检索结果-南通市图书馆

Genetically engineered M2-like macrophage-derived exosomes for ***-suppressed cementum regeneration:From mechanism to therapy

引用

Bioactive Materials 2024年第2期32卷 473-487页

作者： Xin Huang Yifei Deng Junhong Xiao Huiyi Wang qiudong yang Zhengguo Cao State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanChina Department of Periodontology School&Hospital of StomatologyWuhan UniversityWuhanChina

Cementum,a thin layer of mineralized tissue covering tooth root surface,is recognized as the golden standard in periodontal ***,current efforts mainly focus on alveolar bone regeneration rather than cementum regeneration,and rarely take Porphyromonas gingivalis(Pg),the keystone pathogen responsible for periodontal tissue destruction,into *** M2 macrophage-derived exosomes(M2-EXO)show promise in tissue regeneration,the exosome-producing M2 macrophages are induced by exogenous cytokines with transitory and unstable effects,restricting the regeneration potential of ***,exosomes derived from genetically engineered M2-like macrophages are constructed by silencing of casein kinase 2 interacting protein-1(Ckip-1),a versatile player involved in various biological ***-1 silencing is proved to be an effective gene regulation strategy to obtain permanent M2-like macrophages with mineralization-promoting ***,exosomes derived from Ckip-1-silenced macrophages(sh-Ckip-1-EXO)rescue Pg-suppressed cementoblast mineralization and ***,sh-Ckip-1-EXO delivers Let-7f-5p targeting and silencing Ckip-1,a negative regulator also for cementum formation and cementoblast *** deeply,downregulation of Ckip-1 in cementoblasts by exosomal Let-7f-5p activates PGC-1α-dependent mitochondrial *** all,this study provides a new strategy of genetically engineered M2-like macrophage-derived exosomes for cementum regeneration under Pg-dominated inflammation.

关键词： Casein kinase 2 interacting protein-1 M2 macrophage Exosome Cementum regeneration Porphyromonas gingivalis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gas Microsensors Based on Polymer-Carbon Black Composites

Gas Microsensors Based on Polymer-Carbon Black Composites

引用

2004 7th International Conference on Solid-State and Integrated Circuits Technology（ICSICT 2004）

作者： qiudong yang~([a]) Haifen Xie~([a b]) Xiaoxiang Sun~([a]) Yiping Huang~([a]*) ASIC and System State Key Lab Department of Microelectronics Fudan University Handan Road 220 Shanghai 200433 [b]Department of Physics East China University of Science and Technology Xuefu Road 1000 Jinshan District Shanghai

＜正＞In this paper,we describe a novel chemical gas sensor arrays based on polymer-carbon black *** four different polymers which are poly（4-vinyl phenol）, poly（ethylene oxide）,polycapraclactone（PCL）and polyethylene-co-vinylacetate（PEVA）are employed as the sensing materials which are immobilized on the array of the interdigitated microelectrode *** resistance changes of sensors to four organic gases （acetone,ethanol,toluene and methanol）at 500ppm concentration have been *** principle component analysis of responses of micro-sensors,it is clear that four kinds of the same concentration different gases can be easily *** some gases such as ethanol and acetone are detected using the sensing membrane of poly（4-vinyl phenol）and poly（ethylene oxide）,the relationship between the resistance changes and gas concentration in the range from 300ppm to 1500ppm can be approximated to a straight line.

关键词： micro-sensors gas sensors polymer carbon black

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Novel Gas Sensor Based on Nano-zeolite Films for the Nerve agent simulant Dimethylmethylphosphonate detection

Novel Gas Sensor Based on Nano-zeolite Films for the Nerve a...

引用

2004 7th International Conference on Solid-State and Integrated Circuits Technology（ICSICT 2004）

作者： Haifen Xie~(a,b) Xiao Xiang Sun~a qiudong yang~a Jianye Wang~a Yiping Huang~(a*) aASIC and System State Key Lab,Department of Microelectronics,220 Handan Road,Shanghai,China,200433 bPhysics department of East China University of Science and Technolegy,Jinshan campuse 1000 Xuefu Road,Shanghai, China,201512

A novel gas sensor based on nanosized zeolite for the detection of nerve agent simulant gas Dimethylmethylphosphonate(DMMP)is developed in this *** ZSM-5 zeolite films and Ag modified ZSM-5 zeolites films as a novel sensing membrane materials are immobilized on the piezoelectric sensor device QCM(Quartz Crystal Microbalance).A frequency shift with different concentrations of DMMP is *** gas sensor based on nanosized zeolite in resonating mode,whose resonant frequency shifts due to mass loading,has shown high sensitivity for detecting *** minimum detection concentration of DMMP is 1ppm in the N at *** frequency shift is about 60H for lppm *** order to improve the selectivity of the sensor to the DMMP from other organic gases,different pore size zeolite films such as ZSM-5 zeolites and Ag modified ZSM-5 zeolites are studied. The frequency shifts to another two organic gases such as acetone and ethanol at lppm concentration are observed for the sensor selectivity *** relationship between frequency shift and temperature for lppm DMMP has been *** best adsorption temperature is 303K and the desorption temperature is at the DMMP boiling point,*** principle component analysis(PCA);we can easily qualify and quantify the DMMP gas.

关键词： Zeolite QCM DMMP Gas sensor PCA

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Parametric equations for notch stress concentration factors of rib—deck welds under bending loading

引用

Frontiers of Structural and Civil Engineering 2021年第3期15卷 595-608页

作者： qiudong WANG Bohai JI Zhongqiu FU Yue YAO College of Civil and Transportation Engineering Hohai UniversityNanjing210098China

The effective notch stress approach for evaluating the fatigue strength of rib-deck welds requires notch stress concentration factors obtained from complex finite element *** improve the efficiency of the approach,the notch stress concentration factors for three typical fatigue-cracking modes(i.e.,root-toe,root-deck,and toe-deck cracking modes)were thoroughly investigated in this ***,we developed a model for investigating the effective notch stress in rib-deck ***,we performed a parametric analysis to investigate the effects of multiple geometric parameters of a rib-deck weld on the notch stress concentration *** this basis,the multiple linear stepwise regression analysis was performed to obtain the optimal regression functions for predicting the notch stress concentration ***,we employed the proposed formulas in a case *** notch stress concentration factors estimated from the developed formulas show agree well with the finite element analysis *** results of the case study demonstrate the feasibility and reliability of the proposed *** also shows that the fatigue design curve of FAT225 seems to be conservative for evaluating the fatigue strength of rib-deck welds.

关键词： notch stress concentration factor rib—deck weld parametric analysis regression analysis parametric equation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Climate-driven acceleration of glacier mass loss on global and regional scales during 1961–2016

引用

Science China Earth Sciences 2021年第4期64卷 589-599页

作者： Yaojun LI Yongjian DING Donghui SHANGGUAN Fengjing LIU qiudong ZHAO Slate Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Key Laboratory of Ecohydrology of Inland River Basin Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China China-Pakislan Joint Research Center on Earth Sciences CAS-HECIslamabad 45320Pakistan School of Forest Resources and Environmental Science.Michigan Technological University Houghton M149931USA

During the past decades, glacier mass loss is becoming increasingly significant worldwide but knowledge about the acceleration is still limited despite its potentially profound impacts on sea level rise, water resources availability and glacial hazards. In this study, we analyzed the acceleration of glacier mass loss based on in-situ measurements and on the latest compilation dataset of direct and geodetic observations for the period 1961–2016. The results showed that the rate of glacier mass loss has increased worldwide during the past decades. At the global scale, the rate of glacier mass loss has been accelerating at 5.76±1.35 Gt a-2 as well as 0.0074±0.0016 m w.e.a-2 on mass balance(refer to the area-averaged mass change value) during the whole period. At regional scales, for mass change rate, the heavily glacierized regions excluding Antarctic and Subantarctic exhibited a larger acceleration compared to other regions. The highest acceleration of mass change was found in Alaska glaciers(1.33±0.47 Gt a-2) over the full period. As for mass balance, high acceleration occurred on the regions with small glaciers as well as on the heavily glacierized regions. Central Europe exhibited the highest acceleration(0.024±0.0088 m w.e.a-2) during 1961–2016. High level of consistency between the acceleration and temperature implies that climate warming had a significant effect on the accelerating of glacier mass loss. Moreover, acceleration of the contribution from the Greenland ice sheet(0.028 to0.070 mm a-2) and Antarctic ice sheet(0.023 to 0.058 mm a-2) to sea level rise exceeds acceleration of the contribution from global glaciers(0.019±0.013 mm a-2). These results will improve our understanding of the glacier retreat in response to climate change and provide critical information for improving mitigation strategies for impacts that may be caused by glacier melting.

关键词： Glaciers Mass loss Acceleration Climate warming

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

高速12位D/A转换器

引用

Journal of Semiconductors 2006年第Z1期27卷 365-369页

作者：李荣强刘道广严刚何开全刘玉奎谭开州张静杨秋冬钟怡舒曼徐婉静徐世六国家模拟集成电路重点实验室重庆400060 中国电子科技集团公司第24研究所重庆400060 清华大学微电子学研究所北京100084

介绍了高速12位D/A转换器的电路设计,采用2μm等平面高速双极工艺,研制出数据更新率≥80MHz,线性误差≤3LSB,微分非线性≤3LSB的12位D/A转换器电路.

关键词： D/A转换器线性误差数据更新率

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于BiCMOS技术的高速数字/模拟转换器

引用

Journal of Semiconductors 2006年第Z1期27卷 271-274页

作者：刘道广李荣强石建刚何开全刘玉奎谭开州张静杨秋冬钟怡舒曼徐婉静徐世六清华大学微电子学研究所北京100084 国家模拟集成电路重点实验室重庆400060 中国电子科技集团电子24所重庆400060

基于BiCMOS技术,进行了高速数字/模拟转换器研究.以并行输入类型,电流工作模式的16位D/A转换器为载体,进行了电路设计、工艺制作和测试.在±5.0V工作电压下,测试得到转换速率≥30MSPS,建立时间为50ns,增益误差为±8%FSR,积分非线性误差... 详细信息

基于BiCMOS技术,进行了高速数字/模拟转换器研究.以并行输入类型,电流工作模式的16位D/A转换器为载体,进行了电路设计、工艺制作和测试.在±5.0V工作电压下,测试得到转换速率≥30MSPS,建立时间为50ns,增益误差为±8%FSR,积分非线性误差为1/2 LSB,功耗为500mW.

关键词：数字/模拟混合电路双极Bi/CMOS兼容工艺 D/A转换器

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Estimation of water balance in the source region of the Yellow River based on GRACE satellite data

引用

Journal of Arid Land 2013年第3期5卷 384-395页

作者： Min XU BaiSheng YE qiudong ZHAO ShiQing ZHANG Jiang WANG State Key Laboratory of Cryospheric Science Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of Sciences Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences

Water storage has important significance for understanding water cycles of global and local domains and for monitoring climate and environmental changes. As a key variable in hydrology, water storage change represents the sum of precipitation, evaporation, surface runoff, soil water and groundwater exchanges. Water storage change data during the period of 2003-2008 for the source region of the Yellow River were collected from Gravity Recovery and Climate Experiment （GRACE） satellite data. The monthly actual evaporation was estimated according to the water balance equation. The simulated actual evaporation was significantly consistent and correlative with not only the observed pan （20 cm） data, but also the simulated results of the version 2 of Simple Biosphere model. The average annual evaporation of the Tangnaihai Basin was 506.4 mm, where evaporation in spring, summer, autumn and winter was 130.9 mm, 275.2 mm, 74.3 mm and 26.1 mm, and accounted for 25.8%, 54.3%, 14.7% and 5.2% of the average annual evaporation, respectively, The precipitation increased slightly and the actual evaporation showed an obvious decrease. The water storage change of the source region of the Yellow River displayed an increase of 0.51 mm per month from 2003 to 2008, which indicated that the storage capacity has significantly increased, probably caused by the degradation of permafrost and the increase of the thickness of active layers. The decline of actual evaporation and the increase of water storage capacity resulted in the increase of river runoff.

关键词： actual evaporation GRACE satellite data water storage change water balance equation source region of the Yellow River

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Applications of Cubic MgZnO Thin Films in Metal-Insulator-Silicon Structures

引用

Chinese Physics Letters 2004年第6期21卷 1135-1138页

作者： LIANGJun WUHui-Zhen LAOYan-Feng qiudong-Jiang CHENNai-Bo XUTian-Ning StateKeyLaboratoryofFunctionalMaterialsforInformatics ShanghaiInstituteofMicrosystemandInformationTechnologyChineseAcademyofSciencesShanghai200050 DepartmentofPhysics ZhejiangUniversityHangzhou310027

Cubic Mg0.55Zn0.45O thin film alloys have been deposited on Si substrates at low growth temperature. The topography of the cross section of the epitaxial film by scanning electronic microscope demonstrates good morphology and high interfacial quality. The high (001) orientation and wide band-gap (Eg>5.5eV) of the cubic Mg0.55Zn0.45O thin films accord with the guidelines for metal–insulator–silicon (MIS) device applications. Using the cubic ternary thin films as insulators, MIS structures have been fabricated. The capacitance–voltage measurements show the flat band voltage shift VFB of 11.8V and mobile ion density Dmc of 5.57×1010cm−2 for the MIS structure. Leakage current density as low as ~10−7A/cm2 is obtained at E = 700kV/cm by the current–voltage measurements. These unique structural and electrical properties of the fabricated MIS devices indicate that cubic MgZnO materials could become a new candidate for high-κ dielectrics used in silicon integrated circuit technologies.

关键词： Thin films

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anodic-Aluminium-Oxide Template-Assisted Growth of ZnO Nanodots on Si （100） at Low Temperature

引用

Chinese Physics Letters 2004年第7期21卷 1327-1329页

作者： XUTian-Ning WUHui-Zhen LAOYan-Feng qiudong-Jiang CHENNai-Bo DAINing DepartmentofPhysics ZhejiangUniversityHangzhou310028 StateKeyLaboratoryofFunctionalMaterialsforInformatics ShanghaiInstituteofMicrosystemandInformationTechnologyChineseAcademyofSciencesShanghai200050 StateKeyLaboratoryforInfraredPhysics ShanghaiInstituteofTechnicalPhysicsChineseAcademyofSciencesShanghai200083

ZnO nanodots have been grown on Si (100) assisted by anodic aluminium oxide (AAO) template at low temperature (350 degrees C). Regular arrangement to a certain extent in local for ZnO nanodots is observed, and the average diameter of nanodots is about 9.7nm. Photoluminescence studies at room temperature for photon energy between 2.0 and 3.6eV reveal a strong single exciton peak at 3.274eV (378.8nm) with the green emission fully quenched. Narrow full width at half maximum (FWHM) of the UV emission band (0.14eV) suggests the as-grown ZnO nanodots have a narrow size distribution.

关键词： Nanodots

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：