检索结果-南通市图书馆

Amino acid transporters: Emerging roles in drug delivery for tumor-targeting therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2020年第2期15卷 192-206页

作者： Ling Zhang Chengguang Sui Wenhan Yang qiuhua luo Department of Biotherapy The First Affiliated Hospital of China Medical UniversityShenyang 110001China Department of Pharmacy The First Affiliated Hospital of China Medical UniversityShenyang 110001China Department of Pharmacy China Medical UniversityShenyang 110001China

Amino acid transporters,which play a vital role in transporting amino acids for the biosynthesis of mammalian cells,are highly expressed in types of *** studies have shown the feasibility of amino acid transporters as a component of tumortargeting *** this review,we focus on tumor-related amino acid transporters and their potential use in tumor-targeting ***,the expression characteristics of amino acid transporters in cancer and their relationship with tumor growth are ***,the recognition requirements are discussed,focusing on the“acidbase”properties,conformational isomerism and structural ***,recent developments in amino acid transporter-targeting drug delivery strategies are highlighted,including prodrugs and nanocarriers,with special attention to the latest findings of molecular mechanisms and targeting efficiency of transporter-mediated *** aim to offer related clues that might lead to valuable tumor-targeting strategies by the utilization of amino acid transporters.

关键词： Amino acid transporter Tumor-targeting Drug delivery Prodrug Nanocarriers

Recent advances in bacteriophage-based therapeutics:Insight into the post-antibiotic era

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2022年第12期12卷 4348-4364页

作者： Hao Ling Xinyu Lou qiuhua luo Zhonggui He Mengchi Sun Jin Sun Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China Department of Pharmacy The First Affiliated Hospital of China Medical UniversityShenyang 110001China

Antibiotic resistance is one of the biggest threats to global health, as it can make the treatment of bacterial infections in humans difficult owing to their high incidence rate, mortality, and treatment costs. Bacteriophage, which constitutes a type of virus that can kill bacteria, is a promising alternative strategy against antibiotic-resistant bacterial infections. Although bacteriophage therapy was first used nearly a century ago, its development came to a standstill after introducing the antibiotics. Nowadays, with the rise in antibiotic resistance, bacteriophage therapy is in the spotlight *** bacteriophage therapy is safe and has significant anti-bacterial activity, some specific types of bacteriophages(such as bacteriophage phi X174 and Pyo bacteriophage complex liquid) entered into phase Ⅲ clinical trials. Herein, we review the key points of the antibiotic resistance crisis and illustrate the factors that support the renewal of bacteriophage applications. By summarizing recent state-of-the-art studies and clinical data on bacteriophage treatment, we introduced(i) the pharmacological mechanisms and advantages of antibacterial bacteriophages,(ii) bacteriophage preparations with clinical potential and bacteriophage-derived anti-bacterial treatment strategies, and(iii) bacteriophage therapeutics aimed at multiple infection types and infection-induced cancer treatments. Finally, we highlighted the challenges and critical perspectives of bacteriophage therapy for future clinical development.

关键词： Antibiotic resistance Bacteriophage therapy Bacteriophage preparations Bacteriophage-derived anti-bacterial treatment strategies

A boronic acid conjugation integrates antitumor drugs into albumin-binding prodrugs-based nanoparticles with robust efficiency for cancer therapy

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第5期16卷 7422-7430页

作者： Weiyue Ban qiuhua luo Chengda Yan Xiaoying Fan Guorui Zhu Maosheng Cheng Zhonggui He Mengchi Sun Jin Sun Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China Department of Pharmacy The First Hospital of China Medical UniversityShenyang 110001China Phase I Clinical Trials Center The First Hospital of China Medical UniversityShenyang 110102China Key Laboratory of Structure-Based Drug Design and Discovery Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China

Despite great therapeutic effect of Abraxane®,complex preparation technology and unfavorable pharmacokinetics still restricted the clinical application of albumin-based paclitaxel(PTX)nanoparticles(NPs).Herein,we reported that an albumin-binding prodrug,phenylboronic acid-conjugated PTX(P-PTX),can form the uniform NPs with the diameters around 100 nm with the help of albumin via simple one-step nano-precipitation *** albumin-based nanomedicines were stabilized by the integration of a single boronic acid with PTX due to the increased affinity based on multiple intermolecular *** found that albumin-based P-PTX NPs exhibited superior colloidal stability over albumin-based PTX NPs through one-step nanoprecipitation approach,achieving longer in vivo circulation time and higher concentration in tumor than those of the marketed Abraxane®.Furthermore,the albumin-based P-PTX NPs with great stability and enhanced intratumoral enrichment,increased the maximum tolerated dose of PTX,remarkably suppressed the growth of breast tumor and lung metastasis,prolonged survival of melanoma tumors-bearing *** a convenient and effective system gains an insight into the impact of phenylboronic acid group on the albumin-based PTX NPs,provides potent strategy for the rational design of albumin-based antitumor nanomedicines.

关键词： drug delivery Abraxane® albumin-based paclitaxel nanoparticles phenylboronic acid group antitumor nanomedicines

An mmWave Dual-Band Integrated Substrate Gap Waveguide Single Cavity Filter with Frequency Selectivity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Communications 2024年第1期21卷 188-199页

作者： qiuhua Lin Dongya Shen Lihui Wang Zhiyong luo School of Electronics and Communication Engineering Sun Yat-sen UniversityShenzhen 518107China School of Information Science and Engineering Yunnan UniversityKunming 650091China Pengcheng Laboratory Shenzhen 518107China Shenzhen Key Laboratory of Navigation and Communication Integration Shenzhen 518107China

A novel dual-band ISGW cavity filter with enhanced frequency selectivity is proposed in this paper by utilizing a multi-mode coupling *** cavity is designed to control the number of modes,and then the ports are determined by analyzing the coupling relationship between these selected *** synthesizing the coupling matrix of the filter,a nonresonating node(NRN)structure is introduced to flexibly tune the frequency of modes,which gets a dualband and quad-band filtering response from a tri-band filter no the ***,a frequency selective surface(FSS)has been newly designed as the upper surface of the cavity,which significantly improves the bad out-of-band suppression and frequency selectivity that often exists in most traditional cavity filter designs and *** results show that its two center frequencies are f01=27.50 GHz and f02=32.92GHz,*** with the dual-band filter that there is no the FSS metasurface,the out-of-band suppression level is improved from measured 5 dB to18 dB,and its finite transmission zero(FTZ)numbers is increased from measured 1 to 4 between the two designed *** with the tri-band and quadband filter,its passband bandwidth is expanded from measured 1.17%,1.14%,and 1.13% or 1.31%,1.50%,0.56%,and 0.57% to 1.71% and 1.87%.In addition,the filter has compact,small,and lightweight characteristics.

关键词： coupling topology frequency selectivity non-resonating node(NRN) out-of-band suppression single ISGW cavity filter

Characteristics of Paleontological Communities in Surface Sediments of the Southern South China Sea and Their Paleoclimatic and Paleoenvironmental Significance

在线全文

学校读者我要写书评

暂无评论

Journal of Earth Science 2024年第1期35卷 144-154页

作者： Jing Zhao Li Zhang Xiaoyan Wang Jinglian Ge Min Xu Wei Chen Mao luo Qianyong Liang qiuhua Yu Shuaibing luo Wenkun Qie Key Laboratory of Marine Mineral Resoures Ministry of Natural ResourcesGuangzhou Marine Geological SurveyChina Geological SurveyGuangzhou 511458China National Engineering Research Center for Gas Hydrate Exploration and Development Guangzhou 511458China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China

Understanding the spatial and temporal distribution of different paleontological communities in the southern South China Sea(SCS)is fundamental to explore its paleoclimatic and paleoenvironmental *** this study,foraminifera,pollen and diatoms from 100 surface sediment samples covering 40000 km^(2) of sea floor in the southern SCS were comprehensively investigated in terms of their assemblage and *** results showed the existence of abundant foraminifera and pollen in most of the samples,although diatom communities were relatively *** were dominated by ***,***,***,while diatoms were characterized by ***,*** and ***,indicating a typical tropical marine *** pollen assemblages showed a better reflection of montane rainforest,tropical rainforest and *** spatial differences among foraminifera assemblages may indicate the effect of water depth and a warmer environment in the southeast part of the study area,while the spatial patterns of diatom and pollen assemblages imply the influence of coastal *** study also noted that the compositions of paleontological communities in the SCS can vary significantly in a short distance,and synthesized studies on multiple biological groups are needed to reconstruct the Quaternary climate and the oceanographic environment.

关键词： southern South China Sea sediments foraminifera diatom pollen

头孢克肟联合蒲地蓝消炎口服液对儿童泌尿系统感染的疗效分析

在线全文

学校读者我要写书评

暂无评论

首都食品与医药 2023年第3期30卷 88-90页

作者：罗秋华广东省深圳市龙岗区妇幼保健院广东深圳518000

目的分析头孢克肟联合蒲地蓝消炎口服液治疗儿童泌尿系统感染的应用价值.方法选取2019年3月-2022年6月60例儿科收治小儿泌尿系统感染的患儿,按照治疗方案分组.对照组单用头孢克肟治疗,观察组则在对照组基础上加入蒲地蓝消炎口服液.比较... 详细信息

目的分析头孢克肟联合蒲地蓝消炎口服液治疗儿童泌尿系统感染的应用价值.方法选取2019年3月-2022年6月60例儿科收治小儿泌尿系统感染的患儿,按照治疗方案分组.对照组单用头孢克肟治疗,观察组则在对照组基础上加入蒲地蓝消炎口服液.比较两组患儿临床疗效以及临床症状缓解时间差异,同时比较两组患儿治疗前后血清炎症因子指标变化,最后比较两组患儿药物不良反应发生情况.结果观察组患儿疗效高于对照组患儿(P<0.05);观察组患儿临床症状缓解时间明显短于对照组患儿(P<0.05);观察组治疗前后hs-CRP分别为(21.7±4.5)mg/L和(7.3±2.1)mg/L;对照组治疗前后hs-CRP分别为(21.6±4.6)mg/L和(14.6±3.0)mg/L,观察组患儿治疗后血清炎症因子指标低于对照组患儿(P<0.05).结论头孢克肟、蒲地蓝消炎口服液的联合应用,可以显著缩短患儿下尿路症状、发热缓解时间,减轻血清炎症反应,且具有较高的安全性,值得推广使用.

关键词：头孢克肟蒲地蓝消炎口服液儿童泌尿系统感染

彩色多普勒超声诊断仪血流速度示值误差测量值的不确定度评定

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

计量与测试技术 2017年第9期44卷 12-13页

作者：罗秋华龙岩市计量所福建龙岩364000

本文依据JJF 1436-2013《彩色多普勒超声诊断仪(血流测量部分)校准规范》,对彩色多普勒超声诊断仪的血流速度示值误差的测量进行不确定度评定分析。

关键词：彩色多普勒超声诊断仪血流速度误差不确定度

对比分析硫酸沙丁胺醇雾化吸入溶液与特布他林雾化液治疗小儿咳嗽性疾病的效果及安全性

在线全文

学校读者我要写书评

暂无评论

首都食品与医药 2023年第19期30卷 71-73页

作者：罗秋华广东省深圳市龙岗区妇幼保健院广东深圳518000

目的研究门诊小儿咳嗽性疾病治疗期间,特布他林雾化液、硫酸沙丁胺醇雾化吸入溶液治疗的作用及成效。方法在2021年1月-2023年1月门诊内符合小儿咳嗽性疾病指征患儿中选取研究样本70例,遵循抛币法的分组方式,将其分成对照组、研究组进行... 详细信息

目的研究门诊小儿咳嗽性疾病治疗期间,特布他林雾化液、硫酸沙丁胺醇雾化吸入溶液治疗的作用及成效。方法在2021年1月-2023年1月门诊内符合小儿咳嗽性疾病指征患儿中选取研究样本70例,遵循抛币法的分组方式,将其分成对照组、研究组进行对比研究,每组各35例。对照组实施硫酸沙丁胺醇雾化吸入溶液治疗,研究组予以特布他林雾化液治疗,对两组患儿的咳嗽消失时间、治疗有效率以及不良反应发生率进行统计学对比。结果对照组患儿咳嗽消失时间长于研究组,研究组治疗有效率高于对照组,统计学分析有意义(P0.05)。结论特布他林雾化液治疗有效性及安全性均较高,对改善患儿病情具有积极意义,可以缩短患儿咳嗽消失时间,降低相关不良反应的发生率,实施价值高,可广泛应用。

关键词：小儿咳嗽性疾病特布他林雾化液硫酸沙丁胺醇效果及安全性

双联抗血小板治疗脑梗死急性期的安全性和有效性分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国药业 2017年第17期26卷 37-39页

作者：罗秋华张蓓四川省成都市第二人民医院神经内科四川成都610017

目的探讨双联抗血小板治疗脑梗死急性期的安全性和有效性。方法选择医院首次诊断为急性脑梗死的患者300例,采用随机数字表法分为对照组和观察组,各150例。对照组采用阿司匹林肠溶片200 mg,1次/天;观察组应用口服阿司匹林肠溶片100 mg,1... 详细信息

目的探讨双联抗血小板治疗脑梗死急性期的安全性和有效性。方法选择医院首次诊断为急性脑梗死的患者300例,采用随机数字表法分为对照组和观察组,各150例。对照组采用阿司匹林肠溶片200 mg,1次/天;观察组应用口服阿司匹林肠溶片100 mg,1次/天,同时口服硫酸氢氯吡格雷片75 mg,1次/天,连续服用21 d停服氯吡格雷,仅口服阿司匹林。两组患者治疗时间均为4周。结果治疗后,两组患者血清C反应蛋白水平较治疗前降低,且观察组改善更明显(P0.05)。结论双联抗血小板治疗急性期脑梗死安全性相似,但有效性更好,值得临床推广。

关键词：双联抗血小板脑梗死急性期安全性有效性