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Reasons,safety and efficacy analysis for conversion of HAART to TAF/ FTC/BIC among HIV-infected patients

Chinese Medical Journal 2023年第24期136卷 2931-2937页

作者： Jiang Xiao Guiju Gao Yi Ding Jialu Li Chengyu Gao qiuhua xu Liang Wu Hongyuan Liang Liang Ni Fang Wang Yujiao Duan Di Yang Hongxin Zhao Clinical and Research Center of AIDS Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Background:This study aimed to determine the reasons for conversion and elucidate the safety and efficacy of transition to tenofovir alafenamide/emtricitabine/bictegravir sodium(TAF/FTC/BIC)in highly active antiretroviral therapy(HAART)-experienced HIV-infected patients in real-world settings.Methods:We conducted a retrospective cohort study.The treatment conversion rationales,safety,and effectiveness in 1684 HIV-infected patients with previous HAART experience who switched to TAF/FTC/BIC were evaluated at Beijing Ditan Hospital from September 2021 to Auguest 2022.Results:Regimen simplification(990/1684,58.79%)was the most common reason for switching,followed by osteoporosis or osteopenia(375/1684,22.27%),liver dysfunction(231/1684,13.72%),decline in tenofovir alafenamide/emtricitabine/elvitegravir/cobicistat(TAF/FTC/EVG/c)with food restriction(215/1684,12.77%),virological failure(116/1684,6.89%),and renal dysfunction(90/1684,5.34%).In patients receiving non-nucleotide reverse transcriptase inhibitors(NNRTI)-containing regimens,lipid panel changes 1 year after switching indicated a difference of 3.27±1.10 mmol/L vs.3.40±1.59 mmol/L in triglyceride(P=0.014),4.82±0.74 mmol/L vs.4.88±0.72 mmol/L in total cholesterol(P=0.038),3.09±0.70 mmol/L vs.3.18±0.66 mmol/L in low-density lipoprotein(P<0.001),and 0.99±0.11 mmol/L vs.0.95±0.10 mmol/L in high-density lipoprotein(P<0.001).Conversely,among patients receiving booster-containing regimens,including TAF/FTC/EVG/c and lopinavir/ritonavir(LPV/r),lipid panel changes presented decreased trends.We also observed an improved trend in viral load suppression,and alanine transaminase(ALT),aspartate transaminase(AST),estimated glomerular filtration rate(eGFR),and serum creatinine levels after the transition(P<0.001).Conclusion:The transition to TAF/FTC/BIC demonstrated good treatment potency.Furthermore,this study elucidates the motivations behind the adoption of TAF/FTC/BIC in real-world scenarios,providing clinical evidence supporting the stable conversion to TAF/FTC/BIC for HAA

关键词： HIV Antiretroviral therapy,highly active Conversion Viral load Efficacy Safety

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The impact of investor structure on stock price crash sensitivity:Evidence from China's stock market

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Journal of Management Science and Engineering 2021年第3期6卷 312-323页

作者： Ningning Pan qiuhua xu Hongquan Zhu School of Finance Southwestern University of Finance and EconomicsChengdu611130China School of Economics and Management Southwest Jiaotong UniversityChengdu610031China

Stock price crash sensitivity refers to the conditional probability of a stock crash when the market collapses.It focuses on individual stocks'sensitivity to the market crash and can affect stock pricing significantly.Although the crash sensitivity of China's stock market is very high as a whole(Weigert,2016),different individual stocks show varying degrees of crash sensitivity.This paper,adopting the perspective of institutional investors,explores the reasons for the difference in crash sensitivity in China's stock market,and finds that:First,institutional investors'shareholdings is positively related to firms'stock price crash sensitivity.However,after dividing institutional investors into professional(represented by financial institutions)and non-professional institutional investors(represented by general legal persons),we find that only professional institutional investors'shareholdings is negatively related to firms'stock price crash sensitivity.Second,the impact of professional institutional investors on the crash sensitivity is influenced by stock liquidity and media sentiment:when the stock liquidity of listed companies is good or the media sentiment is strong,the negative impact of professional institutional investors on the crash sensitivity is accordingly high.This paper,by highlighting the investor structure,attempts a pioneering exploration of the influencing factors of the difference in stock price crash sensitivity in China.Our empirical results enrich research on stock price crash sensitivity and the heterogeneity of institutional investors.They can also serve to guide regulatory authorities'development of institutional investors and efforts to maintain market stability.

关键词： Crash sensitivity Investor structure Professional institutional investors Non-professional institutional investors

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Evaluating the fractionation of ion-adsorption rare earths for in-situ leaching and metallogenic mechanism

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Journal of Rare Earths 2018年第12期36卷 1333-1341页

作者： qiuhua xu Lifeng Yang Dashan Wang Xiao Hou Yuanyuan Sun xuezhen Zhou Xinmu Zhou Yongxiu Li Research Center for Rare Earths Micro/Nano-Functional Materials Nanchang University College of Environmental and Chemical Engineering Nanchang Hangkong University

The fractionation of ion adsorption rare earths(IAREs) along the depth in a shaft of a deposit at Dajishan,Jiangxi, China was comparatively evaluated using the partition values(PVs) and relative fractionation values(RFVs) of the leached rare earths(REs). It is found that both PVs and RFVs can objectively reflect the migration and fractionation of REs, but RE content and abrasion pH could not. However, the RFVs can provide more information to quantitatively evaluating the migration and fractionation characteristics of REs along the selected direction and region than PVs could, which is of significance for designing the optimal procedures of in-situ leaching based on the determined flow direction of injecting solution. It is demonstrated that the migration of Ce, Pr, and Nd along the depth direction is inert, and that of REs post Sm and Y is active. Meanwhile, the migration of La shows region characteristics which is active in the upper and inert in lower region. More interesting, the dependence of RFVs on atomic number of REs displays a tetrad group variation trend. However, the fractionation of REs among clay minerals with different particle sizes is not evident, especially for the clay in the bottom region. These results indicate that the migration and fractionation of REs not only are dominated by the adsorption of their hydrated ions, but also rely on their hydrolysis tendency, which provide information for understanding the metallogenic mechanism of IAREs.

关键词： Ion-adsorption rare earth In-situ leaching Fractionation Metallogenic

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基于鸟类生境需求的城市湖岸带设计与修复评估——以梁平双桂湖为例

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中国城市林业 2024年第1期22卷 43-52页

作者：任璐袁嘉伍叶丹徐秋华游奉溢重庆大学建筑城规学院重庆400044 重庆大学山地城镇建设与新技术教育部重点实验室重庆400044 重庆大学三峡库区消落区生态修复与治理研究中心重庆400044 重庆市梁平区林业局重庆404000 朴草(重庆)生态环境科技有限公司重庆400000

过度开发和休闲游憩等人类干扰导致湖岸带生境的均质化和退化,影响鸟类生存并制约湖泊湿地的生态服务功能。文章以重庆市梁平区双桂湖国家湿地公园为案例,对2019年实施“环境-生物-结构”协同设计的湖岸带修复工程4年后的鸟类群落及生... 详细信息

过度开发和休闲游憩等人类干扰导致湖岸带生境的均质化和退化,影响鸟类生存并制约湖泊湿地的生态服务功能。文章以重庆市梁平区双桂湖国家湿地公园为案例,对2019年实施“环境-生物-结构”协同设计的湖岸带修复工程4年后的鸟类群落及生境进行调查,结合生境制图法量化生境特征。结果表明:双桂湖湖岸带共有鸟类49种、实验区45种、对照区22种;实验区鸟类香农-威纳指数(北岸2.665、西岸2.984)高于东岸对照区(2.563),其中,西岸新增小微湿地面积较北岸更多,水鸟种类及其种群数量增加更为显著。鸟类多样性与生境多样性、鸟类数量与生境丰富度之间呈显著正相关关系(P<0.01)。综上可知,修复工程有效促进了鸟类生境单元多样性的增加;构建湖岸带小微湿地和“林-草-湿”复合生境格局能使生境异质性和鸟类多样性得到持续提升。

关键词：城市湖泊湿地湖岸带鸟类生境生物多样性

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Preparation and physical properties of p-MgFe2O4-p-NiFe2O4 mixed ionic magnetic liquid

Preparation and physical properties of p-MgFe2O4-p-NiFe2O4 m...

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中国化学会第九届全国无机化学学术会议

作者： qiuhua xu Huang Yan Chao gan Dongsheng Hu Yu Xie Department of Materials Chemistry Nanchang Hang Kong University

Using chemical coprecipitation preparation of p-Mg Fe2O4 and p-Ni Fe2O4 magnetic nanoparticles, Then the prepared magnetic particles with an acid and deionized water by mixing in proportion to get different volume fraction of unit ionic magnetic fluid. Finally, two kinds of unit magnetic liquid that the volume fraction is same in a volume ratio of 1:1 by mixing is to be binary ionic magnetic liquid p-Mg Fe2O-p-Ni Fe2O4. Characterized analyzing of the magnetic nanoparticles by XRD, compared with the standard ratio of cards, finding the location of the peak to move a small range to the direction of small angle, also finding some miscellaneous peak, it may be due to a little residual impurities in the experiment. Still can see the nanoparticles of p-Mg Fe2O4 and p-Ni Fe2O4 are amorphous state, the shapes of the two kinds of particles are approximately spherical. Measuring the intensity of the transmission light of unit ionic magnetic fluid and binary ionic magnetic fluid under an applied magnetic field. The results show that both the p-Mg Fe2O4 and p-Ni Fe2O4 magnetic liquid, the intensity of transmission light does not substantially change with the applied magnetic field strength varies, But the intensity of transmission light will decrease with the increase of magnetic liquid volume fraction. For binary ionic magnetic liquids,circumstances are basically the same as unit of ionic magnetic fluid.And observed changes in the microstructure of the magnetic fluid over time in different intensity of uniform magnetic field with an optical microscope, it is found that the magnetic particles of the three kinds of magnetic fluids move very slow in the magnetic field. This also confirms the phenomenon that the intensity of transmission light varies with the change of the intensity of the magnetic field.

关键词： magnetic fluid binary magnetic fluid chemical coprecipitation XRD magneto-optical effect

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Characteristics of Paleontological Communities in Surface Sediments of the Southern South China Sea and Their Paleoclimatic and Paleoenvironmental Significance

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Journal of Earth Science 2024年第1期35卷 144-154页

作者： Jing Zhao Li Zhang Xiaoyan Wang Jinglian Ge Min xu Wei Chen Mao Luo Qianyong Liang qiuhua Yu Shuaibing Luo Wenkun Qie Key Laboratory of Marine Mineral Resoures Ministry of Natural ResourcesGuangzhou Marine Geological SurveyChina Geological SurveyGuangzhou 511458China National Engineering Research Center for Gas Hydrate Exploration and Development Guangzhou 511458China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China

Understanding the spatial and temporal distribution of different paleontological communities in the southern South China Sea(SCS)is fundamental to explore its paleoclimatic and paleoenvironmental changes.In this study,foraminifera,pollen and diatoms from 100 surface sediment samples covering 40000 km^(2) of sea floor in the southern SCS were comprehensively investigated in terms of their assemblage and distribution.The results showed the existence of abundant foraminifera and pollen in most of the samples,although diatom communities were relatively scarce.Foraminifera were dominated by G.sacculifer,G.menardii,G.ruber,while diatoms were characterized by T.simonsenii,T.nitzschioides and T.longissima,indicating a typical tropical marine environment.The pollen assemblages showed a better reflection of montane rainforest,tropical rainforest and mangrove.The spatial differences among foraminifera assemblages may indicate the effect of water depth and a warmer environment in the southeast part of the study area,while the spatial patterns of diatom and pollen assemblages imply the influence of coastal current.Our study also noted that the compositions of paleontological communities in the SCS can vary significantly in a short distance,and synthesized studies on multiple biological groups are needed to reconstruct the Quaternary climate and the oceanographic environment.

关键词： southern South China Sea sediments foraminifera diatom pollen

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围绕碳减排进行的固碳和碳转化新方法、新原理和新技术

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当代化工研究 2023年第14期 165-167页

作者：李迪许秋华南昌航空大学环境与化学工程学院江西330063

CO_(2)过度排放引起了严重的环境与资源危机,将其转化为高附加值产品极为重要。甲酸等C1产品由于其液体高能量密度的较大优势而成为近年研究热点。立足于甲酸盐、甲醇等选择性合成的研究成果,简述了二者的生成机理,综述了提高C1产品产... 详细信息

CO_(2)过度排放引起了严重的环境与资源危机,将其转化为高附加值产品极为重要。甲酸等C1产品由于其液体高能量密度的较大优势而成为近年研究热点。立足于甲酸盐、甲醇等选择性合成的研究成果,简述了二者的生成机理,综述了提高C1产品产率和选择性的金属基、碳基及分子催化剂的研究进展,探讨了界面调控、杂原子掺杂等多种策略对催化性能的影响,并为固碳和碳转化的发展提供了一些简单的思路。

关键词：二氧化碳电化学催化 C1产品

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具有截面相关的变系数面板数据模型的估计及应用

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系统工程理论与实践 2019年第4期39卷 817-828页

作者：徐秋华张梓玚西南财经大学金融学院成都611130

本文建立了一类变系数面板数据模型.此模型假设自变量的系数是某一平滑变量的未知函数,允许自变量,平滑变量和误差项存在通过共同因子结构引入的截面相关.由于一些共同因子的不可观测性,本文采用局部线性共同相关效应估计方法对未知的... 详细信息

本文建立了一类变系数面板数据模型.此模型假设自变量的系数是某一平滑变量的未知函数,允许自变量,平滑变量和误差项存在通过共同因子结构引入的截面相关.由于一些共同因子的不可观测性,本文采用局部线性共同相关效应估计方法对未知的函数进行估计并给出了估计量的渐近性质.蒙特卡罗模拟结果表明该估计方法具有良好的小样本性质.利用1990-2012年中国省级面板数据,本文对我国外商直接投资与经济增长之间的关系进行了实证分析,结果表明:外商直接投资和经济增长之间存在明显非线性关系,各省份不同的初始经济水平会导致外商直接投资对经济增长的影响不同.

关键词：面板数据模型截面相关变系数局部线性估计共同相关效应

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尾部风险承担与基金网络

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经济学（季刊） 2022年第3期22卷 911-932页

作者：陆艺升徐秋华罗荣华西南财经大学金融学院

本文在基金锦标赛理论框架下,结合基金网络结构特征探讨了基金的尾部风险承担行为。研究结果发现,基金的尾部风险承担行为在不同市场状态中存在差异。在牛市中,承担尾部风险能够带来显著的收益提升,年中赢家基金在下半年会相对输家基金... 详细信息

本文在基金锦标赛理论框架下,结合基金网络结构特征探讨了基金的尾部风险承担行为。研究结果发现,基金的尾部风险承担行为在不同市场状态中存在差异。在牛市中,承担尾部风险能够带来显著的收益提升,年中赢家基金在下半年会相对输家基金承担更多的尾部风险。基金的网络中心度一方面通过信息交流渠道促使基金增加下半年尾部风险,另一方面通过资金流的网络外溢渠道抑制基金下半年尾部风险的增加幅度。不同于牛市,前述现象在熊市中并不显著。

关键词：尾部风险网络中心度锦标赛效应

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Glass Formation and Optical Band Gap Studies on Bi_2O_3-B_2O_3-BaO Ternary System

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Journal of Wuhan University of Technology(Materials Science) 2009年第5期24卷 716-720页

作者：陈飞飞戴世勋 College of Information Science and Engineering Ningbo University

The glass forming region of Bi2O3-B2O3-BaO ternary system was investigated. A serial of glass samples with high Bi2O3 content in Bi2O3-B2O3-BaO system were prepared by using conventional melting and quenching meld, and the refractive indexes and absorption spectra of samples were measured. It is found that the refractive index of samples as well as the UV absorption increase with the increase of BaO content. According to the Tauc law, optical band gap Eopg which is assumed to be the effective energy band gap Eg is calculated and decreases with the increasing BaO content, and the ratio of Eg/Eopg is 1.3.

关键词： glass formation bismuth glass refractive index optical band gap

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