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Morphology of impact fragmentation distribution of single spherical and ellipsoidal particles in drop weight experiments

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Particuology 2024年第3期86卷 137-148页

作者： qiuhua Miao Peng huang Wenchang Zhu School of Mechanical Engineering Southeast UniversityNanjing211189China

Particle shape is an important factor affecting the fragmentation distribution of the ore *** investigate the influence of particle shape on the morphological fragmentation distribution characteristics,the crushable ore particles are defined as prolate,oblate ellipsoid and spherical particles,which have different aspect ratios(AR)and sphericity(S).Based on the drop weight experiment,the influence of the net drop height on the macroscopic mechanical behavior and crushing distribution characteristics of the single spherical and ellipsoidal particles is *** results show that different peak-shifting characteristics exist during particle *** fragmentation distribution peak shifts left when the increased impact energy is eventually only enough to break medium-sized ***,it shifts right when impact energy is increased enough to break largest-sized ***,regardless of whether the net drop height changes,the maximum continuous fragmentation degree presents"M"-shaped characteristic with the increased *** with the ellipsoid particles,the single spherical particle is more difficult to be broken by impact,with wider equivalent particle fragmentation *** the increase of particle sphericity,the maximum continuous fragmentation degree of a single ellipsoid particle has an overall trend of initial increase and subsequent *** when particle sphericity is 0.9

关键词： Ellipsoid particles Fragmentation distribution Drop weight experiment Numerical simulation

Axial segregation characteristics and size-induced flow behavior of particles in a novel rotary drum with curved sidewalls

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Particuology 2024年第4期87卷 1-19页

作者： qiuhua Miao Wenchang Zhu Yudong Cao Peng huang Chaobin Hu Minping Jia School of Mechanical Engineering Southeast UniversityNanjing211189China Jiangsu Key Laboratory for Elevator Inteligent Safety Changshu215500China

Particle mixing and segregation are common phenomena in rotary drums,which are challenging to be controlled and driven artificially in powder *** this work,the discrete element method(DEM)was applied to construct the novel rotary drum composed of different shaped curved *** varying the operation parameters of particle and sidewall shapes as well as the length-to-diameter(L/D)ratio of drums,the axial mixing and segregation processes of binary size-induced particles were *** results show that the axial flow velocity of the particle mixtures is noticeably weakened once the particle angularity increases,making the non-spherical particles to mix better in rotary drums compared to the spherical ***,in the short drums with size-induced spherical particles,the axial segregation characteristics are significantly enhanced by the convex sidewalls while suppressed by the concave ***,for size-induced non-spherical particles,the axial segregation structure can be present in rotary drums with plane and concave sidewalls while not in drums with convex ***,the axial segregation band structure of spherical particles eventually increases proportionally with the increased drum L/D *** contrast,the non-spherical particles cannot form obvious multi-proportional segregation bands.

关键词： Axial flow behaviors Size-induced particles Curved sidewalls Non-spherical particles Rotary drum

Reinforcement of Self-Healing Polyacrylic Acid Hydrogel with Acrylamide Modified Microcrystalline Cellulose

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Chinese Journal of Chemistry 2020年第5期38卷 494-500页

作者： Changzhuang Bai qiuhua huang Xiaopeng Xiong Department of Materials Science and Engineering College of MaterialsXiamen UniversityXiamenFujian 361005China

Self-healing hydrogel such as polyacrylic acid(PAA)hydrogel has attracted increasing attention based on its promising potential ***,it usually suffers from low strength especially as mechanical ***,a commercial microcrystalline cellulose(MCC)was modified with acrylamide to graft polyacrylamide(PAM)chains on the particle *** acrylamide-modified MCC(AM-MCC)was then dispersed in monomer solution of acrylic acid to prepare composite *** mechanical properties of the obtained composite hydrogels and the self-healed hydrogels were carefully measured by compressive and tensile tests,and by dynamic mechanical *** results demonstrate that introduction of a small amount of AM-MCC such as 3 wt%can not only reinforce the original hydrogel and the healed hydrogel markedly,but also improve self-healing efficiency *** analyses indicate that in addition to the reversible multi-interactions such as hydrogen bonding and ionic interactions,the entanglements between the PAA chains of the hydrogel matrix and the PAM chains grafted on the MCC particles have also played an important role on the improvement in mechanical performances and the healing ability of the ***,the responsiveness to exterior ion has been tested to indicate potential application of the composite hydrogel as self-healable sensor.

关键词： surface. chains acrylic

A systematic survey of LU domain-containing proteins reveals a novel human gene,LY6A,which encodes the candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors

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Frontiers of Medicine 2023年第3期17卷 458-475页

作者： Dan Liu Chunhui Xu Yanting Liu Wen Ouyang Shaojian Lin Aining Xu Yuanliang Zhang Yinyin Xie qiuhua huang Weili Zhao Zhu Chen Lan Wang Saijuan Chen Jinyan huang Zhe Bao Wu Xiaojian Sun Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Key Laboratory of Systems Biomedicine Ministry of EducationShanghai Center for Systems BiomedicineShanghai Jiao Tong UniversityShanghai 200240China CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthShanghai Institutes for Biological SciencesUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Department of Neurosurgery Center of Pituitary TumorRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Biomedical Big Data Center First Affiliated HospitalZhejiang University School of Medicineand Cancer CenterZhejiang UniversityHangzhou 310000China Department of Neurosurgery First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China

The Ly-6 and uPAR(LU)domain-containing proteins represent a large family of cell-surface *** particular,mouse Ly-6A/Sca-1 is a widely used marker for various stem cells;however,its human ortholog is *** this study,based on a systematic survey and comparative genomic study of mouse and human LU domain-containing proteins,we identified a previously unannotated human gene encoding the candidate ortholog of mouse Ly-6A/*** gene,hereby named LY6A,reversely overlaps with a lncRNA gene in the majority of exonic *** found that LY6A is aberrantly expressed in pituitary tumors,but not in normal pituitary tissues,and may contribute to *** to mouse Ly-6A/Sca-1,human LY6A is also upregulated by interferon,suggesting a conserved transcriptional regulatory mechanism between humans and *** cloned the full-length LY6A cDNA,whose encoded protein sequence,domain architecture,and exon‒intron structures are all well conserved with mouse Ly-6A/*** expression of the LY6A protein in cells demonstrates that it acts the same as mouse Ly-6A/Sca-1 in their processing and glycosylphosphatidylinositol anchoring to the cell ***,these studies unveil a novel human gene encoding a candidate biomarker and provide an interesting model gene for studying gene regulatory and evolutionary mechanisms.

关键词： LU domain-containing protein family novel human gene LY6A pituitary tumor biomarker nonsynonymous SNP GPI-anchored protein

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Disabled homolog 2 is required for migration and invasion of prostate cancer cells

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Frontiers of Medicine 2015年第3期9卷 312-321页

作者： Yinyin Xie Yuanliang Zhang Lu Jiang Mengmeng Zhang Zhiwei Chen Dan Liu qiuhua huang State Key Laboratory of Medical Genomics Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Shanghai Center for Systems Biomedicine Shanghai Jiao Tong University Shanghai 200240 China

Disabled homolog 2 （DAB2） is frequently deleted or epigenetically silenced in many human cancer cells＇ Therefore, DAB2 has always been regarded as a tumor suppressor gene. However, the role of DAB2 in tumor progression and metastasis remains unclear. In this study, DAB2 expression was upregulated along with human prostate cancer （PCa） progression. DAB2 overexpression or knockdown effects in LNCaP and PC3 cell lines were verified to address the biological functions of DAB2 in PCa progression and metastasis. LNCaP and PC3 cell lines were generated from human PCa cells with low and high metastatic potentials, respectively. The results showed that DAB2 shRNA knockdown can inhibit the migratory and invasive abilities of PC3 cells, as well as the tumorigenicity, whereas DAB2 overexpression enhanced LNCaP cell migration and invasion. Further investigation showed that DAB2 regulated the cell migration associated genes in PC3 cells, and the differential DAB2 expression between LNCaP and PC3 cells was partly regulated by histone 4 acetylation. Therefore, DAB2 may play an important role in PCa progression and metastasis.

关键词： DAB2 prostate cancer migration invasion acetylation

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文运重造与主体性成长:沈从文的“乡下人”建构(1933—1936)

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汉语言文学研究 2022年第1期13卷 92-101页

作者：黄秋华北京大学中文系

沈从文在1933年至1936年着意实践的“乡下人”建构,一方面是要批评以左派文人为代表的“海派”,重造新文学运动的健康生态,另一方面,是要与学院派进行对话,显现出文化立场与文类选择上的某种区隔。从创作层面看,“乡下人”建构的具体意... 详细信息

沈从文在1933年至1936年着意实践的“乡下人”建构,一方面是要批评以左派文人为代表的“海派”,重造新文学运动的健康生态,另一方面,是要与学院派进行对话,显现出文化立场与文类选择上的某种区隔。从创作层面看,“乡下人”建构的具体意涵是确立以湘西民族的崇高“人性”为基础,以城市文明的知识理性为激活机制的艺术生命与文学理想。“乡下人”建构隐含着主体性成长的意义:在将自我的生命经验、文学事业与新文学的前途、民族国家的复兴勾连起来后,沈从文作为现代知识分子的主体性正式确立。

关键词：沈从文 “乡下人”建构文运重造主体性成长

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基于GIS与RS的广东省化州市土地利用演变及生态敏感性评价

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惠州学院学报 2022年第6期42卷 60-65,128页

作者：黄秋华翁健惠州学院地理与旅游学院广东惠州516007

土地利用格局变化与生态敏感性关系到区域生态环境的动态稳定。以广东省化州市为研究区域,通过RS与GIS技术的统计分析,研究化州市2013年与2019年的土地利用特点及动态变化特征,并挑选出土地利用类型、高程、水体缓冲区、植被覆盖度、坡... 详细信息

土地利用格局变化与生态敏感性关系到区域生态环境的动态稳定。以广东省化州市为研究区域,通过RS与GIS技术的统计分析,研究化州市2013年与2019年的土地利用特点及动态变化特征,并挑选出土地利用类型、高程、水体缓冲区、植被覆盖度、坡度、坡向6个生态敏感性因子,利用GIS的分析技术与变异系数法得到化州市2019年单因子与综合生态敏感性成果。结果表明:土地利用方面,化州市2013年到2019年林地、未利用地、耕地3个土地用地类型面积减少,而建设用地和水域则面积增加,土地利用总体有一定动态变化,但变化程度不大,状态相对稳定;综合生态敏感性分布方面,中度敏感区面积占比最高,在化州市北部分布最多;而极度、高度敏感区多位于化州市北部镇区边界线;不敏感、轻度敏感区位于化州市南部极少数中部地区,在化州市北部也有零散分布。总体来说,化州市需要树立人地和谐理念,加强生态保育功能,以促进化州市生态文明建设。

关键词：化州市土地利用格局生态敏感性

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HVDC Macrogrid Modeling for Power-flow and Transient Stability Studies in North American Continental-level Interconnections

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CSEE Journal of Power and Energy Systems 2017年第4期3卷 390-398页

作者： Marcelo A.Elizondo Nihal Mohan James O’Brien qiuhua huang David Orser Warren Hess Hilary Brown Wenchun Zhu Divya Chandrashekhara Yuri V.Makarov Dale Osborn James Feltes Harold Kirkham David Duebner Zhenyu huang Pacific Northwest National Laboratory RichlandWA 99354USA Midcontinent Independent System Operator EaganMN 55121USA Siemens PTI SchenectadyNY 12305USA

voltage direct current(HVDC)transmission lines are being constructed throughout the world,aided by advancements in power electronics and the potential value to transfer power between distant areas and off-shore *** HVDC lines within and across large AC interconnections could bring about economic benefits such as interregional capacity exchange and transfer of low-cost,distant electric energy directly to load *** addition,network configuration of HVDC lines could result in additional benefits that have not been deeply *** paper describes the modeling process for continentallevel power system interconnections with the addition of multiple HVDC lines configured as a *** models used for study are based on industry-accepted power-flow and dynamic system models for the North American Eastern and Western *** model provides insight on feasibility and initial steady-state and stability tests of the HVDC macrogrid and its interactions with the existing electricity infrastructure,opening the door to analysis of the technical value of such a macrogrid.

关键词： HVDC models HVDC transmission modeling power-flow power system dynamic stability power system planning

Intra-heterogeneity in transcription and chemoresistant property of leukemia-initiating cells in murine Setd2^(-/-) acutemyeloid leukemia

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Cancer Communications 2021年第9期41卷 867-888页

作者： Jiachun Song Longting Du Ping Liu Fuhui Wang Bo Zhang Yinyin Xie Jing Lu Yi Jin Yan Zhou Gang Lv Jianmin Zhang Saijuan Chen Zhu Chen Xiaojian Sun Yuanliang Zhang qiuhua huang Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025P.R.China Novel Bioinformatics Co. LtdShanghai 201114P.R.China Central Laboratory Renji Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127P.R.China

Background:Heterogeneity of leukemia-initiating cells(LICs)is a major obstacle in acute myeloid leukemia(AML)*** evidence indicates that the coexistence of multiple types of LICs with different pathogenicity in the same individual is a common feature in ***,the functional heterogeneity including the drug response of coexistent LICs remains ***,this study aimed to clarify the intra-heterogeneity in LICs that can help predict leukemia behavior and develop more effective ***:Spleen cells from the primary Setd2^(-/-)-AML mouse were transplanted into C57BL/6 recipient mice to generate a transplantable *** cytometry was used to analyze the immunophenotype of the leukemic ***-genome sequencing was conducted to detect secondary hits responsible for leukemia transformation.A serial transplantation assay was used to determine the self-renewal potential of Setd2^(-/-)-AML cells.A limiting-dilution assay was performed to identify the LIC frequency in different subsets of leukemia *** and single-cell RNA sequencing were performed to analyze the transcriptional heterogeneity of *** molecular inhibitor screening and in vivo drug treatment were employed to clarify the difference in drug response between the different subsets of ***:In this study,we observed an aged Setd2^(-/-)mouse developing AML with co-mutation of Nras^(G12S) and Braf^(K520E).Further investigation identified two types of LICs residing in the c-Kit^(+)B220^(+)Mac-1^(-)and c-Kit^(+)B220^(+)Mac-1^(+)subsets,*** vivo transplantation assay disclosed the heterogeneity in differentiation between the coexistent ***,an intrinsic doxorubicinresistant transcriptional signature was uncovered in c-Kit^(+)B220^(+)Mac-1^(+)***,doxorubicin plus cytarabine(DA),the standard chemotherapeutic regimen used in AML treatment,could specifically kill c-Kit^(+)B220^(+)Mac-1^(−)cells,but it hardly affected c-Kit^(+)B220^(

关键词： heterogeneity leukemia-initiating cell Setd2−/−acute myeloid leukemia single-cell RNA sequencing drug response