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Spatial distribution of water and wind erosion and their influence on the soil quality at the agropastoral ecotone of North China

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International Soil and Water Conservation Research 2020年第3期8卷 253-265页

作者： Yanzai Wang Yifan Dong zhengan Su Simon M.Mudd qiuhong zheng Gang Hu Dong Yan Institute of International Rivers and Eco-Security Yunnan UniversityKunming650091PR China Key Laboratory of Mountain Hazards&Surface Process Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu610041PR China College of Geography and Tourism Chongqing Normal UniversityChongqing401331PR China School of GeoSciences University of EdinburghEdinburghEH89XPUK China Meteorological Administration Training Center CMABeijing100081PR China School of Tourism and Geography Sciences Qingdao266071ShandongPR China National Institute for Radiological Protection Chinese Center for Disease Control and PreventionBeijing100088PR China

In semiarid regions,wind and water erosion are serious environmental and ecological problems around *** have different impacts on soil quality over a range of spatial *** the spatial distribution of soil erosion and understanding the impacts of wind and water erosion on soil quality at the regional scale is vital for mitigating soil erosion *** this study we explore the spatial distributions of water and wind erosion around Zhangjiakou city which suffers both water and wind erosion contemporaneously,and detect the influence of soil erosion on soil *** find that annual wind erosion intensities range 4.99-10.05 t ha-1 yr-1,and annual water erosion intensities range 2.92-4.14 t ha-1 *** with higher potential wind and total erosion risk occur mainly in northwest and southeast Zhangjiakou city,whereas potential water erosion risk is highest in the southwest and central *** highest erosion rates are concentrated in gentle parts of the landscape,where agriculture has led to low vegetation *** portions of the landscape,which remain forested,have lower erosion *** spatial patterns are dominated by higher wind erosion,which correlates with sur-face soil coarsening and higher water infiltration,whereas the soil water holding capacity decreases with increasing wind erosion *** regions with high water infiltration rates,we find the intensity of water erosion *** mitigate risks of soil degradation,suitable erosion measures should be imple-mented according to the dominant erosion type,which varies in space.

关键词： Soil erosion Soil quality Spatial distribution Agropastoral ecotone

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Research of Software Failure Prediction Based on Support Vector Regression

Research of Software Failure Prediction Based on Support Vec...

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2012年计算机应用与系统建模国际会议

作者： zheng qiuhong College of Computer Science and Information Technology Zhejiang Wanli University

Software failure prediction is currently a hot subject of research all over the world. The support vector regressions (SVRs) are very efficiency for solving regression problems. The parameters just as C 、ε、γ performs very important roles in the generalization of SVR, and it’s hard for beginner to choose them. But in formar models, they diden’t care about this problem.A SVR-based generic model adaptive to the characteristic of the given data set is used for software failure time prediction. We also compare the prediction accuracy of software reliability prediction models based on 1-norm SVM, 2-norm SVM, vSVM and artificial neural network (ANN). Experimental results by four data sets show that the new software reliability prediction model could achieve higher prediction accuracy than that of the ANN-based or SVM-based models.

关键词： Software Reliability Prediction Support Vector Regression Artificial Neural Network

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The prognostic significance of infiltrating immune cells subtypes in invasive ductal carcinoma of the breast

The prognostic significance of infiltrating immune cells sub...

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第十一届全国免疫学学术大会

作者： Xu yangmei zheng qiuhong Fujian provincial cancer hospital

Objective: To explore the correlation between tumor infiltrating immune cell subsets and breast cancer prognosis. Methods: Our cohort included 102 patients with breast invasive ductal carcinoma. Specimens were analyzed for immune-related markers(CD8, CD20, Fox P3 and CD68). The number of positive cells in 3 most highly-stained intratumoral stroma areas of the primary tumor were counted. The medium number of each marker was calculated and used to divide patients into two groups respectively(CD8high/CD8 low group, CD20high/CD20 low group, FOXP3high/ FOXP3 low group and CD68high/CD68 low group). The correlation between the data we obtained and the patient’s clinical data, overall survival(OS) and disease-free(DFS) was analyzed. Results:(1)Kaplan–Meier survival analysis showed:(A) For the 102 invasive ductal carcinoma patients, high tumorinfiltrating CD8 CTLs and CD20 B lymphocytes, low tumor-infiltrating Fox P3 Treg and CD68 macrophages all increased the OS and DFS(P<0.05);(B) For the 35 ER negative breast invasive ductal carcinoma patients, both high tumor-infiltrating CD8 CTLs and CD20 B lymphocytes increased the overall survival OS and DFS(P<0.05);(C)For the 45 lymphonode negative breast invasive ductal carcinoma patients, high tumor-infiltrating CD8 CTLs and low tumorinfiltrating Fox P3 Treg and CD68 macrophages increased the OS and DFS(P<0.05).(2)Multivariate analysis of OS showed for the 102 invasive ductal carcinoma patients, high tumor-infiltrating CD8 CTLs and CD20 B lymphocytes, low tumor-infiltrating Fox P3 Treg positive status, ER positivity were all related to good OS and DFS(P<0.05);Multivariate analysis of DFS showed for the 102 invasive ductal carcinoma patients, high tumor-infiltrating CD8 CTLs, low tumor-infiltrating Fox P3 and CD68, PR positivity were all related to good OS and DFS(P<0.05).Conclusion: These results suggest that high numbers of tumor-infiltrating CD8 and low number of Fox P3 T lymphocytes both could function as independent prognostic

关键词： infiltrating immune cells immunoscore breast invasive ductal cancer immunohistochemistry

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Identification of CTCs and CTSCs in colorectal cancer by flow cytometry

Identification of CTCs and CTSCs in colorectal cancer by flo...

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第十届全国免疫学学术大会

作者： Yangmei Xu qiuhong zheng Qinying Liu Fujian provincial tumor hospital

Objective:To identify perioperative circulating tumor cells(CTCs)and markers of circulating tumor stem cells(CTSCs)in peripheral blood from patients with colorectal cancer,and further analyze their correlations with clinical ***:Altogether 50 colorectal cancer patients who hadn’t received any previous chemotherapeutic treatment were *** 15ml peripheral blood was drawn from each patient at two time points:one week before and one week after *** was used to separate mononuclear cells from *** were averaged into two *** portion was tagged respectively with CTC surface markers:CD45,Ep CAM and CK,the other with CD45,Ep CAM,CD44 and *** cytometry was used to enumerate CTCs and *** was defined as CD45-Ep CAM+CK+and CTSC was categorized into three groups:CTSC1(CD45-Ep CAM+CD44+),CTSC2(CD45-Ep CAM+-CD133+)and CTSC3(CD45-Ep CAM+CD44+CD133+).The cutoff values of≥3 CTCs/per7.5m L of peripheral blood and≥1CTSC/7.5m L were ***:(1)Pre-operative CTC detection rate was 34%,CTSC1 44%and CTSC2 4%;post-operative CTC detection ratewas 38%,CTSC1 54%and CTSC2 6%.CTSC3 was not detected at either time point.(2)Both pre-and post-operative CTC level were associated with the T stages of tumor(PP1 level was associated with the T stages of tumor(P1 level had no significant correlation with any clinicopathological ***:Post-operative CTC may serve as a better predictive biomarker for colorectal cancer than pre-operative CTC;Ep CAM and CD44 could be used together to identify CTCSs,another potential predictive biomarker for colorectal cancer.

关键词： Circulating tumor cells Circulating tumor stem cells Colorectal cancer

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Effect of dendritic cell-cytokine induced killer cells in patients with triple-negative breast cancer

Effect of dendritic cell-cytokine induced killer cells in pa...

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第十一届全国免疫学学术大会

作者： Xie Yunqing Liu Jian Lin Xiaowei Liu Shijia Ying Mingang zheng qiuhong Fujian Provincial Key Laboratory of Tumor Biotherapy

Purpose: Triple-negative breast cancer(TNBC) is a breast cancer type with poor prognosis due to the absence of targets for the treatment of endocrine and anti-HER-2 therapy. Furthermore, only about 20% of TNBC are sensitive to conventional chemotherapy. Therefore, this study aimed to evaluate the clinical efficacy of adjuvant dendrtic cell(DC)-cytokineinduced killer cells(CIK) immunotherapy combined with chemotherapy with/without radiotherapy in patients with postoperative ***: From December 1,2006 to February28,2011, 68 patients with postoperative TNBC were included in this retrospective study: 43 cases received chemotherapy with/without radiotherapy;25 cases received DC-CIK cells infusion combined with chemotherapy with/without ***: Survival analysis showed the 5-years disease-free survival(DFS) rate was significantly higher in the DC-CIK group compared with the non- DC-CIK group(P=0.049). Further subgroup analysis stratified according to tumor–node–metastasis(TNM) stages showed that the 5-years DFS was significantly increased in DC-CIK group with advanced TNM stages(including IIb,III,IV TNM stage) than the non- DC-CIK, and 5-year OS rate in advanced-stage subgroup was also improved although it only approved borderline statistical significance(P=0.051).Conclusions: Our results demonstrated that TNBC patients with advanced TNM stages could benefitted from adjuvant DC-CIK cells infusion combined with conventional therapy in terms of preventing disease relapse and increasing overall survival.

关键词： dendritic cells cytokine-induced killer cells adjuvant immunotherapy triple-negative breast cancer

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MicroRNA-148b suppresses hepatic cancer stem cell by targeting neuropilin-1

MicroRNA-148b suppresses hepatic cancer stem cell by targeti...

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第十四届全国肿瘤生物治疗大会

作者： Qinying Liu Yangmei Xu Shenghong Wei Wei Gao Mingang Ying qiuhong zheng Fujian Provincial Key Laboratory of Tumor Biotherapy Teaching Hospital of Fujian Medical University Fujian Provincial Tumor Hospital Department of Abdominal Surgery Teaching Hospital of Fujian Medical University Fujian Provincial Tumor Hospital Department of Abdominal Tumor Teaching Hospital of Fujian Medical University Fujian Provincial Tumor Hospital

Background: The existence of cancer stem cells is considered as a direct reason for the failure of clinic treatment in hepatocellular carcinoma. Growing evidences have demonstrated that micro RNAs play an important role in regulation of stem cell proliferation, differentiation and self-renewal, and their aberrances cause the formation of cancer stem cells and eventually result in carcinogenesis. Purpose: We recently identified micro RNA-148 b as one of the micro RNAs specifically down-regulated in side population cells of PLC/PRF/5 cell line. However, it remains elusive how micro RNA-148 b regulates cancer stem cell properties in hepatocellular carcinoma. Methods: Side population(SP) cells were analyzed by flow cytometry. micro RNA and CSC-related gene were analyzed by QRT-PCR. mi R-148 b was knocked-down or over-expressed by lentiviral transfection. Real time cellular analysis, soft agar assay, tumor invasion assay and tumorigenicity experiment were performed to analyze CSC-like properties. Dual luciferase assay was used to identify the target gene. Xenograft tumor model was used to test the tumorigenicity of mi R-148 b knocked-down or over-expressed tumor cells. Results: In this study, we observed that over-expression or knock-down of mi R-148 b through lentiviral transfection could affect the proportion of side population cells as well as cancer stem cell-related gene expression in hepatocellular carcinoma cell lines. In addition, mi R-148 b blocking could stimulate cell proliferation, enhance chemosensitivity,as well as increase cell metastasis and angiogenesis in vitro. More importantly, mi R-148 b could significantly suppress tumorigenicity in vivo. Further studies revealed that Neuropilin-1, a transmembrane coreceptor involved in tumor initiation, metastasis and angiogenesis, might be the direct target of micro RNA-148 b. Conclusion:Taking together, our findings define that mi R-148 b might play a critical role in maintenance of side population cells with can

关键词： microRNA-148b side population cell Neuropilin-1 hepatocellular carcinoma cancer stem cell

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液体活检和肿瘤精准医疗

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中国肿瘤生物治疗杂志 2016年第5期23卷 589-594页

作者：许扬梅郑秋红福建医科大学附属肿瘤医院福建省肿瘤医院国家临床重点肿瘤专科福建省肿瘤生物治疗重点实验室福建福州350014

精准医疗新技术——液体活检,既有极高的科研价值,又具备助力推进精准医疗临床实践的巨大潜能。它可用于癌症早期筛查、诊断、监控、治疗方案指导和疗效评估等众多领域,液体活检的优势使其成为最具发展潜力的肿瘤诊疗手段。本文围绕液... 详细信息

精准医疗新技术——液体活检,既有极高的科研价值,又具备助力推进精准医疗临床实践的巨大潜能。它可用于癌症早期筛查、诊断、监控、治疗方案指导和疗效评估等众多领域,液体活检的优势使其成为最具发展潜力的肿瘤诊疗手段。本文围绕液体活检在临床肿瘤精准医疗的应用前景,从概念、特点、研究方法和个体化肿瘤治疗、临床应用及研究现状等方面进行阐述,展示了液体活检巨大的临床应用价值和市场前景。

关键词：液体活检精准医疗循环肿瘤细胞循环肿瘤DNA 循环肿瘤干细胞

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Dendritic cell-cytokine induced killer cells infusion prolongs overall and progression-free survival rates in advanced colorectal cancer

Dendritic cell-cytokine induced killer cells infusion prolon...

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第十四届全国肿瘤生物治疗大会

作者： YunQing Xie qiuhong zheng LiJie Huang XiaoWei Lin ShiJia Liu ShanShan Chen 福建省肿瘤医院

Purpose: To evaluate the activity of dendritic cells-cytokine induced killer(DCs-CIK) cells infusion as an adjuvant therapy for colorectal carcinoma patients combined with first-line treatment. Methods: A total of 142 patients with stage III/IV colorectal carcinoma who treated with first-line therapy were studied retrospectively. Among them, 71 patients received first-line treatment, another 71 patients received DC-CIK cells infusion combined with first-line treatment. These patients were followed up until Aug. 2014. Data were analyzed by Kaplan-Meier and Cox regression. Results: Our results showed that the 5-years overall survival(OS) rate for the DC-CIK group versus non-DC-CIK group was 41.3% versus 19.4%,(P=0.001). In addition, the 5-years progression-free survival(PFS) rate was 57.4% versus 33.6%,(P= 0.022), respectively. Conclusion: DC-CIK immunotherapy combined with first-line therapy significantly prolongs 5-year OS and 5-year PFS for advanced colorectal cancer.

关键词： dendritic cells cytokine-induced killer cells adjuvant immunotherapy colorectal cancer

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可分散性纳米二氧化硅增强硅橡胶

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复合材料学报 2006年第6期23卷 57-63页

作者：刘丰郑秋红李小红丁涛张治军河南大学特种功能材料重点实验室开封475001 北京化工大学北京市新型高分子材料制备与成型加工重点实验室北京100029

采用表面经过硅烷偶联剂原位修饰的纳米二氧化硅增强硅橡胶。通过扫描电子显微镜和Payne效应考察了纳米二氧化硅在硅橡胶中的分散特性;用DSC分析了复合体系的低温结晶行为;考察了填料对硅橡胶力学性能的影响。结果表明,由于修饰后纳米... 详细信息

采用表面经过硅烷偶联剂原位修饰的纳米二氧化硅增强硅橡胶。通过扫描电子显微镜和Payne效应考察了纳米二氧化硅在硅橡胶中的分散特性;用DSC分析了复合体系的低温结晶行为;考察了填料对硅橡胶力学性能的影响。结果表明,由于修饰后纳米颗粒表面非极性有机基团的存在和表面能的降低,无须加入分散剂,纳米颗粒就能在硅橡胶中有较好的分散;在各自最优添加量时,DNS-3链状纳米二氧化硅增强的硅橡胶相对于气相法二氧化硅增强的硅橡胶在拉伸强度、撕裂强度及断裂伸长率上有显著提高;DNS-2纳米二氧化硅增强性能与气相法二氧化硅的相当,但前者混炼胶黏度较小,有较好的加工性。

关键词：纳米二氧化硅硅橡胶增强力学性能

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医院HIS的信息化建设优化策略分析

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电子技术（上海） 2022年第11期51卷 37-39页

作者：郑秋鸿福建医科大学附属第二医院福建362000

阐述医院HIS信息化建设的优化策略,运用云计算技术提升用户接入量、创建多层次的安全防御体系、构建信息交互、信息自动分类系统。

关键词：计算机工程信息化建设信息交互系统 HIS

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