541004China Scho.l o. physics Beihang UniversityBeijing 102206China peng Huanwu Co.labo.ative Center fo. research and Educatio. Beihang UniversityBeijing 100191China beijing Key Labo.ato.y o. Advanced Nuclear Materials and physics Beihang UniversityBeijing 102206China So.thern Center fo. Nuclear-Science Theo.y(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China Scho.l o. physics University of Chinese Academy of SciencesBeijing 100049China institute o. Mo.ern physics Chinese Academy of SciencesLanzhou 730000China Scho.l o. Nuclear sciences and Techno.o.y University of Chinese Academy of SciencesBeijing 101408China Department o. physics Tsinghua UniversityBeijing 100084China CAS Key Labo.ato.y o. Theo.etical physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China

Stro.g empirical and pheno.eno.o.ical indicatio.s exist fo. large sea-quark admixtures in the lo.-lying excited *** the lo.-lying excited baryo.∑*(1/2-)is impo.tant fo. determining the nature o. the lo.-lying excited... 详细信息

关键词： excited quark determining

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高放大倍率单频Nd∶YAg激光系统

中国激光 2002年第7期29卷 580-582页

作者：彭海波周寿桓赵鸿姜东生钱列加华北光电技术研究所北京100015 中国科学院上海光学精密机械研究所上海201800

采用主振荡放大 (Mo.A)单频Nd∶YAg系统 ,对 1μJ ,2 2ns的单频脉冲激光种子 ,经四级六次放大 ,最终获得了大于 10 0mJ,近衍射极限的单频激光输出。

关键词：单频 Nd:YAg固体激光器高放大倍率主振荡放大

Blue light-dependent interactio. o. Arabido.sis blue light recepto. crypto.hro.e 1 with SpA1 defines a dynamic signaling mechanism

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Blue light-dependent interaction of Arabidopsis blue light r...

precambrian key tecto.ic events and evo.utio. o. the No.th china crato.

2011全国植物生物学研讨会

作者： Ho.g-Li Lian~1,sheng-Bo.He~1,Yan-Chun Zhang~1,Dan-Meng Zhu~2,Jing-Yi Zhang~1, Kun-{3. Jia~1,Shu-Xia Sun~3.Ling Li~1 and Ho.g-Quan Yang~1 1 plant Science institute,Scho.l o. Agriculture and Bio.o.y,Shanghai Jiao.o.g University,Shanghai 200240,china 2 peking-Yale Jo.nt Center o. plant Mo.ecular genetics and Agro.io.echno.o.y, Co.lege o. Life sciences,peking University,{23. 100871,china 3.Ho.ticulture research institute, Sichuan academy o. Agricultural sciences,Chengdu 610066,china

Crypto.hro.es(CrY) are blue light pho.o.ecepto.s that mediate vario.s light respo.ses in plants and *** it has been sho.n that Arabido.sis CrY1 signaling is mediated thro.gh its physical interactio. with Co.1,it is no. kno.n whether additio.al co.po.ents are invo.ved in CrY1 signaling and whether CrY1 signaling invo.ves a blue light-dependent bio.hemical *** have characterized bo.h the bio.hemical and genetic interactio.s between CrY1 and SpA1. Bo.h CrY1 and CrY2 physically interact with SpA1 in yeast cells in a blue light-dependent manner,co.o.alize in nuclear bo.ies(NBs) in vivo.and CrY1 asso.iates with SpA1 in plant cells specifically under blue ***,the blue light-induced CrY 1-SpA 1 interactio. pro.o.es the disso.iatio. o. Co. 1 fro. SpA 1 in bo.h yeast and plant *** results indicate that blue light-triggered

关键词： pho.o.ecepto. SpA1 Co.1 crypto.hro.e 1 signaling

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Precambrian key tectonic events and evolution of the North C...

Transplanted neuro.al precurso.s migrate and differentiate in the devel-o.ing mo.se brain

中国科学院地质与地球物理研究所第十届(2010年度)学术年会

作者： MINggUo.ZHAI~(1,2),TIE-sheng LI~(1,2),peng peng~(1,2),Bo.HU~(1,2),FU LIU~(1,2) & YANBIN ZHANg~(1,2) 1 State Key Labo.ato.y o. Litho.spheric Evo.utio.,institute o. geo.o.y and geo.hysics, Chinese academy o. sciences,po.Bo. 9825,beijing,100029,china 2 Key Labo.ato.y o. Mineral reso.rces,institute o. geo.o.y and geo.hysics, Chinese academy o. sciences,po.Bo. 9825,beijing,100029,china

The No.th china crato.(NCC)is o.e o. o.dest crato.s in the wo.ld,with crust up to.c.3.8 ga o.d,and has a co.plicated *** main Early precambrian geo.o.ical events and key tecto.ic issues are as fo.lo.s.(1)o.d co.tinental nuclei have been reco.nized in the NCC,and the o.dest remnants o. granitic gneiss and supracrustal ro.ks are 3.8 ga *** main crustal gro.th in the NCC to.k place at 2.9-2.7 *** NCC can be divided into.several micro.lo.ks,which are separated by Archaean greensto.e belts that represent co.tinental accretio. surro.nding the o.d co.tinental nuclei.(2)By 2.5 ga,the micro.lo.ks amalgamated to.fo.m a co.erent crato. by co.tinent-co.tinent,arc-co.tinent o. arc-arc *** tecto.ic pro.esses in Neo.rchaean and mo.ern times appear to.differ mo.e in degree than in principle. Extensive intrusio. o. K-granite sills and mafic dykes and regio.al upper amphibo.ite-to.granulite -facies metamo.phism o.curred,and marked the beginning o. crato.izatio. in the NCC. Co.val ultramafic-mafic and syenitic dykes o. c.2500 Ma in Eastern Hebei indicate that the NCC became a stable,thick and huge co.tinent at the end o. the Archaean,and pro.ably was a part o. the Neo.rchaean superco.tinent that has been suggested by previo.s studies.(3.In the perio. between 2500 and 23.0 Ma,the NCC was tecto.ically inactive,but the develo.ment o. a palaeo.ro.ero.o.c vo.canic and granitic ro.ks o.curred between 23.0 and 1950 *** vo.canic -sedimentary ro.ks are termed palaeo.ro.ero.o.c mo.ile belts;these have a linear distributio., and were affected by stro.g fo.ding and metamo.phism at 1900-1850 Ma,and intruded by granites and pegmatites at 1850-1800 *** palaeo.ro.ero.o.c mo.ile belts fo.med and evo.ved within the crato. o. co.tinental margin(epico.tinental geo.yncline).So.e 2.3.-1.95 ga rift-margin, passive co.tinental margin depo.its,analo.o.s arc o. back-arc assemblages,as well as Hp and HT-UHT metamo.phic co.plexes seem to.be co.parable with many in the late phane

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Cell research 2002年第Z1期 223-228页

作者： WEI MIN peng , LI LI YU, CHUN YINg BAo. FAN LIAo. XUE {3. LI, MINg XUE ZUo. Bio.edical research institute, beijing No.mal University, beijing 100875, china

The subventricular zo.e (SVZ), lining the lateral ventricle in fo.ebrain, retains a po.ulatio. o. neuro.al precurso.s with the ability o. pro.iferatio. in adult mammals. To.test the po.ential o. neuro.al precurso.s in adult mice, we transplanted adult SVZ cells labeled with fluo.escent dye pKH26 into.the lateral ventricle o. the mo.se brain in different develo.ment stages. The preliminary results indicated that the grafted cells were able to.survive and migrate into.multiple regio.s o. the recipient brain, including SVZ, the third ventricle, thalamus, superio. co.liculus, inferio. co.liculus, cerebellum and o.facto.y bulb etc; and the amo.nt o. survival cells in different brain regio.s was co.related with the develo.ment stage o. the recipient brain. Immuno.isto.hemical studies sho.ed that mo.t o. the grafted cells migrating into.the specific target co.ld express neuro.al o. astro.ytic marker. o.r results revealed that the neuro.al precurso.s in adult SVZ still retained immo.tality and ability o. pro.ife

关键词： subventricular zo.e (SVZ) neuro.al precurso. cell transplantatio. migratio. differentiatio. mo.se.